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Molekul: Jurnal Ilmiah Kimia

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Published by Universitas Jenderal Soedirman

ISSN : 19079761 EISSN : 25030310 DOI : -

Core Subject : Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry

MOLEKUL is a peer-reviewed journal of chemistry published by the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Soedirman University, Indonesia. Publishing frequency 2 issues per year, on May and November. This Journal encompasses all branches of chemistry and its sub-disciplines including Pharmaceutical, Biological activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry.

Arjuna Subject : -

Articles 331 Documents

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Determination of Cu and Pb concentrations based on urease activity inhibition of Durio zibethinus L. seeds Zusfahair, Zusfahair; Fatoni, Amin; Ningsih, Dian Riana; Riapanitra, Anung
Molekul Vol 16, No 2 (2021)
Publisher : Universitas Jenderal Soedirman

The determination of heavy metal concentrations has been carried out using sophisticated instruments, and therefore a simple and reliable alternative method is needed as a comparison. The study aimed to determine Cu and Pb concentration of standard solution using the urease activity inhibition method ofÂ Durio zibethinusÂ L.Â Â seeds.Â Â The research started with urease extraction fromÂ DurioÂ D.Â zibethinusÂ L.Â seeds. The activity of the obtained extract was determined using the Nessler method. The optimum substrate concentration was also determined. Urease activity inhibition was carried out using various metal solution concentrations, which continued by plotting a log graph of urea concentration vs. %inhibition. The obtained graph would then determine the metal concentration in a synthetic water sample.Â The data was then compared to the measurement, determined by the Atomic Absorption Spectrophotometry (AAS) method.Â Results of the study showed that the urease activity ofÂ D. zibethinusÂ L.seeds was 296.774 U/mL. Urease activity was optimum at a urea concentration of 0.3 M. The comparisonÂ Cu, and PbÂ concentration determination using the urease inhibitory activity and AAS methods showed no significant difference at 95% confidence level. This research showed that urease ofÂ D. zibethinusÂ L. seed could be used to determine Cu and Pb's concentration based on its inhibiting activity.

Removal of Iron(II) Using Ni/Al Layered Double Hydroxide Intercalated with Keggin Ion Lesbani, Aldes Lesbani; Normah, Normah; Palapa, Neza Rahayu; Taher, Tarmizi; Andreas, Roy; Mohadi, Risfidian
Molekul Vol 15, No 3 (2020)
Publisher : Universitas Jenderal Soedirman

Layered double hydroxide (LDH) Ni/Al-NO3 was synthesized using a coprecipitation method under base condition following with intercalation using Keggin ion [a-SiW12O40]4- to form Ni/Al-[a-SiW12O40] LDH. The LDHs were characterized using XRD, FTIR, BET, and pHpzc analyses. Furthermore, LDHs were applied as adsorbent of iron(II) from aqueous solution. The adsorption process was studied through the effect of adsorption time, the concentration of iron(II), and temperature adsorption. The results show the interlayer distance of LDHs was increased from 7.408 Ã… to 10.533 Ã… after intercalation process. The adsorption of iron(II) on LDHs showed that adsorption of iron(II) on both LDHs follows pseudo first-order kinetic model with R2 value is close to one. The adsorption process was spontaneous, with adsorption capacity up to 36.496 mg g-1.

Physical, Thermal Stability, and Mechanical Characteristics of New Bioplastic Elastomer from Blends Cassava and Tannia Starches as Green Material Christwardana, Marcelinus; Ismojo, I.; Marsudi, Sidik
Molekul Vol 16, No 1 (2021)
Publisher : Universitas Jenderal Soedirman

This paper presents the study results of the morphology, physical properties, thermal stability, and mechanics of bioplastic blends made from tannia and cassava starch, with a varying weight from 0 to 95%. The addition of tannia to the cassava starch-based bioplastic composition has the ability to reduce the number of pores, density, and water absorption with an average thickness of 0.21-0.29 mm. It also increased moisture content due to its nature, which is more hydrophilic than cassava starch. The result showed that the tensile strength of bioplastic ranged from 0.81-1.33 MPa and elongated from 31-35%. In addition, the thermal analysis data showed that the glass transition temperature shifted marginally due to intermolecular activity. This shows that tannia starch has promising potential as an alternative raw material for bioplastics to replace cassava starch which is more dominantly used as a food source.

Computational Study of Scorpion Venom (Lychas Mucronatus) Activity as Antimicrobial Peptides (AMPs) to the SARS-CoV-2 Main Protease for the Future Coronavirus Disease (COVID-19) Inhibitors Taufik Muhammad Fakih
Molekul Vol 16, No 2 (2021)
Publisher : Universitas Jenderal Soedirman

The 2019 coronavirus pandemic disease (COVID-19) is still declared a global pandemic by the World Health Organization (WHO). Therefore, an effort that is considered effective in finding therapeutic agents is needed to prevent the spread of COVID-19 infection. One of the steps that can be chosen is by utilizing antimicrobial peptides (AMPs) from animal venom by targeting the specific receptor of SARS-CoV-2, namely the main protease (Mpro). Through this research, a computational approach will be conducted to predict antiviral activity, including protein-peptide docking using PatchDock algorithm, to identify, evaluate, and explore the affinity and molecular interactions of four types of antimicrobial peptides (AMPs), such as Mucroporin, Mucroporin-M1, Mucroporin-S1, and Mucroporin-S2 derived from scorpion venom (Lychas mucronatus) against main protease (Mpro) SARS-CoV-2. These results were then confirmed using protein-peptide interaction dynamics simulations for 50 ns using Gromacs 2016 to observe the molecular stability to the binding site of SARS-CoV-2 Mpro. Based on protein-peptide docking simulations, it was proven that the Mucroporin S-1 peptides have a good affinity against the active site area of SARS-CoV-2 Mpro, with an ACE score of −779.56 kJ/mol. Interestingly, Mucroporin-S1 was able to maintain the stability of its interactions based on the results of RMSD, RMSF, and MM/PBSA binding free energy calculations. The results of the computational approach predict that the Mucroporin-S1 peptide is expected to be useful for further research in the development of new antiviral-based AMPs for the COVID-19 infectious disease.

Analysis of Solid-State Interactions of Ketoprofen-Coformer Binary Mixtures by DSC and Hot Stage Microscopy Yudi Wicaksono; Dwi Setyawan; Siswandono Siswandono
Molekul Vol 15, No 2 (2020)
Publisher : Universitas Jenderal Soedirman

Ketoprofen is a non-steroidal anti-inflammatory drug with poor water solubility, so the absorption is less than optimal. One method to improve the solubility of ketoprofen is through the formation of multicomponent solid forms. The success of the formation of the multicomponent solid forms is strongly influenced by interactions between components in their solids. In this study, the analysis of the interactions in solid form of ketoprofen-coformers was carried out using the differential scanning calorimetry (DSC) and hot stage microscopy (HSM) with adipic acid and isonicotinamide as coformers. From the experimental results, the mixtures of ketoprofen-adipic acid show a solid-liquid phase diagram that indicates a simple eutectic system with eutectic points on the molar fraction of ketoprofen 0.9 and temperature at 92.9 °C. The ketoprofen-isonicotinamide mixtures have a eutectic system with the peritectic point. The solid-liquid phase diagram has indicated that the ketoprofen-adipic acid in eutectic composition forms a miscible liquid phase without interaction in its solid form, whereas the ketoprofen-isonicotinamide forms a miscible liquid phase accompanied by interaction with the excess component. The results of the HSM analysis showed the same phenomenon as the result of the DSC experiment and have confirmed with the FTIR analysis

Characterization of Glucomannan Extracted from Fresh Porang Tubers Using Ethanol Technical Grade Nurlela Nurlela; Nina Ariesta; Dwi Sutari Laksono; Edi Santosa; Tjahja Muhandri
Molekul Vol 16, No 1 (2021)
Publisher : Universitas Jenderal Soedirman

Glucomannan is a polysaccharide consisting of β-1.4-linked D-mannose and D-glucose monomers, which have many benefits especially in the food and pharmaceutical industry. It has been widely reported that one of the main sources of glucomannan is porang tuber (Amorphophallus muelleri Blume). Generally, glucomannan extracted or purified from porang flour. However, the drying process causes other compounds than glucomannan stick strongly, resulting low levels of glucomannan. This study was to obtain glucomannan extract in an easy, effective, and inexpensive method, by direct extraction from fresh porang tubers using ethanol technical grade. We performed two extraction methods. The first is a fixed concentration method, the sample was repeatedly extracted using 50% ethanol (FC50) and 96% ethanol (FC96) 3 times, respectively. The second is a multilevel concentration method, the sample was repeatedly extracted using ethanol 60% (first step), 80% (second step), and 96% (third step), one replication each step. The highest glucomannan content (66.56%) was obtained by a multilevel concentration method. Moisture, lipid, protein, crude fiber, calcium oxalate level significantly reduce to 13.58%, 0.07%, 4.03%, 4.95%, 0.56% respectively. FTIR spectra confirmed the presence of functional groups (O-H, C=O, C-O, C-H), that compose the glucomannan compound. SEM image showed that the granules form of glucomannan were round and oval, began to change its phase from amorphous to crystalline, related to XRD data. The results showed that the direct extraction from fresh porang tuber using ethanol technical grade with a multilevel concentration method was an effective method to extract the glucomannan

Backmatter (Instruction for author and back cover) Amin Fatoni
Molekul Vol 16, No 1 (2021)
Publisher : Universitas Jenderal Soedirman

Backmatter (Instruction for author and back cover)

Characterization of Curcuminoid from Curcuma xanthorrhiza and Its Activity Test as Antioxidant and Antibacterial Sri Atun; Nurfina Aznam; Retno Arianingrum; Senam Senam; Bian Ihda An Naila; Astuti Lestari; Nur Aini Purnamaningsih
Molekul Vol 15, No 2 (2020)
Publisher : Universitas Jenderal Soedirman

Curcuminoids are the main component found in many Zingiberaceae family plants. The aim of this study was to characterize curcuminoid and its activity test as an antioxidant and antibacterial. Dryed powder of C. xanthorrhiza (1 kg) was macerated with ethanol for 24 hours at room temperature. Ethanol extract of C. xanthorrhiza was subsequently fractionated with n-hexane and chloroform to take the yellow or orange indicated contain of curcuminoids. Analysis of total phenolic levels was carried out by the Follin-Ciaocalteau method. The isolation of curcuminoid componens from this fraction was carried out by chromatographic method and the structure elucidation was performed by interpretation of spectroscopic data, including UV, IR, 1H and 13C NMR 1D and 2D. The antioxidant activity test used the DPPH (2,2-diphenylpicrylhydrazyl) method, while the antibacterial activity test used Kirby Bauer test diffusion method. The results showed that the curcuminoid fraction yield was 10.06% from ethanol extract C. xanthorrhiza. The total phenolic content of curcuminoids fraction was 745.45 ± 18.5 mg galic acid (GA)/g extract. Curcuminoids fraction was isolated a known compound desmethoxycurcumin (1). The content of demethoxycurcumin (1) in curcuminoid fraction is 20.97 %.The antioxidant activity of curcuminoids fraction showed strongest activity with IC50 24.98 µg/ml. Antibacterial activity against of the four pathogenic bacteria showed medium activity. The study suggests that curcuminoids extract from C. xanthorrhiza rhizome have potential compounds could be suitable for antioxidant and the treatment of various infections caused of microbial.

Synthesis of Carbon Microparticles from Red Dragon Fruit (Hylocereus undatus) Peel Waste and Their Adsorption Isotherm Characteristics Asep Bayu Dani Nandiyanto; Rina Maryanti; Meli Fiandini; Risti Ragadhita; Dian Usdiyana; Sri Anggraeni; Wafa Raihana Arwa; Abdulkareem Sh. Mahdi Al-Obaidi
Molekul Vol 15, No 3 (2020)
Publisher : Universitas Jenderal Soedirman

This study aims to demonstrate the preparation of carbon microparticles obtained from red dragon fruit peel waste and their adsorption isotherm characteristics. The carbon microparticles were prepared by combining carbonization (at 250°C) and saw-milling process, and to get carbon microparticles with a specific size, sieve analysis was used. The adsorption isotherm was done by testing the adsorption ability of carbon microparticles with a specific size into curcumin solution in the batch-type reactor. The adsorption results were then compared to several standard isotherm models (i.e., Langmuir, Freundlich, Temkin, and Dubinin-Radushkevich models) for understanding what phenomena happen during the adsorption process. The adsorption analysis was also confirmed by testing several sizes of the carbon microparticles to predict the proposal mechanism in the adsorption process. The analysis results showed that the multilayer adsorption process occurs for all sizes in the micrometer range, and the process involves physical interactions between adsorbate and surface of adsorbent. The existence of multilayers is due to the possibility in the existence of porous structure in the carbon microparticles. This study is important for giving an alternative solution for reusable organic waste as well as supporting the fundamental researches in the further applications of carbon particles as catalyst and adsorbent.

Frontmatter (Front Cover, Editorial Team, Preface and Table of Contents) Amin Fatoni
Molekul Vol 16, No 2 (2021)
Publisher : Universitas Jenderal Soedirman

Frontmatter (Front Cover, Editorial Team, Preface and Table of Contents)

Page 27 of 34 | Total Record : 331

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Contact Name
Amin Fatoni

Contact Email
aminfatoni@unsoed.ac.id

Phone
-

Journal Mail Official
j.molekul@gmail.com

Editorial Address
Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location
Kab. banyumas,

Jawa tengah

INDONESIA