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JFL : Jurnal Farmasi Lampung
Published by Universitas Tulang Bawang
ISSN : 23552506     EISSN : 25984896     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health
The focus of JFL is to become a media for the publication of articles on Pharmaceutical and related practice-oriented subjects in the pharmaceutical sciences, natural medicine and clinic community. The scope of the journal is Pharmaceutical sciences, its research and its application.
Arjuna Subject : -
Articles 173 Documents
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EFEK HEPATOPROTEKTOR INFUSA DAUN BINAHONG (ANREDERA CORDIFOLIA) TERHADAP SGOT DAN SGPT TIKUS TERINDUKSI PARASETAMOL: Hepatoprotective Effect Of Binahong (Anredera Cordifolia) Leaf Infusion On SGOT And SGPT Levels In Paracetamol-Induced Rats Novita Sari; Salsa Azzahrany Suseno; Akbar R Saputra
JFL : Jurnal Farmasi Lampung Vol. 15 No. 1 (2026): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/bphhpk31

Abstract

A hepatoprotector is a compound that can protect the liver from damage caused by toxic substances and facilitates the repair of liver tissue. Liver damage can be indicated by increased elevated levels of the enzymes SGOT (Serum Glutamic Oxaloacetic Transaminase) and SGPT (Serum Glutamic Pyruvic Transaminase). Binahong leaves (Anredera cordifolia) contain flavonoid compounds that have potential as hepatoprotective agents. This study aimed to evaluate the activity of binahong leaf infusion on SGOT and SGPT levels in white rats induced with paracetamol. This was an experimental study using a post-test group design involving 25 rats divided into five groups: a negative control group (0.5% CMC), a positive control group (Hepamax at a dose of 11.81 mg/200 g BW), and treatment groups I, II, and III, which received binahong leaf infusion at doses of 100 mg/200 g BW, 200 mg/200 g BW, and 300 mg/200 g BW, respectively, for 7 days orally. Subsequently, all groups were induced with paracetamol at a dose of 270 mg/200 g BW for 1 day. Analysis of SGOT and SGPT levels using One-way Analysis of Variance (ANOVA) followed by Duncan’s test. The results showed that administration of binahong leaf infusion at 300 mg/200 g BW (Group III) produced the most significant reduction in liver enzyme levels. The average SGPT level in Group III was 63.2 U/L, and SGOT was 26.4 U/L. These results were statistically significantly different compared to the negative control group (p < 0.05) and demonstrated effectiveness approaching that of the positive control (Hepamax). Keywords:  Anredera cordifolia, Binahong leaves, Hepatoprotector, Paracetamol, SGOT, SGPT
PERBANDINGAN POTENSI ANALGESIK VARIASI EKSTRAK ETANOL DAN EKSTRAK N-HEKSANA DAUN PEPAYA (Carica papaya L.): Comparison Of The Analgesic Potential Of Variations Of Ethanol Extract And N-Hexane Extract Of Papaya Leaves (Carica Papaya L) Herlina Ramadhani; Ade Maria Ulfa; Tutik Tutik
JFL : Jurnal Farmasi Lampung Vol. 15 No. 1 (2026): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/gvnt6y38

Abstract

Abstract This research aimed to test and compare the analgesic effectiveness of n-hexane and ethanol extracts of papaya leaves in mice (Mus musculus) at doses of 400 mg/kgBB and 800 mg/kgBB. Maceration extraction resulted in a yield of 5.06% (n-hexane) and 8.5% (ethanol). Phytochemical screening showed that both extracts were positive for flavonoids and steroids. The analgesic test was conducted using the acetic acid induction method by observing the number of writhing movements. The test groups included a negative control, a positive control (mefenamic acid), and n-hexane and ethanol extracts at the two aforementioned doses. The results showed that all extract groups significantly reduced writhing compared to the negative control (p<0.05). The percentage of protection for n-hexane was 69.44% (400 mg) and 74.12% (800 mg), while ethanol achieved 83.5% (400 mg) and 88.56% (800 mg). The positive control provided 97.23% protection. ANOVA demonstrated a significant difference between the groups (p=0.000). Post hoc tests confirmed that the 800 mg/kgBB ethanol extract was the most effective among the tested extracts, with no significant difference from the positive control. Keywords: Analgesic, Carica papaya, Ethanol Extract, n-Hexane Extract, Mice  
Formulasi Sabun Cair Antibakteri dari Minyak Jelantah dengan Ekstrak Portulaca oleracea L. Terhadap Staphylococcus aureus: Formulation Antibacterial Liquid Soap From Used Cooking Oil With Portulaca Oleracea Extract Against Staphylococcus Aureus Khairunnisa; Meri Oktarina; Najma Annuaria Fithri
JFL : Jurnal Farmasi Lampung Vol. 15 No. 1 (2026): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/fny66b43

Abstract

Minyak goreng bekas merupakan produk limbah rumah tangga yang berpotensi mencemari lingkungan jika tidak dimanfaatkan kembali. Di sisi lain, krokot (Portulaca oleracea L.) merupakan gulma yang mengandung metabolit sekunder seperti saponin yang memiliki aktivitas antibakteri. Penggunaan kedua bahan ini sebagai sabun cair antibakteri merupakan alternatif yang bermanfaat untuk meningkatkan kebersihan dan mengurangi pencemaran lingkungan. Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi ekstrak etanol krokot terhadap kualitas fisik sabun cair dan aktivitas antibakterinya terhadap Staphylococcus aureus. Sabun cair dibuat dalam tiga formula dengan variasi konsentrasi ekstrak krokot (10%, 15%, dan 20%). Evaluasi formula meliputi uji organoleptik, homogenitas, pH, berat jenis, uji aktivitas antibakteri menggunakan metode difusi sumur, dan uji saponin kualitatif. Semua formula memiliki karakteristik organoleptik yang serupa: aroma mawar, warna hijau muda, tekstur lembut, dan homogenitas yang baik. pH berkisar antara 5,5–6,25, dan berat jenis 1,03–1,09 g/mL memenuhi standar sabun cair. Formula III (ekstrak 20%) menunjukkan aktivitas penghambatan tertinggi terhadap Staphylococcus aureus pada diameter 23 mm, termasuk dalam kategori kuat. Formula I dan II menunjukkan aktivitas penghambatan lemah. Kata kunci: Sabun cair antibakteri, minyak goreng bekas, krokot (Portulaca oleracea L.), Staphylococcus aureus, dan saponin.

Page 18 of 18 | Total Record : 173

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