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Molekul: Jurnal Ilmiah Kimia

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Published by Universitas Jenderal Soedirman

ISSN : 19079761 EISSN : 25030310 DOI : -

Core Subject : Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry

MOLEKUL is a peer-reviewed journal of chemistry published by the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Soedirman University, Indonesia. Publishing frequency 2 issues per year, on May and November. This Journal encompasses all branches of chemistry and its sub-disciplines including Pharmaceutical, Biological activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry.

Arjuna Subject : -

Articles 331 Documents

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UJI AKTIVITAS ANTIKANKER EKSTRAK ETANOL DAUN Rhizopora mucronata TERHADAP SEL MYELOMA Hartiwi Diastuti; Warsinah Warsinah; Purwati Purwati
Molekul Vol 3, No 2 (2008)
Publisher : Universitas Jenderal Soedirman

The mangrove plant have been long used the people for traditional medicine to cure various diseases, one of them to cancer therapy. Investigation the anticancer potent of R. mucronata has not been carried yet. This research was aimed to toxicity test of R. mucronta leaves extracts againts Artemia salina Leach, then cytotoxicity test of R. mucronata leave extracts againts Myeloma cancer cells. The extraction of R. mucronata leaves was peformed by maseration with ethanol. The ethanol extracts was partitioned with chloroform, ethylacetate and methanol. The ethanol extracts of R. mucronata leaves respectively was examined their toxicity againts A. salina Leach larv. The toxic exctracts was examined their citotoxicity againts Myeloma cells. The ethanol extract of R. mucronata leaves has toxic character because has LC50 < 1000 mg/mL. Citotoxicity test againts Myeloma cells showed that the chloroform fraction of ethanol extract of R. mucronata leaves have a high activity against Myeloma cell, LC50 value equal to 28,72 mg/mL. Phytochemical study showed that the active fractions contained terpenoid and alkaloid.

FOTODEGRADASI SIANIDA DALAM LIMBAH CAIR TAPIOKA Kapti Riyani; Tien Setyaningtyas
Molekul Vol 8, No 1 (2013)
Publisher : Universitas Jenderal Soedirman

Sianida banyak terdapat pada limbah cair tapioka. Sianida dapat didegradasi menggunakan fotokatalis TiO2 dengan aktivasi sinar UV, sinar UV dapat berasal dari lampu UV dan sinar matahari.Tujuan dari penelitian ini adalah mendegradasi sianida menggunakan fotokatalis TiO2 menggunakan sumber sinar lampu UV dan sinar matahari.Fotokatalis TiO2 yang digunakan dalam penelitian ini dibuat lapis tipis pada plat kaca dengan ukuran 7 x 10 cm2. Variasi sumber sinar yaitu lampu UV dan sinar matahari dipelajari pada pH 9.Hasil penelitian menunjukkan bahwa penurunan kadar sianida menggunakan sumber sinar lampu UV dengan lama penyinaran 8 jam sebesar 90,69 %, sedangkan penurunan kadar sianida menggunakan sumber sinar matahari dengan lama penyinaran 8 jam sebesar 98,74 %.

Liquid Soap from Nyamplung Seed Oil (Calophyllum inophyllum L) with Ketapang (Terminalia catappa L) as Antioxidant and Cardamom (Amomum compactum) as Fragrance Senny Widyaningsih; Mochammad Chasani; Hartiwi Diastuti; Wawan Nur Fredyono
Molekul Vol 13, No 2 (2018)
Publisher : Universitas Jenderal Soedirman

The non-edible oil from nyamplung seed (Callophyllum inophylum L.) has been widely used as a soap ingredient. The soap production from nyamplung seed oil with the addition of antioxidant and fragrance had been carried out in this research. Ketapang (Terminalia catappa L) fruit extract and Cardamom (Amomum compactum) were used as antioxidant and fragrance substances, respectively. The variation of concentration of antioxidant and fragrance has been carried out to obtain the high quality of soap. Characterization was done to know the quality of soap in accordance with SNI 06-4085-1996. The antioxidant activity was analyzed using DPPH (1,1-diphenyl-2-picrylhydrazyl). The results showed that the addition of 1% ketapang fruit extract and 3% cardamom fragrance exhibited the best characteristics. The antioxidant activity test showed that the IC50 value of the best antioxidant soap is 79.51 ppm, indicating that the soap is a strong category

POTENSI BIOAKTIF EKSTRAK ALGA MERAH (Gracillaria verrucosa) TERHADAP KADAR MALONDIALDEHIDA (MDA) DAN GAMBARAN HISTOLOGI PARU TIKUS PUTIH (Rattus novergicus) PASCA INDUKSI FORMALIN Anggun Tanduwinata; Helmi Auliyah Istiqomah; Jamilah Jamilah; Ni Luh Kemmy Caesaria; Rizki Rahmat Saputra; Aulanni'am Aulanni'am
Molekul Vol 10, No 2 (2015)
Publisher : Universitas Jenderal Soedirman

Indonesia merupakan negara megabiodiversitas yang banyak mengandung kekayaan alam, salah satunya alga merah. Alga merah (Glacillaria verrucosa) mengandung senyawa fikosianin, fikoeretin dan karotenoid yang berperan sebagai antioksidan. Penelitian ini dilakukan untuk mengetahui potensi bioaktif ekstrak alga merahuntuk terapi hewan coba tikus putih (Rattus novergicus) berdasarkan kadar malondialdehida (MDA) dan gambaran histologi paru. Metode penelitian yang dilakukan meliputi ekstraksi alga merah dan karakterisasi, induksi hewan coba (R. novergicus) dengan formalin, kemudian terapi ekstrak alga merah dengan variasi dosis. Berdasarkan uji fitokimia, analisis dengan FTIR dan LCMS, ekstrak alga merah mengandung senyawa flavonoid, terpenoid, alkaloid, β-karoten , β-apo-8’-carotenal dan α-tokoferolyang berperan sebagai antioksidan. Formalin dapat meningkatkan kadar MDA serta menyebabkan kerusakan sel epitel bronkus dibandingkan dengan keadaan normal. Pemberian terapi dengan dosis yang sesuai akan menurunkan kadar MDA dan memperbaiki keadaan sel epitel bronkus. Berdasarkan pengamatan parameter penelitan, diketahui bahwa dosis optimum yang sesuai untuk terapi kanker paru adalah 100 mg/kg BB

PEMURNIAN ASAP CAIR DARI KULIT DURIAN DENGAN MENGGUNAKAN ARANG AKTIF Adhitya Rinaldi; Alimuddin Alimuddin; Aman Sentosa Panggabean
Molekul Vol 10, No 2 (2015)
Publisher : Universitas Jenderal Soedirman

Limbah kulit durian dapat diolah menghasilkan asap cair dan karbon aktif dengan metode pirolisis. Untuk menghasilkan asap cair yang dapat digunakan sebagai pengawet makanan, asap cair perlu di proses dengan metode pemurnian seperti destilasi, pemurnian dengan zeolit aktif dan arang aktif. Hasil karakterisasi asap cair dari kulit durian hasil pirolisis, destilasi, pemurnian dengan zeolit aktif dan pemurnian dengan arang aktif diperoleh nilai pH berturut-turut 4,09; 3,24; 3,46; dan 2,09. Kadar asam asetat berturut-turut 6,07; 7,59; 9,11; dan 10,63 (mg/L). Berdasarkan karakteristik komponen senyawa menggunakan GC-MS asap cair hasil pirolisis terdeteksi 17 senyawa, asap cair hasil destilasi 12 senyawa, asap cair pemurnian zeolit aktif 10 senyawa dan asap cair pemurnian arang aktif 6 senyawa dengan mayoritas komponen senyawa terdiri dari asam asetat, fenol dan karbonil serta tidak mengandung senyawa karsinogenik, sehingga asap cair dari kulit durian dapat digunakan sebagai pengawet makanan.

Evaluation of Free Radical Scavenging Activity in Ethanolic Extract from Promising Accessions of Curcuma aeruginosa RoxB. Waras Nurcholis; Nurul Khumaida; Muhamad Syukur; Maria Bintang
Molekul Vol 12, No 2 (2017)
Publisher : Universitas Jenderal Soedirman

This study evaluated the free radical scavenging activity in ethanolic extracts from 20 accessions of Curcuma aeruginosa. The radical scavenging activity of the extract accessions was investigated with 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. IC50 values for DPPH radical scavenging activity ranged from 89.81 to 505.65 µg mL-1. Based on IC50 values, twenty accessions of C. aeruginosa can be divided into three groups: strong (two accessions); moderate (seventeen accessions); and low (one accession) of DPPH scavenger. Sukoharjo (SH) and Muara Bungo (MB) showed promising accessions for antioxidant potential, thus these accessions important to selection for future breeding program in pharmaceutical products.

SIFAT-SIFAT BIOKIMIAWI EKSTRAK KASAR LIPASE EKSTRASELULER DARI BAKTERI Azospirillum sp. JG3 Puji Lestari; Santi Nur Handayani; Oedjijono Oedjijono
Molekul Vol 4, No 2 (2009)
Publisher : Universitas Jenderal Soedirman

Lipases are valuable biocatalysts because they act under extremely mild conditions, are stable in organic solvents, show broad substrate specificity and exhibit high stereoselectivity. Lipases play important role in various industries such as detergent, cosmetics, flavor, pharmacy and synthesis of organic compounds. The increasing of lipases requirements in industries is goading research to get new lipases resources commited. One of potential lipase resource is Azospirillum sp.JG3 bacteria from Microbiology Laboratory of Biology Faculty University of Jenderal Soedirman. The specific targets of this research are to get crude extract of lipase and investigate its biochemical characteristics. The method used were rejuvenation of Azospirillum sp.JG3 bacteria, inoculum production, determination of optimum production time and bacterium growth phase, extraction and production of lipase to get crude extract, and characterization the biochemical properties of lipase crude extract. The research resulted that crude extract of lipase from Azospirillum sp.JG3 had optimum temperature at 40 °C and optimum pH at pH 7. The lipase was a metalloenzyme with Ca2+ as its cofactor. The lipase was stable in three organic solvents tested, (chloroform, n-hexane and ether).

UJI POTENSI ANTIPLASMODIUM EKSTRAK BUAH PARE (Momordica charantia L.) TERHADAP Plasmodium falcifarum Susilawati Susilawati; Hermansyah Hermansyah
Molekul Vol 9, No 1 (2014)
Publisher : Universitas Jenderal Soedirman

Malaria masih menjadi salah satu penyakit endemis dan masalah kesehatan utama di Indonesia. Buah pare (Momordica charantia L.) secara tradisional sering digunakan sebagai obat. Tujuan dari penelitian ini adalah untuk menguji potensi antiplasmodium in vitro ekstrak buah pare terhadap Palsmodium falciparum sehingga dapat digunakan sebagai obat anti malaria. Buah pare diekstrak dengan metode maserasi menggunakan pelarut metanol. Uji aktivitas antiplasmodium dilakukan secara pengamatan mikroskopik pada kultur strain P. falcifarum 3D7. Berdasarkan hasil pengujian, sampel ekstrak metanol buah pare memiliki aktivitas penghambatan terhadap pertumbuhan parasit P. falciparum 3D7. Kekuatan aktivitas antimalaria dengan nilai IC50 = 0,39 µg/mL.

Î²- Sitosterol and Betulonic Acid from n-Hexane Extract the Stem Bark of Tetracera indica Muharni, Muharni; elfita, elfita; Julunar, Julinar; Yohandini, Heni; oktaviani, muthia
Molekul Vol 14, No 2 (2019)
Publisher : Universitas Jenderal Soedirman

The Tetraceraindicahasbeen used traditionally to treat various diseases including skin medications, lower blood pressure, fever, headache, wound andgout medicine. The objective of the research was isolatedand characterizedthe ?-sitosterol (1) and betulonicacid (2) fromn-hexaneextract of the stem bark of Tetraceraindica. The dry powder thestembark (550 g)wasmaceration with n-hexane for 24 hrs.Thisextraction process was repeated three times. The n-hexane extract was separated and purified by chromatographytechnique. The structure of isolatedcompound wasdetermined by spectroscopy data UV, IR, NMR and compared with reported data. Two compounds have been isolated and base on spectroscopy data thecompounds is ?-sitosterol (1) andbetulonic acid (2). Betulonic acid is being reported for the first time from T.indica,meanwhile the?-sitosterolpreviously reported from MeOHextractof leaves of T. indicabut is being reported for the first time from the stembarkof T.indica.

Quantitative Structure-Activity Relationship Analysis of Xanthone Derivates as Cytotoxic Agents in Liver Cancer Cell Line HepG2 Isnatin Miladiyah; Iqmal Tahir; Jumina Jumina; Sofia Mubarika; Mustofa Mustofa
Molekul Vol 11, No 1 (2016)
Publisher : Universitas Jenderal Soedirman

The study of xanthone derivatives as cytotoxic agents in cancer is increasing. This study was conducted to explore the Quantitative Structure-Activity Relationship (QSAR) of xanthones as cytotoxic agents in HepG2 cells, to find compounds with better potency. The data set were taken from the previous study, involving 26 xanthone derivates and their cytotoxic activities in Inhibitory Concentration 50% (IC50). The parameters (descriptors) were obtained from quantum mechanics calculation using semiempirical AM1 method and QSAR models determined with principle component regression, with log (1/IC50) as a dependent variable and five latent variables as independent variables. From the 26 main descriptors, PCR reduced them to five latent variables (1st– 5th LV). The QSAR analysis gave the best model as follows: log (1/IC50) = 4.592 – 0.204 LV1 + 0.295 LV2 + 0.028 LV3 (n = 26, r = 0.571, SE = 0.234, Fcount/Ftable ratio = 1.165, PRESS value = 3.766). The study concluded that the descriptors contributed to anticancer activity were volume, mass, surface area, log P, dipole moment, HOMO energy, LUMO energy, and atomic net charge of some atoms. Modifications of substitution that would contribute to cytotoxic activity can be performed at phenyl ring A and C, but not at B.

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Amin Fatoni

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Home Page

OAI Link

Editorial Team

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Reviewer

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Contact Name Amin Fatoni

Contact Email aminfatoni@unsoed.ac.id

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Journal Mail Official j.molekul@gmail.com

Editorial Address Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location Kab. banyumas, Jawa tengah INDONESIA

Abstract

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Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Amin Fatoni

Contact Email
aminfatoni@unsoed.ac.id

Phone
-

Journal Mail Official
j.molekul@gmail.com

Editorial Address
Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location
Kab. banyumas,

Jawa tengah

INDONESIA