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SRIWIJAYA JOURNAL OF MEDICINE
Published by Universitas Sriwijaya
ISSN : -     EISSN : 26223589     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Sriwijaya Journal of Medicine (SJM) is a scientific journal managed by Faculty of Medicine Universitas Sriwijaya, Indonesia. It publishes original research articles and reviews in Biomedical Sciences, Medicine (Neurology, Cardiovascular, Respiratory, Gastrointestinal, Urogenital, Endocrine and Metabolism, Integument, Mental Health, Obstetry and Gynecology, Ophtalmology, ENT, Musculosceletal) and Public Health Medicine. Sriwijaya Journal of Medicine (SMJ) published three times a year (January, April, October).
Arjuna Subject : Kedokteran - Anatomi
Articles 315 Documents
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Relationship Between Occupation and The Incidence Of Condyloma Akuminata in The Skin And Genital Clinic of Dr. H. Abdul Moeloek General Hospital in Lampung Province For The Period 2018-2020 Dinda Dwi Anjani; Eka Silvia; Abdurrohman Izzuddin; Arif Effendi
Sriwijaya Journal of Medicine Vol. 4 No. 2 (2021): Vol 4, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v4i2.103

Abstract

Sexually transmitted infections (STIs) are one of the causes of health, social and economic problems in many countries, it was reported that in the last 35 years the prevalence of Human papilloma virus infections worldwide continues to increase. Economic deprivation, low education, economic inequality, and economic-driven migration and mobility are all linked to the risk of transmitting STIs including condyloma acuminata. Determine the relationship between occupation and the incidence of condyloma acuminata in the skin and genital clinic of Dr. H. Abdul Moeloek in Lampung province for the period 2018-2020. Using an analytical observational study with a cross-sectional research design. Sampling using total sampling technique. Data collection by medical record respondents and analyzed using spearman correlation test. It was found that 102 respondents with the highest frequency of occupation were private workers, 33 people (32.4%). The spearman correlation test result obtained p=0,033 (p<0,05), which means that there is a significant relationship between occupation and incidence of condyloma acuminata in the skin and genital clinic in Dr. H. Abdul Moeloek in Lampung province.
The Effect of History of Low Birth Weight in Newborns and Maternal Anemia in Pregnancy on the Risk of Stunting in Toddlers Age 0-24 Months in Tanjung Bintang Health Center South Lampung Regency Dian Isti Angraini; Kristian Pieri Ginting; Efriyan Imantika
Sriwijaya Journal of Medicine Vol. 4 No. 2 (2021): Vol 4, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v4i2.104

Abstract

Stunting is the condition in children when their height is shorter than a child of his age because of stunted growth due to chronic malnutrition. Stunting can be caused by low birth weight in newborns and maternal anemia. The objective of the study is to know the effect of low birth weight in newborns and maternal anemia on the risk of stunting in the toddler with the age range between 0-24 months in the Tanjung Bintang Primary Health Care. This research is an observational-analytic study with a cross-sectional approach. This research was conducted in the region of Tanjung Bintang Primary Health Care. The sample was 73 toddlers with an age range between 0-24 months. Data were analyzed with a Chi-square test to know the influence of the independent variable with a value of α = 0,05. The results found a 37% risk of stunting, 12.3% history of low birth weight in newborns, and 34.2% history of maternal anemia. The results of the bivariate analysis was no influence of a history of low birth weight in newborns on the risk of stunting (p-value = 0.718) and there was an influence of maternal anemia on the risk of stunting in toddlers (p-value = 0.001). There is no influence history of low birth weight in newborns on the risk of stunting and there is an influence of maternal anemia on the risk of stunting in toddlers aged range between 0-24 months in the region of Tanjung Bintang Primary Health Care.
Relationship between Plasma Cell Density and Clinico-histopathological Characteristics of DLBCL Nyimas Chodijah; Krisna Murti; Riana Sari Puspita Rasyid
Sriwijaya Journal of Medicine Vol. 4 No. 2 (2021): Vol 4, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v4i2.105

Abstract

Diffuse Large B Cell Lymphoma (DLBCL) is a malignancy derived from the malignant transformation of B cells from the germinal center. This type of non-Hodgkin's lymphoma is the most common and represents about 30-40% of all cases. The tumor microenvironment of B-cell lymphoma plays an important role in the regulation of tumor cell survival and proliferation. Plasma cells in the tumor microenvironment have an important role in the formation of the anti-tumor immune response, even in low numbers, these cells can produce large amounts of cytokines and antibodies. The purpose of this study was to determine the relationship between plasma cell density and clinico-histopathological characteristics of DLBCL patients. A cross-sectional study was conducted. The samples of this study were paraffin blocks of DLBCL patients referred to Anatomic Pathology Departement Faculty of Medicine Universitas Sriwijaya/RSUP Dr. Mohammad Hoesin Palembang. From 50 cases during the 2018-2020 period, 32 samples were selected. Plasma cells were morphologically identified on HE slides. Statistical analysis was performed using the chi-square test. The distribution of DLBCL cases found more in the age group <60 years (56,3%), male gender (68,8%), extranodal tumor location (56,3%). Centroblastic variants were higher (78,1%) than others, and the non-GCB subtype (78,1%) was higher than the GCB. There is no significant relationship between plasma cell density and the clinico-histopathological characteristics of DLBCL age, sex, tumor location, variant, and subtype.
The Impact of Body Fat Percentage towards the Attention Aspect of the Cognitive Function in Pre-Clinical University Students of Atma Jaya Mariani Santosa; Alvin Edwin Wiyono; Robi Irawan
Sriwijaya Journal of Medicine Vol. 4 No. 2 (2021): Vol 4, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v4i2.106

Abstract

In 2016, World Health Organization (WHO) predicts that 650 million adults aged 18 and more have obesity. Many research shows that obesity affects brain function and impairs the cognitive function of the brain. To understand whether body fat percentage has an impact on the attention aspect of the cognitive function in university students. This study is a cross-sectional study approach. The data was collected from August 2020 until March 2021 with a total of 72 respondents. The data was collected using the body fat percentage formula from the British Journal of Nutrition to assess body fat percentage and Stroop Test for attention. Kruskal-Wallis and spearman were used to assess the correlation between body fat percentage and attention. The result shows that body fat percentage affects the attention aspect of the cognitive function (p = 0.001, r = 0.71). In conclusion, based on 72 university students, it proves that body fat percentage has an impact on the attention aspect of the cognitive function. The impact that high body fat percentage does is lowering the attention aspect of the cognitive function.
The Correlation Between Absolute Lymphocyte Count and Quantitative CRP Level Related to Disease Severity in COVID-19 Patients at RSUP dr. Mohammad Hoesin Palembang Nadia Karimah Amalia Zulfadli; Zen Ahmad; Mgs Irsan Saleh; Ahmad Rasyid
Sriwijaya Journal of Medicine Vol. 4 No. 2 (2021): Vol 4, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v4i2.107

Abstract

COVID-19 is a contagious acute respiratory disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus. Changes in some laboratory markers such as absolute lymphocyte count and quantitative CRP in COVID-19 can be associated with the course and clinical phases of the patient whose results can be useful in grading and predicting the severity of COVID-19 disease. This study aims to determine the correlation between absolute lymphocyte count and quantitative CRP on the severity of COVID-19. This study was an observational correlative analytic study with a cross sectional design. The research was conducted in all COVID-19 treatment isolation wards at RSMH Palembang from March 2021 to April 2021 with the research subjects being patients with confirmed cases of COVID-19 with various degrees of disease. Routine blood tests of absolute lymphocyte counts and quantitative CRP were performed at the Clinical Pathology Laboratory of RSMH Palembang. The statistical analysis of the correlation test with Spearman for numerical data was not normally distributed, and Gamma for categorical ordinal data was followed by a regression test to determine the prognostic value of the two parameters. Samples obtained were 83 patients, namely 24 patients (28.9%) mild degree, 40 patients (48.2%) moderate degree, 10 patients (12%) severe degree and 9 patients (10.8%) critical degree. The correlation between the absolute lymphocyte count and quantitative CRP obtained the correlation coefficient value r = – 0.525. The correlation between the absolute lymphocyte count and the degree of COVID-19 disease obtained a correlation coefficient of r = – 0.605, while the correlation between the quantitative CRP value and the degree of disease was obtained r = 0.875. Based on the prognostic test, the absolute lymphocyte count (cutoff point of 1,157 cells / mm3) was obtained with a sensitivity of 68.4% and a specificity of 68.75%. Meanwhile, quantitative CRP with a cutoff point of 77.5 mg/L obtained a sensitivity of 89.4% and a specificity of 89%. The absolute lymphocyte count has a strong negative correlation with the quantitative CRP value and the disease degree in COVID-19, while the quantitative CRP value has a positive correlation with a very strong degree. Thus these two parameters can be used as predictors of disease severity, however, the quantitative CRP value can be an independent prognostic marker or a single predictor of the severity of COVID-19 disease.
Level of Haemoglobin and Knowledge Regarding Anemia and Its Prevention Among Adolescent Desi Oktariana; Evi Lusiana; Nia Savitri Tamzil; Gita Dwi Prasasty
Sriwijaya Journal of Medicine Vol. 4 No. 2 (2021): Vol 4, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v4i2.108

Abstract

Anemia is a condition in which hemoglobin (Hb) concentration being lower than a specific threshold. The prevalence of anemia among adolescents is varies among country and its proportion is higher in developing countries. In Indonesia, the proportion of anemia in the 15-24-year age group was 32%. Anemia in adolescents has a negative impact on decreased immunity, impaired physical growth and mental development, concentration, learning achievement, adolescent fitness and productivity. Knowledge of the extent and causes of anemia in adolescence is very important because it is a window of opportunity for interventions to improve adolescent health. This study aims to describe level of Hb and knowledge regarding anemia and its prevention among adolescents. This research is a descriptive study with a cross sectional method using Hb meter to assess Hb level and questionnaire to assess knowledge regarding anemia and its prevention among adolescents, conducted in November 2019. The respondents were 42 adolescents in SMPN 9 Palembang. The ages of respondents in this study ranged from 12-13 years, consisting of 36% boys and 64% girls. The mean value of Hb level in all adolescent was 13.78 g/dL with 12% of respondents had anemia. A total of 76% adolescents had poor knowledge, while 24% adolescents had good knowledge. The mean value of Hb level in all adolescent was normal, only few adolescents had anemia. This study also shows majority of the adolescents have poor knowledge about anemia and its prevention.
The Effectiveness of Cinnamon extract (Cinnamomum burmannii) to reducing ureum level in male Rattus norvegicus Unilateral Ureteral Obstruction (UUO) model Evi Lusiana; Theodorus Theodorus; Nita Parisa; Fatmawati Fatmawati; M. Ivan Pratama
Sriwijaya Journal of Medicine Vol. 5 No. 1 (2022): Vol 5, No 1, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v5i1.112

Abstract

Cinnamon extract's effectiveness as a renoprotective has not been previously investigated due to its widespread use in daily life, either as a cooking ingredient or as a herb. The aim of this study is to determine the effectiveness extract of cinnamon (Cinnamomum burmannii) as a renoprotective in lowering urea levels in the kidneys. An in vivo experimental study with a pre-post test and control group design was conducted at the Faculty of Medicine's Animal House and Biotechnology Laboratories. Male white rats (Rattus norvegicus) were used as the research subjects. Thirty rat were divided into five groups: negative control, positive control, cinnamon extract at 50 mg/kgBW, 100 mg/kgBW, and 200 mg/kgBW. The data were processed using SPSS 22.0. Cinnamon extract doses of 100 mg/kgBW and 200 mg/kgBW were the most effective in reducing urea levels and suspending the progression of the renal fibrosis process in Wistar male white rats with unilateral ureteral obstruction (UUO) model.
Hubungan Antara Kadar Interleukin 10 Serum dengan Tingkat Depresi Penderita Lupus Eritematosus Sistemik di RSUP Dr. Mohammad Hoesin Palembang Eunike Aryaningrum; Eddy Mart Salim; M. Ali Apriansyah; Erial Bahar; Yulianto Kusnadi
Sriwijaya Journal of Medicine Vol. 4 No. 3 (2021): Vol 4, No 3, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v4i3.117

Abstract

Lupus Eritematosus Sistemik (LES) merupakan penyakit kronik inflamatif autoimun. Perjalanan penyakitnya ditandai dengan episode remisi dan eksaserbasi sering menyebabkan gejala depresi yang signifikan. Penyakit LES dan depresi memiliki kesamaan dalam proses dan penyebabnya yakni Interleukin-10 (IL-10). Sitokin antiinflamasi (IL-10) pada LES ini selain mempengaruhi tingkat keparahan aktivitas LES, juga berkontribusi terhadap patofisiologi depresi yang menurunkan kualitas hidup pasien LES. Tujuan penelitian ini untuk menentukan hubungan kadar IL-10 dengan tingkat depresi melalui penilaian skor BDI (Beck’s Depression Inventory) pada penderita LES. Penelitian ini adalah studi observasional analitik dengan rancangan cross sectional dan menggunakan uji hubungan untuk melihat hubungan IL-10 dengan tingkat depresi pada pasien LES yang dilakukan di ruang poliklinik dan perawatan penyakit dalam RSUP dr. Mohammad Hoesin Palembang dari November 2019 hingga Maret 2020. Jumlah subjek penelitian sebanyak 40 sampel yang merupakan pasien LES dengan depresi yang telah dilakukan perhitungan tingkat depresi menggunakan skor BDI. Terdapat 40 subjek penelitian dengan median umur 30,50 tahun dan rentang umur 18-56 tahun. Subjek dengan tingkat depresi ringan 17 orang (42,5%), sedang 14 orang (35%) dan berat 9 orang (22,5%). Pada aktifitas LES, terdapat 5 orang (12,5%) dengan aktifitas LES ringan, 20 orang (50%) dengan aktifitas LES sedang, dan 15 orang (37,5%) dengan aktifitas LES berat. Pada penelitian ini terdapat hubungan yang bermakna antara tingkat depresi dengan tingkat keparahan aktifitas LES (MEX SLEDAI) (r= 0,444 p=0,004). Namun, tidak terdapat hubungan bermakna antara kadar IL-10 serum dengan tingkat keparahan aktifitas LES (p= 0,170, r = 0,221) dan kadar IL-10 serum dengan tingkat depresi (p = 0,437, r= 0,126). Pada penelitian ini tidak terdapat hubungan antara IL-10 serum dan tingkat depresi pada pasien LES di RSUP Dr. Mohammad Hoesin Palembang.
Pengaruh Pemberian Vitamin C Terhadap Kadar Serum LDH dan Kualitas Hidup Pasien Limfoma Non–Hodgkin Shahnaz Fathia; Mediarty Syahrir; Monnika Anastasia; Erial Bahar
Sriwijaya Journal of Medicine Vol. 4 No. 2 (2021): Vol 4, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v4i2.118

Abstract

Limfoma Non-Hodgkin (LNH) merupakan keganasan primer limfosit yang dapat berasal dari limfosit B, limfosit T. Vitamin C berperan sebagai antioksidan didalam tubuh. Penelitian ini untuk mengetahui pengaruh pemberian vitamin C terhadap kadar serum LDH dan kualitas hidup pada pasien LNH di RSMH Palembang. Penelitian ini merupakan pilot study dengan uji klinik terbuka, dilakukan mulai Februari 2021 sampai Mei 2021. Terdapat 15 subjek penelitian (usia 18-60 tahun) diberikan suplementasi Vitamin C 2 gram perhari selama 8 minggu. Sebelum dan setelah perlakuan diperiksakan kadar LDH, serum vitamin C, mengisi kuesioner FFQ (asupan vitamin C) dan kuesioner EORTC C30 (kualitas hidup). Didapatkan penurunan kadar LDH antara sebelum dan sesudah perlakuan pada kelompok low grade (p = 0.008) dan pada kelompok high grade (p= 0,000). Didapatkan perbaikan kualitas hidup antara sebelum dan sesudah perlakuan pada kelompok low grade (p< 0,05). Didapatkan korelasi negatif kuat pada kelompok high grade antara kadar vitamin C dengan kadar LDH sebelum perlakuan (r= -0,75; p= 0,031) dan sesudah perlakuan (r= -0,819; p= 0,013). Pada kelompok high grade setelah perlakuan didapatkan korelasi positif kuat antara nutrisurvey vitamin C dengan skala fungsi (r= 0,790; p= 0,02) dan korelasi negatif kuat dengan skala gejala (r= -0,74; p= 0,03). Suplementasi vitamin C mempengaruhi penurunan kadar serum LDH pada semua stadium klinis pasien LNH dan mempengaruhi perbaikan kualitas hidup serta mempengaruhi korelasi antara kadar vitamin C dengan komponen skala gejala kualitas hidup pasien LNH stadium lanjut atau high grade di RSMH Palembang.
Efektifitas Pemberian Ekstrak Bawang Putih Terhadap Penurunan Kadar Interleukin-6 Serum dan Dialisat pada Pasien Continous Ambulatory Peritoneal Dialysis Margaretha Kendenan; Zulkhair Ali; Nova Kurniati; Irsan Saleh
Sriwijaya Journal of Medicine Vol. 4 No. 2 (2021): Vol 4, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v4i2.119

Abstract

Penelitian Chronic Renal Insufficiency Cohort (CRIC) menunjukkan 86% subjek PGK terbukti menderita inflamasi. Sejumlah studi longitudinal melaporkan peningkatan inflamasi dengan mengukur interleukin-6 (IL-6) pada pasien PD baik kadarnya di sistemik dan intraperitoneal. Bawang putih dan komponennya memiliki aktivitas antiinflamasi dan antioksidan. Efek antiinflamasi dari ekstrak bawang putih, dengan menghambat aktivasi jalur pro-inflamasi serta menghambat aktivasi makrofag dan efek antioksidan dan menghambat enzim pro-oxidant. Penelitian ini merupakan studi crossover randomized placebo controlled double blind trial. Subjek penelitian 20 orang pasien PGK stadium 5 yang menggunakan CAPD, dibagi secara acak menjadi 2 kelompok, yaitu kelompok yang mendapat ekstrak bawang putih 800 mg perhari (2x400 mg) selama 8 minggu dan kelompok yang mendapatkan placebo, kemudian dilakukan periode wash out selama 2 minggu dan setelah itu kedua kelompok diberikan perlakuan bergantian. Masing masing kelompok diukur kadar IL-6 serum, IL-6 dialisat dan net ultrafiltrasi sebelum dan sesudah perlakuan. Didapati kadar IL-6 serum sebelum dan sesudah pemberian ekstrak bawang putih 7,10 ±2,30 pg/ml dan 5,00±3,00 pg/ml dengan p= 0,005. Kadar IL-6 dialisat sebelum dan sesudah pemberian ekstrak bawang putih 39,20±2,10 pg/ml dan 33,20±7,80 pg/ml dengan p = 0,000. Disimpulkan penurunan kadar IL-6 serum dan dialisat sesudah ekstrak bawang putih pada penderita PGK stadium V yang menggunakan CAPD di RSMH Palembang.

Page 21 of 32 | Total Record : 315

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