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JFL : Jurnal Farmasi Lampung
Published by Universitas Tulang Bawang
ISSN : 23552506     EISSN : 25984896     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health
The focus of JFL is to become a media for the publication of articles on Pharmaceutical and related practice-oriented subjects in the pharmaceutical sciences, natural medicine and clinic community. The scope of the journal is Pharmaceutical sciences, its research and its application.
Arjuna Subject : -
Articles 178 Documents
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EFEK HEPATOPROTEKTOR INFUSA DAUN BINAHONG (ANREDERA CORDIFOLIA) TERHADAP SGOT DAN SGPT TIKUS TERINDUKSI PARASETAMOL: Hepatoprotective Effect Of Binahong (Anredera Cordifolia) Leaf Infusion On SGOT And SGPT Levels In Paracetamol-Induced Rats Novita Sari; Salsa Azzahrany Suseno; Akbar R Saputra
JFL : Jurnal Farmasi Lampung Vol. 15 No. 1 (2026): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/bphhpk31

Abstract

A hepatoprotector is a compound that can protect the liver from damage caused by toxic substances and facilitates the repair of liver tissue. Liver damage can be indicated by increased elevated levels of the enzymes SGOT (Serum Glutamic Oxaloacetic Transaminase) and SGPT (Serum Glutamic Pyruvic Transaminase). Binahong leaves (Anredera cordifolia) contain flavonoid compounds that have potential as hepatoprotective agents. This study aimed to evaluate the activity of binahong leaf infusion on SGOT and SGPT levels in white rats induced with paracetamol. This was an experimental study using a post-test group design involving 25 rats divided into five groups: a negative control group (0.5% CMC), a positive control group (Hepamax at a dose of 11.81 mg/200 g BW), and treatment groups I, II, and III, which received binahong leaf infusion at doses of 100 mg/200 g BW, 200 mg/200 g BW, and 300 mg/200 g BW, respectively, for 7 days orally. Subsequently, all groups were induced with paracetamol at a dose of 270 mg/200 g BW for 1 day. Analysis of SGOT and SGPT levels using One-way Analysis of Variance (ANOVA) followed by Duncan’s test. The results showed that administration of binahong leaf infusion at 300 mg/200 g BW (Group III) produced the most significant reduction in liver enzyme levels. The average SGPT level in Group III was 63.2 U/L, and SGOT was 26.4 U/L. These results were statistically significantly different compared to the negative control group (p < 0.05) and demonstrated effectiveness approaching that of the positive control (Hepamax). Keywords:  Anredera cordifolia, Binahong leaves, Hepatoprotector, Paracetamol, SGOT, SGPT
PERBANDINGAN POTENSI ANALGESIK VARIASI EKSTRAK ETANOL DAN EKSTRAK N-HEKSANA DAUN PEPAYA (Carica papaya L.): Comparison Of The Analgesic Potential Of Variations Of Ethanol Extract And N-Hexane Extract Of Papaya Leaves (Carica Papaya L) Herlina Ramadhani; Ade Maria Ulfa; Tutik Tutik
JFL : Jurnal Farmasi Lampung Vol. 15 No. 1 (2026): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/gvnt6y38

Abstract

Abstract This research aimed to test and compare the analgesic effectiveness of n-hexane and ethanol extracts of papaya leaves in mice (Mus musculus) at doses of 400 mg/kgBB and 800 mg/kgBB. Maceration extraction resulted in a yield of 5.06% (n-hexane) and 8.5% (ethanol). Phytochemical screening showed that both extracts were positive for flavonoids and steroids. The analgesic test was conducted using the acetic acid induction method by observing the number of writhing movements. The test groups included a negative control, a positive control (mefenamic acid), and n-hexane and ethanol extracts at the two aforementioned doses. The results showed that all extract groups significantly reduced writhing compared to the negative control (p<0.05). The percentage of protection for n-hexane was 69.44% (400 mg) and 74.12% (800 mg), while ethanol achieved 83.5% (400 mg) and 88.56% (800 mg). The positive control provided 97.23% protection. ANOVA demonstrated a significant difference between the groups (p=0.000). Post hoc tests confirmed that the 800 mg/kgBB ethanol extract was the most effective among the tested extracts, with no significant difference from the positive control. Keywords: Analgesic, Carica papaya, Ethanol Extract, n-Hexane Extract, Mice  
Formulasi Sabun Cair Antibakteri dari Minyak Jelantah dengan Ekstrak Portulaca oleracea L. Terhadap Staphylococcus aureus: Formulation Antibacterial Liquid Soap From Used Cooking Oil With Portulaca Oleracea Extract Against Staphylococcus Aureus Khairunnisa; Meri Oktarina; Najma Annuaria Fithri
JFL : Jurnal Farmasi Lampung Vol. 15 No. 1 (2026): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/fny66b43

Abstract

Minyak goreng bekas merupakan produk limbah rumah tangga yang berpotensi mencemari lingkungan jika tidak dimanfaatkan kembali. Di sisi lain, krokot (Portulaca oleracea L.) merupakan gulma yang mengandung metabolit sekunder seperti saponin yang memiliki aktivitas antibakteri. Penggunaan kedua bahan ini sebagai sabun cair antibakteri merupakan alternatif yang bermanfaat untuk meningkatkan kebersihan dan mengurangi pencemaran lingkungan. Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi ekstrak etanol krokot terhadap kualitas fisik sabun cair dan aktivitas antibakterinya terhadap Staphylococcus aureus. Sabun cair dibuat dalam tiga formula dengan variasi konsentrasi ekstrak krokot (10%, 15%, dan 20%). Evaluasi formula meliputi uji organoleptik, homogenitas, pH, berat jenis, uji aktivitas antibakteri menggunakan metode difusi sumur, dan uji saponin kualitatif. Semua formula memiliki karakteristik organoleptik yang serupa: aroma mawar, warna hijau muda, tekstur lembut, dan homogenitas yang baik. pH berkisar antara 5,5–6,25, dan berat jenis 1,03–1,09 g/mL memenuhi standar sabun cair. Formula III (ekstrak 20%) menunjukkan aktivitas penghambatan tertinggi terhadap Staphylococcus aureus pada diameter 23 mm, termasuk dalam kategori kuat. Formula I dan II menunjukkan aktivitas penghambatan lemah. Kata kunci: Sabun cair antibakteri, minyak goreng bekas, krokot (Portulaca oleracea L.), Staphylococcus aureus, dan saponin.
HUBUNGAN PENGETAHUAN IBU HAMIL DAN KEPATUHAN KONSUMSI TABLET TAMBAH DARAH DI KOTA MAKASSAR: The Association Bertween Pregnant Women’s Knowledge And Adherence To Iron Supplementation Tablet Consumption In Makassar City Weldhea Putri Maylani; Hardiyanti Syarif; Muhammad Akbar Bahar
JFL : Jurnal Farmasi Lampung Vol. 15 No. 1 (2026): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/ff6s0m12

Abstract

Abstract Preterm birth is a leading cause of mortality among children under five years old, with maternal anemia as one of its major risk factors. Limited knowledge and poor adherence among pregnant women in consuming iron supplementation tablets may increase the risk of anemia, which contributes to preterm birth. This study aimed to analyze the association between pregnant women’s knowledge levels and their adherence to iron supplementation tablets in preventing preterm birth at community health centers in Makassar City. This cross-sectional study involved 117 pregnant women from four community health centers in Makassar (Sudiang, Tamalanrea, BTN Antara, and Kassi-Kassi). Data were collected using a knowledge questionnaire and the Medication Adherence Rating Scale (MARS). The results showed that 58.1% of pregnant women were adherent to iron supplementation tablets. Bivariate analysis indicated significant associations between education duration of more than 12 years (OR: 4.911; 95% CI: 1.847–13.057; p=0.001) and employment status (OR: 2.622; 95% CI: 1.064–6.461; p=0.036) with adherence. Multivariate analysis revealed that a good level of knowledge was significantly associated with adherence (AOR: 6.613; 95% CI: 1.484–29.456; p=0.013). Higher knowledge levels were associated with better adherence to iron supplementation tablets. Keywords:  Adherence, Iron, Suplementation Tablets, Knowledge, Pregnant Women, Preterm Birth
PENGARUH PEMBERIAN EDUKASI TERHADAP PENGETAHUAN TENTANG BEYOND USE DATE KEPADA IBU RUMAH TANGGA DI DESA BANGUN SARI KABUPATEN LAMPUNG UTARA TAHUN 2026: The Effect Of Educational Intervention On Knowledge Of Beyond Use Date (BUD) Among Housewives In Bangun Sari Village, North Lampung Regency In 2026 Novita Tri Wahyuni; Isbiyantoro Isbiyantoro; Hijrah Hijrah; Achriz Oemara
JFL : Jurnal Farmasi Lampung Vol. 15 No. 1 (2026): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/ge11fz47

Abstract

  Abstract  The storage of medicines in households is a common practice for self-medication purposes. However, many people are only familiar with the Expiration Date (ED) and do not understand the concept of the Beyond Use Date (BUD). A lack of public understanding regarding Beyond Use Date (BUD) can lead to the use of medications that are no longer safe or effective.Lack of public understanding regarding Beyond Use Dates (BUD) can lead to the use of drugs that are no longer safe and effective. This study aims to determine the effect of providing education on the level of knowledge of housewives about BUD in Bangun Sari Village, North Lampung. The research method was quantitative with a quasi-experimental design (pretest–posttest approach with a control group) on 102 respondents divided into counseling, leaflet, and control groups. The results of the paired t-test showed that the counseling group experienced the most significant increase in knowledge (p = 0.000) with the majority of respondents (64.7%) reaching the good category after the intervention. The leaflet group also experienced a significant increase (p = 0.000), while the control group showed no change (p = 0.184). It was concluded that providing education had a significant effect on increasing BUD knowledge, where the counseling method was more effective than the leaflet media. Keywords Uric acid, gout arthritis, herbal medicine, bay leaf, soursop leaf, ginger, celery, curcumin, xanthine oxidase inhibition, antihyperuricemia.
FORMULASI DAN UJI SEDIAAN HAIR TONIC EKSTRAK BUNCIS (Phaseolus vulgaris L.) SEBAGAI PERTUMBUHAN RAMBUT TERHADAP KELINCI PUTIH JANTAN: Formulation And Test Preparation Of Hair Tonic Bean Extract (Phaseolus Vulgaris L.) As Hair Growth Against Male White Rabbits Subur Widodo; Laila Susanti; Samsuar Samsuar; Fiona Khoirunnisya
JFL : Jurnal Farmasi Lampung Vol. 15 No. 1 (2026): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/t5kfc033

Abstract

  Hair loss is a condition experienced by many individuals, influenced by both internal and external factors. One effort to treat it is the use of natural hair tonics. Bean (Phaseolus vulgaris L.)  is known to contain flavonoids that have the potential to promote hair growth through their antioxidant, anti-inflammatory, and scalp microcirculation-improving properties. This study aims to formulate and evaluate the preparation of a hair tonic using bean extract (Phaseolus vulgaris L.) as a hair growth agent in male white rabbits by testing its hair growth activity. The standardization of simplicia and extracts was carried out using specific and non-specific parameters, both of which met the applicable requirements. The extract was formulated in three  concentration: FI (9% bean extract), FII with 12% bean extract and FIII with 15% bean extract. The evaluation of hair tonic preparations from the results of this study showed that the three hair tonic formulas, both in terms of their characteristics and physical and chemical properties: organoleptic, homogeneity, sprayability, pH, viscosity, stability, and irritation test, met the existing requirements.. The results of the hair growth activity test showed that FI had a hair growth ability of 0.41 cm ± 0,009 with a hair weight of 59,90 mg ± 1,141, FII had a hair growth ability of 0,45 cm ± 0,005 with a weight of 65,90 mg ± 0,415 and FIII had the best hair growth ability of other formulas namely 0,49 cm ± 0,005 with a weight of 71 mg ± 0,418.  Keywords : Bean (Phaseolus vulgaris L.), hair tonic hair grower, male white  rabbit.
FORMULASI GEL EKSTRAK KOMBINASI DAUN KOPI ROBUSTA (Coffea canephora) DAN DAUN SIRIH (Piper betle L.) TERHADAP AKTIVITAS Staphylococcus aureus: Formulation Of Gel Extract Of Combination Of Robusta      Coffee Leaves (Coffea Canephora) And Betel Leaves (Piper Betle L.) On The Activity Of Staphylococcus Aureus Yuli Wahyu Tri Mulyani; Inda Pratiwi; Annisa Mulia Anasis; Sabina Zahra
JFL : Jurnal Farmasi Lampung Vol. 15 No. 1 (2026): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/333yqk83

Abstract

Abstract Skin infections caused by Staphylococcus aureus continue to pose a significant public health concern. Therefore, the development of natural topical antibacterial formulations that are effective, safe, and associated with minimal side effects is highly needed. Robusta coffee leaves (Coffea canephora) and betel leaves (Piper betle L.) are known to contain active compounds such as flavonoids, alkaloids, tannins, and saponins with potential antibacterial activity. This study aimed to formulate a gel preparation combining both extracts and to evaluate its antibacterial activity against Staphylococcus aureus.nThe extraction method used was maceration with 70% ethanol as the solvent. The gel formulations were prepared in four variations of robusta coffee leaf and betel leaf extract concentrations, namely F0 (0%:0%), F1 (10%:14%), F2 (14%:10%), and F3 (12%:12%). Evaluation parameters included organoleptic properties, homogeneity, pH, spreadability, adhesiveness, viscosity, and stability using a cycling test. Antibacterial activity was tested using the disk diffusion method by measuring the inhibition zone. The results showed that F1 produced an inhibition zone of 18.65 mm, F2 of 17.36 mm, and F3 of 19.70 mm, all categorized as strong, while F0 showed no inhibition. The positive control exhibited an inhibition zone of 17.88 mm. The best formulation was F3 (12%:12%), which demonstrated the largest inhibition zone (19.70 mm), higher than the positive control within the same category. Physical evaluation indicated that the gel met the criteria of a good and stable preparation. In conclusion, the combination of both extracts containing flavonoids, alkaloids, tannins, and saponins can be formulated into a stable gel. Keywords: Antibacterial, Betel leaves, Gel, Robusta coffee leaves,Staphylococcus aureus 
PENGETAHUAN DAN KEPATUHAN MINUM OBAT SEBAGAI DETERMINAN OUTCOME KLINIS PADA PASIEN DIABETES MELITUS TIPE 2 RAWAT JALAN: Knowledge And Medication Adherence As Determinants Of Clinical Outcomes In Outpatients With Type 2 Diabetes Mellitus Lilik Koernia Wahidah; Nopiyansyah Nopiyansyah; Nola Harissa; Asih Widiyastuti; Kartika Handayani; Dian Permata Sari
JFL : Jurnal Farmasi Lampung Vol. 15 No. 1 (2026): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/aj9k1j02

Abstract

ABSTRACT   Therapeutic success in patients with type 2 diabetes mellitus is influenced by patient-related factors, including knowledge and medication adherence, which contribute to clinical outcomes. This study aimed to analyze knowledge and medication adherence as determinants of clinical outcomes in outpatients with type 2 diabetes mellitus. A cross-sectional study was conducted involving 189 respondents. Variables included patient characteristics, knowledge level (DKQ-24 instrument), medication adherence measured using the MMAS-8, and clinical outcomes. Data were analyzed using the Chi-square test with a significance level of 0.05. The results showed that most respondents were aged >60 years (50.3%), female (61.9%), had a senior high school education (39.2%), and were unemployed (67.7%). The majority had moderate knowledge (52.4%), low medication adherence (55.6%), and unsuccessful clinical outcomes (77.8%). The Chi-square test showed a significant association between knowledge and clinical outcomes (p = 0.000), as well as between medication adherence and clinical outcomes (p = 0.000). In conclusion, knowledge and medication adherence are significantly associated with clinical outcomes and act as important determinants of therapeutic success in patients with type 2 diabetes mellitus.   Keywords: Clinical outcomes; knowledge; medication adherence; MMAS-8; type 2 diabetes mellitus

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