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Jambura Journal of Chemistry
Published by Universitas Negeri Gorontalo
ISSN : 26563665     EISSN : 26566834     DOI : 10.34312/jambchem
Core Subject : Science,
Chemistry
Jambura Journal of Chemistry is peer-reviewed and open access journal published by Chemistry Depertment, Faculty Mathematic and Natural Science. Jam.J.Chem that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. Jambura Journal of Chemistry publish two issues (numbers) annually (February and August).
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Articles 3 Documents
 1 
Search results for , issue "Vol 8, No 1 (2026): February" : 3 Documents clear
Analisis Kadar Antioksidan Pada Hasil Infusa Jahe Merah (Zingiber Officinale Var. Rubrum), Kombinasi Kunyit (Curcuma Longa) dan Sereh (Cymbopogon citratus) Sabunge, Annisa; Isa, Ishak; Hasan, Hamsidar; Papeo, Dizky Ramadani Putri; Ramadani, Fika Nuzul
Jambura Journal of Chemistry Vol 8, No 1 (2026): February
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v8i1.35606

Abstract

Jahe merah, kunyit, dan sereh merupakan tanaman rempah yang dikenal memiliki kandungan metabolit sekunder seperti flavonoid, fenolik, dan terpenoid yang berperan penting dalam aktivitas antioksidan. Dalam penelitian ini, dilakukan pengujian aktivitas antioksidan pada kombinasi infusa jahe merah–kunyit dan jahe merah–sereh untuk mengetahui potensi keduanya sebagai sumber antioksidan alami. Proses ekstraksi dilakukan dengan metode infusa pada suhu 90°C selama 15 menit, kemudian dilakukan analisis kualitatif melalui uji skrining fitokimia dan kromatografi lapis tipis (KLT), serta analisis kuantitatif menggunakan metode ABTS pada panjang gelombang 734 nm dengan spektrofotometri UV-Vis dan vitamin C sebagai pembanding. Hasil analisis menunjukkan bahwa kedua kombinasi infusa positif mengandung flavonoid, fenolik, dan terpenoid yang berperan sebagai senyawa antioksidan. Nilai IC₅₀ infusa jahe merah–kunyit sebesar 35,83 µg/mL dan jahe merah–sereh sebesar 51,68 µg/mL. kombinasi jahe merah-kunyit termasuk kategori aktivitas antioksidan sangat kuat (IC₅₀ 50 µg/mL) dan jahe merah-sereh termasuk kategori kuat (IC₅₀ 100 µg/mL). Temuan ini menunjukkan bahwa kombinasi infusa jahe merah–kunyit dan jahe merah–sereh memiliki potensi besar sebagai sumber antioksidan alami yang dapat dikembangkan dalam sediaan herbal farmasi.Kata kunci: Antioksidan, Infusa, Jahe merah (Zingiber Officinale Var. Rubrum), Kunyit (Curcuma Longa), Sereh (Cymbopogon citratus), ABTS, IC₅₀
Evaluasi Komprehensif in silico Profil ADME Aqneursa dan Miplyffa: Strategi Seleksi Senyawa Baru yang Disetujui FDA untuk Terapi Niemann-Pick Tipe C Dienna, Annisha Noor; Utri, Chynthia Azhari; Hikmah, Sitti Ainun; Nurbaiti, Novalia
Jambura Journal of Chemistry Vol 8, No 1 (2026): February
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v8i1.34936

Abstract

Niemann-Pick disease type C (NPC) is a rare neurodegenerative disorder requiring new therapeutic options, where ADME (Absorption, Distribution, Metabolism, Excretion) profiles are critical for drug development. This study aimed to conduct a comparative in silico prediction of the ADME profiles of two novel FDA-approved compounds, Aqneursa and Miplyffa, as candidate therapies for NPC. The result in silico profiling was developed from the web-based tool, SwissADME, such as physicochemical characteristics, lipophilicity, solubility, pharmacokinetics, and drug-likeness. Aqneursa follows all the key drug-likeness rules (Lipinski, Ghose, Veber, Egan, Muegge), has a low molecular weight (173.21 g/mol), a well-soluble, a high gastrointestinal absorption, and  a balanced lipophilicity (Log P 0.66). In contrast, Miplyffa presented significant pharmacokinetic challenges, including a high molecular weight (505.90 g/mol), extreme hydrophilicity (Log P -0.21), high polarity (TPSA 202.65 Ų), low GI absorption, and multiple violations of drug-likeness criteria. Although both compounds were predicted to be non-substrates of P-glycoprotein and non-inhibitors of major CYP450 enzymes, neither was predicted to cross the blood-brain barrier (BBB). In conclusion, Aqneursa is good for oral drugs and worthy of further development for NPC, whereas Miplyffa requires alternative formulation strategies or structural modifications.
Profil Kandungan Kimia dan Potensi Senyawa Aktif Limbah FABA untuk Pengembangan Pupuk Berkelanjutan Kunusa, Wiwin Rewini; Duengo, Suleman; Tangio, Julhim S.; Mohamad, Erni; Harun, Nurul Fadilla; Duengo, Humairah Amatullah; Syaifudin, Nuur Arif
Jambura Journal of Chemistry Vol 8, No 1 (2026): February
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v8i1.37015

Abstract

Fly ash and bottom ash (FABA) generated from coal combustion in steam power plants have the potential to cause environmental contamination; however, their mineral content enables their reutilization as raw materials for inorganic fertilizers. This study aimed to evaluate the major metal element content in FABA-based fertilizer produced from the Anggrek Steam Power Plant, North Gorontalo Regency, in order to assess its potential as a nutrient source. Ca and Mg were analyzed using titration methods, while Al, Fe, P, and K were determined by UV–Vis spectrophotometry with good calibration curve linearity (r 0.97). The results showed that the K content in fertilizer samples 1 and 2 was 0.0189% and 0.0140%, respectively. Ca concentrations ranged from 16.8–21.6 mg/L and Mg from 7.29–10.21 mg/L. Al was detected within the range of 3.68–4.44 ppm, while Fe and P were identified in measurable amounts. The presence of Ca, Mg, and K as macronutrients indicates that FABA waste has potential as a raw material for inorganic fertilizer, while also supporting sustainable industrial waste management practices.

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