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SRIWIJAYA JOURNAL OF MEDICINE
Published by Universitas Sriwijaya
ISSN : -     EISSN : 26223589     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Sriwijaya Journal of Medicine (SJM) is a scientific journal managed by Faculty of Medicine Universitas Sriwijaya, Indonesia. It publishes original research articles and reviews in Biomedical Sciences, Medicine (Neurology, Cardiovascular, Respiratory, Gastrointestinal, Urogenital, Endocrine and Metabolism, Integument, Mental Health, Obstetry and Gynecology, Ophtalmology, ENT, Musculosceletal) and Public Health Medicine. Sriwijaya Journal of Medicine (SMJ) published three times a year (January, April, October).
Arjuna Subject : Kedokteran - Anatomi
Articles 315 Documents
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Potential of Anti-Secretory and Cytoprotective Effect from Azadiradione as GERD Prevention Corinna Faustina; Villicia Angellika; Alya Rahmadani; Rosalie Dorothea; Ricky Fajar Adiputra; Ziske Maritska
Sriwijaya Journal of Medicine Vol. 5 No. 2 (2022): Vol 5, No. 2, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v5i2.144

Abstract

Gastroesophageal Reflux Disease (GERD) is a pathological state due to stomach reflux within the esophagus, which causes necrosis of esophageal mucosa, resulting in erosions, ulcers, and other complications. GERD is still a growing global issue with 783.95 million cases worldwide in 2019. Although PPIs were used as medications to treat GERD, there were refractions and adverse effects to the patients. Azadiradione, terpenoids that can be found in A. indica and various plants, has potential as alternative H+/K+ ATPase inhibitor sources with its anti-secretory and cytoprotective activity. Some studies explain that there is also adverse effects of azadiradione. Further research are needed to determine alternative sources, safety dosage, usage duration, side effects, also drug-food or drug-drug interaction of azadiradione.
Utilization of Kersen Leaves as Antihyperuricemia Nita Parisa; Aprilia Paskah Samosir; Fatmawati Fatmawati; Rachmat Hidayat; Marlyani Tamara; Karina Nurul Fahira; Alfiyah Munawwaroh Abdullah; Rischka Salsabila Maulini; Rohaya Rohaya
Sriwijaya Journal of Medicine Vol. 5 No. 2 (2022): Vol 5, No. 2, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v5i2.145

Abstract

Kersen (Muntingia calabura), a tropical plant originating from Latin America, is a wild plant that has many benefits. Kersen contains flavonoid compounds, tannins, triterpenes, saponins, alkaloids that are useful as anti-inflammatory, anti-tumor, and anti-uric acid. Hyperuricemia is a metabolic disease characterized by high levels of uric acid in the blood which precipitates uric acid crystals in the kidneys and joints. Most patients with hyperuricemia do not require medical therapy, but lifestyle modifications can be made such as regular eating, adequate exercise, and avoiding foods and drinks high in protein and purines. This study aims to investigate the benefits of Kersen Leaf as an anti-uric acid. The method used in this study is a literature study based on library sources excavated through national and international sites such as Google, Google Scholar, and PubMed.
The Role of Mtor Inhibitors in Endocrine Resistance Therapy of Breast Cancer Type ER+ Syarinta Adenina; Bantari Wisynu Kusuma Wardhani
Sriwijaya Journal of Medicine Vol. 6 No. 1 (2023): Vol 6, No. 1, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v6i1.146

Abstract

Breast cancer is the leading cause of death in women. Although hormonal therapy has produced positive results in HR+ breast cancer, resistance to this therapy remains a challenge in the treatment of breast cancer. Various mechanisms have been proposed as an explanation of resistance in breast cancer, one of which is the activation of the PI3K/AKT/mTOR pathway. The PI3K/AKT/mTOR pathway is a transduction pathway that regulates many important aspects in both normal cells and cancer cells, including cell proliferation, apoptosis, cell morphology and migration, protein synthesis, and integrase metabolism. Preclinical dan clinical data show inhibition of this pathway can improve survival, especially in resistant hormonal therapy models. The use of mTOR inhibitors (everolismus) has been approved by the FDA as a combination therapy with exemestane for postmenopausal women with HR+/HER2-breast cancer.
Genetic Factors Affecting Neuroplasticity Ziske Maritska; Muhammad Fakhri Altyan; Ardy Oktaviandi; Muhammad Barkah; Amirah Dhia Nabila Sinum; Emelda Emelda; Hawari Martanusa; Rini Nindela; Nita Parisa; Bintang Arroyantri Prananjaya; Puji Rizki Suryani; Eka Febri Zulissetiana
Sriwijaya Journal of Medicine Vol. 6 No. 2 (2023): Vol 6, No. 2, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v6i2.152

Abstract

Neuroplasticity pertains to the brain's ability to adjust functions or structure in response to events and is an important factor for skill-learning development as well as functional recovery from a neurological disorder. Numerous factors could influence neuroplasticity processes. This literature review aims to discuss the roles of genetic factors in neuroplasticity. The literature search was conducted using the keywords “neuroplasticity”, genetics”, “genes”, and polymorphism” in search engines like google scholar and PubMed, covering original articles, reviews, and text book both in Bahasa Indonesia and English for the last ten years. Genetic variation including gene polymorphism was responsible for the impact of BDNF, ApoE, and dopamine on the functional neural repair of the brain. Certain processes might directly influence neuroplasticity; others might interfere indirectly through the process. A deeper insight into genetic influence regarding neuroplasticity could lead to a better understanding and potential improvement of treatment.
Antibiotic Susceptibility of Staphylococcus sp. in Diabetic Ulcer Patients at Dr. Mohammad Hoesin General Hospital, Palembang Imaulina Sri Chelsee; Rizki Andini Nawawi; Masayu Farah Diba
Sriwijaya Journal of Medicine Vol. 6 No. 1 (2023): Vol 6, No. 1, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v6i1.153

Abstract

The high prevalence of diabetic ulcers and the resistance of Staphylococcus sp. to antibiotics can complicate the treatment of diabetic ulcer patients with Staphylococcus sp. This study aimed to determine the pattern of susceptibility of Staphylococcus sp. in patients with diabetic ulcer at Dr. Mohammad Hoesin General Hospital Palembang in January 2019-August 2022. This research was an observational descriptive study using total sampling conducted in September-November 2022 at Dr. Mohammad Hoesin General Hospital Palembang. Data was obtained from patient medical records and laboratory results of patients with diabetic ulcer disease infected with Staphylococcus sp. from January 2019 to August 2022. Prevalence of Staphylococcus sp. infection in diabetic ulcer patients was low (15 of 77 diabetic ulcer patients, 19.5%). There were 19 bacterial isolates from 15 diabetic ulcer patients. A total of 8 coagulase-negative Staphylococcus sp. (CoNS) and 11 coagulase-positive Staphylococcus sp. (CoPS) isolates were tested for their susceptibility to antibiotics. Both CoPS and CoNS bacteria in diabetic ulcer patients were most susceptible to linezolid (90.9% for CoPS and 100% for CoNS) and most resistant to benzylpenicillin (81.8% for CoPS and 87.5% for CoNS).
GLUT4 as A Protein Target for Type 2-Diabetes Mellitus Therapy With Natural Compounds Vivi Hendra Sutandar; Mgs. Irsan Saleh; Ziske Maritska
Sriwijaya Journal of Medicine Vol. 6 No. 1 (2023): Vol 6, No. 1, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v6i1.154

Abstract

WHO reported 1.9 million death cases of diabetes patients in 2019. Diabetes is caused by damage in the pancreas which resulted in a lack of insulin or insulin resistance.  Medication for Type 2-Diabetes Mellitus (T2DM) mainly focuses on lowering blood glucose and treating affected organs. Current medications are still lacking; thus research is needed in finding novel medications to accommodate T2DM. This paper aims to present the current research on potential plant extract in increasing GLUT4 translocation in diabetes conditions. insulin resistance state affecting GLUT4 translocation which is important in affecting glucose uptake. Some research shows that plant extract proved to be potential in increasing the translocation of GLUT4 and helping lowering blood glucose levels.
Risk Factor Analysis of the Incidence of Placenta Previa at RSUP Dr. Mohammad Hoesin Palembang in 2020–2021 Dian Widia Lestari; Firmansyah Basir; Ziske Maritska; Hartati Hartati; Rara Inggarsih
Sriwijaya Journal of Medicine Vol. 5 No. 3 (2022): Vol 5, No. 3, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v5i3.156

Abstract

Placenta previa is a placenta that lies at the bottom of the uterus, above or very close to the internal cervical ostium. The exact cause of placenta previa is still unknown, but several factors have been associated with an increased risk of placenta previa. This study aims to determine the relationship between maternal age, parity, distance between pregnancies, history of placenta previa, history of cesarean delivery, history of curettage, assisted reproductive technology, multiple pregnancies, and fetal gender on the incidence of placenta previa at RSUP Dr. Mohammad Hoesin Palembang in 2020-2021. This study is an observational analytic study with a case control design. This study used secondary data from medical records of obstetric patients at RSUP Dr. Mohammad Hoesin Palembang in 2020-2021 that met the inclusion criteria and exclusion criteria. The study sample amounted to 100 people consisting of 50 cases and 50 controls. The results of bivariate analysis using the chi-square test and the fisher exact alternative test showed that maternal age (p=0.010), parity (p=0.038), history of cesarean delivery (p=0.000), and history of curettage (p=0.001) had a significant relationship with the incidence of placenta previa. Distance between pregnancies (p=0.204), history of placenta previa (p=0.242), and fetal sex (p=0.162) did not have a significant relationship with the incidence of placenta previa. The results of multivariate analysis using binary logistic regression test showed that the most influential risk factors for the incidence of placenta previa were history of cesarean delivery (OR=54.751) and history of curettage (OR=20.204). It can be concluded that a history of cesarean delivery and a history of curettage are the most influential risk factors for the incidence of placenta previa.
The Role of Probiotics in The Prevention of Colorectal Cancer Muhammad Ridho Mandiri; Wendy P; Pariyana Pariyana
Sriwijaya Journal of Medicine Vol. 6 No. 2 (2023): Vol 6, No. 2, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v6i2.161

Abstract

Colorectal cancer (CRC) is the most common malignant tumor of the colon and rectum in the gastrointestinal tract which is one of the major health problems in the world with the fourth leading cause of death in the world. Various sources state that the incidence of CRC is caused by an imbalance of intestinal micro flora. It is important to maintain a balance of live microorganisms in sufficient quantities to provide health benefits called probiotics. Probiotics can maintain intestinal integrity, regulate bowel movements, increase lactose intolerance, thereby boosting immunity and helping prevent overgrowth of harmful bacteria and fungal infections. Through non-specific physiological mechanisms and immunological mechanisms, probiotics have roles such as initiating antiproliferative responses and apoptosis of CRC cells, supporting the function of the intestinal mucosal barrier by producing mucus, inhibiting the enzymatic activity of pathogenic bacteria such as β-glucuronidase, β-glucosidase, azoreductase, and nitroreductase so as to prevent colorectal cancer. In addition, it is necessary to make a diet and regulate a good diet in order to create homeostasis of microorganisms, normal intestinal flora.  
Risk Factors of Spontaneous Abortion Dinda Rizki Nawawi; Iman Ruansa; Mariana Mariana
Sriwijaya Journal of Medicine Vol. 5 No. 3 (2022): Vol 5, No. 3, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v5i3.163

Abstract

Spontaneous abortion is defined as a pregnancy loss at the gestational age of under 20 weeks or within the first trimester, which is usually marked by intravaginal bleeding and expulsion of conceptus through the cervix. In 20% of pregnancies, vaginal bleeding occurs prior to 20 weeks of gestational age, and 50% of these cases develop into spontaneous abortion. More than 80% of spontaneous abortion occurs before 12 weeks of gestational age. There are many factors contributing to the incidence of spontaneous abortion such as prior miscarriage and maternal age. Several chronic diseases are also known to trigger spontaneous abortion, such as diabetes and autoimmune diseases. Immediate postpartum conception and infections, such as cervicitis, vaginitis, HIV, syphilis and malaria are also common risk factors. In some cases, fetal chromosomal abnormalities may also cause spontaneous abortion. Environmental contaminants such as arsenic, lead, and organic solvents are thought to be factors that may induce spontaneous abortion.
Knowledge, Attitudes, and Preventive Behaviors Towards Stroke: A Study Among Employees of PT. PP London Sumatra Indonesia Tbk. Palembang Branch Fatimah Khairunnisa Lubis; Pinto Desti Ramadhoni; Rini Nindela
Sriwijaya Journal of Medicine Vol. 5 No. 3 (2022): Vol 5, No. 3, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v5i3.166

Abstract

A stroke occurs when a blood vessel that carries oxygen and nutrients to the brain is either blocked or ruptured. If the blood supply to part of the brain is interrupted or stopped, this can cause brain cells to die. Stroke is a health problem that must be noticed and understood by the whole community considering the high mortality and disability rates among working-age adults caused by this disease. Limited public knowledge towards stroke will result in no/lack of prevention efforts and can lead to delays in treating stroke. This research is a descriptive study with a cross-sectional approach that aims to describe the knowledge, attitudes, and preventive behaviors towards stroke among employees of PT. PP London Sumatra Indonesia Tbk. Palembang Branch. The primary source for the data used was an online questionnaire addressed to 48 employees of PT. PP London Sumatra Indonesia Tbk. Palembang Branch as the study subjects. Based on the results of measuring the variables, it can be concluded that most of the employees of PT. PP London Sumatra Indonesia Tbk. Palembang Branch have poor knowledge, good attitudes, and poor preventive behaviors towards stroke.

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