Garuda - Garba Rujukan Digital

THE EFFECTIVENESS OF LEMON JUICE (Citrus limon) TOWARD PYRAMIDAL NEURON CELLS OF MALE WHITE MICE’SCEREBRAL CORTEX THAT EXPOSED BY MONOSODIUM GLUTAMATE (MSG) Pepi Arifiyani; Hikmah Fitriani; Rachmanda Haryo Wibisono
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: The consumption rate of Monosodium Glutamate (MSG) in Indonesia remains high. Lemon is an antioxidant and neutralizer of free radicals which contains vitamin C and phytochemicals to prevent the long-term effects of MSG to pyramida cells. This study aims to test the effect of oral administration of lemon juice (Citrus limon) to the number of pyramidal neuron cells. Methodology: This experimental study employed 30 male white mice aged 2.5 to 3 months. Those mice were randomly divided into five control-groups: Normal Control (KN), Negative Control (K-) was treated with 4 mg/grBB MSG, Dose Group 1 (KD1) was treated with 3.33 ml/kgBB lemon juice, Dose Group 2 (KD2) was treated with 6.67 ml/kgBB lemon juice, and Dose Group 3 (KD3) was treated with 13.33 ml/kgBB lemon juice. Kruskal Wallis test was used to determine the difference in distribution between groups, followed with Post hoc Mann Whitney test. Results: After 28 days of treatment, the average number of pyramidal neuron cells in dose group 1 (637 cells) was higher than in negative control (589.5 cells) (p=0.078). The average number of pyramidal neuron cells in dose group 3 (482,5 cells) was lower than in the negative control (589.5 cells) (p=0.016). The statistical result shown that there were groups with a significant difference in pyramidal cells number. Mann-Whitney analysis of pyramidal cells number had shown that there was a significant differencebetween group KD3 and KD1, KD3 and K (-), KD3 and KD2. Conclusion: Lemon juice (Citrus limon) in precise dose has a beneficial effect to reduce the excitotoxic effect of MSG. Further studies is needed to validate the active compound and toxicity effect of lemon juice. Keywords: Pyramidal neuron cells, monosodium glutamate, lemon (Citrus limon)

THE RELATIONSHIP BETWEEN KNOWLEDGE, ATTITUDE, AND BEHAVIOR OF BREASTFEEDING AND INTAKE OF COMPLEMENTARY FEEDING WITH NUTRITIONAL STATUS OF CHILDREN AGED 6-24 MONTHS AT KESUNEAN HEALTH CENTER CIREBON Mauli Ardhiya; Ignatius Hapsoro; Shofa Nur Fauzah
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: The insufficient nutrient intake in the certain time may affect physical growth and development of children. The percentage of babies with exclusive breast feeding are only 37.3%. It is still under the national target. This research aims to examine the correlation of knowledge, attitude, and behavior of breastfeeding and intake of complementary feeding with nutritional status of children. Methodology: This study was a cross sectional research conducted in Kesunean Health Center, Cirebon City. Totally 100 mothers of children aged 6 to 24 months was selected by consecutive sampling. The nutritional status was calculated based on weight of age whereas the predictors (knowledge, attitude, behavior) was asked by 31 questions. The statistical analysis used Spearman test. Results: The results of this study found that knowledge (p=0.001 and r=0.561), attitude (p=0.001 and r=0.498), and behavior (p=0.001 and r=0.606) had a correlation with nutritional status in Kesunean Health Center. Conclusion: Knowledge, attitude, and behavior of mother had correlation with nutritional status. Public health center should promote the importance of breast milk and provide the counseling to the mother. Keywords: breastfeeding, intake of complementary feeding, nutritional status of children

ANTIDIABETIC EFFECT OF COMBINED Muntingia calabura L. LEAF EXTRACT AND METFORMIN ON RATS Adhy Nugroho; Risnandya Primanagara; Pahmi Budiman Sahputra Basyir
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Diabetes mellitus is a disease that causes blood glucose levels to increase. There are several therapies that can be done to reduce blood glucose levels in diabetes such as metformin, biguanides medicine and kersen (Muntingia calabura L.) leaves as an alternative. Treatment with combination of both is expected to further reduce blood glucose levels. This study aims to measure the effectiveness of the combination of metformin and Muntingia calabura L. leaf extract on blood glucose levels. Methods: This was an experimental research with pretest-posttest control group. The samples were 24 Sprague-Dawley rats divided into 4 groups, first group (K1) negative control was given only aquadest, second group (K2) positive control (+) was given 45 mg/kgBW metformin, third group (K3) was treated with 300 mg/kgBW Muntingia calabura leaf extract, and the fourth group (K4) was given the combination of 300 mg/kgBW Muntingia calabura leaf extract and 45 mg/kgBW metformin. Blood glucose levels were measured and analyzed using paired t-test and one-way ANOVA. Results: The combination of 300 mg/kgBW of Muntingia calabura extract and 45 mg/kgBB of metformin reduces 131.77 ± 3.57 mg/dl of blood glucose levels (p<0.05). This result is better than only metformin (92.68 ± 3.10 mg/dl) or only Muntingia calabura leaf extract (91.70 ± 4.40 mg/dl). There is a possibility that the synergistic effect of Muntingia calabura leaf extract and metformin caused the increased effectivity in reducing blood sugar level. Conclusion: The combination of Muntingia calabura and metformin is more effective in reducing blood glucose levels compared to a single dose of metformin or Muntingia calabura L. extract alone. Keywords: Diabetes mellitus, M. calabura leaf extract, blood sugar levels.

THE CORRELATION BETWEEN ANTENATAL CARE, PARITY AND MATERNAL AGE AMONG PREGNANT WOMEN WITH ANTEPARTUM HEMORRHAGE INCIDENCE AT GONDOSARI COMMUNITY HEALTH CENTER, KUDUS Akbar Dito Erlangga; Tissa Octavira TPermatasari; Ouve Rahadiani Permana
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Antepartum hemorrhage is one of the main cause of maternal mortality. The Maternal Mortality Rate (MMR) in Indonesia currently reaches 305 every 100,000 live births which is still quite high from the MDGs target. Risk factors for antepartum hemorrhage will increase with increasing age and maternal parity, while, the cause of maternal death can be prevented via regular Antenatal Care (ANC). This present study aimed to determine the correlation between the frequency of antenatal care, parity, and age of pregnant women with the incidence of antepartum hemorrhage in the CommunityHealth Center, Kudus City. Method: This was an observational analytic study with cross-sectional design. This study used secondary data obtained from maternal cohort books and Local Area Monitoring of Mother and Child Health (PWS-KIA) databooks. Using simple random sampling technique, a total of 323 individuals were recruited. Univariate analysis, bivariate analysis and multivariate analysis were performed on the data obtained. Results: The Spearman’s correlation test showed that there was significant correlation between frequency of Antenatal Care (ANC) (p=0.001), parity (p= 0.001) and age (p=0.001) with antepartum hemorrhage. The correlation coefficient showed that antenatal care (ANC) has a strong negative correlation with antepartum hemorrhage (r= -0.541), parity has a medium correlation with antepartum hemorrhage (r= 0.418) and age has a medium correlation with antepartum hemorrhage (r= 0.465). Multivariate analysis showed that age had the strongest influence on the incidence of antepartum hemorrhage (PR= 274.573), while other variables had the weakest influence smaller effect on the incidence of antepartum hemorrhage (ANC, PR= 0.001 and parity, PR= 0.041) Conclusion: The frequency of antenatal care (ANC), parity and age have correlation with antepartum hemorrhage in the working area in Gondosari Community Health Center, Kudus. Age is the most influential factor in the incidence of antepartum hemorrhage. Keywords: Antenatal Care, Antepartum Hemorrhage, Maternal Age, Parity.

THE CORRELATION OF ADOLESCENT’S KNOWLEDGE AND ATTITUDE TO DRUGS WITH ADOLESCENT’S DRUG ABUSE BEHAVIOR IN THE COMMUNITY HEALTH CENTER OF KESUNEAN, CIREBON Ayatullah Ouve Rahadiani Permana; Uswatun Khasanah
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: The reports on the number of drug abuse in Indonesia by the National Narcotic Agency (NNA) showed 3.3 million drug users in 2008 and 3.8 million drug users in 2014 in which its number keeps increasing year after year. The number of teenagers who become drug users in Cirebon is quite high, i.e. 25% compared to unemployed people of 19%, and followed by private employees and government employees of 56%. Data from community health center show that drug users who underwent treatment and were sent to rehabilitation center in 2017 were 32 people; it was higher than in 2016, i.e. 10 people. Adolescence is a transition period between childhood and adulthood. There are several factors influencing mental abilities, knowledge, and attitudes. It makes adolescents may consume narcotics, psychotropic abuse and other drug addictive substances. The community health center of Kesunean has an Integrated service post (ISP) program called REMPONG PISAN (an ISP who cares for HIV/AIDS and Narcotics) aiming to make adolescent understand about HIV/AIDS and drugs and to make them healthy. This ISP program is conducted once a month with one of the activities is education about HIV/AIDS and drugs. Aim: To observe the correlation of adolescent’s knowledge and attitudes to drugs with drug abuse behavior among adolescents at the ISP. Method: This research was an observational analytic study with a cross-sectional design. The sample was determined using consecutive sampling technique during the implementation of the ISP at the 2 neighborhood in the community health center of Kesunean. The data were analyzed using Pearson correlation to determine the correlation of adolescent’s knowledge and attitudes to drugs with drug abuse behavior among adolescents. Results: Statistical analysis shows that there was no significant correlation between knowledge and drug abuse behavior (p = 0.180 and; r = -0,201), there was no significant correlation between attitudes with drug abuse behavior (p = 0.264; r= -0,168), however, there was a significant correlation between knowledge and attitudes towards drug abuse (p = 0.000; r = 0,710**). Conclusion: The better the adolescent’s knowledge about drugs, the better their attitude will be. In this case, good teen behavior is influenced by good knowledge and attitude. Keywords: NNA, Drug, Knowledge, Attitude, Drug Abuse Behavior

THE EFFECT OF LEMON JUICE (Citrus limon) IN LIVER HISTOPATHOLOGIC APPEARANCE OF MALE MICE (Mus musculus L.) EXPOSED BY MONOSODIUM GLUTAMATE (MSG) Dela Destiani Aji; Ruri Eka Maryam Mulyaningsih; Ahmad Fariz MZZ
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Excessive consumption of MSG can cause the formation of free radicals in the body. Continuous use of MSG will cause free radical accumulation and oxidative stress in the liver. An antioxidant is one of the substances that has an ability to eliminate free radicals and protect the liver from oxidative stress. Lemon is a fruit that has benefits as a natural antioxidant. This study aims to determine the effect of administering lemon juice on the histopathological appearance of the liverexposed by MSG. Methodology: This post-test only control group design experimental study used 30 male white mice which were randomly divided into five groups: NC group, C(-) group, D1 group, D2 group, and D3 group. After 7 days of adaptation and randomized grouping, the mice were treated differently based on their group. All groups, except the NC group, were exposed to 4mg/gBW dose of MSG orally for 14 days. On the 15th day, MSG exposure was stopped and after that D1 group, D2 group, and D3 group were given lemon juice with a dose of each group 3.33ml/kgBW, 6.67 ml/kgBW, 13.33 ml/kgBW. The lemon juice was given once a day for 14 days using the gastric sonde. Histopathology examination was analyzed by pathologist in Gunung Jati Hospital, Cirebon, Indonesia. Results: Significant differences of liver histopathology were obtained between the normal control group with the dose 3 group (p = 0.005), the normal control group with the dose 2 group (p = 0.019), the normal control group with the dose group (p = 0.019) and between the negative control groups with dose 3 group (p = 0.027). Dose 3 group has higher liver damage compared to a normal control group and negative control group characterized by the form of parenchymatous degeneration. Conclusion: Lemon juice has a negative effect on the histopathology appearance of male white mice’s (Mus musculus L.) liver exposed by monosodium glutamate (MSG). Further studies are needed to validate the effect of the active compound and toxicity of lemon juice and to reveal the precise mechanisms on how lemon juice affects the hepatocytes. Keywords: Monosodium Glutamate (MSG), Citrus lemon, Histopathology Liver

THE COMPARISON OF DIARRHEA INCIDENCE BETWEEN 0-6 MONTHS OLD INFANTS WHO WERE EXCLUSIVELY BREASTFED, NON-EXCLUSIVELY BREASTFED AND GIVEN MILK FORMULA IN CIREBON CITY, INDONESIA Dewi Sukmawati; Witri Pratiwi; Ahmad Fariz Malvi
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Infant diarrhea is one of the major health issues in Indonesia due to its high incidence and mortality. In 2015, the mortality rate of diarrhea and gastroenteritis in infants under one year in hospitals in Cirebon was 21%. Inappropriate infant feeding practice is one of the risk factors of diarrhea in infants. WHO recommends that every infant should get exclusive breastfeeding during the first 6 months of life and continued breastfeeding until 24 months of age. The aim of this study is to findout the difference in diarrhea incidence between 0-6 months old infants who were exclusively breastfed, non-exclusively breastfed, and given infant milk formula. Methods: This was an observational study with cross-sectional design. A total of 89 infants aged 0-6 months old were recruited by purposive sampling. The primary data were obtained using questionnaires that were filled by the mother or caregiver of the infants. The data were analyzed using the Chi-Square test and Prevalence Ratio was calculated. Results: The Chi-Square test showed a significant difference in diarrhea incidence between 0-6 months old infants who were exclusively breastfed, non-exclusively breastfed and infant milk formula (p=0,028). Infants who were not breastfed have 4 times higher risk of diarrhea (PR=4.145; CI95%= 1.198-14.400) compared to infants who were breastfed. Infants who were not exclusively breastfed has 3 times higher risk of diarrhea incidence compared to the infants receiving exclusive breastfeeding(RP=3.286; CI95%=1.144-9.434) Conclusion: Proper breastfeeding practice can decrease diarrhea incidence in infants aged 0-6 months. Mothers should be encouraged to exclusively breastfeed her baby during the first 6 months of life. Keywords: Diarrhea, breastfeeding, infant milk formula, infant feeding practice

CALCULATING COLONY OF Candida spp. AMONG CHILDREN WITH INTELLECTUAL DISABILITY IN CIREBON Dhini Oktaviani; Amanah Amanah; Eni Suhaeni; Risnandya Primanagara
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Children and adults with Intellectual Disability and Autism Spectrum Disorders (ASD) have decreased intestinal permeability and enzyme activity, causing gastrointestinal (GI) problems that are more frequent and more severe than in children from the general population. The immune system which is part of the intestinal barrier in children with Intellectual Disability (ID) experiences various disorders and becomes more susceptible to fungal invasion, such as Candida spp. This present studyaims to calculate the colony of Candida spp. in the digestive tract of Children with Intellectual Disability (ID) in the city of Cirebon. Method: This is an observational study with cross-sectional design using purposive sampling. The study was conducted in November 2018-February 2019. The sample (ID) group consists of 31 individuals from Special Needs School and 60 individuals from National elementary school (non-ID) in the city of Cirebon. The inclusion criteria were children ages 6-12 years and the exclusion criteria were children under antifungal treatment and children under cytotoxic or immunosuppressive drugs. The fecalsamples from the ID group and non-ID were examined at the Laboratory of the Faculty of Medicine, Universitas Swadaya Gunung Jati Cirebon, Indonesia using Digital Colony counter. Collected data were stored and analyzed using computer aided Statistical program. Mann-Whitney analysis of variance techniques were used to test the hypotheses. Results: The results showed that there are significant differences in the colonies of Candida spp. between the ID group and non-ID group. Median colony of Candida spp. in the ID group is 39.00 with mean colony of 126.90 while the median colony of non-ID group is 3.00 with mean colony of 40.93(p<0.001). Conclusion: There are significant differences between the Candida spp. colonies in the ID group with the non-ID. Keywords: Intellectual Disability (ID), Candida spp., Gastrointestinal

THE CORRELATION BETWEEN EDUCATION, WORK, AND MATERNAL KNOWLEDGE ON COMPLEMENTARY FEEDING WITH 6-24 MONTHS' NUTRITIONAL STATUS Dina Alfiana; Witri Pratiwi; Muhammad Edial Sanif
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Indonesian Basic Health Research in 2018 reported that the prevalence of malnutrition in Indonesia was 17.7% which consists of 13.8% malnutrition and 3.9% severe malnutrition. In West Java Province, the prevalence of malnutrition and severe malnutrition is still high at 15.6%. The aim of this study is to examine the correlation between education, work, and maternal knowledge about complementary feeding with baby nutrition status aged 6-24 months. Methodology: This was a cross sectional study. The sample of this study was 100 mothers of infants aged 6 to 24 months in the Tegalgubug Health Center, in Cirebon City which selected by cluster sampling. Data have been collected from questionnaires and anthropometric measurement of weight for age Z (WAZ). Nutritional status was categorized into malnutrition status if z score <-2 SD up to <-3 SD, and good nutrition status if z score -2 SD to 2 SD. The analysis of the study was tested by Spearman correlation. Results: From 100 respondents,51% of them were low educated mother, 55% were working mother, 51% had good knowledge, and 83% had good nutrition’s babies. The bivariate analysis showed that education, working status, and mother’s knowledge about complementary feeding were statistically significant correlated with nutritional status of infants (p=0.021, p=0.020, p=0.013, respectively). Conclusion: Education, working status, and knowledge were significant correlated with nutritional status of infants aged 6 to 24 months. Malnutrition of infants can be greatly reduced by educating maternal about complementary feeding and given accurate information about nutritional status of infants. Keywords: Education, complementary feeding knowledge, nutritional status

INFLUENCE OF GIVING BREADFRUIT (Artocarpus altilis (Park) Fosberg.) LEAVES EXTRACT TO DECREASE URIC ACID LEVELS IN WISTARS RATS HYPERURICEMIC Hagi Wibawa; Hikmah Fitriani; Rama Samara; Irwan Meidi L
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Hyperuricemic is a condition where the uric acid levels in blood more than 7 mg/dl. In 2010, Hyperuricemic was included as one of non-communicable disease with incidence rate up to 30% and can cause the mortality. This study aims to examine the effective dose of breadfruit (Artocarpus altilis (Park) Fosberg.) leaves extract to decrease uric acid levels in Wistar rats Hyperuricemic. Methodology: This study was an experimental with pre-posttest with control group design. 30 Wistar rats aged three months was divided into 2 control groups (K1 and K2) and 3 treatment groups (K3, K4, and K5). Control groups were given purine (K1= standard, K2=high) and aquadest. Differently, treatment groups were given high purine and breadfruit leaf extract (K3=0.25g /KgBW, K4=0.5g /KgBW, K5=0.75g/KgBW). All the treatments were given one time daily in the morning for 7 days. Datawere analyzed by the Shapiro-Wilk test followed by the One-Way ANOVA test and then Post-hoc Tamhane test. Result: The control groups revealed negative average reduction of uric acid in mg/dl (K1= -0.05, K2= -0.09) whereas the treatment groups revealed the positive average reduction of uric acid in mg/dl (K3=2.19, K4= 4.26, K5=5.87). The significant differences (p<0.05) of uric acid levels before and after treatment in each treatment groups had meaning that giving the Breadfruit leaf extract could reduce the uric acid level rats. Post-hoc Tamhane test result showed that the mean decrease of each group wassignificantly different. Particularly, K5 was the most effective treatment compared with others. Conclusion: Breadfruit leaves extract with dose of 0.75g/KgBW was the most effective treatment to reduce the uric acid level in blood. Stakeholders in health field should promote the Breadfruit as the traditional medicine method to reduce the uric acid in blood. Keywords: Breadfruit leaves, uric acid, Hyperuricemic, Wistar rats, flavonoids

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Dyah Anantalia Widyastari, BSPH., MPH., Ph.D (Cand.)

Contact Email
info@inschool.id

Phone
-

Journal Mail Official
icash@inschool.id

Editorial Address
-

Location
Kota semarang,

Jawa tengah

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Dyah Anantalia Widyastari, BSPH., MPH., Ph.D (Cand.)

Contact Email info@inschool.id

Phone -

Journal Mail Official icash@inschool.id

Editorial Address -

Location Kota semarang, Jawa tengah INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Dyah Anantalia Widyastari, BSPH., MPH., Ph.D (Cand.)

Contact Email
info@inschool.id

Phone
-

Journal Mail Official
icash@inschool.id

Editorial Address
-

Location
Kota semarang,

Jawa tengah

INDONESIA