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Molekul: Jurnal Ilmiah Kimia

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Published by Universitas Jenderal Soedirman

ISSN : 19079761 EISSN : 25030310 DOI : -

Core Subject : Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry

MOLEKUL is a peer-reviewed journal of chemistry published by the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Soedirman University, Indonesia. Publishing frequency 2 issues per year, on May and November. This Journal encompasses all branches of chemistry and its sub-disciplines including Pharmaceutical, Biological activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry.

Arjuna Subject : -

Articles 331 Documents

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HIDRASI IKATAN RANGKAP C7-8 SENYAWA KALANON DAN UJI SITOTOKSISITASNYA TERHADAP SEL LEUKEMIA L1210 Mochamad Chasani; Eva Vaulina; Ponco Iswanto; Yayu Rahayu
Molekul Vol 5, No 1 (2010)
Publisher : Universitas Jenderal Soedirman

Calanone is anticancer compound that is isolated from species Calophyllum. The biological activity of calanone againts leukemia cell L1210 is relatively low showed by IC50 value at 59.4 μg/mL. A compound have a high biological activity if the value of IC50 under 10 μg/mL. This research aimed to obtained calanone hydrat compound which has a higher activity to inhibit leukemia L1210 cancer cell growth. Calanone hydrat compound is got through with two step reaction, first step was protonated double bond by acetic acid reagent and the second step is nucleophilic addition by water. Initial analysis for the synthesize product compound is done with thin layer chromatography (TLC) using n-hexane and ethyl acetate 2:1 (v/v) eluent. Coloum Chomatography and recrystallization is used to pure the synthesize product compound with n-hexane and methylen chloride 1:1 (v/v) solvent. The result analyzed by thin layer chromatography. The synthesized product give Rf at 0.4545 and rendement 4.72% (w/w), forming of brownish yellow chromatic powder and melting point at 190oC-192oC. Identification structure of synthesize product compound is done with mass spectrometer. The result of mass spectrometer identification were moleculer ion M+-18 (M+ 424) with fragments m/e=409, m/e=395, m/e=381, m/e= 331, m/e=317, m/e=303, me/=176, m/e=105, and m/e=77. Citotoxicity test againts leukemia cell L1210 yield the value IC50 equal to 45.64 μg/mL.

ANTIBACTERIAL ACTIVITY CAMBODIA LEAF EXTRACT (Plumeria alba L.) to Staphylococcus aureus AND IDENTIFICATION OF BIOACTIVE COMPOUND GROUP OF CAMBODIA LEAF EXTRACT Dian Riana Ningsih; Zusfahair Zusfahair; Purwati Purwati
Molekul Vol 9, No 2 (2014)
Publisher : Universitas Jenderal Soedirman

A wide variety of flora can be found and can be used, as a medicinal plant. Medicinal plants are a majorsource of new chemical compounds discovery with therapeutic effects. One of the plants that can be used as a medicinal plant is a cambodia plant (Plumeria alba L cv. Acutifolia). Cambodia plants including theApocynaceae family. Cambodia is a traditional crop plants that are reported to have various properties,including its leaves as a laxative, itching and antibacterial, fruit and bark reported anti-inflammatory effect.The purpose of this study was to determine the potential of cambodia leaves as antibacterial, determining the Minimum Inhibitory Concentration Growth (KHTM) of cambodia leaf extract which has the highest inhibitoryactivity and determine what class of chemical compounds contained in extracts of cambodia leaves which hasthe highest antibacterial activity . Research results showed that the leaf extract of cambodia leaves with 1000 ppm can inhibit the growth of S. aureus bacteria. Concentration of 30 ppm is the lowest concentration thatcould inhibit the growth of S. aureus with inhibition zone of 1.3 mm. Analysis of FT-IR spectrophotometer,the ethanol leaves extract of the cambodia have functional group of C-H sp3 (methyl) (methyl), C-C, C = Calkenes aliphatic, OH and CO.

KAJIAN AKTIVITAS ANTIBAKTERI KAIN TERCELUP KOMPOSIT KITOSAN-SILIKA Intan Permatasari; Dina Kartika Maharani
Molekul Vol 7, No 2 (2012)
Publisher : Universitas Jenderal Soedirman

Telah dilakukan penelitian tentang pengaruh jumlah proses pencelupan kain menggunakan komposit kitosan-silika terhadap aktvitas antibakteri kain kitosan-silika. Proses pelapisan kitosan-silika pada kain dilakukan dengan metode pencelupan atau dip-coating dengan teknik pengeringan pad-dry-cure pada temperatur dry 80 oC dan temperatur curing 140 oC. Uji aktivitas antibakteri kain kitosan-silika terhadap bakteri S.aureus dilakukan dengan metode Shake flask turbidimetry. Hasil penelitian menunjukkan adanya pengaruh jumlah proses pencelupan kain dalam larutan kitosan-silika terhadap persentase aktivitas antibakterinya. Persentase aktivitas antibakteri setelah 24 jam pada kain tercelup komposit kitosan-silika dengan variasi pencelupan 5 kali adalah sebesar 18,52%, kain dengan 10 kali pencelupan adalah sebesar 22,06%, kain dengan 15 kali pencelupan adalah sebesar 32,87% dan dengan variasi pencelupan sebanyak 30 kali diperoleh persentase aktivitas antibakteri sebesar 39,32%.

Studies on Synthesis, Characterization, and Adsorption of Cationic Dyes from Aqueous Solutions Using Magnetic Composite Material from Natural Clay in Central Kalimantan, Indonesia I Made Sadiana; Karelius Karelius; Retno Agnestisia; Abdul Hadjranul Fatah
Molekul Vol 13, No 1 (2018)
Publisher : Universitas Jenderal Soedirman

Clay is a natural material from crystalline silicate with layered structures, has high cation exchange capacity, and large surface area. These advantages can be used as an adsorbent for the removal of contaminants in aqueous solutions, such as heavy metals and dyes. In Indonesia, clays from Java, Sulawesi, and Sumatra islands have been used as adsorbent, furniture, and construction materials. Due to limited information about basic characteristics of clay from Kalimantan, this clay has not been utilized well. Therefore, natural clay from Kalimantan, especially in Central Kalimantan, was used as adsorbent of cationic dyes in this present study. However, the clay has difficulty for separating the solid phase from aqueous solution after adsorption process. To solve this problem, combining clay with magnetic material was opted. The objectives of this study are to synthesize the magnetic composite material from natural clay by coprecipitation method and to characterize the synthesized magnetic composite material using an x-ray diffraction method, transmission electron microscopy, and vibrating sample magnetometer. The adsorption properties of the synthesized magnetic composite material were evaluated using rhodamine B and methylene blue dyes in aqueous solution. Before magnetic composite material was synthesized, the clay was previously being activated for removing impurities. The magnetic material formed in the structure of clay had magnetite with particle size of 2.75 nm and the magnetization value of 24.91emu/g. The adsorption capacities of natural clay, activated clay, and magnetic composite of clay in rhodamine B were 34.29, 76.27, and 81.46 mg/g, respectively, while in methylene blue were 30.25, 83.92, and 133.90 mg/g, respectively. These results suggested that magnetic composite of clay can increase the adsorption capacities against dyes and accelerate the separation of the adsorbent solid phase from aqueous solution with largest adsorption capacity on methylene blue dye.

SINTESIS DAN KARAKTERISASI CROSSLINK KITOSAN DENGAN TRIPOLIFOSFAT pH 3 Mardiyah Kurniasih; Nurul Hidayat Aprilita; Indriana Kartini
Molekul Vol 6, No 1 (2011)
Publisher : Universitas Jenderal Soedirman

Chitosan is polycationic in acidic media and can interact with negatively charged species such as tripolyphosphate (TPP), which is a nontoxic crosslinking agent. The synthesis of TPP crosslinked chitosan was perfomed by reacting TPP solution (pH 3) with chitosan solution. The aim of this study was to prepared and characterize the crosslinked chitosan-tripolyphosphate samples. Characterization included determination of water and ash degree, moreover crosslinked chitosan-tripolyphosphate powder characterize with FTIR and XRD spectroscopy. The result showed that process efficiency of crosslinked chitosan-tripolyphosphate was 88.49%, with degree of water and ash were 25.70 and 16.72%, respectively.

PENGUJIAN JUMLAH CEMARAN MIKROBA DALAM SIMPLISIA DAN EKSTRAK PEGAGAN SEBELUM DAN SETELAH PROSES PASTEURISASI SINAR GAMMA Eriawan Rismana; Susi Kusumaningrum
Molekul Vol 10, No 1 (2015)
Publisher : Universitas Jenderal Soedirman

Telah dilakukan pengujian cemaran mikroba dalam simplisia dan ekstrak pegagan (Centella asiatica) sebelum dan setelah proses pasteurisasi dengan sinar Gamma dalam beberapa dosis penyinaran. Proses penyinaran terhadap simplisia dan ekstrak pegagan mampu menurunkan secara signifikan jumlah cemaran mikroba yakni dari > 104menjadi < 10 -100 koloni. Pada dosis penyinaran sinar gamma 2,5 – 10,0 kGy mampu menurunkan cemaran mikroba pada ekstrak menjadi < 10 koloni. Hasil uji menunjukkan bahwa penyinaran sinar gamma pada ekstrak lebih efektif dibandingkan pada simplisia. Hasil analisis KLTmenunjukkan bahwa proses penyinaran tidak merusak senyawa kimia aktifdalam ekstrak.

Gene Expression Changes and Anti-proliferative Effect of Noni (Morinda Citrifolia) Fruit Extract Analysed by Real Time-PCR Hermansyah Hermansyah; Susilawati Susilawati
Molekul Vol 12, No 1 (2017)
Publisher : Universitas Jenderal Soedirman

To elucidate the anti-proliferative effect of noni (Morinda citrifolia) fruit extract for a Saccharomyces cerevisiae model organism, analysis of gene expression changes related to cell cycle associated with inhibition effect of noni fruit extract was carried out. Anti-proliferative of noni fruit extract was analyzed using gene expression changes of Saccharomyces cerevisiae (strains FY833 and BY4741).Â Transcriptional analysis of genes that play a role in cell cycle was conducted by growing cells on YPDAde broth medium containing 1% (w/v) noni fruit extract, and then subjected using quantitative real-time polymerase chain reaction (RT-PCR).Â Transcriptional level of genes CDC6 (Cell Division Cycle-6), CDC20 (Cell Division Cycle-20), FAR1 (Factor ARrest-1), FUS3 (FUSsion-3), SIC1 (Substrate/Subunit Inhibitor of Cyclin-dependent protein kinase-1), WHI5 (WHIskey-5), YOX1 (Yeast homeobOX-1) and YHP1 (Yeast Homeo-Protein-1) increased, oppositely genes expression of DBF4 (DumbBell Forming), MCM1 (Mini Chromosome Maintenance-1) and TAH11 (Topo-A Hypersensitive-11) decreased, while the expression level of genes CDC7 (Cell Division Cycle-7), MBP1 (MIul-box Binding Protein-1) and SWI6 (SWItching deficient-6) relatively unchanged. These results indicated that gene expression changes might associate with anti-proliferative effect from noni fruit extract. These gene expressions changes lead to the growth inhibition of S.cerevisiae cell because of cell cycle defect.

PENURUNAN BOD DAN COD LIMBAH CAIR INDUSTRI TEKSTIL DI KABUPATEN PEKALONGAN DENGAN METODE MULTI SOIL LAYERING Irmanto Irmanto; Suyata Suyata
Molekul Vol 3, No 2 (2008)
Publisher : Universitas Jenderal Soedirman

Multi Soil Layering (MSL) system is a method of wastewater treatment that increase the soils function to purify wastewater. In the construction of MSL, soils mixed with the charcoal and then filled into the box of size 50x14x50 cm in layers structured like brick pattern. The aims of this research are to determine the concentration of BOD and COD on textile industrial wastewater before and after the process by MSL method. It also determines the optimal loading rate of wastewater on the MSL system, and then it can determine the efficiency of MSL system on reducing the concentration of BOD and COD on textile industrial wastewater. The method which used in this research is an experimental method. The wastewater on the MSL system is loaded on the loading rate variety: 160, 320, 480, 640, and 800 L m-2 day-1. The efficiency of MSL system to removing BOD and COD on textile industrial wastewater are determined on optimal loading rate. The research gave result that MSL method could remove BOD and COD on textile industrial wastewater on the optimal loading rate 320 L m-2 day-1. The efficiency of MSL system in removing BOD and COD on textile industrial wastewater are 96.52 and 80.87% respectively. This indicated that the method MSL serve the purpose of effective alternative method in processing of liquid waste textile industry.

SESKUITERPEN FURANODIENON DARI RIMPANG Curcuma xanthorrhiza DAN AKTIVITAS ANTIBAKTERINYA Hartiwi Diastuti; Yana Maolana Syah; Lia Dewi Juliawaty; Marlia Singgih
Molekul Vol 8, No 2 (2013)
Publisher : Universitas Jenderal Soedirman

ABSTRAK [Full Text]Curcuma xanthorrhiza dikenal sebagai tanaman obat Indonesia, rimpangnya sering digunakan dalam pengobatan tradisional. Penelitian ini bertujuan untuk mengisolasi senyawa seskuiterpen dari rimpang Curcuma xanthorrhizadan menguji aktivitas antibakterinya. Isolasi senyawa dilakukan dengan kromatografi kolom vakum cair dan kromatografi radial. Identifikasi struktur dilakukan secara spektroskopi (FTIR (Fourier Transfrom Infra Red), NMR (Nuclear Magnetic Resonance) 1D dan 2D, serta MS (Mass Spectroscopy)). Uji antibakteri dilakukan dengan metode mikrodilusi, terhadap beberapa bakteri uji yaitu Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis dan Staphylococcus aureus,. Isolat yang diperoleh berupa minyak tak berwarna yang teridentifikasi sebagai senyawa seskuiterpen furanodienon. Furanodienon menunjukkan aktivitas antibakteri dengan nilai MIC dan MBC 125,0 dan 250,0 µg/mL .

Quality Improvement of Used Cooking Oil by Using Nanocellulose from Sugarcane Bagasse as Adsorbent Winda Trisna Wulandari; Rosmaya Dewi
Molekul Vol 14, No 1 (2019)
Publisher : Universitas Jenderal Soedirman

Frying oil can produce substances that are harmful for health. One way that can be used to eliminate these dangerous compounds is by using adsorbent. Recently, many adsorbents from natural fibers have been developed. One of them is cellulose which contains 40-50 % in bagasse. Nano sized cellulose or called by nanocellulose is reported have better properties than cellulose. So, this research is aimed to utilize nanocellulose from sugarcane bagasse as adsorbent for used cooking oil. Cellulose produced from bagasse is hydrolyzed using 50% H2SO4at 40 ⁰C for 10 minutes. Used cooking oil soaked with nanocellulose for 1x24 hour, 2x24 hours and 3x24 hours. Then, the quality of used cooking oil was tested through organoleptic, acid number, peroxide number and water content test. Nanocellulose produced from hydrolysis process by using acid has a particle size distribution in nanometer range, with 95.3% having a particle size of 437.5 nm. Immersion of cooking oil by nanocellulose for 2 x 24 hours can reduce the value of free fatty acids until 18.01%, the peroxide number decreases by 57.69% and the water content decreases to 99.99% even though organoleptic changes are not very noticeable. Based on this results, nanocellulose has high potential to be used as adsorbent in used cooking oil.

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Home Page

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Contact Name Amin Fatoni

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Editorial Address Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

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Abstract

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Abstract

Contact Name
Amin Fatoni

Contact Email
aminfatoni@unsoed.ac.id

Phone
-

Journal Mail Official
j.molekul@gmail.com

Editorial Address
Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location
Kab. banyumas,

Jawa tengah

INDONESIA