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Eksakta : Berkala Ilmiah Bidang MIPA
Published by Universitas Negeri Padang
ISSN : -     EISSN : 25497464     DOI : https://doi.org/10.24036/eksakta/
Core Subject : Science, Education, Agriculture, Social, Engineering,
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Energy Engineering Environmental Science Materials Science & Nanotechnology Mathematics Mechanical Engineering
Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) is an open access journal and peer-reviewed that publishes either original article or reviews. The journal is dedicated towards dissemination of knowledge related to the advancement in scientific research. The prestigious interdisciplinary editorial board reflects the diversity of subjects covered in this journal. Under the realm of science and technology, the coverage includes environmental science, pure and applied mathematics, agricultural research and engineering, biology, biotechnology, bioinformatics, Healthcare sciences (including clinical medicine, preventive medicine & public health), physics, biophysics, computer science, chemistry and bioengineering, to name a few. This Journal Is Published at 3 Month intervals on January-Marc, April-June, July-September and October-December
Arjuna Subject : Umum - Umum
Articles 310 Documents
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The Evaluation of Microplastic Reduction in Biofloc Aquaculture for Sustainable Nile Tilapia Cultivation Deswati, Deswati; Zein, Rahmiana; Novsimapera, Gatri; Putra, Adewirli
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 26 No. 03 (2025): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol26-iss03/609

Abstract

Sustainable aquaculture requires environments free from microplastic contamination. However, microplastics are now commonly found in aquatic systems, including fish farms, where they can accumulate in organisms and enter the food chain. This study evaluates the effectiveness of biofloc technology in reducing microplastic levels in water and Nile tilapia (Oreochromis niloticus), using ecological risk indices: Pollution Hazard Index (PHI), Pollution Load Index (PLI), and Potential Ecological Risk Index (PERI). The experiment lasted 50 days with four treatments, including polyethylene (PE) and polyethylene terephthalate (PET) exposure. Microplastic concentrations ranged from 0.12 to 0.33 particles/L, with highest accumulation in the fish esophagus (39.2 ± 6.87 particles/g). Identified polymers included PE, PVC, and PA. Risk indices showed PHI = 166.69, PLI = 1.01–1.66, and PERI = 21.49, indicating medium to high ecological risks. Results show that biofloc effectively reduces microplastic levels, making it a promising solution for sustainable aquaculture. The study highlights the need for better plastic waste management policies and stricter regulation of PVC and PET near farming areas.
Yield Responses of Red Chili (Capsicum Annuum L.) Cultivars to Nutrient Solution Volumes and Agricultural Building Types Salsabila, Syifa; Farida, Farida; Kusumiyati, Kusumiyati
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 26 No. 03 (2025): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol26-iss03/616

Abstract

This study aimed to evaluate the yield responses of red chili to three agricultural buildings (greenhouse, screenhouse, open field), four nutrient solution volumes (100%, 75%, 50%, 25% ETc) and two cultivars (Pilar and Osaka). This is the first study to assess the combined effects of agricultural buinding type, nutrient volume based on ETc, and two red chili cultivars (Pilar and Osaka) using a split-splt plot design under tropical-dry season conditions. The experiment was conducted from August 2024 to February 2025 at Padjadjaran University, Indonesia, using a split-split plot design with 24 treatment combinations and three replications. Data were analyzed using ANOVA and DMRT at the 5% level. The results showed no interaction among three factors but each had a significant individual effect. Greenhouse conditions significantly increase the number of fruits per plant, fruit weight per plant, individual fruit weight and fruit length. Nutrient volume of 75% ETc and 100% ETc produced comparable result for fruit number and fruit weight per plant. The Pilar cultivar outperformed Osaka in fruit weight and diameter. These findings suggest that greenhouse cultivation with 75% ETc and Pilar cultivar enhance yield and supporting sustainable chili production in tropical regions.  
Molecular Pathway of Phytochemicals in Preventing Sarcopenia Sari, Desy Nofita; Goenarjo, Roman Ardian; Sianipar, Imelda Rosalyn
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 26 No. 03 (2025): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol26-iss03/621

Abstract

Sarcopenia, the age-related decline in muscle mass and function, poses a significant global health challenge. This systematic review synthesizes evidence from preclinical studies published between 2020 and 2025 to elucidate the molecular pathways through which phytochemicals prevent sarcopenia. Following PRISMA guidelines, a systematic search of databases identified 16 eligible studies. The analysis reveals that phytochemicals, including flavonoids, polyphenols, and botanical extracts, mitigate muscle atrophy by concurrently enhancing anabolic signaling via the IGF-1/PI3K/Akt/mTOR axis, suppressing proteolysis, improving mitochondrial biogenesis, and reducing oxidative stress and inflammation. Notably, combinatorial formulations and multi-target extracts demonstrate superior efficacy. The review concludes that phytochemicals represent a promising multi-targeted strategy against sarcopenia; however, this promising potential necessitates future validation through standardized clinical trials to establish efficacy and safety in human populations.
Evaluation of Straw Mushroom Color Stability during Storage: The Role of Nano Edible Coating, Packaging, and Temperature Sitompul, Kiki Nuratni; Mubarok, Syariful; Kusumiyati, Kusumiyati
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 26 No. 04 (2025): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol26-iss04/619

Abstract

Straw mushrooms are one of the nutritious edible mushrooms with high economic value. However, color changes during storage are one of the problems that impact the marketability. Post-harvest treatment in the form of the use of nano edible coatings, packaging, and storage temperatures can prevent gas exchange, control humidity and anti-browning agents in straw mushrooms. This study aims to evaluate the effect of nano edible coatings, packaging types, and different storage temperatures on the color stability of straw mushrooms. This study used a Completely Randomized Design consisting of a combination of nano edible coating treatments (nano sodium alginate and nano aloe vera), packaging types (vacuum, biodegradable, wrap packaging), and storage temperatures (room temperature (±25°C), 10°C, and 5°C), so that there are 18 treatment combinations. Each treatment was repeated twice so there were 36 experimental units. Each experimental unit consisted of two samples so that there were 72 samples at each observation time (1, 3, 5 days after storage), so that the total samples were 216. The results of the study showed that the combination treatment of nano sodium alginate with wrap packaging at a temperature of 10°C showed the best L*, a*, and hue values during 5 days of storage.
Molecular Viability Assay: Improving Leprosy Diagnosis beyond Current Gold Standard Imaniar, Clara; Ibnu Agus Ariyanto; Yeva Rosana
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 26 No. 04 (2025): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol26-iss04/568

Abstract

Neglected tropical diseases are still part of the health problems faced by the world. One of the neglected tropical diseases that has not yet reached 100% elimination is leprosy. Mycobacterium leprae is the pathogen responsible for leprosy, a chronic infectious disease that affects the skin and peripheral nerves and can lead to significant disability if left untreated. Currently, the gold standard for diagnosis is detecting acid-fast bacilli (AFB) with Ziehl-Neelsen staining; however, this method cannot distinguish between living and dead bacteria, complicating treatment assessment, relapse detection, and resistance tracking. Therefore, more accurate diagnostic instruments that can differentiate bacterial viability are needed. Since M.leprae cannot be cultured in artificial media, molecular-based assays are promising tools for rapid diagnosis. This study aims to identify recent assays for assessing bacterial viability in leprosy. Articles used are limited to the publication year between 2019 until 2024 from databases such as PubMed, ProQuest, Scopus and Google Scholar, using PRISMA methods. After filtration, from 143 articles we found 5 articles that discussed the viability of leprosy-causing bacteria. The selected studies showed that molecular assays to determine bacterial viability can be used and explored to strengthen the existing gold standard for monitoring treatment of leprosy patients
Gastrointestinal Dysfunction after Traumatic Brain Injury: Mechanisms Linking The Gut, Inflammation, and the HPA Axis Dwi Hastuti; A Jusman, Sri Widia; Reni Paramita
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 26 No. 04 (2025): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol26-iss04/601

Abstract

Traumatic brain injury (TBI) is a major global health problem that often leads to systemic complications beyond neurological damage, notably gastrointestinal (GI) dysfunction. The mechanisms linking TBI to GI complications remain inconclusive. We conducted a systematic review using current clinical evidence on the pathophysiological processes underlying post-TBI GI dysfunction, focusing on two principal mechanisms: inflammatory-oxidative processes and hypothalamic–pituitary–adrenal (HPA) axis alterations. A comprehensive search was conducted through PubMed, Cochrane Library, and Scopus to identify eligible studies. Evidence indicates that surges of proinflammatory mediators and chemokines, along with reduced anti-inflammatory mediators, drive systemic immune imbalance. Moreover, iNOS upregulation and gut microbiota dysbiosis contribute to mucosal injury. Concurrently, HPA axis dysregulation exerts a bidirectional impact. Elevated ACTH and cortisol reflect an intact stress response that may stabilise metabolism if combined with early enteral nutrition, whereas critical illness-related corticosteroid insufficiency (CIRCI) and hypergastrinemia are strongly associated with gastrointestinal bleeding and mortality. Together, these findings underscore the synergistic role of inflammatory and endocrine disturbances in driving gastrointestinal vulnerability after TBI. Understanding these mechanisms is crucial for developing biomarker-based monitoring and targeted interventions to improve prognosis and reduce GI-related complications in TBI patients.
Flavonoid Role as Autophagy Modulators in Breast Cancer Treatment Strategy Dany, Frans; Arsianti, Ade; Erlina, Linda; Rinendyaputri, Ratih
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 26 No. 04 (2025): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol26-iss04/624

Abstract

Autophagy is a tightly regulated catabolic process that enables cancer cells to survive under metabolic stress and contributes to the development of chemoresistance. Targeting autophagy has therefore emerged as a promising strategy to enhance cancer therapy efficacy. Flavonoids, a diverse class of polyphenolic compounds abundantly found in plants, have gained considerable attention due to their broad-spectrum biological activities, including anticancer effects. Recent studies highlight their ability to modulate key signaling pathways involved in cell proliferation, apoptosis, and autophagy. Several flavonoids, such as fisetin, apigenin, and quercetin, exhibit roles as autophagy modulators depending on the cellular context, offering therapeutic flexibility. Their low toxicity and synergistic potential with conventional drugs underscore their relevance as adjuvant agents. This review discusses the critical role of autophagy in cancer progression and drug resistance, and examines current evidence supporting the integration of flavonoids as autophagy modulators in the design of more effective and targeted anticancer strategies, particularly in breast cancer therapy.
Production, Characterization, and Application of Palm Fruit (Arenga pinnata Merr.) Flour in Boba Pearls Azima, Fauzan; Desniarti, Desniarti; Iqbal, Muhammad; Khaira, Bunga Silvana
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 26 No. 04 (2025): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol26-iss04/628

Abstract

Widely consumed food products can be strategically fortified with dietary fiber to enhance population-level fiber intake. This study examined the physicochemical and functional properties of palm fruit flour to determine its potential as a dietary fiber-enhancing substitute in tapioca-based boba. Initially, palm fruit flour was characterized for its physicochemical and functional properties. Afterwards, it was substituted for 20% of the tapioca in tapioca-based boba pearls and compared to a control (100% tapioca). Analyses of both the raw flour and the boba included its physicochemical and functional properties. Characterization of palm fruit flour showed a high water absorption capacity (8.79 mL/g) and whiteness degree (92.12%). Substituting 20% of the tapioca with palm fruit flour resulted in a product with a high dietary fiber content (20.73%), increased moisture content (68.46 ± 1.25), and a lowered caloric value (2.24 kcal). In conclusion, palm fruit flour is an effective ingredient for fortifying boba nutritionally, though it changes the texture, producing a softer product. Thus, it presents a potentially valuable approach for formulating novel functional foods for healthy consumers, offering a redefined sensory experience. This study is the first to evaluate palm fruit flour as a partial tapioca substitute for fiber-enriched boba production.
Application of Skim and Cream Separation Technology to Improve the Quality of Minyak Tanak: A Case Study in Nagari Sikabu Lubuk Alung, West Sumatra, Indonesia Rahadian Zainul; Ariusni Elida
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 25 No. 04 (2024): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol25-iss04/519

Abstract

This research explores the application of skim and cream separation technology to improve the traditional production process of minyak tanak in Nagari Sikabu, Lubuk Alung, West Sumatra. The study aims to evaluate whether applying modern separation technology can enhance both the quality and efficiency of the production process. The research was conducted using a case study method, where data were collected through field observations, interviews with local oil producers, and laboratory tests. The oil was analyzed based on its clarity, aroma, taste, moisture content, and resistance to oxidation before and after applying the separation technology. The results indicate a significant improvement in oil clarity, a stronger coconut aroma, and a longer shelf life due to reduced moisture content. Additionally, the separation process time was reduced by 50%, increasing overall production efficiency. However, high initial costs and the need for specialized training present barriers to widespread adoption. The skim and cream separation technology effectively enhances the quality of minyak tanak, making it a valuable tool for improving traditional production methods, though additional support is required for broader application.
In Silico Evaluation of Natural Compounds as Dual Inhibitors of Exotoxin A and LasB (Elastase) Virulence Proteins in Pseudomonas aeruginosa Fariska, Andrias Bayu; Linda Erlina; Ade Arsianti; Aryo Tedjo
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 26 No. 04 (2025): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol26-iss04/631

Abstract

Pseudomonas aeruginosa is an opportunistic pathogen whose virulence is largely mediated by Exotoxin A and LasB (elastase), making them promising anti-virulence drug targets. This study aimed to evaluate the inhibitory potential of natural compounds against these two key proteins using an in silico approach. Pharmacophore-based virtual screening of HerbalDB compounds was performed by LigandScout software, followed by molecular docking using AutoDockTools-1.5.7 against Exotoxin A (PDB ID: 1AER) and LasB (PDB ID: 1U4G). Native ligands and co-crystallized inhibitors were used as docking controls to validate binding accuracy. Among the screened compounds, Epicatechin-(4β-6)-epicatechin-(4β-8)-catechin exhibited the strongest binding affinity to Exotoxin A (ΔG = −10.72 kcal·mol⁻¹), while Carpaine showed the highest affinity for LasB (ΔG = −8.91 kcal·mol⁻¹). The predicted interactions involved hydrogen bonds and hydrophobic interactions with active-site residues, comparable to the native inhibitors. Furthermore, ADMET analysis indicated favorable pharmacokinetic and drug-likeness properties. These findings suggest that selected natural compounds possess potential dual inhibitory activity against Exotoxin A and LasB, warranting further experimental validation as anti-virulence candidates for controlling P. aeruginosa infections.

Page 30 of 31 | Total Record : 310

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