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INDONESIA
Jurnal Respirologi Indonesia
Published by Perhimpunan Dokter Paru Indonesia
ISSN : 08537704     EISSN : 26203162     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Respirologi Indonesia (JRI) is an online and printed scientific publication of the Indonesian Society of Respirology (ISR). The journal is published thrice-monthly within a year (January, April, July and October). The journal is focused to present original article, article review, and case report in pulmonary and critical care medicine.
Arjuna Subject : -
Articles 364 Documents
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The Relationship of Genetic Polymorphism Micromal Epoxide Hydrolase (EPHX1) His139Arg and Lung Cancer Rosidah Hanum Hasibuan; Noni Novisari Soeroso; Setia Putra Tarigan; Yahwardiah Siregar; Erna Mutiara; Lucia Aktalina
Jurnal Respirologi Indonesia Vol 42, No 2 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i2.305

Abstract

Background: Microsomal epoxide hydrolase 1 (EPHX1) plays an important role in both activation and detoxification of polycyclic aromatic hydrocarbons (PAH) and aromatic amines. Polymorphism EPHX1 His139Arg in susceptibility to lung cancer has been reported with inconsistent outcomes. Aim of this study was to analyze the relationship between this polymorphism and lung cancer in smokers.Method: Consecutive sampling and case-control study was applied. Genotyping was performed by PCR-RFLP assay. The chi-square test with p<0.05 considered as significant.Results: Of all 84 subjects, in case and control groups, wild-type variant His139His were 34 (81%) and 30 (71.4%), heterozygote variant His139Arg were 8 (19%) and 12 (28.6%), there was no homozygote variant Arg139Arg identified. (p=0.36).Conclusion: The EPHX1 His139His represents a common polymorphism in both of subject groups. There is no association between His139Arg polymorphism of EPHX1 and lung cancer.
Correlation Between CEA Serum Level on NSCLC Patients with EGFR Mutation from Tissue and Plasma Sample Frenky Hardiyanto Hendro Sampurno; Suryanti Dwi Pratiwi; Ngakan Putu Parsama Putra
Jurnal Respirologi Indonesia Vol 42, No 2 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i2.299

Abstract

Background: Patients with NSCLC can have EGFR mutation and increased level of CEA. EGFR mutation test on NSCLC has very important role for EGFR tyrosine kinase inhibitor (TKI) therapy.CEA is also expected to predict treatment efficiency of EGFR-TKI therapy. Tumor tissue biopsy is an invasive method and has come constraints, despite the golden standard testing. Circulating tumor DNA (ctDNA) is a new and less invasive for detecting EGFR mutation using plasma sample. In this study, we investigated the relationship between serum CEA and EGFR mutations in tissue and plasma in NSCLC patient.Methods: This cross-sectional observational research was conducted in Dr. Saiful Anwar General Hospital Malang from August 2018 until July 2019, 76 NSCLC patients who had undergone test of EGFR mutation from tissue, ctDNA, and serum CEA level. Extracted DNA from plasma and tissue samples from citology or biopsy was checked for the EGFR mutation. The serum CEA levels were analyzed using electrochemical luminescence.Results: EGFR mutation from tissue samples positive detected on 34 subjects and ctDNA detected 19 subjects. Serum level of CEA >5 ng/ml was significantly associated with EGFR mutation from tissue sample (p=0.037) with an odds ratio of 2.778 (95% CI: 1.050-7.348), the area under curve for CEA was 68,8% and cut-off CEA 9.14 ng/ml. Serum level of CEA >5 ng/ml wasalso significantly associated with ctDNA (p=0.015) with an odds ratio of 4.8 (95% CI: 1.259-18.299), the area under curve for CEA was 78,1% and cut-off CEA 14.8 ng/ml.Conclusion: Serum CEA level has poor correlation with mutation of EGFR from tissue and moderate correlation with mutation of EGFR from ctDNA in NSCLC patients. Patients with increased level of CEA >5 ng/ml are 2.778 times more at risk to had EGFR mutation and 4.8 times more at risk to had ctDNA positive mutation.
An evaluation of short-acting β2-agonist prescriptions and associated clinical outcomes in asthma management in Indonesia – the SABINA Indonesia study Wiwien Heru Wiyono; Muhammad Amin; Susanthy Djajalaksana; Amira Permatasari Tarigan; Febrina Susanti; Hisham Farouk; Helyanna Helyanna
Jurnal Respirologi Indonesia Vol 42, No 2 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i2.295

Abstract

Background: Asthma is a chronic inflammatory disease, therefore inhaled corticosteroid (ICS) should be as the cornerstone of asthma treatment. However patients tend to rely on short-acting β2-agonist (SABA) due to immediate symptom relief and underuse ICS, thereby undertreating the underlying inflammation. As part of the multi-country SABA use IN Asthma (SABINA) III study, we aimed to describe SABA prescription patterns and asthma-related clinical outcome in Indonesia.Methods: Cross-sectional study in asthma patients (> 12 years old) during August 2019 –  January 2020. Disease characteristic, prescribed asthma treatment in the 12 months before the study visit, and clinical outcomes, were recorded during a single visit and entered into an electronic case report form.Results: Of 219 patients recruited, the mean number of SABA canisters prescribed was 4 canisters per year. SABA over-prescription (≥ 3 canisters/year) seen in 37% patients, and was greater in moderate-to-severe vs mild asthma (40% vs 17.9%). 47.5% of patients had at least 1 severe exacerbation; and 7.3% of patients had ≥3 severe exacerbations, in the past 12 months. Almost half of the patients (40.2%) were prescribed oral corticosteroids (OCS). Overall, the well-, partly, and uncontrolled patients were 41.6%, 37.4%, and 21%, respectively.Conclusion: SABA over-prescription occurs in approximately one third of asthma patients, especially among moderate-to-severe patients and almost half of asthma patients experienced at least 1 severe exacerbation in the previous year. This highlights a public health concern and the need to improve asthma care by aligning with global recommendations including reducing SABA over-reliance in Indonesia
Comparison of Eutectic Mixture of Local Anesthesia Cream and Subcutaneous Lidocaine to Reduce Chest Tube Removal Pain and Willingness to Repeat Procedure Roman Diaz; Yusup Subagio Sutanto; Ahmad Farih Raharjo
Jurnal Respirologi Indonesia Vol 42, No 2 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i2.297

Abstract

Background:. Patients with chest tube have allodynia (pain from stimuli that is normally painless) and hyperalgesia (increased sensitivity to pain). Anesthetics has not been used routinely when removing chest tubes assuming that the procedure is brief and that the pain is short-lived, even though it could be the most painful part of chest tube procedures.Objective: This study compared the effectiveness of local anesthetic EMLA cream and subcutaneous infiltration of lidocaine to reduce pain of chest tube removal, 10 minutes after, and it’s effect on the patient's willingness to repeat the procedure.Method: A quasi-experimental clinical trial conducted on 28 patients undergoing chest tube removal at dr. Moewardi from September 2020. The EMLA group (n = 14) received 2 grams of topical EMLA cream applied 2 hours before chest tube removal. The lidocaine group (n = 14) received subcutaneous infiltration of 2% lidocaine 5 minutes before chest tube removal. Pain was measured by VAS pain before, during, and 10 minutes after the chest tube was removed, followed by filling out a willingness to repeat procedure questionnaire.Results: Topical EMLA cream was comparable to 2% lidocaine infiltration for reducing pain during chest tube removal (p = 0.679) and 10 minutes thereafter (p = 0.833). EMLA cream did not increase the patient's willingness to repeat the procedure (p = 0.815)Conclusion: Topical EMLA cream able to replace the subcutaneous infiltration of 2% lidocaine as a local anesthetic for chest tube removal but does not increase the patient's willingness to repeat the procedure.
The Effect of Roflumilast on Absolute Neutrophil Count, MMP-9 Serum, % VEP1 Value, and CAT Scores in Stable COPD Patients Ratna Adhika; Suradi Suradi; Yusup Subagio Sutanto
Jurnal Respirologi Indonesia Vol 42, No 2 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i2.265

Abstract

Background: Chronic obstructive pulmonary disease is the leading cause morbidity and mortality worldwide. Cigarette smoke and noxious agent causing oxidative stress activated nuclear factor-κB then increase inflammatory cell releases. Roflumilast have antiiinflammatory effect which can be use as addition therapy for stable COPD.Methods: The pretest and postest experimental clinical trial was carried out in 40 patients with stable COPD in the pulmonology outpatient clinics of Dr. Moewardi Surakarta and dr. Soehadi Prijonegoro Sragen hospital from 6 January to 6 March 2020. Forty subjects were grouped into treatment group (n=20) receiving standart therapy along with roflumilast 500 mg/day and placebo group (n=20) receiving standart therapy only for 28 days. Decreased inflammation measured by ANC and serum MMP-9, improvement of obstruction measured by % FEV1, and clinic improvement measured by CAT score.Results: Our finding revealed decreases of ANC and MMP-9 serum in the treatment group, although statistically insignificant (p=0,449), (p= 0,195) respectively. %VEP1 value increased insignificant in the treatment groups (p=0,189). Chronic obstructive pulmonary disease assessment test (CAT) score decreased significantly in the treatment group (p=0.000).Conclusion: Roflumilast administration reduce inflammation as it can lower not significant ANC, MMP-9 serum, higher not significant %VEP1, and improves the clinical condition of patients with stable COPD based on a decrease in CAT score.
Gastro-Esophageal Reflux Is Not a Common Cause of Chronic Cough; A Singapore Case Series Vijo Poulose
Jurnal Respirologi Indonesia Vol 42, No 2 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i2.300

Abstract

Background: Gastro-esophageal reflux disease (GERD) is believed to be a common cause of chronic cough.  There is a paucity of data on GERD-related cough (GERC) from Singapore. Our aim was to examine the prevalence, demographics and clinical features of GERC patients seen in a large teaching hospital in Singapore.Methods: We did a retrospective review of patients referred to the respiratory clinic for evaluation of chronic cough (≥ 6 weeks in duration). All patients diagnosed with GERC were further classified into 2 groups based on the likelihood of esophageal reflux being the cause of cough. 1) Likely GERC and 2) Possible GERC. We describe the demographics, clinical characteristics and the outcomes of these patients.Results: Of the 330 chronic cough patients seen over a 6 years period, 45 patients (13%) were diagnosed with GERC.  Most were women (69%), the median age was 53 years and the median duration of symptoms was 26 weeks. Fourteen patients were in the Likely group and 31 in the Possible group.  Throat symptoms or signs were found in 77 % of patients.Conclusions: Amongst patients referred for cough to a specialist clinic, GERD was not seen as a common cause.  Throat signs and symptoms were common and could add weight to the diagnosis of GERC. There was no particular timing for the cough with regards to day or night.
The Surfactant Protein D (SP-D) Serum Levels in Limestone Mining Worker Sita Laksmi Andarini; Anna Yusrika; Sri Wening Pamungkasningsih; Farhan Hilmi Taufikulhakim; Ahmad Hudoyo; Widhy Yudistira Nalapraya; Agus Dwi Susanto
Jurnal Respirologi Indonesia Vol 42, No 2 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i2.301

Abstract

Background: Limestone is sedimentation rocks consist of minerals calcite and aragonite, often contains silica, and fossils, commonly used in building materials. Limestone mining workers are at high risk to pneumoconiosis. Surfactant protein D(SP-D) is part of collectin family, and served as innate immune system of pathogen recognition receptor (PRR). SP-D level were usually increased in fibrotic lung disease. In this study, we sought the serum level of SP-D as marker for early pneumoconiosis in limestone worker in Indonesia.Method: This study was cross-sectional observational study. Participant of the study were 65 limestone workers, willing to participate in this study by signing informed consent, were questionnaire, and blood sample were collected to measure SP-D level by ELISA.Results: This study found that characteristic subjects dominated by male with the median of age was 42 years old and last education mostly elementary school. Majority duration of working <6 years and time working in a day >8 hours per day. The limestone mining workers mostly did not wear mask and had normal weight group. Majority limestone mining workers ever smoker, mean SP-D level in limestone workers was (66.3±5.5ng/mL), slightly higher than normal subject. Smoking status, gender, working hour were correlated with higher SP-D level.Conclusion: Although not statistically significant, the SP-D serum levels in limestone mining workers might be used as monitoring for early screening for pneumoconiosis in limestone workers.
Factors Affecting the Outcomes of COVID-19 Patients Treated at Dr. M. Djamil Padang General Hospital Yessy Susanty Sabri; Dewi Wahyu Fitrina; M. Hari Nandi Pinto; Lusi Agustini Arda; Nova Indriyani; Kornelis Aribowo; Ilham Ilham; Dimas Bayu Firdaus
Jurnal Respirologi Indonesia Vol 42, No 3 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i3.273

Abstract

Background: COVID-19 has spread rapidly throughout the world with high morbidity and mortality. This study aimed to determine the factors that influenced the outcomes of COVID-19 patients treated at RSUP. Dr. M. Djamil Padang.Methods: This was an observational analytic study conducted with a retrospective cohort design on COVID-19 patients at RSUP Dr. M. Djamil Padang. Data were taken from medical records from January to March 2021. Association between comorbidities and the outcome of COVID-19 patients were analyzed using Chi- Square/Fisher Exact Test.Results: Majority of the patients were female (56.4%) and aged above 50 years (64.3%). Hypertension was the most common comorbidity (41.1%). Diabetes mellitus affected the final outcome of treatment. The number of comorbidities the patients had was associated with a worse outcome for COVID-19.Conclusion: Most of COVID-19 patients at RSUP Dr. M. Djamil Padang were male and more than 50 years old. There was a correlation between age, gender, and comorbidities in COVID-19 patients with the outcomes.
Correlation of Antibiotic Resistance with Sepsis Incidence, Hospital Mortality, and Time of Sepsis Onset in Community Acquired Bacterial Pneumonia Kresentia Anita Raniputri; Harsini Harsini; Reviono Reviono; Leli Saptawati
Jurnal Respirologi Indonesia Vol 42, No 3 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i3.359

Abstract

Background: Community acquired pneumonia is associated with high morbidity and mortality. Treatment of multidrug-resistant organisms (MDRO) infection in pneumonia is a challenge. Antibiotic resistance is a major factor determining clinical treatment unresponsiveness and rapid progression to sepsis. Septic patients with MDRO have a higher hospital mortality. The correlation of antibiotic resistance with the incidence of sepsis and hospital mortality is yet to be known. This study analyzed the correlation of antibiotic resistance with sepsis incidence, hospital mortality, and time of sepsis onset.Methods: Retrospective cohort study of patients with community acquired bacterial pneumonia from July-December 2019 at RSUD Dr. Moewardi. The correlation between antibiotic resistance and incidence of sepsis, hospital mortality was tested by using Chi Square and Fisher's exact test correction. Association between two variables with relative risk. Survival analysis and log rank test were used to examine the time differences of sepsis onset.Results: There was a correlation between antibiotic resistance and incidence of sepsis in community acquired bacterial pneumonia (r = 0.417, p = 0.000) with RR = 4,294 (95% CI 2,886-6,390). The median time of sepsis onset was day 0 in the MDRO group and day 4 in non-MDRO group (p = 0.000).Conclusion: There is a correlation between antibiotic resistance and incidence of sepsis in community acquired bacterial pneumonia with a fairly strong and significant correlation value. The presence of antibiotic resistance increases the incidence of sepsis fourfold. Antibiotic resistance also affects the time of sepsis onset.
Surfactant Protein D Level in Cement Workers Nurlinah Jalil; Sita Laksmi Andarini; Muhammad Ilyas; Feni Fitriani Taufik
Jurnal Respirologi Indonesia Vol 42, No 3 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i3.280

Abstract

Background: Pneumoconiosis occurs almost all over the world. Pneumoconiosis is a threat to cement workers. Serological abnormalities are observed in pneumoconiosis. Surfactant protein D (SP-D) levels were increased in workers exposed to silica. SP-D may be useful as a biomarker for the early diagnosis of pneumoconiosis but it has not been studied in Indonesia.Methods: This cross-sectional study was conducted with consecutive sampling technique. The number of subjects was 61 people, consisting of 44 workers exposed to cement and 17 controls from September 2017 to March 2018. Serum level of SP-D was measured using ELISA method. Cement exposed workers were workers in the production area and workers in quarry areas.Results: All of the study subjects were male (100%) with mean age of 42.5 years old. The youngest and oldest subjects were 21 and 55 years old, respectively. Majority of the subjects was in the normal weight group (47.7%). Based on smoking history, there were 26 subjects (59.1%) had never smoked, 12 subjects (27.3%) as smokers, and 6 subjects (13.6%) as former smokers. Duration of exposure <10 years was found in 9 subjects (20.5%) while exposure ≥10 years was observed in 35 subjects (79.5%). Good category of using self-respiratory safety instrument was observed in 5 subjects (11.4%), moderate category in 36 subjects (81.8%) and poor category in 3 subjects (6.8%). Mean serum SP-D levels in the exposed group was 111.027 ng/ml and in control group was 67.648 ng/ml. Serum SP-D levels were significantly higher in the exposed group than control group (P=0.014).Conclusion: Serum SP-D levels was statistically higher in the exposed group than in control group.

Page 18 of 37 | Total Record : 364

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