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JFL : Jurnal Farmasi Lampung
Published by Universitas Tulang Bawang
ISSN : 23552506     EISSN : 25984896     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health
The focus of JFL is to become a media for the publication of articles on Pharmaceutical and related practice-oriented subjects in the pharmaceutical sciences, natural medicine and clinic community. The scope of the journal is Pharmaceutical sciences, its research and its application.
Arjuna Subject : -
Articles 157 Documents
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ANTIBACTERIAL ACTIVITY OF ETHANOLIC EXTRACT OF SELIGI LEAVES (Phyllanthus buxifolius (BLUME) MULL. ARG) AGAINST THE GROWTH OF Staphylococcus epidemicdis ATCC 12228: Antibacterial Potential of Ethanol Extract of Seligi Leaves (Phyllanthus buxifolius (Blume) Mull. ARG) Against Staphylococcus epidermidis ATCC 12228 in Vitro Yeliza, Adniana; Kusniawati, Mega Ayu; Hamidu, La; Oktariyana, Hani
JFL : Jurnal Farmasi Lampung Vol. 14 No. 2 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/14f8qw67

Abstract

By interfering with the metabolism of these dangerous germs, antibacterial compounds may hinder, combat, and ultimately destroy the development of microbes. Finding out how effective seligi leaf ethanol extract is against Staphylococcus epidermidis bacteria and what dosage produces the optimal inhibitory zone are the primary goals of this research. Maceration with a 96% ethanol solvent was used to extract the Seligi leaves. Each of the five groups underwent the test three times: those receiving a negative control (aquadest), those receiving a positive control (clindamycin 5%), and those receiving nutritional agar medium containing 25%, 50%, or 75% seligi leaf extract. Using a caliper, the antibacterial activity test determined the inhibitory zone diameter in millimeters.To find out how the different treatment groups differed, the collected data were subjected to analysis of variance and post hoc LSD. Antibacterial action against the development of Staphylococcus epidermidis was shown by the findings of ethanol extracts of seligi leaves at concentrations of 25%, 50%, and 75%. With an average inhibition diameter of 7.53 mm, the most active component was a 75% ethanol extract of seligi leaves, was on par with the positive controls. Keywords:  Antibacterial, seligi leaf extract, diameter of inhibition zone
RELATIONSHIP BETWEEN PARENTS' KNOWLEDGE LEVEL OF CHILD PATIENTS WITH ACUTE RESPIRATORY TRACT INFECTION (ARI) AND ANTIBIOTIC USE BEHAVIOR AT TANJUNG BINTANG COMMUNITY HEALTH CENTER IN 2024: Relationship Between Parents Knowledge Level Of Child Patients With Acute Respiratory Infection (ARI) And Antibiotic Use Behavior At Tanjung Bintang Community Health Center In 2024 Isbiyantoro, Isbiyantoro; Wahyuni, Novita Tri; Hijrah, Hijrah; Faliandra, Dinda Renanti
JFL : Jurnal Farmasi Lampung Vol. 14 No. 2 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/akdt3x05

Abstract

Infectious diseases are one of the most common public health problems, especially in developing countries. The causes include age, season, living conditions and existing health problems. One of the infectious diseases is Acute Respiratory Infection or better known as (ARI). Efforts to treat ARI caused by bacteria with the use of antibiotics. This study aims to determine the relationship between the level of knowledge of parents of pediatric patients with acute respiratory infections (ARI) and antibiotic use behavior at the Tanjung Bintang Health Center in 2024. This type of research uses quantitative analytical cross-sectional design, the sampling technique uses the accidental sampling method with a total of 80 respondents. Data analysis in this study used the chi-square test technique. The results of this study obtained the level of parental education of elementary school (52.2%), junior high school education (15.0%) high school-college education (32.5%). Respondents with work as many as (75.5%) and unemployed as many as (25.5%), children aged 5-8 years (61.3%), aged 9-12 years (38.8%), male gender (52.5%) and female (47.5%) and mild ISPA (31.3%), moderate ISPA (63.8) and severe ISPA (5.0%), respondent knowledge level of knowledge level less (26.3%) and good knowledge level (73.8%), parental behavior less (26.3%) and good behavior (73.8%). Based on the chi-square test there is a significant relationship between the level of knowledge and parental behavior towards the use.   Keywords : Antibiotics, Behavior, ISPA, Knowledge
PENGARUH PENGETAHUAN DAN SIKAP TERHADAPPERILAKU PENYIMPANAN DAN PEMUSNAHAN OBAT DI RUMAH  PADA MASYARAKAT DESA MATARAMKABUPATEN PRINGSEWU TAHUN 2025: The Effect Of Knowledge And Attitudes On The Behavior Of Storing As Well As Destroying Drugs At Home In The Community Mataram Village, Pringsewu Regency In 2025 Handayani, Kartika; Nopiyansyah; Muslihah, Nur Nisa'i
JFL : Jurnal Farmasi Lampung Vol. 14 No. 2 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/rq7ttf49

Abstract

Tingginya tingkat konsumsi dan penyimpanan obat di rumah yang tidak disertai pemahaman yang memadai mengenai cara penyimpanan dan pemusnahan obat yang benar merupakan latar belakang penelitian ini. Penelitian ini bertujuan untuk mengetahui pengaruh pengetahuan dan sikap terhadap perilaku penyimpanan dan pemusnahan obat di rumah pada masyarakat Desa Mataram, Kabupaten Pringsewu. Jenis penelitian ini adalah kuantitatif dengan pendekatan cross sectional. Sampel penelitian berjumlah 179 responden yang dipilih menggunakan teknik total sampling. Instrumen yang digunakan berupa kuesioner yang telah divalidasi, dan data dianalisis menggunakan uji regresi linier berganda (uji t) diolah menggunakan SPSS versi 27. Hasil dari analisis univariat, karakteristik responden dominan berjenis kelamin perempuan presentase 76,5%, usia 26-35 tahun presentase 26,8%, pendidikan terakhir SMA presentase 27,4%, dan responden yang aktif bekerja presentase 54,2%. Hasil penelitian juga menunjukkan bahwa mayoritas responden memiliki pengetahuan mengenai penyimpanan obat sebesar (64,8%) dan pemusnahan obat sebesar (53,6%), sikap terhadap penyimpanan obat sebesar (52,5%) dan pemusnahan obat sebesar (60,9%), perilaku penyimpanan obat sebesar (54,2%) dan pemusnahan obat sebesar (62,0%). Berdasarkan analisis bivariat dengan uji regresi linier berganda (uji t) didapatkan bahwa variabel bebas pengetahuan dan sikap memiliki pengaruh terhadap variabel terikat perilaku penyimpanan dan pemusnahan obat yang ditandai dengan nilai P-Value < 0,05. Pengetahuan berpengaruh terhadap perilaku penyimpanan obat dengan nilai (t = 3,567; p < 0,05) dan pemusnahan obat (t = 17,632; p < 0,05). Sikap juga berpengaruh terhadap perilaku penyimpanan obat dengan nilai (t = 4,467; p < 0,05) dan pemusnahan obat (t = 17,555; p < 0,05).
EFFECT OF GIVING WHITE WALET BIRD'S NEST (Collacalia fuciphaga) TO THE BRONCHIOLUS MUSCLE OF FEMALE MENCITES    PENGARUH PEMBERIAN SARANG BURUNG WALET PUTIH (Collacalia fuciphaga) TERHADAP OTOT POLOS BRONKIOLUS MENCIT BETINA: Effect Of Giving White Walet Bird's Nest (Collacalia Fuciphaga) To The Bronchiolus Muscle Of Female Mice Dwiyanti, Made; Primadiamanti, Annisa; Nofita, Nofita
JFL : Jurnal Farmasi Lampung Vol. 14 No. 2 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/xvjdgb90

Abstract

Penyakit saluran pernapasan seperti asma dan PPOK masih menjadi penyebab utama morbiditas dan mortalitas global, sementara alternatif terapi alami dengan efek antioksidan dan antiinflamasi masih terbatas. Kandungan asam sialik dalam sarang burung wallet yang berpotensi menekan inflamasi saluran napas dengan menghambat pelepasan sitokin pro-inflamas. Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh pemberian larutan sarang burung walet (Collacalia sp) terhadap otot polos bronkiolus pada mencit betina yang diinduksi ovalbumin. Penelitian menggunakan desain true experimental post-test only control group design dengan 36 ekor mencit betina yang dibagi menjadi enam kelompok, yaitu kontrol normal, kontrol negatif (OVA + Na-CMC), kontrol positif (teofilin), serta dua kelompok perlakuan dengan larutan sarang burung walet dosis 0,1 mg/kgBB, dan 1 mg/kgBB. Induksi asma dilakukan dengan sensitisasi dan paparan ovalbumin, kemudian perlakuan diberikan sesuai kelompok. Ketebalan otot polos bronkiolus dianalisis melalui preparat histopatologi pewarnaan Hematoksilin-Eosin. Hasil penelitian menunjukkan bahwa pemberian larutan sarang burung walet putih dosis 1 mg/kgBB terbukti signifikan menurunkan ketebalan otot polos bronkiolus mencit yang diinduksi ovalbumin, dengan efek yang mendekati kontrol positif teofilin.   Respiratory diseases such as asthma and COPD remain a major cause of global morbidity and mortality, while natural therapeutic alternatives with antioxidant and anti-inflammatory effects are still limited. The content of sialic acid in swallow's nest has the potential to suppress airway inflammation by inhibiting the release of pro-inflammatory cytokines. This study aims to determine how the effect of swallow's nest solution (Collacalia sp) on bronchiolar smooth muscle in ovalbumin-induced female mice. The study used a true experimental post-test only control group design with 36 female mice divided into six groups, namely normal control, negative control (OVA + Na-CMC), positive control (theophylline), and two treatment groups with swallow's nest solution doses of 0.1 mg/kgBB, and 1 mg/kgBB. Asthma induction was performed by sensitization and exposure to ovalbumin, then treatment was given according to the group. Bronchiolar smooth muscle thickness was analyzed through Hematoxylin-Eosin staining histopathology preparations. The results showed that the administration of white swallow nest solution at a dose of 1 mg/kgBB proved to significantly reduce the thickness of bronchiolar smooth muscle in mice induced by ovalbumin, with an effect close to the positive control of theophylline.
Potassium-Competitive Acid Blocker (P-CAB) Generasi Baru: Studi Farmakologi dan Klinis Vonoprazan Fumarate: A New Generation of Potassium-Competitive Acid Blockers (P-CAB): Pharmacological and Clinical Studies of Vonoprazan Fumarate Ilahi, Ade Rezki; Febrina, Ellin
JFL : Jurnal Farmasi Lampung Vol. 14 No. 2 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/hf4n3x55

Abstract

The aim of this study was to determine the pharmacological profile, clinical effectiveness, and safety of Vocinti (vonoprazan fumarate) as a P-CAB class gastric acid secretion inhibitor therapy. The method used was a literature review with a qualitative-descriptive approach. Information was collected, manually sorted and critically reviewed to ensure its validity and relevance, in order to produce a comprehensive picture of the pharmacological aspects, clinical effectiveness, and safety of Vocinti use. Based on the available literature review, Vocinti (vonoprazan fumarate) as a P-CAB class gastric acid secretion inhibitor therapy shows a superior pharmacological profile compared to conventional PPIs. Vonoprazan works through reversible competitive inhibition of the H+/K+-ATPase enzyme, resulting in faster, stronger, and more consistent acid suppression, with a longer duration of action and independence from acid activation. Thus, vonoprazan is worthy of consideration as an alternative primary therapy for gastric acid disorders, especially in refractory patients or those requiring long-term therapy. Keywords: P-CAB, Vonoprazan Fumarate Clinical, Pharmacological Studies, Vocinti
HUBUNGAN EFEK SAMPING OBAT TERHADAP KEPATUHAN MINUM OBAT PADA PASIEN HIV/AIDS DI PUSKESMAS SUKARAJA BANDAR LAMPUNG TAHUN 2025: The Relationship Between Drug Side Effects And Medication Adherence In Hiv/Aids Patients At Sukaraja Health Center, Bandar Lampung, In 2025 Harissa, Nola; Wahidah, Lilik Koernia; Salsabila, Jauza
JFL : Jurnal Farmasi Lampung Vol. 14 No. 2 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/cbwvq431

Abstract

HIV/AIDS is one of the top infectious diseases that cause death. Side effects of drug use are associated with decreased adherence to medication, where according to the literature, patients who experience unpleasant reactions after taking medication show reduced adherence. Adherence to Antiretroviral treatment is very important to achieve optimal therapeutic results in HIV/AIDS sufferers. The purpose of this study was to determine the relationship between side effects of taking medication and adherence to medication in HIV/AIDS patients at Sukaraja Health Center, Bandar Lampung in 2025. This study used a cross-sectional method with prospective data collection, a sample of 74 patients and the use of purposive sampling for the sampling technique.The Data obtained were analyzed by using the chi-square test to find out the relation between the dependent variable which is medication adherence  and the independent variable, namely of drug side effects. The results of the analysis showed that most respondents were aged 26-35 years 34 patients, (45.9%), male 61 patients ( 82.4%), had the highest education level of high school 40 patients (54.1%), and were employed 55 patients (74.3%)This study found medication adherence rates in HIV/AIDS patients based on the MMAS scale, with 48 (64.9%) being adherent and 26 (35.1%) being non-adherent. Twenty-eight (33.8%) patients experienced side effects, while 49 (66.2%) did not. There was a relationship between medication side effects and medication adherence in HIV/AIDS patients with a p-value of 0.030.
PENGARUH RASIONALITAS PENGGUNAAN OBAT TERHADAP OUTCOME KLINIS PADA PASIEN DEMAM BERDARAH DENGUE (DBD)DI RUMAH SAKIT X TAHUN 2023: THE EFFECT OF RATIONAL MEDICATIO USE ON CLINICAL OUTCOMES OF DENGUE (DBD) FEVER PATIENTS AT X HOSPITAL IN 2023 Widiyastuti, Asih; Kurniati, Rizki; Asti, Windi; Muzdalifah, Hidayatul Tasya Nur
JFL : Jurnal Farmasi Lampung Vol. 14 No. 2 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/pc6hqp63

Abstract

DBD merupakan ancaman bagi kesehatan secara global, terutama di wilayah tropis dan subtropis termasuk Indonesia sebagai salah satu negara endemis dengue. Virus dengue ditularkan ke manusia melalui gigitan nyamuk Aedes Aegypty dan Aedes Albopictus. Tujuan penelitian ini untuk mengetahui pengaruh rasionalitas penggunaan obat terhadap outcome klinis pada pasien demam berdarah dengue di Rumah Sakit X pada tahun 2023. Outcome klinis yang dinilai adalah keadaan klinis pasien, tanda vital pasien, data laboratorium yaitu hematokrit, trombosit, leukosit serta lama perawatan 3-7 hari. Penelitian ini merupakan penelitian non eksperimental dengan rancangan deskriptif yaitu data diambil secara retrospektif dengan teknik purposive sampling. Untuk mengetahui pengaruh rasionalitas terhadap outome klinis menggunakan analisis bivariate uji SPSS Chi-Square. Hasil penelitian menunjukkan, hasil karakteristik dari 100 pasien yang diteliti paling banyak terjadi pada rentang usia 17–25 tahun sebanyak 31%, jenis kelamin laki-laki sebanyak 51%, lama perawatan 3 hari sebanyak 68%. Profil penggunaan obat untuk terapi penggunaan obat pasien demam berdarah dengue paling banyak digunakan yaitu Paracetamol sebanyak 100% dan Ringer Laktat sebanyak 100%. Hasil Penelitian dari 100 pasien menunjukan tepat obat sebanyak 100%, tepat dosis 100%, teoat cara pemberian 100% dan tepat interval pemberian seanyak 90%. Outcome klinis pada pasien demam berdarah dengue di rumah sakit X tahun 2023 yang tercapai sejumlah 73% yaitu dengan meredanya gejala yang di alami pasien tersebut. Berdasarkan hasil analisis Chi- Square menunjukan bahwa terdapat pengaruh yang signifikan dengan (p= 0,01) antara rasionalitas penggunaan obat terhadap outcome klinis di Rumah Sakit X .   Kata Kunci: Demam Berdarah Dengue, Outcome Klinis, Rasionalitas.

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