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JSFK (Jurnal Sains Farmasi & Klinis)
Published by Universitas Andalas
ISSN : 24077062     EISSN : 24425435     DOI : 10.25077
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Sains Farmasi & Klinis (J Sains Farm Klin) adalah jurnal ilmiah di bidang kefarmasian yang diterbitkan oleh Fakultas Farmasi Universitas Andalas bekerjasama dengan lembaga profesi "Ikatan Apoteker Indonesia" (IAI) daerah Sumatera Barat sejak tahun 2014.
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Articles 509 Documents
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Pengaruh Kehadiran Apoteker Terhadap Pelayanan Kefarmasian di Apotek di Kota Padang Dwi Dominica; Deddi Prima Putra; Yulihasri Yulihasri
Jurnal Sains Farmasi & Klinis Vol 3, No 1 (2016): J Sains Farm Klin 3(1), November 2016
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (281.738 KB) | DOI: 10.29208/jsfk.2016.3.1.106

Abstract

Standard pharmacy services is measure used especially in implementing pharmacist pharmacy services. This study examines effect of presence of Pharmacists to pharmacy services, is crosssectional study using questionnaires in February - August2015. The research sample 90 Pharmacists in pharmacies taken random. results Showed the percentage of the presence of the pharmacist in the pharmacy Padang city 58.67% and Pharmaceutical Services Categorized less (inspection recipe 57.06%, 55.12% prescription preparation, and delivery prescriptions 51.89%) with average percentage 54,69%. Linear regression analysis of test results can be known effect X on Y positive. Testing shows the product moment correlation coefficient X to Y Strong where: r=0.910, in testing the coefficient of determination shows X higher influence on Y equal to 82.8% and 17.2% influenced other factors. Based on the F test 422,579 with significance of 0.000. Due significant levels <0.05, can concluded that the presence of Pharmacists have influence on Pharmaceutical Services.
Persepsi dan Kecenderungan Keterlibatan Apoteker di Apotek pada Proses Rekonsiliasi Obat Eko Setiawan; Sylvi Irawati; Bobby Presley; Susilo Ari Wardhani
Jurnal Sains Farmasi & Klinis Vol 2, No 1 (2015): J Sains Farm Klin 2(1), November 2015
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (363.371 KB) | DOI: 10.29208/jsfk.2015.2.1.55

Abstract

The objective of this study was to gain insight into the perception and the likelihood to practice medication reconciliation among pharmacists working at the apotek. Two guiding questions were given to each participant and participants were asked to write the answer on the paper. Thematic analysis was used to analyse the data. There were 31 pharmacists involved in this study. All of participants perceived that medication reconciliation was important to be implemented. Almost all of participants (i.e 30 from 31 pharmacists) clearly stated that they would like to implement medication reconciliation. And, there were 3 themes found as the main motivation factors in implementing the medication reconciliation. Pharmacists who were working at the apotek had a good perception about medication reconciliation and also showed the likelihood to implement medication reconciliation. Further research need to be conducted in order to explore the barriers in implementing medication reconciliation.
Karakterisasi dan Studi Aktivitas Antioksidan dari Ekstrak Etanol Secang (Caesalpinia sappan L.) Febriyenti Febriyenti; Netty Suharti; Henny Lucida; Elidahanum Husni; Olivia Sedona
Jurnal Sains Farmasi & Klinis Vol 5, No 1 (2018): J Sains Farm Klin 5(1), April 2018
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (511.73 KB) | DOI: 10.25077/jsfk.5.1.23-27.2018

Abstract

Secang (Caesalpinia sappan L.) secara tradisional digunakan untuk mengobati berbagai penyakit. Secang mengandung senyawa fenolik seperti asam gallat, brazilin dan brazilein. Tujuan penelitian ini adalah untuk mengkarakterisasi simplisia dan ekstrak etanol secang, mengevaluasi kandungan fenolik total dan menentukan aktivitas antioksidan ekstrak etanol secang. Karakterisasi simplisia secang diperoleh susut pengeringan sebesar 10,349 %, kadar sari larut air sebesar 3,293 %, kadar sari larut etanol sebesar 6,026 %, kadar abu total sebesar 0,6509 % dan kadar abu tidak larut asam simplisia adalah sebesar 0,480 %. Karakterisasi ekstrak etanol secang diperoleh kadar abu total sebesar 1,26 %, kadar abu tidak larut asam ekstrak sebesar 0,059 %, kadar air ekstrak didapatkan hasil 8,63 %. Kadar fenolik total ekstrak etanol secang adalah 71,144 g/100g. Semakin tinggi kadar fenolik total, maka semakin tinggi pula aktivitas antioksidannya. Aktivitas antioksidan ekstrak etanol secang ditentukan dengan metode FRAP (Ferric Reducing Antioxidant Power) dan hasilnya adalah 13,99 mmol Fe(II)/100g.
Karakterisasi Fisikokimia Sistem Biner Siprofloksasin HCl – PEG 4000 Resva Meinisasti; Auzal Halim; Erizal Zaini
Jurnal Sains Farmasi & Klinis Vol 2, No 1 (2015): J Sains Farm Klin 2(1), November 2015
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (995.186 KB) | DOI: 10.29208/jsfk.2015.2.1.45

Abstract

"Physicochemical Characterization of Binary Systems Ciprofloxacin HCl - PEG 4000" has been reseach. This study aimed to characterize ciprofloxacin HCl formula that was developed to 9, with a comparison between ciprofloxacin - PEG 4000 following formula I (1: 9), formula II (2: 8), formula III (3: 7), formula IV (4: 6), formula V (5: 5), formula VI (6: 4), formula VII (7: 3), formula VIII (8: 2) and formula IX (9: 1). Binary system made by the manufacture of solid dispersion by melting method. The results of the binary System were characterized by analysis Differential Thermal Analysis (DTA), X-ray diffraction, IR spectrophotometry, and Scanning Electron Microscope (SEM). The results of this analysis have results of the binary solid dispersion systems a good formula this VII.
Peningkatan Laju Disolusi Dispersi Padat Amorf Genistein dengan PVP K-30 Erizal Zaini; Vike Zulia Putri; Maria Dona Octavia; Friardi Ismed
Jurnal Sains Farmasi & Klinis Vol 4, No 1 (2017): J Sains Farm Klin 4(1), November 2017
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1102.522 KB) | DOI: 10.29208/jsfk.2017.4.1.197

Abstract

Amorphous solid dispersions of a poorly water-soluble drug genistein in PVP K-30 were prepared by solvent co-evaporation technique using organic solvent methanol. Solid dispersions system was prepared with several variations of drug to polymer 2:1, 1:1 dan 1:2 w/w. Solid state properties of solid dispersion system were evaluated by powder X-ray diffraction, Fourier transform infrared spectroscopy, and differential scanning calorimetry, and microscopic SEM. Dissolution rate profile were conducted in distilled water medium by using dissolution tester apparatus type II USP. Base on X-ray diffractometry analysis, differential scanning calorimetry and microscopic SEM, crystalline phase of genistein decreased in crystallinity index and formation of amophous state. Dissolution rate profile showed that genistein in amorphous solid dispersion had a faster dissolution rate in comparison to intact genistein. This study proved that preparation of solid dispersion of genistein in PVP K-30 is an effective approach to improve dissolution rate of genistein.
Aktivitas Antioksidan dan Tabir Surya Ekstrak Etanol Daun Stroberi (Fragaria x ananassa A.N. Duchesne) Widyastuti Widyastuti; Ariya Eka Kusuma; Nurlaili Nurlaili; Fitriani Sukmawati
Jurnal Sains Farmasi & Klinis Vol 3, No 1 (2016): J Sains Farm Klin 3(1), November 2016
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.528 KB) | DOI: 10.29208/jsfk.2016.3.1.92

Abstract

Ekstrak buah stroberi mengandung senyawa polifenol yang mempunyai aktivitas antioksidan dan dapat menghambat pertumbuhan sel kanker. Pada penelitian ini dicoba untuk melihat aktivitas dari daun stroberi (Fragaria x ananassa A.N. Duchesne) apakah juga mempunyai aktivitas antioksidan dan tabir surya. Pengujian antioksidan menggunakan metode DPPH dengan pembanding vitamin C. Dari hasil penelitian didapatkan nilai IC50 ekstrak etanol daun stroberi sebesar 363,551 ppm dan untuk vitamin C sebesar 33,573 ppm. Pada pengujian aktivitas sebagai tabir surya menggunakan metode spektrofotometri dimana ekstrak etanol daun stroberi mempunyai nilai SPF diatas 15 pada konsentrasi 175 ppm, yaitu sebesar 20,090 dengan persentase eritema sebesar 5,496 dan persentase pigmentasi sebesar 5,074. Dari hasil penelitian dapat disimpulkan ekstrak etanol daun stroberi mempunyai aktivitas antioksidan dan tabir surya.
Kajian Deskriptif Retrospektif Regimen Dosis Antibiotik Pasien Pneumonia Anak di RSUP. Dr. M. Djamil Padang Dian Ayu Juwita; Helmi Arifin; Nelfa Yulianti
Jurnal Sains Farmasi & Klinis Vol 3, No 2 (2017): J Sains Farm Klin 3(2), Mei 2017
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (242.909 KB) | DOI: 10.29208/jsfk.2017.3.2.115

Abstract

Pneumonia is one of acute respiratory tract infection which a major causes mortality in children and infant. The role of antibiotics in reducing morbidity and mortality this infectious disease is still dominant. Improper use of antibiotics can lead to the development of bacteria resistant to antibiotics and the occurrence of toxicity/side effects of drugs. The objective of this study was to determine the appropriateness of dosage regimen of antibiotics in children with pneumonia compared to standard literature. The study was conducted by retrospective descriptive analysis, using medical records of children with pneumonia during 2013. The results showed inappropriateness in several dosage regimen of antibiotics, such as chloramphenicol (5%), meropenem (50%), erythromycin (100%), azithromycin (100%), ceftazidime (100%), clindamycin (100%), ampicillin (100%) and gentamicin (100%). The inappropriateness of frequency of administration (administration interval) was also found in ampicillin (50%), gentamicin (20%), and cefotaxime (100%). The inappropriateness of dosage duration was found in amoxicillin (44.45%), chloramphenicol (45%), gentamicin (70%), meropenem (33.34%), ceftriaxone (66.67%), ampicillin (50%), cefotaxime (100%). While the route of administration of antibiotics was 100% appropriate.
Pola Penggunaan Antibiotik Profilaksis pada Pasien Bedah Caesar (Sectio Caesarea) di Rumah Sakit Pekanbaru Medical Center (PMC) Tahun 2014 Husnawati Husnawati; Fitra Wandasari
Jurnal Sains Farmasi & Klinis Vol 2, No 2 (2016): J Sains Farm Klin 2(2), Mei 2016
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (216.979 KB) | DOI: 10.29208/jsfk.2016.2.2.74

Abstract

The research has been done on the use of prophylactic antibiotics in caesarean section at Pekanbaru Medical Center (PMC) hospital in 2014. The aim of this study was to overview the use of prophylactic antibiotics caesarean section. Type of research was an observational study designed a descriptive by conducting a review of the medical records of patients that using prophylactic antibiotics in cesarean section during Januari until December 2014. The samples used were 73 patients who met the inclusion criteria with purposive sampling. The results of this study suggest that the use of prophylactic antibiotics in cesarean section at Pekanbaru Medical Center hospital is a single-dose Ceftriaxone 1g (58.9%) and a combination of gentamicin (80 mg) with Ceftriaxone (1g) (41.1%), where all the form generic drugs (100%) with the time of prophylactic antibiotics for the majority that is 0-2 hours before surgery (100%) with the intravenous route (100%).
Pengaruh Karakteristik Pasien Terhadap Kualitas Hidup Terkait Kesehatan Pada Pasien Kanker Payudara di RSUP Dr.M. Djamil Padang, Indonesia Dian Ayu Juwita; Almahdy Almahdy; Rizka Afdhila
Jurnal Sains Farmasi & Klinis Vol 5, No 2 (2018): J Sains Farm Klin 5(2), Agustus 2018
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (650.22 KB) | DOI: 10.25077/jsfk.5.2.126-133.2018

Abstract

Kualitas hidup merupakan suatu bagian penting dalam penilaian hasil terapi terutama pada penyakit kronis. Faktor karakteristik individu pada pasien kanker dapat mempengaruhi persepsi kesehatan general dan kualitas hidup keseluruhan. Penelitian ini bertujuan untuk mengetahui pengaruh karakteristik demografis (umur, tingkat pendidikan, lama terdiagnosa, jenis kemoterapi) dan karakteristik klinis (siklus kemoterapi, setting kemoterapi) pasien kanker payudara yang menjalani kemoterapi di RSUP Dr. M. Djamil Padang. Pengukuran dilakukan dengan menggunakan kuesioner EORTC QLQ-C30. Sampel diambil dengan memilih semua pasien kanker payudara di RSUP Dr. M. Djamil Padang yang memenuhi kriteria inklusi selama bulan Maret – Mei 2018. Data yang diperoleh dari pengisian kuwsoner kemudian ditaransformasikan nilainya ke dalam rentang 0-100 menggunakan rumus transformasi linear, kemudian dilakukan analisa statistik menggunakan uji Mann-whitney dan Kruskall-wallis. Dari hasil penelitian didapatkan karakteristik demografi tidak berpengaruh terhadap terhadap nilai kualitas hidup pasien kanker payudara (p>0,05). Sedangkan karakteristik klinis mempunyai pengaruh bermakna terhadap nilai kualitas hidup pasien kanker payudara (p<0,05). Kata kunci: karakteristik pasien;kualitas hidup;kanker payudara;karakteristik demografi;karakteristik klinis;kuesioner EORTC QLQ-C30
Pemeriksaan Residu Pestisida Profenofos pada Selada (Lactuca sativa L.) dengan Metode Kromatografi Gas Yohannes Alen; Zulhidayati Zulhidayati; Netty Suharti
Jurnal Sains Farmasi & Klinis Vol 1, No 2 (2015): J Sains Farm Klin 1(2), Mei 2015
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (436.746 KB) | DOI: 10.29208/jsfk.2015.1.2.30

Abstract

The determination of profenofos pesticidal residue in the lettuce (Lactuca sativa L.) by using gas chromatography using flame photometric detector (FPD) had been investigated. The lettuce was collected from Padang Luar area, Agam distric, West Sumatera. Sample for determination of profenofos residue divided into three groups: unwashed (A), washed with water (B), and washed with detergent (C). Maceration with sonication was used for the extraction using ethylacetateas a solvent. The results showed that profenofos pesticide residue in sample A, B and C were 0.204, 0.080 and 0.061 ppm, respectively. These profenofos pesticidal residue are over than the Maximum Residue Limits (MRL) that established by The Japan Food Chemical Research Foundation (0.05 ppm) even though World Health Organization (WHO) has not established Maximum Residue Limits (MRL) profenofos on lettuce. Based on the statistical analysis one-way method (Anova) using SPSS 20.0 showed that there was a significant concentrations difference between lettuce A from lettuce B and lettuce C with p < 0.05.

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