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INDONESIA
Jurnal Farmasi Indonesia
Published by Universitas Setia Budi
ISSN : 16938615     EISSN : 23024291     DOI : -
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology
Jurnal Farmasi Indonesia (e-ISSN : 2302-4291 dan ISSN : 1693-8615) merupakan jurnal yang dikelola oleh Fakultas Farmasi, Universitas Setia Budi yang terbit sejak Februari 2004 dan terbit 2 kali dalam setahun yaitu periode bulan Maret dan November. Jurnal Farmasi Indonesia menerima naskah tentang hasil penelitian laboratorium, lapangan, studi kasus, telaah pustaka yang erat kaitannya dengan bidang kefarmasian, kesehatan dan lingkungan hidup.
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Articles 12 Documents
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Search results for , issue "Vol 17 No 2 (2020): Jurnal Farmasi Indonesia" : 12 Documents clear
Uji Aktivitas Antibakteri dan Antijamur Dari Kombinasi Minyak Nyamplung (Calophyllum Inophyllum L.) Dengan Virgin Coconut Oil Dan Pengembangannya Sebagai Face Anif Nur Artanti; Khairunisa Nursita Rahmawati; Fea Prihapsara
Jurnal Farmasi Indonesia Vol 17 No 2 (2020): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v17i2.760

Abstract

Face oil merupakan salah satu perawatan kulit yang pada pengembangannya, perlu dicari suatu agen yang memiliki sifat antimikroba, contohnya adalah minyak nyamplung dan VCO. Minyak nyamplung yang diperoleh dari pengepresan biji nyamplung akan dikombinasikan dengan VCO pada seri konsentrasi 25:75, 40:60, 50:50, 60:40 dan 75:25% (v/v) yang kemudian diuji antibakteri serta antijamur menggunakan Propionibacterium acnes dan Malassezia furfur dengan menggunakan metode difusi cakram serta diamati diameter zona hambatnya. Perbandingan kombinasi kedua minyak yang memiliki aktivitas antimikroba tertinggi akan dikembangkan menjadi sediaan face oil yang kemudian diuji sifat fisik sediaan diantaranya uji stabilitas, organoleptis, pH, homogenitas, daya sebar, serta uji kadar air selama 4 minggu penyimpanan pada suhu ruang. Hasil penelitian menunjukkan bahwa kombinasi minyak nyamplung dan VCO yang memiliki aktivitas antibakteri paling tinggi adalah seri konsentrasi 25:75 dan 50:50% (v/v) (DDH=12,33 mm), namun kombinasi minyak tersebut tidak memiliki aktivitas antijamur (DDH=0 mm). Hasil analisis data uji sifat fisik diuji menggunakan Repeated Measures ANOVA dengan Post Hoc Bonferroni dan diketahui bahwa sediaan face oil stabil selama 4 minggu penyimpanan, namun pada uji pH sediaan face oil mulai tidak stabil pada minggu ke-3 dan ke-4.
Stimulantia Effect Of Single Bulb Garlic Extract (Allium Sativum Var.Solo Garlic) in Swiss Webster Mice Ika Buana Januarti
Jurnal Farmasi Indonesia Vol 17 No 2 (2020): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v17i2.762

Abstract

Stimulant is an agent that stimulates the central nervous system thereby increasing physical and mental abilities and minimizing fatigue. The use of synthetic caffeine stimulants of 10 mg / kg BW is known to have side effects of increasing total cholesterol and increasing LDL, therefore alternative stimulants from natural ingredients are needed. Natural materials that have been studied contain flavonoids and phenolic as a stimulant compound is a single garlic bulbs. The purpose of this study was to determine the stimulant effect of a single garlic bulbs ethanolic extract on mice from the difference in swimming time. The research experimental used Pre test and Post test control design. Sample of this research used mice which were divided into 6 groups. Group 1 pretest dose 5 g / kgBB, group 2 (negative control), group 3 (caffeine), group 4 extract dose 5g / kgBB, group 5 dose 10g / kgBB and group 6 dose 20g / kgBB. Data was analyze using one way Anova continued with Post Hoc test. The group of single garlic bulb ethanolic extract dose 20 g / kgBB had the highest stimulant effect with 222,722 minutes fatigue time difference and statistically have significant difference (p <0.05) than the negative control group. Group of single garlic bulb extract can influence the time of fatigue of mice by extending the swimming time of mice so that it has a longer fatigue time which means it has a stimulant effect
Pengaruh Pemberian Ekstrak Adas (Foeniculum vulgare Mill ) Pada Tikus Laktasi Terhadap Sel Neuroglia Anak Tikus Dwi Ningsih
Jurnal Farmasi Indonesia Vol 17 No 2 (2020): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v17i2.794

Abstract

Breast Milk is a natural baby food that is rich in nutrients and contains higher immunological factors compared to formula milk. Foeniculum vulgare Mill plants have long been used by the community as enhancing the production of breast milk (ASI). The purpose of this study was to determine the effect of lactogogum extracts of Foeniculum vulgare Mill leaves and stems in lactation mice, as seen from mouse neuroglia cells. Foeniculum vulgare Mill extract was made by maceration method using 96% ethanol solvent. The test animals used in the study were white rats, divided into 6 groups namely, normal control, control without drugs (cmc-na 0.5%), comparison of asifit drugs (67.86 mg / KgBB), ethanol extract groups of leaves and stems fennel dosage 315 mg / kg body weight, 630 mg / kg body weight, and 945 mg / kg body weight. The results of the research that have been done show that the ethanol extract of Foeniculum vulgare Mill leaves and stems dose 315 mg / kg body weight, 630 mg / kg body weight, and 945 mg / kg body weight have a lactagogum effect seen from the parameters of the number of glia cells in the brains of breastfed mice. The effect increase is not as large as the dose increase given. The ethanol extract of Adas leaves and stems of 630 mg / kg BW has an optimal lactagogum effect equivalent to drug control on the market as seen from the parameters of the number of glia cells in the brains of breastfed rat.
Formulasi, Uji kualitas Dan Uji Organoleptik Sabun Mandi Padat Menggunakan Bahan Aditif Daun Jambu Biji (Psidium guajava L.) Sri Handayani; Aris Tiana Anjali
Jurnal Farmasi Indonesia Vol 17 No 2 (2020): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v17i2.798

Abstract

Guava leaves have flavonoids, tannins, and alkaloids as main compounds which have been shown to be active as antibacterial and anticarcinogenic agents. However, they have never been used as additives in skin care products because they have a rough texture. The purpose of this research are to formulate the method in the production of bath soap with the leaves as additives, and they were examined in quality and organoleptic tests. Formulation in production of the soap was carried out by means of variations of the method of extracting guava leaves as additives, namely: without additive as a control (A), with water solvent (B), with vegetable oil solvent (C), and powder dried as a scrub (D). The soap quality tests based on SNI 2016 including tests for alkaline or free fatty acid levels, insoluble ingredients in ethanol and unsaponified fat fractions. Organoleptic test was carried out involving 20 panelists. Data were analyzed by ANOVA-Duncan test. It was found that soap quality test for all samples meet INS except free alkali levels in D soap. The hedonic test results show that all soap samples can be accepted by panelists. Based on quality and organoleptic tests, the formulation method for adding guava leaf extract as an additive that produces the best soap is extraction using a water solvent (soap B). For the next study, it is necessary to confirm the biological activity of soap with guava leaf additives because it is very potential to be used as an antimicrobial soap.
Enoxaparin vs Fondaparinux Dalam Penurunan CK-MB yedy purwandi sukmawan; Keni Idacahyati; Rezky Fahrizal Firdaus
Jurnal Farmasi Indonesia Vol 17 No 2 (2020): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v17i2.810

Abstract

Ischemic Heart Disease (Non ST Elevated Myocardial Infarction-NSTEMI) is the leading cause of death in Indonesia after Stroke. Enoxaparin and Fondaparinux are the drugs of choice for this condition. However, there is a little study about these drugs in Indonesian people. Therefore, the objective of the study is to determine the effectivity of enoxaparin and fondaparinux in CK-MB reduction in Indonesian people. The methods of the study is retrospective observational study. A total of 43 patients were met inclusion criteria (32 in the enoxaparin group and 11 in the fondaparinux group). The outcome of the study was CK-MB reduction and the time of dyspnea was disappeared. The results of the study showed no statistic difference between enoxaparin and fondaparinux in reducing CK-MB blood plasma level (-29.00 vs -33.09; p 0.715), and also the time of dyspnea was disappeared (3.44 vs 3.09 days; p 0.347). Therefore, the choice of these agents are based on clinical condition, adverse effects and pharmacoeconomic aspects.
Analisis Biaya Riil Dan Kesesuaian Dengan Tarif INA-CBGs Pada Pasien Kanker Ovarium Di RSUD Dr. Moewardi Surakarta Tahun 2018 Eka Oktafiani
Jurnal Farmasi Indonesia Vol 17 No 2 (2020): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v17i2.824

Abstract

Ovarian cancer according to the Indonesian Society of Gynecological Oncology ranks second after cervical cancer. Treatment of ovarian cancer is done by surgery, radiotherapy, and chemotherapy. The study aimed to understand the suitability of real costs with INA-CBG rates and the factors that influence real costs in ovarian cancer patients at hospital Dr. Moewardi Surakarta. The study was taken analytically, the data was taken retrospectively. Subjects were ovarian cancer patients hospitalized at Dr. Moewardi Surakarta in 2018. The analysis used a t-test sample and multivariate analysis to find out research on aid funds with factors related to aid. The results of the study there were 93 patients, 87 patients included in the classification of chemotherapy and 24 patients included in the classification of surgery. Chemotherapy C-4-13-I class 3 has a difference of Rp-2,685,296, in surgery W-1-20-I class 1 the difference is Rp-3,486,814, for class 3 the difference is Rp -6,933,878, W-1 surgery -20-II class 2 the difference is Rp -6,492,889, grade 3 the difference is Rp -20.450.634, and in surgery W-4-10-III class 2 the difference is Rp -13,714,831. The factor that influences the real cost is LOS (Length Of Stay) (p = 0,000) on chemotherapy. The irregular cycle of chemotherapy leads to the cost of chemotherapy for patient ovarian cancer in Dr Moewardi Surakarta 2018.
the Faktor-Faktor yang Berpengaruh terhadap Adverse Drug Reaction pada penggunaan Obat Anti Tuberkulosis Lucia Vita Inandha Dewi
Jurnal Farmasi Indonesia Vol 17 No 2 (2020): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v17i2.903

Abstract

Adverse Drug Reaction (ADR) in the treatment of tuberculosis can reduce the quality of life and compliance of patients, long-term treatment has a risk of ADR, to prevent dangerous ADRs need to be monitored properly, the predictors that affect ADR are very important to be sought as an effort to prevent the incidence ADR. This study was a cross-sectional study conducted on pulmonary tuberculosis patients at the Public Health Center (PKM) of Bantul Regency Yogyakarta, inclusion criteria were patients who received fixed-dose combination tuberculosis (KDT), age> 17 years old, ADR monitoring was carried out since the month of two treatments up to the 6th month by interview method for each control patient to the PKM. Data processing was performed by multinomial regression multivariate tests. The results showed that ADR occurred in 58% of the old age group; 51.8% of the middle age group and 50% of the young age group, there was no significant effect of age on ADR in this study. Based on sex, ADR occurred in 58.5% of men, and 47.3% of women, with no significant effect of gender on ADR. Based on BMI, ADR occurred in the underweight, normal, and overweight groups with a percentage of 78%, 26%, and 40% there was a significant influence between BMI and the incidence of ADR, p-value 0.01 OR = 7,650 (2,350-24,898) CI = 95 %. Based on the BTA ADR group occurred in the positive and negative BTA groups with a percentage of 52% and 62%, there was no significant effect between the BTA and the ADR incidence Key words : Adverse Drug Reaction, Tuberculosis, Fixed-dosed combination-Antituberculosis Drug (FDC)
Pengaruh Medication Therapy Management (MTM) terhadap Tingkat Pengetahuan dan Kualitas Hidup Pasien Diabetes Melitus Di Puskesmas Kota Yogyakarta Nita Trinovitasari; Nanang Munif Yasin; Chairun Wiedyaningsih
Jurnal Farmasi Indonesia Vol 17 No 2 (2020): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v17i2.906

Abstract

The problem that often occurs in diabetes patients is the lack of knowledge related to treatment and illness. This problem can be overcome by providing education to patients collaboratively and continuously. One intervention that can be done is the Medication Therapy Management (MTM) service. MTM is a service that aims to optimize patient therapy outcomes. This recently implemented service has quite a several elements. So, this study modifies MTM service referenced from the MTM BPJS (Social Security Administering Body). This study aims to determine the effect of MTM services to the level of knowledge and quality of life on diabetes mellitus patients in Yogyakarta Public Health Center. The employed research method was quasi-experimental one-group design with pretest-posttest design and experiments were conducted in March to April 2020. The sampling method uses a purposive sampling technique. This study uses a questionnaire as a research instrument. Data were analyzed using SPSS. Results show a slight increase in the patients’ knowledge from 8.9 ± 2.3 to 11.6 ± 1.5 after MTM services were given with p-value of 0.000, and a slight increase in the quality of life of patients from 50.56 ± 3.9 to 52.84 ± 4.3 with a p-value of 0.003. In conclusion, the MTM-based services from pharmacists can significantly increase the knowledge and quality of life of diabetic patients.
Oral Short-course Antibiotics Compliance Survey at Several Public Health Centres in Surabaya Ilil Maidatuz Zulfa; Widya Handayani
Jurnal Farmasi Indonesia Vol 17 No 2 (2020): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v17i2.911

Abstract

Patients compliance is commonly occured in short-course antibiotics therapy. Patients compliance not only contributed to the therapeutics effect but also to prevent antibiotics resistance. Qualitatively, uncompliance in using antibiotics is affected by patients knowledge about antibiotics, improving symptomps, false in interpretating drug labels, activities, the lack of family suppor, and the lack of information given by healthcare provider. This study was aimed to observe patients compliance in using antibiotics assessed in how and howmany times they take their dosage, how they give interval between the doses, and whether they complete their course or not. The reasons behind their behaviour also investigated in this study. The survey was conducted at three public health centres in Surabaya. Patients who received short-course (3-5 days) antibiotics therapy were asked to participate in this study. The compliance was assessed using online developed self-assessment questionnaire containing 17 questions asking how they use their antibiotics and how many pills left sent in the last dosage day. The antibiotics prescription data was recorded as a refference in evaluating patients compliance. During research periods, a total of 100 patients were enrolled in this study. Of that, there were only 12.0% categoryzed as compliant. Most of patients did not give the same time interval between their doses (63,0%) and did not finished or prolonged their course (46,0%). The majority reasons behind their behaviour was feelings better or improving symptomps and simply forgot to take their antibiotics. A strengtnen in counselling and monitoring during their antibiotics course is needed in order to increase their compliance.
Effect Effect of Black Rice Bran on the Pharmacokinetics Profile of Glibenclamide in Hyperglycemic Rats Arifah Sri Wahyuni
Jurnal Farmasi Indonesia Vol 17 No 2 (2020): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v17i2.953

Abstract

Black rice bran (BBH) which contains anthocyanins has the ability to lower blood sugar. In therapy diabetes mellitus (DM) it is possible that BBH is used together with the oral antidiabetic Glibenclamide (Gli). Glibenclamide, a weak acid, is well absorbed in the gastrointestinal tract. The absorption of BBH is also good under acidic conditions. So, it is necessary to study the pharmacokinetic interactions between Gli and BBH. The study was designed using a one-way completely randomized design of ten (10) hyperglycemic rats, divided into two groups. Group I rats received Gli 5 mg / kgBW treatment, and group II received Gli 5 mg/kgBW along with BBH 50 mg / kgBW. Sampling was carried out at 1, 2, 4,6, 8 and 24 hours after treatment. Gli levels in the blood were determined by Liquid Chromatography/Mass Spectroscopy (LC/MS). The results showed that in the absorption phase, giving BBH with Gli did not affect the Gli profile in terms of parameters Tmax, Cmax and AUC0-inf. Likewise, in the distribution and elimination phases in terms of parameters VD, ClT and elimination half-time (t1/2). So that the provision of BBH does not affect the pharmacokinetic parameters of Gli in hyperglycemic rats.

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