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JSFK (Jurnal Sains Farmasi & Klinis)
Published by Universitas Andalas
ISSN : 24077062     EISSN : 24425435     DOI : 10.25077
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Sains Farmasi & Klinis (J Sains Farm Klin) adalah jurnal ilmiah di bidang kefarmasian yang diterbitkan oleh Fakultas Farmasi Universitas Andalas bekerjasama dengan lembaga profesi "Ikatan Apoteker Indonesia" (IAI) daerah Sumatera Barat sejak tahun 2014.
Arjuna Subject : -
Articles 509 Documents
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Hubungan Ketepatan Switch Therapy Terhadap Kesembuhan Luka, Lama Rawatan dan Biaya Pengobatan Antibiotik Pasien Appendisitis Lathvi Masyithah; Armenia Armenia; Almahdy Almahdy
Jurnal Sains Farmasi & Klinis Vol 2, No 2 (2016): J Sains Farm Klin 2(2), Mei 2016
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (249.302 KB) | DOI: 10.29208/jsfk.2016.2.2.69

Abstract

Antibiotic Switch therapy is defined by the switch of intravenous antibiotic therapy to oral form. This research aimed to learn about the relationship of switch therapy toward the value of wound healing, lenght of stay and the antibiotic expenditure. The data of this cross sectional study was collected from medical record and by direct investigation to patients for their macroscopis the wound healings value. T-test was used to compared the relationship of the patient wound healings value, lenght of stay and the antibiotic expenditure between the those with and accurate switch therapy and those without it. The result showed that there was no different of wound healing value between those groups of patients (P>0,1). On the other hand, lenght of stay and antibiotic expenditure of the patient with the accurate switch therapy was cuted on the patient with the accurate switch therapy. These indicated that accuracy of switch therapy will proceed a benefit outcome to the patient with appendicitis, especially to there lenght of stay and antibiotic expenditure as well.
Development and Validation of Loperamide Hydrochloride Tablet Analysis Method with Absorbance and Area under Curve Methods Spectrophotometrically Harrizul Rivai; Renny Puspita; Sesry Misfadhila
Jurnal Sains Farmasi & Klinis Vol 5, No 2 (2018): J Sains Farm Klin 5(2), Agustus 2018
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (456.428 KB) | DOI: 10.25077/jsfk.5.2.94-101.2018

Abstract

Development and validation of loperamide hydrochloride tablet method of analysis with absorbance method and area under the curve method have been done. This study used methanol and hydrochloric acid 0.1 N (9: 1) as the best solvent with maximum absorption at wavelength 259.00 nm. Linearity of loperamide hydrochloride was obtained in the concentration range 200-600 ppm with correlation coefficient value with absorbance method and the areas under the curve method were 0.9998 and 0.9865, respectively. The results showed that the levels of loperamide hydrochloride in generic tablets obtained by absorbance method and the area under the curve method were 105.71% and 96.20%, respectively. The results of determination of loperamide levels in tablets of trademark obtained by absorbance method and the area under the curve method were 102.85% and 98.57%, respectively. The level of both samples met the requirements of Pharmacopoeia Indonesia edition V that is 90% -110%.
Pengaruh Pemberian Vanadil Sulfat dan Kromium (III) Klorida terhadap Fungsi Ginjal Mencit Putih Diabetes Dwisari Dillasamola; Surya Dharma; Helmi Arifin
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (346.715 KB) | DOI: 10.29208/jsfk.2014.1.1.14

Abstract

The objective of this study was to identify the effect of two heavy metals, vanadyl sulphate and chromium (III) chloride on creatinine level of hyperglycemic mice induced by dexamethasone 11mg/kg. The experimental animals were grouped into five groups comprised of 5 white mice. Group I was used as control group, only received standard feeding and food supplement. Group II-V were induced with dexamethasone 11mg/kg to increase the blood glucose level. Group III was also given chromium (III) chloride 5.2 ug/20g. Group IV was also given vanadyl sulphate at the dose of 0.78 mg/20g. Group V received combination of vanadyl sulphate 0.39 mg/20g and chromium (III) chloride 2.6 ug/20g. The level of blood creatininewas determined by enzymatic method conducted for 42 days and observations were taken at day 7, 21 and 42. This study concluded that administration of vanadyl sulphate and chromium (III) chloride combination significantly reduced blood creatinine level of white mice (p<0,05).
Studi Penggunaan Antipsikotik dan Efek Samping pada Pasien Skizofrenia di Rumah Sakit Jiwa Sambang Lihum Kalimantan Selatan Mawar Dwi Yulianty; Noor Cahaya; Valentina Meta Srikartika
Jurnal Sains Farmasi & Klinis Vol 3, No 2 (2017): J Sains Farm Klin 3(2), Mei 2017
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (320.623 KB) | DOI: 10.29208/jsfk.2017.3.2.108

Abstract

Based on RISKESDAS 2013, schizophrenia prevalence in South Kalimantan is 1.4 per one thousand population. The main therapy for schizophrenia is anti-psychotic medication. A variety of side effects arise from the use of antipsychotic drugs including extrapyramidal syndrome and metabolic syndrome. The aim of the study was to evaluate the prescription pattern and side effects of antipsychotic drugs in patients with schizophrenia at Sambang Lihum Psychiatric Hospital, South Kalimantan, Indonesia. The type of this study was non-experimental observation with prospective data collection. Population in this study was all of the schizophrenia inpatients in February 2016 who met the inclusion criteria. The data were collected from 59 patients. The results showed that anti-psychotics combination therapy was the most widely used medications (90.6%), in which the combination of haloperidol-clozapine was the most frequent one (26.04%). The side effects commonly observed were extrapyramidal syndrome (98.3%); orthostatic hypotension (86,4%); anticholinergic effect (76.3%); sedation (44.1%); nausea / vomiting (27.1%); diarrhea (27.1%); insomnia (16.9%); loss of appetite (10.2%); red-itchy rashes (6.8%); anorexia (5.1%); frequent urination (5.1%); decreased consciousness (1.7%), shortness of breath and cough (1.7%); impairment of Hb (1.7%); increase in AST (1.7%); increase in ALT (1.7%); and foaming from nose (1.7%).
Pengaruh Pemberian Sari Wortel (Daucus carota L.) terhadap Tukak Lambung Pada Tikus Putih Jantan Suhatri Suhatri; Rusdi Rusdi; Emi Sugesti
Jurnal Sains Farmasi & Klinis Vol 2, No 1 (2015): J Sains Farm Klin 2(1), November 2015
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1708.814 KB) | DOI: 10.29208/jsfk.2015.2.1.56

Abstract

A study on the effect of carrot decoction to the gastric ulcer of white male rats induced by absolute ethanol 1 ml/200 g orally has been conducted. The study showed that carrot decoction in the doses of 3; 6; and 12 ml/kg could improve the ulcer by amount of 28.41; 46.79; and 75.76 %, respectively. The decoction could also reduce the pH of gastric juice significantly toward the normal level (P<0.01).
Pengaruh Brief Counseling Terhadap Konsumsi Lemak Pada Pasien Hipertensi di RSUD dr. H. Moch Ansari Saleh Banjarmasin Saftia Aryzki; Akrom Akrom
Jurnal Sains Farmasi & Klinis Vol 5, No 1 (2018): J Sains Farm Klin 5(1), April 2018
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (471.056 KB) | DOI: 10.25077/jsfk.5.1.33-40.2018

Abstract

Perilaku pasien dengan asupan lemak tinggi yang dapat menyebabkan tidak tercapainya tujuan terapi sehingga terjadi penurunan kualitas hidup pasien hipertensi. Penelitian bertujuan untuk mengetahui pengaruh brief counseling-5A terhadap asupan lemak pada pasien hipertensi rawat jalan di RSUD H. Moch.Ansari Saleh Banjarmasin. Penelitian ini merupakan studi kuasi-eksperimental dengan menggunakan two group pretest and postest dengan pengambilan data secara prospektif. Subjek yang memenuhi kriteria inklusi sejumlah 68 pasien menjadi dua kelompok yaitu 34 pasien intervensi dan 34 pasien tidak intervensi. Kriteria eksklusi adalah pasien dengan kondisi hamil, tuli dan tidak hadir pada kunjungan berikutnya. Pengumpulan data dilakukan dengan melakukan wawancara dan pengisian kuesioner tingkat perilaku berobat, kuesioner Food Frequency Questionnaire (FFQ). Hasil penelitian menunjukan bahwa pemberian brief counseling-5A dapat merubah perilaku pasien terhadap asupan lemak pada pasien kelompok perlakuan mengalami perubahan secara signifikan dengan rata-rata nilai peningkatan Δ1= -33,52±24,57 dan p=0,985, pada Δ2=-15,94±17,11 dan p=0,053. Disimpulkan bahwa brief counseling-5A pasien hipertensi secara positif dapat merubah perilaku pasien dalam asupan lemak pasien hipertensi.
Gambaran Tenaga Kefarmasian Dalam Memberikan Informasi Kepada Pelaku Swamedikasi di Apotek-Apotek Kecamatan Tampan, Pekanbaru Septi Muharni; Fina Aryani; Maysharah Mizanni
Jurnal Sains Farmasi & Klinis Vol 2, No 1 (2015): J Sains Farm Klin 2(1), November 2015
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (318.817 KB) | DOI: 10.29208/jsfk.2015.2.1.46

Abstract

The performance of all pharmacist staff including pharmacist, pharmacist assistance and pharmacist technician in drug information service towards self medication patient affect the therapeutic success. Self medication is the way of therapy with drug medication which drugs can be obtained at pharmacy without needing doctor’s prescription. The research aims to evaluate the description of drug information service given by all pharmacist staff on self medication of tooth pain patient at the pharmacy located around Kecamatan Tampan, Pekanbaru. It was conducted using cross sectional planning survey by participative observational method. 30 pharmacist staffs who give mefenamic acid as tooth pain drug were selected as respondent. The assessment was done using Likert scale. The result showed that drug information service given by all pharmacist staffs was in good scale (63.10%) and still conducting passively or they gave drug information if only the patient asked. The detail result demonstrated that 63.20% of pharmacist afforded adequate scale of drug information service, the pharmacist assistant gave 60% of adequate scale, while the pharmacist technician exhibited 63.80% good scale. The route of drug usage was the most common information with very good category (85.33%).
Interaksi Ekstrak Sambiloto (Andrographis paniculata (Burm.F.)Ness) dengan Glibenklamid terhadap Ekspresi Gen CYP3A4 pada Kultur Sel HepG2 Andzar Fikranus Shofa; Anny Victor Purba; Siswa Setyahadi
Jurnal Sains Farmasi & Klinis Vol 4, No 1 (2017): J Sains Farm Klin 4(1), November 2017
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (547.302 KB) | DOI: 10.29208/jsfk.2017.4.1.189

Abstract

Diabetes melitus (DM) merupakan salah satu penyakit metabolik kronis yang ditandai dengan hiperglikemia. Berbagai terapi dilakukan untuk mengatasi hiperglikemia, baik dengan menggunakan obat antidiabetes oral maupun tanaman herbal berkhasiat antidiabetes. Sambiloto (Andrographis paniculata (Burm.F.)Nees) merupakan salah satu herbal antidiabetes yang banyak dikonsumsi masyarakat Indonesia. Andrografolida merupakan zat aktif yang terdapat dalam sambiloto yang berperan sebagai agen antidiabetes. Namun, dalam banyak kasus kombinasi antara herbal dan obat sintesis menyebabkan interaksi jika digunakan pada waktu bersamaan. Penelitian ini bertujuan untuk memperoleh data interaksi ekstrak etanol herba sambiloto dengan glibenklamid terhadap ekspresi gen CYP3A4 pada kultur sel HepG2. Hasil penelitian ini menunjukkan bahwa terjadi penurunan ekspresi gen CYP3A4 pada pengujian sampel tunggal maupun kombinasi antara ekstrak etanol herba sambiloto dan glibenklamid dengan bertambahnya konsentrasi. Pada konsentrasi 50 dan 100 μg/mL sambiloto, glibenklamid, dan kombinasinya menyebabkan penurunan ekspresi gen CYP3A4 sekitar 0,82, 0,70; 0,89, 0,53; 0,84, 0,72. Berdasarkan hasil tersebut dapat disimpulkan terjadi penurunan ekspresi gen CYP3A4 dengan bertambahnya konsentrasi sampel.
Formulasi Tablet Lepas Lambat Natrium Diklofenak Menggunakan Pati Pisang Kepok (Musa balbisiana L) Sebagai Matriks Deni Anggraini; Anita Lukman; Ria Mulyani
Jurnal Sains Farmasi & Klinis Vol 3, No 1 (2016): J Sains Farm Klin 3(1), November 2016
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (254.152 KB) | DOI: 10.29208/jsfk.2016.3.1.93

Abstract

Telah dilakukan formulasi tablet lepas lambat Natrium Diklofenak menggunakan matriks pati pisang kepok dan natrium karboksil metil selulosa sebagai pembandingnya. Tujuan penelitian ini untuk mengetahui apakah sediaan lepas lambat yang dibuat dengan matriks pati pisang kepok memenuhi persyaratan tablet lepas lambat. Hasil uji disolusi menunjukan formula I (Pati Pisang Kepok) terdisolusi sebesar 110,24 %, formula II (Natrium Karboksil Metil Selulosa) sebesar 39,04 % dalam waktu 8 jam. Dari hasil uji disolusi menunjukan bahwa pati pisang kepok belum memenuhi persyaratan sebagai matriks karena belum dapat memperlambat laju disolusi. Kinetika pelepasan zat aktif dari matriks antara kedua formula mengikuti persamaan Higuchi.
Pembentukan Sistem Dispersi Padat Amorf Azitromisin Dihidrat dengan Hikroksipropil Metilselulosa (HPMC) Erizal Zaini; Netty Novitasari; Maria Dona Octavia
Jurnal Sains Farmasi & Klinis Vol 3, No 2 (2017): J Sains Farm Klin 3(2), Mei 2017
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (575.168 KB) | DOI: 10.29208/jsfk.2017.3.2.140

Abstract

The aim of present study is to develop solid dispersion system of azithromycin dihydrate with hydroxypropyl methylcellulose E5 LV (HPMC) for improving the dissolution rate of azithromycin dihydrate. Amorphous solid dispersions were prepared by solvent method at 1:1; 1:2 and 2:1 (w/w) drug to polymer ratios. Solid state properties of amorphous solid dispersion were evaluated by X-ray powder diffraction (XRPD), scanning electron microscopy and spectroscopy FT-IR. Furthermore, the dissolution rate profile was investigated by type II USP dissolution apparatus. Based on X-ray powder diffractometry analysis, azithromycin dihydrate was transformed partially from the crystalline phase to the amorphous state as confirmed by significant reduction of the crystalline peaks intensity. FT-IR spectroscopy analysis revealed the absence of chemical interaction between azithromycin dihydrate and HPMC. The dissolution rate of azithromycin dihydrate from amorphous solid dispersion was substantially higher than azithromycin dihydrate intact and its physical mixture. The dissolution rate of azithromycin dihydrate increased with an increasing drug to polymer ratio.

Page 10 of 51 | Total Record : 509

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