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Molekul: Jurnal Ilmiah Kimia

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Published by Universitas Jenderal Soedirman

ISSN : 19079761 EISSN : 25030310 DOI : -

Core Subject : Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry

MOLEKUL is a peer-reviewed journal of chemistry published by the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Soedirman University, Indonesia. Publishing frequency 2 issues per year, on May and November. This Journal encompasses all branches of chemistry and its sub-disciplines including Pharmaceutical, Biological activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry.

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Articles 331 Documents

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MODEL QSAR SENYAWA FLUOROKUINOLON BARU SEBAGAI ZAT ANTIBAKTERI Salmonella thypimurium Eva Vaulina, Ponco Iswanto Eva Vaulina; Ponco Iswanto
Molekul Vol 1, No 1 (2006)
Publisher : Universitas Jenderal Soedirman

Modelling of novel Fluoroquinolone derivates as antibacterial compund of Salmonella thypimurium was conducted. The research was done as an initial step in discovering some new Fluoroquinolone compounds which have higher activity to Salmonella thypimurium. There are 16 compunds that use as the material of the research and they already have antibacterial activity data that expressed in Minimal Inhibitory Concentration (MIC, mg/mL). Calculation was performed by semiempirical AM1 method. The QSAR model was determined by multilinear regression analysis, with Log MIC as dependent variable and the independent variables are atomic net charges of C5 (qC5) and C7 (qC7), dipole moment (m), polarizability (a), n-octanol-water coefficien partition (Log P), molecular weight (Mw), and surface area of van der Waals (AvdW). The relationship between Log MIC and the descriptors which performed by statistical analysis is:(Log MIC) = -2.119 + 34.541(qC5) – 19.748(qC7) – 0.919polar + 1.170logP + 0.111(Mw) – 0.003(Avdw), with n =16, r = 0.907, r2 = 0.822, SD = 0.288, F calc = 6.938, F table = 3.374 , F calc/F table = 2.056 and PRESS = 0.749. The research can obtain the new coumpounds that modified from compound number 16 (etil fluoroquinolone, MIC prediction = 0.0354 mg/mL), (etil fluoroquinlone fosfate, 2.84. 10-19mg/mL), and (isopropyl fluoroquinlone, 0.1085 mg/mL), and compound number 2 (m-nitro fluoroquinolone sulfonat, 1.32. 10-11mg/mL). This results can be suggested to synthesis step.

Effect Of Non-metal Elements (C, N, S) As Anionic Dopants On Electronic Structure Of Tio2-Anatase By Density-Functional Theory Approach Hari Sutrisno
Molekul Vol 11, No 1 (2016)
Publisher : Universitas Jenderal Soedirman

This article is a theoritical approach to calculate the electronic structure of undoped- and non-metal anions doped-TiO2-anatase. The objective of the research is to calculate abinitio the band structure and the density of states (DOS) of undoped-, C-, N-, and S-doped TiO2-anatase. Kohn-Sham equations are performed with the density functional theory (DFT) using the local density approximation (LDA) for exchange-correlation functional. The first-principle calculations were done using supercell (2x2x1) methods as implemented within Amsterdam Density Functional (ADF)-BAND version 2014.10. The ab-initio calculation of the band structures show that all samples are direct- and indirect-gap type semiconductor. The band gap of TiO2-anatase with DFT using LDA is 2.43 eV. The addition of C atom at 0.943% in 48 atoms produces width intermediate band about 0.76 eV, which is 0.38 eV above the valence band (VB) and 1.38 eV below the conduction band (CB). The addition of N atom at 1.103% and S atom at 2.478% in the lattice structure of TiO2-anatase resulted in the addition of the VB width to 0.47 eV and 0.11 eV, while the resulting gap between the VB and the CB to 1.97 eV and 2.33 eV, respectively.

KARAKTERISASI SIFAT-SIFAT BIOKIMIA EKSTRAK KASAR LIPASE EKSTRASELULER BAKTERI Azospirillum sp.PRD1 Santi Nur Handayani; Puji Lestari; Oedjijono Oedjijono; Tri Joko Raharjo; Sabirin Matsjeh
Molekul Vol 6, No 2 (2011)
Publisher : Universitas Jenderal Soedirman

Enzim lipase mempunyai peranan penting dalam katalis berbagai reaksi industri satu diantaranya pembuatan flavor melalui reaksi esterifikasi. Lipase adalah biokatalis yang berperan besar dalam aplikasi bioteknologi, seperti dalam sintesis biopolimer, biodiesel, produksi obat, dan produksi flavor. Peningkatan penggunaan lipase untuk industri mendorong dilakukan penelitian untuk mendapatkan sumber-sumber lipase baru. Sumber lipase yang potensial salah satunya adalah bakteri Azospirillum sp.PRD1 dari isolat lokal Laboratorium Mikrobiologi, Fakultas Biologi Universitas Jenderal Soedirman. Tujuan penelitian adalah untuk mendapatkan ekstrak kasar lipase dan menentukan karakteristik sifat-sifat biokimiawinya. Metode yang digunakan antara lain peremajaan bakteriAzospirillum sp.PRD1, dan produksi inokulum, penentuan waktu produksi optimum dan fase pertumbuhan bakteri, ekstraksi dan produksi ekstrak kasar lipase dan penentuan karakteristik sifat-sifat biokimiawinya. Hasil penelitian diperoleh ekstrak kasar lipase dari inokulum berumur 7 jam dan medium produksi dengan induser minyak zaitun yang diinkubasi selama 3 jam memiliki aktivitas spesifik 7,0547 Unit/mg. Lipase ekstrak kasar optimum pada pH 7, suhu 40 oC dan waktu inkubasi selama 25 menit. Lipase merupakan metaloenzim dengan kofaktor Zn2+ , Mn2+, Hg2+, Ca2+, Co2+ and Mg2+.

A Cytotoxic Rocaglate Compound from The Stembark of Aglaia argentea (Meliaceae) Ace Tatang Hidayat; Kindi Farabi; Desi Harneti; Nurlelasari Nurlelasari; Rani Maharani; Tri Mayanti; Unang Supratman; Yoshihito Shiono
Molekul Vol 12, No 2 (2017)
Publisher : Universitas Jenderal Soedirman

The Aglaia genus belong to Meliceae family is unique plant species because the presence of rocaglate and rocaglamide which is so far isolated only from Aglaia genus, indicate that type of this compound as a chemical marker for the genus of Aglaia. This type of compound known to have strong activity, such as insecticide and cytotoxic. This study describe the isolation, structure elucidation, and cytotoxic activity of an isolated rocaglate compound. Dried stembark of A. argentea extracted with methanol and partition between n-hexane, ethyl acetate, and n-butanol, respectively The extracts were tested against P-388 murine leukemia cells and the ethyl acetat showed strongest activity with IC50 value of 15.5 mg/mL. The ethyl acetate then was separated and purified with chromatography technique to obtain isolated compound 1. The chemical structure of isolated compounds were elucidated by spectroscopic methods including one and two-dimensional NMR as well as high-resolution mass spectrometric analysis and identified as a methyl rocaglate. Compound 1 showed strong cytotoxic activity with an IC50 value of < 0.1 μg/mL.

AKTIVITAS AMILASE, LIPASE DAN PROTEASE DARI CACING Peryonix excavatus Ari Asnani; Puji Lestari
Molekul Vol 4, No 2 (2009)
Publisher : Universitas Jenderal Soedirman

The ability of Peryonix excavatus to live in extremely dirty area indicates that P. excavatus secretes distinctive enzymes which might be useful for industry. Thus, this research were aimed to isolate amylase, lipase and protease from P. excavatus, and to characterize the enzymes to know the optimum temperature and pH. The isolation procedure consisted of extraction and ammonium sulphate fractionation. The results showed that crude extract and ammonium sulphate fractions of P.excavatus had amylase, lipase, and protease enzymes activities. Among the three enzymes, amylase had the highest enzymatic activity whereas lipase was the least. The optimum temperature of amylase, lipase and protease were 60, 40, and 60 oC, respectively. The optimum pH of amylase, lipase and protease were 7, 7, and 8, respectively.

KARAKTERISASI PAPAIN DARI DAUN PEPAYA (Carica Papaya L. CHARACTERIZATION OF PAPAIN FROM Carica Papaya L. LEAVES Zusfahair Zusfahair; Dian Riana Ningsih; Febrina Nur Habibah
Molekul Vol 9, No 1 (2014)
Publisher : Universitas Jenderal Soedirman

Enzim yang menempati urutan pertama dalam pemanfaatannya di bidang industri adalah protease. Protease dapat digunakan sebagai katalis untuk reaksi yang menggunakan pelarut organik. Penelitian ini bertujuan untuk mengetahui karakteristik ekstrak kasar papain dari daun pepaya (Carica papaya L.) yang meliputi suhu dan pH optimum, pengaruh EDTA dan ion-ion logam, serta kestabilannya dalam pelarut organik seperti metanol, aseton, dan toluena, serta potensinya sebagai katalis dalam pelarut organik.Isolasi papain dari daun pepaya dilakukan untuk mendapatkan ekstrak kasar papain. Ekstrak kasar papain selanjutnya dikarakterisasi suhu dan pH optimum, pengaruh EDTA dan ion-ion logam yang meliputi ion Ca2+, ion Mg2+, Cu 2+, Zn2+, serta aktivitasnya dalam pelarut organik, seperti metanol, aseton, dan toluena.Hasil penelitian menunjukkan bahwa ekstrak kasar papain yang diisolasi dari daun pepaya kalifornia optimum pada suhu 60 oC dan pH 7, sedangkan papain daun pepaya bangkok optimum pada suhu 50 oC dan kisaran pH 7-8. Aktivitas enzim papain daun pepaya kalifornia dan bangkok meningkat dengan adanya ion Zn2+ dan menurun dengan adanya ion Ca2+, ion Mg2+, Cu2+ serta EDTA. Aktivitas papain daun pepaya kalifornia relatif stabil hingga jam ke-6 dengan penambahan pelarut metanol dan menurun setelah jam ke-3 dengan penambahan pelarut aseton dan toluena, sedangkan papain daun pepaya bangkok dengan penambahan pelarut metanol, aseton, ataupun toluena aktivitasnya hanya dapat stabil hingga jam ke-3. Papain dari daun pepaya kalifornia berpotensi digunakan sebagai biokatalis dalam pelarut metanol.

Xylose and Arabinose Fermentation to Produce Ethanol by Isolated Yeasts from Durian (Durio zibethinus L.) Fruit Hermansyah Hermansyah; Fachrijal Fachrijal; Miksusanti Miksusanti; Fatma Fatma; Getari Kasmiarti; Almunadi T Panagan
Molekul Vol 14, No 2 (2019)
Publisher : Universitas Jenderal Soedirman

Xylose and arabinose are pentosesugars that present in hemicellulose, part of lignocellulose biomass.These pentose sugars can be fermented by yeast into ethanol.The aim of this research was to utilize yeast isolated from durian fruit (DuriozibethinusL.) in fermentation of xylose and arabinose to produce bioethanol.Phenotypic test of isolates was conducted by growingthe isolates in various agar media, i.e.YPD (Yeast Peptone Dextrose), YPA (Yeast Peptone Arabinose), and YPX (Yeast Peptone Xylose) containing dextrose, arabinose, xylose, respectively, assole carbon source to see cell growth. The yeast isolates were further identified using API AOC 20C kit method. Yeast isolates were applied for fermentation of glucose, arabinose, and xylosein incubated cultures. Ethanol production in the fermentation was analyzed bygaschromatography. Yeast isolates were identified as Kodamaea ohmeri, Candida famata, Candida guilliermondii, and Crytococcuc laurentii. Based on gas chromatography data, it was found that ethanol produced in the fermentation for three days, the highest ethanol content on xylose substrate was fermented by Candida famata-Awhich is0.021% (v/v) ethanol resulted from initial concentration of 5% xylose (w/v). While on arabinose substrate, the highest ethanol content was fermented by Crytococcus laurentii-Bwhich is 0.0034% (v/v) ethanol resulted from initial concentration of 5% arabinose (w/v).

ALKALINE PROTEASE, AMYLASE AND CELLULASE ACTIVITIES OF YELLOW RASBORA, Rasbora lateristriataBlkr., AT DIFFERENT FEEDING LEVELS Untung Susilo; Purnama Sukardi; Ridwan Affandi
Molekul Vol 11, No 2 (2016)
Publisher : Universitas Jenderal Soedirman

Alkaline proteases, amylase and cellulase activities of digestive organ of yellow rasbora, Rasbora lateristriata Blkr., was evaluated with four different feeding levels of 0.34g protein+0.03g fiber, 1.01g protein+0.10g fiber, 1.69g protein+0.16g fiber and 2.36g protein+0.23g fiber/day/100 g fish biomass. A total of 280 fish with average body weight of 0.71±0.06g were used in this study. The results showed that the difference in the feeding levels resulted in a significant difference in trypsin and chymotrypsin activities (P <. 05), but not for amylase and cellulase activities (P > .05). In conclusion, protein digestion capacity increased, but not to the digestion of starch and fiber in response to different feeding levels and the optimal feeding level for yellow rasbora was 1,01g protein+0,10g fiber/day/100 g fish biomass.

PREPARASI DAN KARAKTERISASI KITIN DARI KULIT UDANG PUTIH (Litophenaeus vannamei) Mardiyah Kurniasih; Dian Windy Dwiasi
Molekul Vol 2, No 2 (2007)
Publisher : Universitas Jenderal Soedirman

Chitin is one of the most abundant natural polysaccharides produced by many living organisms; it is usually found as a component of crustacean shells. In this paper, Chitin have been isolated from white shrimp (Litophenaeus vannamei). The preparation of chitin using chemical products to deproteinize and demineralize the source material. Characterization included determination of water, ash, fat and protein degree; moreover chitin powder characterize with FTIR and XRD spectroscopy. The result showed that process efficiency of chitin from white shrimp (Litophenaeus vannamei) was 20.95%, with degree of water, ash, fat and protein were 5.39, 2.66, 1.54 and 36.16%, respectively.

PENGGUNAAN SPEKTROSKOPI 31P NMR DAN FT-IR UNTUK KARAKTERISASI SENYAWA POLIOKSOMETALAT TIPE DAWSON (NH4)6[b-P2W18O62] DAN (NH4)6[a-P2W18O62] Aldes Lesbani; Risfidian Mohadi; Nurlisa Hidayati
Molekul Vol 7, No 2 (2012)
Publisher : Universitas Jenderal Soedirman

Telah disintesis senyawa polioksometalat tipe Dawson (NH4)6[b-P2W18O62] dan (NH4)6[a-P2W18O62] yang dilanjutkan dengan karakterisasi menggunakan spektrometer 31P NMR dan FT-IR. Hasil penelitian menunjukkan bahwa senyawa polioksometalat tipe Dawson memberikan sinyal 31P NMR yang berbeda untuk struktur b dan a. Struktur b pada (NH4)6[b-P2W18O62] menghasilkan dua puncak pada pergeseran kimia -10,90 dan -11,68 ppm sedangkan struktur a memberikan satu puncak pada pergeseran kimia -12,39 ppm yang mengindikasikan adanya rotasi unit W3O13 pada struktur b sebagai penyusun struktur Dawson. Hal ini diperkuat oleh perbedaan spektra FT-IR pada stuktur b yang memiliki vibrasi pada bilangan gelombang 1164 cm-1 sedangkan struktur a tidak. Secara umum spektra FT-IR untuk polioksometalat tipe Dawson (NH4)6[b-P2W18O62] dan (NH4)6[a-P2W18O62] tidak menunjukkan adanya pebedaan yang signifikan terutama pada bilangan gelombang disekitar 1090 cm-1 yang menunjukkan vibrasi P-O.

Page 13 of 34 | Total Record : 331

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Editorial Address Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

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Contact Name
Amin Fatoni

Contact Email
aminfatoni@unsoed.ac.id

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Journal Mail Official
j.molekul@gmail.com

Editorial Address
Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location
Kab. banyumas,

Jawa tengah

INDONESIA