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Molekul: Jurnal Ilmiah Kimia

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Published by Universitas Jenderal Soedirman

ISSN : 19079761 EISSN : 25030310 DOI : -

Core Subject : Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry

MOLEKUL is a peer-reviewed journal of chemistry published by the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Soedirman University, Indonesia. Publishing frequency 2 issues per year, on May and November. This Journal encompasses all branches of chemistry and its sub-disciplines including Pharmaceutical, Biological activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry.

Arjuna Subject : -

Articles 331 Documents

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ISOLASI DAN IDENTIFIKASI SENYAWA KIMIA SERTA UJI AKTIVITAS ANTICANDIDAISIS SERBUK DAUN SIRIH DUDUK (Piper sarmentosum Roxb. Ex Hunter) Suwandri Suwandri; Hartiwi Diastuti
Molekul Vol 1, No 1 (2006)
Publisher : Universitas Jenderal Soedirman

Sirih duduk or Piper sarmentosum Roxb. ex Hunter have been long used the people in Indonesia for traditional medicine to cure various diseases. One of them was used to treat fungoid diseases. This research was aimed to examine the anticandidaisis activity from extract of P. sarmentosum leaves and to isolate and identify the anticandidaisis compounds from P. sarmentosum leaves. The isolation bioactive compounds of P. sarmentosumleaves was performed by extraction the powder of P. sarmentosum leaves using methanol and the bioactivity tests were performed against Candida albicans. The methanol extracts was then fractionated using organic solvents such as n-hexane, benzene, chloroform, and ethyl acetate. Identification of the bioactive compounds was carried out using ultraviolet-visible spectrometry, fourier transform infra red spectrometry and gas chromatography-mass spectrometry. The result showed that the chloroform fraction of methanol extract of P. sarmentosum leaves have activity against C. albicans. The fractionation was performed by coloumn chromatography using n-hexane-ethyl acetate(1:1) eluent. A bioactive compound of sinamic acid derivative was 4-ethoxy-2-hidroxy-3,5-dimethoxy sinamic acid could be purely isolated.

ISOLASI Rhizopus oligosporus PADA BEBERAPA INOKULUM TEMPE DI KABUPATEN BANYUMAS Ratna Stia Dewi; Saefuddin Aziz
Molekul Vol 6, No 2 (2011)
Publisher : Universitas Jenderal Soedirman

Tempe merupakan makanan tradisional asli Indonesia. Tempe mengandung gizi yang cukup tinggi, mencakup 25% protein, 5% lemak, 4% karbohidrat serta kaya akan mineral dan vitamin B12. Sentra produksi tempe di Indonesia paling banyak di temui di Jawa Tengah, dan salah satunya ada di Kabupaten Banyumas. Tekstur tempe yang kompak dan berwarna putih tercipta dari hasil kerja jamur genus Rhizopus, yang ditambahkan sebagai inokulum pada saat pembuatan tempe. Salah satu jenis jamur yang sering dijumpai dalam ragi tempe adalah Rhizopus oligosporus. Penelitian ini bertujuan untuk mengisolasi jamur R. oligosporus dari beberapa inokulum tempe di Kabupaten Banyumas. 56 jamur diisolasi dari inokulum tempe. Semua isolat termasuk dalam genera Rhizopus. 19 diantaranya dipilih berdasarkan warna konidia, yang terdiri dari isolat dengan konidia coklat keabu-abuan, dan abu-abu. Pengamatan makroskopik dan mikroskopik menunjukkan bahwa isolat terpilih adalah R. oligosporus.

Potential of Lactobacillus casei Shirota Strain Probiotic Toward Total Cholesterol Levels and Sod Activity in Rat with High Cholesterol Diet Kiswanti Surya Utami; Aulanni'am Aulanni’am; Chanif Mahdi
Molekul Vol 12, No 2 (2017)
Publisher : Universitas Jenderal Soedirman

Probiotic of Lactobacillus casei Shirota strain is lactic acid bacteria that have benefits to enhance immunity system, as an antioxidant and has the ability to decrease the cholesterol level. The aim of this study was to determine the potential of Lactobacillus casei Shirota strain probiotic toward total cholesterol decreasing and SOD activity increasing in rats’ aorta with a high-cholesterol diet. This study used 25 male rats of Rattus novergicus Wistar strain that will be divided into 5 groups. The 1st group as the negative control, and the 2nd group as positive control. The positive control group was induced by high-cholesterol diet contained quail egg yolk, pure cholesterol, cholic acid and waste oil that were given for 3 weeks. The 3rd, 4th and 5th group were treated by probiotic Lactobacillus casei Shirota strain with variation dose of 3.6 x 107, 7.3 x 107 and 10.9 x 107 cells/kg bodyweight/day. The results showed that probiotic of Lactobacillus casei Shirota strain therapy dose of 10.9 x 107 cells/kg bodyweight/day can decrease the total blood cholesterol of rats’ serum that were given with high-cholesterol diet of about 32.0%. In addition, the probiotic of Lactobacillus casei Shirota strain therapy also increase the activity of SOD about 50.70%.

LAJU ADSORPSI DAN DESORPSI PARAQUAT PADA TANAH PERTANIAN DESA OESAO KECAMATAN KUPANG TIMUR Sherlly M.F. Ledoh; Hermania Em Wogo; Siti Arianti S.A
Molekul Vol 5, No 1 (2010)
Publisher : Universitas Jenderal Soedirman

The research about determination of kinetic adsorption and desorption rate of paraquat on agriculture area Oesao-east Kupang has been done. The aim of this research was to determine the kinetic of paraquat adsorption before and after saturated and to model the desorption. The research consisted of evaluation of the analitycal procedure for paraquat, pattern of soil kinetic adsorption and paraquat desorption. The result of procedure evaluation showed that reduced paraquat absorbed at λ maximum 606 nm and relative stability at 0-150 minutes. Constant of paraquat kinetic adsorption at natural state bigger than saturated state. k1 value at natural state was 0,011 per minute whereas k1 value at saturated state was 0,003 per minute. Desorption model of paraquat by using three desorbents were ammonium chloride, 29,2% of sea water salinity and aquadest showed the best desorbent was ammonium chloride, followed by sea water and aquadest.

FOTODEGRADASI ZAT WARNA TARTRAZIN LIMBAH CAIR INDUSTRI MIE MENGGUNAKAN FOTOKATALIS TiO2 - SINAR MATAHARI Dian Windy Dwiasi; Tien Setyaningtyas
Molekul Vol 9, No 1 (2014)
Publisher : Universitas Jenderal Soedirman

Salah satu dampak negatif perkembangan industri mie di Indonesia adalah timbulnya pencemaran lingkungan dari limbah cair industri mie yang masih mengandung zat organik seperti zat warna tartrazin. Penurunan kadar zat warna tartrazin dalam limbah cair mie dapat diupayakan dengan cara mendegradasi zat warna tartrazin melalui proses fotodegradasi dengan metode fotokatalis. Pada penelitian ini telah dilakukan fotodegradasi zat warna tartrazin dalam limbah cair mie menggunakan fotokatalis TiO2. Perlakuan meliputi pengaruh variasi waktu kontak dan pH terhadap aktivitas fotokatalis TiO2 menggunakan sinar UV dan sinar matahari. Hasil penelitian menunjukkan bahwa aktivitas fotokatalitik yang terbaik untuk TiO2 adalah pada kondisi limbah cair mie dengan pH 2, dan waktu kontak 1 jam. Persentase penurunan kadar tartrazin dengan menggunakan lampu UV adalah sebesar 56,81%, sedangkan dengan penyinaran sinar matahari sebesar 61,64 %.

Synthesis and Characterization of TiO2-CaO and TiO2-CaO-Fe2O3 Photocatalyst for Removal of Catechol Tahya, Candra Yulius; Irawati, Wahyu; Karnelasatri, Karnelasatri; Purba, Friska Juliana
Molekul Vol 14, No 2 (2019)
Publisher : Universitas Jenderal Soedirman

TiO2-CaO and TiO2-CaO-Fe2O3 photocatalysts have been synthesized through the surfactant-assisted sol-gel method. The catalysts were characterized using XRD, FTIR, SEM-ED Sand BET surface area. XRD pattern showed the formation of anatase TiO2 crystal phase both in TiO2-CaO and TiO2-CaO-Fe2O3. The TiO2-CaO has higher crystallinity than TiO2-CaO-Fe2O3. Based on the peak refinement using Rietveld, there are two peaks identified as Fe2O3 hematite in the sample TiO2-CaO-Fe2O3. BET surface area analysis showed that the average pore size of TiO2-CaO and TiO2-CaO-Fe2O3 catalysts are 8.04 and 8.41 nm respectively, indicating both catalysts are mesoporous.FTIR spectra show that the vibration of Ti-O, Ca-O, and Ca-TiO2 were observed in both catalysts. SEM images confirm that both catalysts are porous material. The catechol removal using TiO2-CaO and TiO2-CaO-Fe2O3 improved with the increase of catalyst concentration. After 360 minutes of UV radiation, the removal of catechol using TiO2-CaO-Fe2O3 reached 46.0%, 48.3%, and 69.2%, while when using TiO2-CaO, it reached 22.1%, 36.8%, and 57.0% for 0.1 g, 0.15 g, and 0.2 g of catalysts, respectively. The photocatalytic activity of TiO2-CaO-Fe2O3 is not so strong compared to TiO2-CaO catalyst but the catechol adsorption property of TiO2-CaO-Fe2O3 is higher than that of TiO2-CaO catalyst.

Preparation of Copper Oxide Nanostructure Thin Film For Carbon Monoxide Gas Sensor Brian Yuliarto
Molekul Vol 11, No 2 (2016)
Publisher : Universitas Jenderal Soedirman

This work reports the synthesis of nanostructure of CuO thin film using dip coating and chemical bath deposition method. Seed layer was deposited by dip coating method using zinc nitrate as a precursor. The CuO nanostructure has successfully grown on CBD process at 95oC for 6 hours. The X Ray Diffraction characterization result shows that the CuO has monoclinic crystallization and good crystallinity. Moreover, the Scanning Electron Microscope characterization results shows that CuO has nanospike-like shape. The CuO thin film as a gas sensor shows relatively high response on CO gas at the temperature working above 200oC. The highest response is obtained at 350oC of working temperature toward 30 ppm CO gas at 186% of sensor response.

ANALISIS KANDUNGAN MINERAL BERPOTENSI TINGGI PADA PASIR GALIAN DI WILAYAH KABUPATEN BANYUMAS Zaroh Irayani; Bilalodin Bilalodin
Molekul Vol 2, No 2 (2007)
Publisher : Universitas Jenderal Soedirman

It have been done analysis high potential mineral contents of sands and sandstone in Banyumas region. Sands and sandstone are taken from mining traditional at rivers and river’s stone grinder place. Sand samples were taken from Tajum, Logawa, Serayu and Klawing river, while sandstone were taken from Banjaran, Logawa and Klawing river’s grinder place. Sand was separate using permanent magnet to disassociated the magnetic and non magnetic mineral content and analyzed by X-ray difraction to reveal the mineral types. The Result indicated that river sand contained 39% magnetic mineral and 61% non magnetic. While identification using X-ray difraction obtained that sand have mineral of complex structured of valuable element such as Fe, Ti, Si and Zn and also rare earth like Y, Ca, Li and La.

PENGARUH PENAMBAHAN MONTMORILLONIT TERHADAP SIFAT MEKANIKKOMPOSIT FILM KARAGENAN-MONTMORILONIT Fajariyah Ulfah; Irwan Nugraha
Molekul Vol 9, No 2 (2014)
Publisher : Universitas Jenderal Soedirman

Telah disintesis dan dikarakterisasi edible film komposit karagenan-montmorilonit. Penelitian ini bertujuan untuk memperoleh komposisi dari komponen penyusunedible film (karagenan sebagai bahan dasar, gliserol sebagai plasticizer, dan montmorilonit sebagai filler), mengetahui pengaruh penambahan montmorilonit terhadap sifat fisik dan mekanik edible film, serta mengetahui interaksi yang terbentuk pada edible film. Penelitian dilakukan dalam tiga tahapan, yaitu preparasi awal montmorilonit, uji pendahuluan, dan sintesis edible film komposit karagenan-montmorilonit. Pecetakan edible film menggunakan metode solvent casting. Hasil yang diperoleh dari uji pendahuluan menunjukkan bahwa konsentrasi karagenan dengan sifat mekanik terbaik adalah 3,0% (b/v) dan gliserol 1,5% (v/v). Komposisi tersebut digunakan untuk mensintesis edible film komposit dengan variasi konsentrasi montmorilonit, yaitu 1,0% ; 2,0% ; 3,0% ; 4,0% ; dan 5,0%. Penambahan montmorilonit 1,0 – 3,0% dapat meningkatkan sifat mekanik edible film. Sifat mekanik terbaik dicapai pada konsentrasi montmorilonit 3,0% dengan ketebalan 0,107 mm, kuat tarik 4,139 Mpa, persentase pemanjangan 48,178%, modulus elastisitas 8,590 Mpa, dan WVTR 11,980 g/jam m2. Interaksi edible film komposit yang terbentuk adalah eksfoliasi dan interkalasi

Correction to: Histochemical Changes Liver and Kidney of Mice Exposed to Mercury and Recovery with Nanogold. Molekul, (2016) 11(1), 80-91. - Editors
Molekul Vol 12, No 1 (2017)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (71.768 KB)

Corrigendum to:In Abstract typed as: "The background of this research is the circulation cosmetic with mercury that occur today in society. The problem of the research is that occur histochemical’s damage liver and kidney after exposure to mercury, and is that nanogold can recovery that damage. The pre-clinical study needed 24 mice (Mus muscullus) were divided into 6 groups, the control is A group, B group was exposed to mercury, Groups C, D, E and F after being exposed to mercury, than recovery by nanogold with concentration each of 5, 10, 15 and 20 ppm. Exposure was performed 1 week and 4 weeks of recovery. Necropsy of mice doing after treatment, liver and kidneys are processed into preparations by blocking with paraffin embedding method. Histochemical staining of liver and kidney tissue with Hematoxylin eosin (HE) to determine changes of cell constituent and staining Van Geyson to determine the structure of collagen constituent. Statistics Manova showed different results between treatment groups. Tissue damage, lysis cell and destruction of collagen can be observed from histochemical techniques for mercury-exposed group compared to the control group. Tissue and collagen recovery process can be observed from group C, D, E and F. The conclusion that the effects of mercury one week exposed through skin give effect to collagen tissue damage at liver and kidneys of mice. 20 ppm of Nanogold can recovery damaged cells and collagen tissue from the liver and kidneys of mice after four weeks of recovery”. In the abstract, some English grammar should be corrected.Erratum:In Abstract section, some English grammars have been corrected. Therefore, the sentence in the Abstract was corrected to “Background study of this research is today phenomena of cosmetic with mercury circulation that occurs in society. This research focused on histochemical’s damage liver and kidney after exposure to mercury did occur or not, and nanogold can recovery that damage or not. The pre-clinical study needed 24 mice (Mus muscullus) which were divided into 6 groups, including A group as a control group, B group which was exposed to mercury, C, D, E and F groups which were exposed to mercury, then recovery by nanogold with concentration each of 5, 10, 15 and 20 ppm. The exposure was performed in 1 week and 4 weeks of recovery time. Necropsy of mice was done after liver and kidneys treatment were processed into preparats by blocking using paraffin embedding method. Histochemical staining of liver and kidney tissue were investigated using Hematoxylin eosin (HE) to determine changes of cell constituent, and staining Van Geyson was used to determine the structure of collagen constituent. Statistics Manova showed different results between treatment groups. Tissue damage, lysis cell and destruction of collagen can be observed from histochemical techniques for mercury-exposed group compared to the control group. Tissue and collagen recovery process can be observed from C, D, E and F group. Thus, it can be concluded that one week mercury exposured through skin gave effect on collagen tissue damage at liver and kidneys of mice. The nanogold concentration of 20 ppm can recovery the damaged cells and collagen tissue from the liver and kidneys of mice after four weeks of recovery time.”

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Home Page

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Contact Name Amin Fatoni

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Editorial Address Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

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Abstract

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Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Amin Fatoni

Contact Email
aminfatoni@unsoed.ac.id

Phone
-

Journal Mail Official
j.molekul@gmail.com

Editorial Address
Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location
Kab. banyumas,

Jawa tengah

INDONESIA