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SRIWIJAYA JOURNAL OF MEDICINE
Published by Universitas Sriwijaya
ISSN : -     EISSN : 26223589     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Sriwijaya Journal of Medicine (SJM) is a scientific journal managed by Faculty of Medicine Universitas Sriwijaya, Indonesia. It publishes original research articles and reviews in Biomedical Sciences, Medicine (Neurology, Cardiovascular, Respiratory, Gastrointestinal, Urogenital, Endocrine and Metabolism, Integument, Mental Health, Obstetry and Gynecology, Ophtalmology, ENT, Musculosceletal) and Public Health Medicine. Sriwijaya Journal of Medicine (SMJ) published three times a year (January, April, October).
Arjuna Subject : Kedokteran - Anatomi
Articles 315 Documents
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Angka Kejadian Posterior Capsular Opacity di Rumah Sakit Khusus Mata Provinsi Sumatera Selatan Leonardo Leonardo; Alie Solahuddin; Wardiansah Wardiansah
Sriwijaya Journal of Medicine Vol. 4 No. 2 (2021): Vol 4, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v4i2.120

Abstract

Posterior Capsular Opacity salah satu komplikasi yang terjadi dari operasi katarak. Sebanyak 8,82% pasien mengalami Posterior Capsular Opacity di RSCM, Jakarta. Penelitian ini bertujuan untuk megetahui angka kejadian Posterior Capsular Opacity di RSKM, Palembang. Penelitian ini merupakan studi deskriptif observasional dengan desain cross-sectional. Sampel penelitian adalah pasien yang telah menjalani operasi katarak di RSKM Provinsi Sumatera Selatan pada periode Januari – Maret 2018 yang dipilih dengan sistem total sampling. Sebanyak 353 pasien memenuhi kriteria inklusi. Data distribusi kejadian dan sosiodemografi posterior capsular opacity didata melalui rekam medik pasien dan dianalisis dengan analisis univariat. Dari 353 pasien yang menjalani operasi katarak, sebanyak 2 orang (0,6%) mengalami posterior capsular opacity. Pada jenis kelamin laki-laki dan perempuan, didapatkan masing-masing 1 orang (0,6%). Dewasa berusia 18 – 60 tahun dan usia lanjut ≥ 60 tahun masing-masing sejumlah 1 orang berusia 54 tahun (1%) dan berusia 66 tahun (0,4%).. Tidak ditemukan kejadian Posterior Capsular Opacity pada anak ≤ 18 tahun. Angka kejadian Posterior Capsular Opacity di Rumah Sakit Khusus Mata Provinsi Sumatera Selatan pada tahun 2018 cukup rendah. Menurut jenis kelamin, didapatkan jumlah kejadian setara. Menurut usia, dewasa berusia dewasa dan lanjut usia setara. Tidak ditemukan kejadian Posterior Capsular Opacity pada anak-anak.
Sinovac Adverse Event Following Immunization (AEFI): Correlation to Gender and History Aefi in Students Mellybeth Indriani Louis; Merlionarsy Tammuan; Novita Wiratasia Parimpun; Gisel Pali Pasulu; Indah Puspasari Kiay Demak
Sriwijaya Journal of Medicine Vol. 5 No. 1 (2022): Vol 5, No 1, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v5i1.121

Abstract

As one of the nations impacted by the COVID-19 pandemic, Indonesia adopting a vaccination policy for its population. After vaccination, there will be a chance to have an AEFI that influenced by gender and the history of AEFI from the previous vaccination. This research designed using a cross-sectional approach. Sample is taken from 365 students of Tadulako University. The questionnaire was developed using information based on Indonesia Ministry of Health and the World Health Organization. All data collected was analyzed using the Contingency Coefficient test. There was a significant relationship between gender and pain (p = 0.004, r = 0.148), redness (p = 0.041, r = 0.107), swelling at the injection site (p = 0.037, r = 0.109), cellulitis (p = 0.037, r = 0.109), and headache (p = 0.006, r = 0.143). There was a significant relationship between history of AEFI and pain (p = 0.000, r = 0.182), redness (p = 0.000, r = 0.274), swelling at the injection site (p = 0.001, r = 0.178), cellulitis (p = 0.000, r = 0.249), fever (p = 0.000, r = 0.382), myalgia (p = 0.000, r = 0.239), arthralgia (p = 0.000, r = 0.268), asthenia (p = 0.000, r = 0.254), and headache (p = 0.000, r = 0.218). More students did not get AEFI than did. AEFI was more common experienced by females and students who had no previous history of AEFI. Most of all AEFI will improve in less than a day.
Persepsi Ibu Tentang Susu Formula dan Model Pemberian Susu Formula Pada Anak Bawah Dua Tahun Muhammad Rusdi; Ardesy Melizah Kurniati; Ella Amalia; Syarif Husin; Fatmawati Fatmawati
Sriwijaya Journal of Medicine Vol. 4 No. 3 (2021): Vol 4, No 3, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v4i3.122

Abstract

Air susu ibu (ASI) direkomendasikan untuk terus diberikan bersama dengan makanan pendamping ASI hingga anak berusia dua tahun. Terdapat beberapa indikasi medis sehingga anak harus mendapatkan susu formula pada rentang usia tersebut. Namun, banyak ibu yang memberikan susu formula tanpa alasan indikasi medis. Belum diketahui apakah keputusan memberikan susu formula tersebut dipengaruhi persepi ibu tentang susu formula. Penelitian ini bertujuan untuk mengetahui persepsi ibu tentang susu formula, model pemberian susu formula, dan hubungan antara kedua variabel tersebut. Penelitian ini merupakan penelitian observational analitik dengan desain potong lintang, pada populasi ibu yang memiliki anak di rentang usia 6-24 bulan yang terdaftar di Puskesmas wilayah kerja Kecamatan Ilir Timur II Palembang. Sampel penelitian diambil dengan menggunakan metode consecutive sampling hingga mencapai 96 responden. Ibu yang memberikan susu formula tanpa indikasi medis dan bersedia berpartisipasi selanjutnya diwawancarai. Sebanyak 70,8% responden memiliki persepsi negatif terhadap susu formula. Sebagian besar memberikan susu formula secara parsial (75%). Uji Chi-Square menunjukkan tidak adanya hubungan antara persepsi ibu tentang susu formula dan model pemberian susu formula (p>0,05). Tidak terdapat hubungan antara persepsi ibu tentang susu formula dengan pemberian susu formula pada anak bawah dua tahun di Kecamatan Ilir Timur II Palembang.
Identification of Soil Transmitted Helminths Eggs on Flies in KM 5 Market, Palembang City Husna Syafira Muthmainnah; Gita Dwi Prasasty; Dalilah Dalilah; Dwi Handayani; Susilawati Susilawati
Sriwijaya Journal of Medicine Vol. 4 No. 3 (2021): Vol 4, No 3, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v4i3.123

Abstract

The prevalence of Soil Transmitted Helminths (STH) infection in the world is still high, especially in areas with poor sanitation. This condition is often found in markets which becomes a favorite place for flies. Flies are insects that have the ability to fly far and habits of life that move around so they can become human health problems as mechanical vectors of STH infection. Therefore, this study aimed to find out the type and number of flies, and the contamination of STH eggs in flies in Pasar KM 5 Palembang City. This research was an observational descriptive study with a cross sectional design. The samples of this study were caught with accidental sampling using insect nets and fly traps. The samples processing and observation were made at the Biooptic and Chemistry Medic Laboratory, Faculty of Medicine Sriwijaya University. The number of flies obtained 419 flies and consisted of 136 Musca domestica (32.4%), 183 Chrysomya megacephala (43.7%), and 100 Lucilia sp. (23,9%). From 42 total samples studied, 14 samples positively contaminated with STH eggs (33.4%), that consisting of 3 samples of Musca domestica (7.2%), 6 samples of Chrysomya Megacephala (14.3%), and 5 samples of Lucilia sp. (11,9%). The number of STH eggs obtained 17 eggs, consisted of 16 eggs of Ascaris lumbricoides (94.1%) that was 3 eggs in Musca domestica (17.7%), 7 eggs in Chrysomya megacephala (41.1%), and 6 eggs in Lucilia sp. (35.3%), and 1 egg of Trichuris trichiura in Chrysomya megacephala (5.9%). The conclusion was that there was contamination of STH eggs on flies in KM 5 Market Palembang City.
Correlation Between Neutrophil to Lymphocyte Ratio (NLR) and Patient with Heart Failure: Haematology Variables in Patient with Heart Failure Fransiskus Xaverius Rinaldi; Stefanus Lembar; Denio Adrianus Ridjab; Leonardo Leonardo; Jessica Lauryn; Erlina Erlina; Gregiorio Gavriel Singgih
Sriwijaya Journal of Medicine Vol. 5 No. 1 (2022): Vol 5, No 1, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v5i1.124

Abstract

Heart failure is a condition of the heart that cannot pump blood adequately resulting in systemic tissue hypoperfusion. This situation will cause systemic inflammatory reactions. Neutrophil to Lymphocyte Ratio (NLR) is an inexpensive and easy parameter that can see inflammatory reactions. This research uses descriptive and analytical studies with cross-sectional studies. The number of samples was 67 heart failure patients who were treated at Atma Jaya Hospital. The statistical test used is unpaired T-test to see if there was a correlation between the NLR value in heart failure, after that NLR cut-off point will be analyzed using a receiver operating curve (ROC). Pearson correlation test was conducted to see the correlation of NLR with laboratory results, including haemoglobin, hematocrit, leukocytes, and platelet. The results showed a significant difference of NLR between controls and heart failure patients (p = 1.0402-10). The cut-off point is 2.16 with an area under the curve of 86.4%, sensitivity 79.1%, and specificity 91%. Analysis of NLR data on heart failure with hemoglobin (p = 0.108), hematocrit (p = 0.091), and platelets (p = 0.832) showed no significant correlation, whereas showed a significant correlation with leukocytes (p = 0.017). This study shows a significant difference of NLR between control and heart failure therefore it can be used to predict the prognosis for heart failure. This study also found no significant correlation between NLR with the amount of haemoglobin, hematocrit, and platelets, while there was a correlation with leukocytes.
Effectivity of Iron Supplementation With and Without Vitamin C for Increasing Hemoglobin Levels Among Women Aged 16-21 Years Old Jessica Lauryn; Freggy S Joprang; Angela Kurniadi; Leonardo Leonardo; Fransiskus Xaverius Rinaldi; Erlina Erlina; Gregiorio Gavriel Singgih
Sriwijaya Journal of Medicine Vol. 5 No. 1 (2022): Vol 5, No 1, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v5i1.125

Abstract

Anemia can be caused by a decrease in hemoglobin (Hb) levels, chronic disease, severe bleeding, nutritional deficiency, and infectious diseases. Iron deficiency is the most common cause of anemia (50%). Vitamin C has an important role in increasing absorption of iron in the body which can indirectly affect the increase in Hb formation. This study was conducted to determine whether iron and vitamin C supplementation affect the changes of Hb levels in women. This study was done by quasi experimental with single blind pretest posttest control group and with a stratified random sampling technique. Respondents were female students in Faculty of Medicine UNIKA Atma Jaya. The total number of sample was 58 which was categorized into two groups. The first group was given iron and vitamin C supplementation. The second was only given iron supplementation. There were 16 respondents (27,6%) aged 16-18 and 42 respondents (72,4%) aged 19-21. The average change in Hb level before and after intervention in group 1 was 1,934 g/dL, and P = 0,000 (P <0,05), the average change in Hb level before and after intervention in group 2 was 1,086 g/dL, and P = 0,000 (P <0,05). The difference of change in Hb levels in groups 1 and 2 had an average of 0,848 g/dL, and P = 0,005 (P <0,05). For conclusion, Iron and vitamin C supplementation has a greater impact on the changes of Hb levels compared to iron supplementation only.
The Relationship between Area of Necrosis with Degree of Lymphocytes Infiltration in Breast Rattus norvegicus Induced by DMBA Ainiyah Fairus; Aufar Zimamuz Zaman Al Hajiri; Hidayatul Ulya; Syihabuddin Farid; Lysa Veterini; Mohammad Nasir
Sriwijaya Journal of Medicine Vol. 5 No. 1 (2022): Vol 5, No 1, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v5i1.126

Abstract

Breast cancer is one of the leading causes of death in women in the world. According to WHO, the incidence of breast cancer is about 2.1 million. The high mortality rate is often influenced by various reasons, one of which is the prognosis in patients. The level of lymphocyte infiltration in tumor cell tissue has been shown to correlate with a better prognosis in patients, while necrotic tissue found in breast cancer often shows worse prognostic value. To determine the relationship between the area of necrosis with the degree of infiltration of lymphocytes in the breast of Rattus norvegicus induced by DMBA. Method: True experimental study with post-test only controlled group design method using 40 Wistar strains of female (Rattus norvegicus) mice 12-13 weeks old. The technique for taking uses simple random sampling. Examining 2 variables, namely the dependent variable area of necrosis and the independent variable degree of lymphocyte infiltration. The treated group is injected with subcutaneous DMBA 10 mg/Kg BW between the two lower nipples during the middle of the fifth week with a three-week interval of administration to reach 14 times the total administration. Cancer tissue is taken in the fifth week. Data are analyzed by the Spearman test. Results: This study shows no relationship (P> 0.05) between the area of necrosis with the degree of lymphocyte infiltration. Conclusions: There is no relationship the area of necrosis with the degree of lymphocytes infiltration in breast Rattus norvegicus Induced by DMBA.
Molecular Docking Study of Garcinia mangostana (Mangosteen) Compounds as SARS-CoV-2 Potential Inhibitors Putri Mahirah Afladhanti; Muhammad Despriansyah Romadhan; Haidar Ali Hamzah; Qherine Bhelqis
Sriwijaya Journal of Medicine Vol. 5 No. 1 (2022): Vol 5, No 1, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v5i1.127

Abstract

COVID-19 pandemic poses a challenge for researchers all over the world to find effective drugs. Previous studies had identified the role of Mpro, TMPRSS2, RdRp, and ACE2 which are useful as promising drug targets to inhibit SARS-CoV-2. This study aimed to identify the potential compounds derived from Garcinia mangostana (mangosteen) as potential SARS-CoV-2 inhibitors using a molecular docking study. A total of 6 compounds of mangosteen such as 8-desoxygartanin, α-mangostin, β-mangostin, Ƴ-mangostin, garcinon e, and gartanine were used in this study. N-acetylcysteine (NAC), nafamostat, remdesivir, and lopinavir were also used as comparative drugs. Compounds and comparative drugs were docked on Mpro, TMPRSS2, RdRP, and ACE2 using AutodocTools 1.5.6 and Autodock Vina. The visualization of molecular interactions was carried out by Discovery Studio v16. All compounds met the criteria as drugs based on Lipinski’s solubility test and were safe to use based on toxicity test with admetSAR. Docking results showed that all compounds had an affinity to all receptor targets. 8-Desoxygartanin showed strong molecular interactions compared to the comparative drugs with binding energies of -8.0, -9.6, - 7.8, and -8.6 kcal/mol for Mpro, TMPRSS2, RdRp, and ACE2, respectively. All compounds have the potential to be developed as potential inhibitors through inhibiting Mpro, TMPRSS2, RdRp, and ACE2. Therefore, in vitro and in vivo investigations are needed to bring these compounds to the clinical setting.
Natural Compounds Derived from Camellia sinensis as Therapeutic Agent to Treat Non-Small Cell Lung Carcinoma (NSCLC): A Molecular Docking Study Haidar Ali Hamzah; Putri Mahirah Afladhanti; Muhammad Despriansyah Romadhan
Sriwijaya Journal of Medicine Vol. 5 No. 1 (2022): Vol 5, No 1, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v5i1.128

Abstract

Cancer is one of the biggest health problems with lung cancer as the first rank in the number of new cases and deaths. Non-small cell lung carcinoma (NSCLC) is a type of lung cancer which accounts for about 85% cases. Previous research identified the role of epidermal growth factor receptor (EGFR) as the most suitable target to treat NSCLC. This study used a molecular docking technique to identify the potential compounds derived from Camellia sinensis (green tea) leaves as therapeutic agent to treat NSCLC. We tested 12 compounds in green tea leaves along with gefitinib as a comparative drug. Docking was carried out on EGFR as receptor target by Autodock Tools and Autodock Vina. Molecular interactions were visualized by Discovery Studio v16. All compounds met the criteria as drugs based on Lipinski’s solubility test and were safe to use based on toxicity test with AdmetSAR. Docking results showed that all compounds had affinity to EGFR receptor. Catechin and myricetin had the same energy bonds as gefitinib which were -7,9 kcal/mol, while theaflavin gallate, theaflavin digallate, epicatechin gallate, epigallocatechin-3-gallate, catechin gallate, thearubigin, quercetin, and kaempferol were proven to have the strongest binding energy compared to gefitinib which were -10.6, -9.8, -8.9, -8.9, -8.5, -8.3, -8.0, and -8.0 kcal/mol, respectively. All compounds have the potential for development into drugs for NSCLC treatment. Further in vitro and in vivo investigations are needed to bring these compounds to the clinical setting.
Lifestyle Alterations During the COVID-19 Pandemic and Its Impact on Obesity amongst Indonesian University Students Nur Jannah Binti Azhar; Zettira Dwi Zahra; Dina Anandita Irawan; Sofa Rahmannia
Sriwijaya Journal of Medicine Vol. 5 No. 1 (2022): Vol 5, No 1, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v5i1.129

Abstract

Covid-19 pandemic caused large-scale mobility restrictions, including for students. This condition might induce lifestyle changes which could impact metabolic conditions. This study aims to (1) investigate lifestyles pre and mid pandemic; (2) investigate the relative differences of the students' BMI early pandemic until recent; (3) estimate the relationship between lifestyle alterations and increased BMI during the pandemic. The research conduct using an online survey of 110 students spread across Indonesia in the first to ninth semesters. Analysis was performed using the Wilcoxon signed-rank test and Spearman's analysis. The results showed that there were lifestyle alterations; namely, 15% of respondents reduced their walking habits, duration, and the number of steps. 9% reduced exercise frequency, with more than 50% of respondents reducing their exercise duration. Nearly 20% increased sedentary frequency. 11% experience stress and take it out on food. As many as 93% of respondents maintain the habit of consuming sweet drinks. Moreover, 66% experienced increased BMI during the pandemic, with almost 30% changing nutritional status from normal to overweight or obese. The median BMI increased by 0.5 kg/m2 with a significant difference (p=0.001). Finally, of all lifestyle alterations during the pandemic, two lifestyles had a significant effect on the increase in BMI, namely changes in the frequency of exercise (p=0.03) and consumption habits of sugary drinks (p=0.05). In conclusion, lifestyle changes in students during the pandemic occurred and impacted the increase in BMI. Priority of intervention should be made in this population to prevent a further increase in obesity in Indonesia.

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