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Molekul: Jurnal Ilmiah Kimia

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Published by Universitas Jenderal Soedirman

ISSN : 19079761 EISSN : 25030310 DOI : -

Core Subject : Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry

MOLEKUL is a peer-reviewed journal of chemistry published by the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Soedirman University, Indonesia. Publishing frequency 2 issues per year, on May and November. This Journal encompasses all branches of chemistry and its sub-disciplines including Pharmaceutical, Biological activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry.

Arjuna Subject : -

Articles 331 Documents

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EKSPLORASI BAKTERI KITINOLITIK DARI SAMPAH ORGANIK : ISOLASI DAN KARAKTRISASI ENZIM KITINASE Purkan Purkan; Badi’atul Azizah; Afaf Baktir; Sri Sumarsih
Molekul Vol 9, No 2 (2014)
Publisher : Universitas Jenderal Soedirman

Enzim kitinase banyak digunakan dalam bidang medis, makanan, bioteknologi dan lingkungan. Banyaknya kebutuhan enzim kitinase menuntut penyediannya yang murah dan melimpah dengan teknologi produksi yang sederhana. Penelitian ini bertujuan untuk isolasi mikroba kitinolitik dari cairan fermentasi sampah organik, produksi dan uji aktivitas enzim kitinase serta mengetahui karakteristik dari enzim kitinase. Isolasi mikroba telah dilakukan dengan metode spread plate. Aktivitas kitinase ditentukan secara kualitatif dengan pengukuran indeks kitinolitik dan secara kuantitatif dengan pengukuran absorbansi menggunakan spektrofotometer Uv-Vis pada panjang gelombang 660 nm berdasarkan banyaknya substrat kitin yang dihidrolisis oleh enzim kitinase. Satu dari beberapa isolat yang didapatkan, yaitu isolat A1 menunjukkan aktivitas kitinolitik tertinggi, yaitu sebesar 1,21. Hasil identifikasi mikrobiologi menunjukkan bahwa isolat A1dinyatakan sebagai Pseudomonas pseudomallei. Bakteri ini mampu menghasilkan kitinase secara optimum pada jam ke 18 waktu fermentasi, dengan penambahan molase 0,5% (b/v) dan 1% kitin (b/v) pada media produksinya. Kitinase yang dihasilkan P. pseudomallei menunjukkan aktivitas optimum pada suhu 50 °C danpH sebesar 6.

PEMBUATAN DEKSTRIN DARI PATI UBI KAYU MENGGUNAKAN ENZIM AMILASE DARI AZOSPIRILLUM sp. JG3 DAN KARAKTERISASINYA Dian Riana Ningsih; Ari Asnani; Amin Fatoni
Molekul Vol 5, No 1 (2010)
Publisher : Universitas Jenderal Soedirman

Amylase enzyme is used to hydrolyze starch into simpler molecules such as dextrin. Amylase can be isolated fromAzospirillum sp. JG3 bacteria. The purpose of this study was to characterize dextrins from cassava starch (Manihot esculenta) is catalyzed by the enzyme amylase from Azospirillum sp. JG3 bacteria. Stages of this study are: determination of optimum substrat and to analyze the chemical and physical dextrins including moisture content, ash content, dexstrosa equivalent (DE) and the yield obtained. The result of this research showed that optimum condition hydrolysis starch of cassava that using amylase from Azospirillium sp. JG3 bacteria was acquired at substrate concentration 3% and the results of analysis obtained dextrins include yield of 96.67%, water content of 9.39%, 0.25% ash content and dexstrosa equivalent (DE) of 16.55.

Biosythesis of Silver Nanoparticles using Putri Malu (Mimosa pudica) Leaves Extract and Microwave Irradiation Method Is Fatimah; Nur Afisa Lintang Mutiara
Molekul Vol 11, No 2 (2016)
Publisher : Universitas Jenderal Soedirman

In this paper, the biosynthesis of silver nanoparticles (AgNPs) using Mimosa pudica extract is discussed. Mimosa pudica leaves extract using water as solvent was used as bio-reductor to an aqueous solution of silver nitrate (AgNO3) and in order to accelerate the reduction, microwave irradiation method was applied. The AgNPs obtained were characterized using UV-Vis spectrophotometry, FTIR spectrophotometry, XRD, SEM-EDX, and particle size analysis based on dynamic scattering method. Effect of preparation method to the formation of AgNPs is also evaluated in antibacterial activity towards E.coli and P. aeruginosa. Rapid and ecofriendly biosynthesis of stable silver nanoparticles was observed in this study. The characterization results and antibacterial assay indicated the uniform and smaller particle size of AgNPs obtained by using microwave method and positively enhance the antibacterial activity against tested bacteria.

PEMANFAATAN MEMBRAN NATA DE COCO SEBAGAI MEDIA FILTRASI UNTUK REKOVERIMINYAK JELANTAH Senny Widyaningsih; Purwati Purwati
Molekul Vol 8, No 1 (2013)
Publisher : Universitas Jenderal Soedirman

Peningkatan kualitas minyak jelantah telah dilakukan dengan metode filtrasi menggunakan membran selulosa bakterial yang terbuat dari nata de coco. Pembuatan membran nata de coco dilakukan dengan cara memurnikannata de coco hasil proses fermentasi bakteri Acetobacter xylinum. Karakterisasi membran meliputi berat jenis, nilai fluks, dan koefisien rejeksi. Proses filtrasi minyak jelantah menggunakan tekanan sebesar 4 kgf/cm2 dengan metode dead-end. Hasil penelitian menunjukkan bahwa karakterisasi membran nata de coco memiliki berat jenis sebesar 0,6314 g/cm3, nilai fluks air sebesar 104,021 L/m2.jam, fluks minyak sebesar 1,004 L/m2.jam dan fluks Dekstran T-500 sebesar 52,208 L/m2.jam. Nilai rejeksi membran sebesar 15,11%. Peningkatan kualitas minyak jelantah dibanding sebelum rekoveri dapat dilihat dari penurunan angka asam sebesar 54,95%, kadar air sebesar 93,22%, serta peningkatan angka penyabunan sebesar 29,09% dan angka iod sebesar 8,14%.

Proximate Compositions and Biological Activities of Caulerpa lentillifera Risa Nofiani; Sigit Hertanto; Titin Anita Zaharah; Sutarman Gafur
Molekul Vol 13, No 2 (2018)
Publisher : Universitas Jenderal Soedirman

Caulerpa lentillifera is an edible and functional seaweed due to its high nutritional compositions and its biological activities. In this study, C. lentillifera was evaluated for its proximate compositions (moisture, ash, protein, lipid and fiber contents) and its biological activities (antimicrobial, anti-oxidant, and toxicity). Moisture content, crude lipid, crude protein, and crude fiber were determined using oven method, soxhlet extraction, semi-micro Kjeldhal, and hydrolysis, respectively. Fresh C. lentillifera of Natuna Island, Indonesia, showed its higher level content of ash, crude lipid, and crude fiber compared to that of fresh C. lentillifera of Penghu, Taiwan. For its biological activity assays, the extracts were prepared from fresh and dry C. lentillifera (FC and DC). Both of the extracts showed the broad spectrum of weak antimicrobial using well-diffusion agar tests and antioxidant activities using a modified linoleic acid emulsion system. The toxicity for both extracts was determined using brine shrimp lethality test. DC extract showed its very low toxicity level and there was no toxicity for FC. Hemolytic activity was determined using red blood assay. Both extracts showed their low hemolytic activities (about 5-13%) for the concentration of 100 and 150 μg/mL, but the activity increased sharply (about 96%) on the concentration of 200 μg/mL. It was concluded that C. lentillifera has a potency as a functional food due to containing secondary metabolites with various biological activities.

BIODEGRADASI POLIETILENA MENGGUNAKAN BAKTERI DARI TPA (TEMPAT PEMBUANGAN AKHIR) GUNUNG TUGEL KABUPATEN BANYUMAS Zusfahair Zusfahair; Puji Lestari; Dian Riana Ningsih; Senny Widyaningsih
Molekul Vol 2, No 2 (2007)
Publisher : Universitas Jenderal Soedirman

Plastic has high potency to become material that much threats human living in this earth, because made from chemical which cannot degraded by microbes in environment. The successful production and marketing of biodegradable plastics will help alleviate the problem of environmental pollution. One of biodegradable plastic that used in our live is polyethylene. This research reveals that local microbes capable to degrading of polyethylene. Biodegradation test was carried out by using bacteria in soil which was obtained from Gunung Tugel disposal center, Banyumas regency. Kind of polyethylene is LDPE (Low Density Polyethylene) which was obtained from Setiakawan Plastic Factory, Kalibogor, Purwokerto formed to thin film. Characterization of the polyethylene used weight loss percentage method, melting point determination and FTIR. Soil bacteria isolated from Gunung Tugel disposal center, Banyumas regency, obtained 5 single colonies, which coded GT. Bacteria isolate which have highest activity in degrading polyethylene was GT 3, with increasing the time of incubation. Weight loss percentage up to 2.33% in 1 month. Melting point of polyethylene after biodegradation was decreased that initially 210-220 °C into 210-213 °C. FTIR spectrophotometer result of polyethylene after biodegradation showed intensity for methylene and methyl cluster was decreased.

KANDUNGAN MERKURI (Hg) DAGING IKAN NILA (Oreochromis niloticus) YANG DIBUDIDAYAKAN DI KOTA PALANGKA RAYA Ciptadi Ciptadi; Akhmad Damsyik; Heriani Heriani
Molekul Vol 10, No 1 (2015)
Publisher : Universitas Jenderal Soedirman

Ikan nila banyak dikonsumsi masyarakat Palangka Raya sedangkan ikan ini sebagian besar dipelihara di lingkungan yang terpapar merkuri. Untuk mengetahui apakah ikan nila tersebut telah terkontaminasi oleh merkuri dalam pemeliharaannya, pada penelitian ini telah dilakukan penentuan tentang kandungan merkuri dalam daging ikan nila yang dibudidayakan di Sungai Kahayan, Palangka Raya Kalimantan Tengah. Ikan yang dianalisis dibedakan berdasarkan umur dan tempat budidaya ikan nila yaitu keramba di Sungai Kahayan dan kolam yang terisolasi dari aliran Sungai Kahayan. Data konsentrasi merkuri pada daging ikan nila yang berumur 5-7 bulan yang dipelihara di dalam keramba digunakan untuk mengidentifikasi kandungan merkuri pada ikan nila yang dikeramba di Sungai Kahayan. Data konsentrasi merkuri pada daging ikan nila yang dipelihara di dalam kolam bertujuan untuk membandingkan kandungan merkuri antara ikan nila yang dipelihara di dalam kolam dengan ikan nila yang dipelihara di dalam keramba yang memiliki umur yang sama. Kandungan merkuri dalam sampel diukur menggunakan Mercury Analyzer. Data konsentrasi merkuri pada daging ikan nila dianalisis dengan menggunakan analisis varian (anova : single factor) dengan taraf nyata (α) sebesar 5%. Hasil penelitian menunjukkan bahwa daging ikan nila yang diperoleh dari keramba di Sungai Kahayan umur 5-7 bulan mengandung merkuri sebesar 0,0145 ± 0,0005 ppm sampai 0,017 ± 0,001 ppm lebih rendah dari batas maksimum cemaran merkuri dalam ikan dan hasil olahannya menurut SNI 7387 Tahun 2009 yaitu adalah 0,5 ppm. Dari hasil analisis varian dapat diketahui bahwa terdapat perbedaan kandungan merkuri pada daging ikan nila berdasarkan umur dan tempat budidaya. Kandungan merkuri pada daging ikan nila umur 5 sampai 7 bulan mengalami peningkatan dan kandungan merkuri pada ikan nila yang dibudidayakan di kolam yang terisolasi lebih rendah daripada kandungan merkuri pada daging ikan nila yang dibudidayakan di keramba pada umur ikan yang sama yaitu sebesar 0,0115 ± 0,0005ppm.

STUDI PENURUNAN ZAT WARNA ACID ORANGE 7 DENGAN PROSES OKSIDASI MENGGUNAKAN FERRAT (FeO4)2- Dian Windy Dwiasi; Suyata Suyata
Molekul Vol 6, No 1 (2011)
Publisher : Universitas Jenderal Soedirman

Colour removal from textile wastewater has been a matter of considerable interest during the last two decades, not only because of the potential toxicity of certain dyes but often due to their visibility in receiving waters and to their low biodegradability. Due to the limited success of some physical and chemical techniques for the treatment of dye effluents it is necessary to develop destructive systems leading to complete mineralization or, at least, to less harmful or easy-to-treat compounds. Oxidation processes using ferrate (FeO4)2- have been found to be very effective in the degradation of dye pollutants and for the treatment of waste waters from the textile industry.Acid Orange 7 (AO7) commonly used as a textile dye and could be degraded by ferrate oxidation processes. In the oxidation degradation of dye by ferrate process, effect of some parameters such as time, pH, and molar ratio of dye was examined at experimental condition. AO7 removal by this process was calculated to be equal to 12 minute at experimental condition. Ferrate can oxidize acid orange 7 effectively at optimum pH of 9.8, with the molar ratio of ferrate : acid orange 7 at 4:1. The percentages of acid orange 7 degradation reached to 98.9%.

Isolation and evaluation of the antioxidant actity of phenolic constituents of the Garcinia sizygiifolia Muharni Muharni; Elfita Elfita; Didi Pratama
Molekul Vol 12, No 1 (2017)
Publisher : Universitas Jenderal Soedirman

Garcinia sizygiifolia is a native plant to the South Sulawesi region popularly known as sula and has been cultivated in several regions in Indonesia. The plant by local community use as a food and source of wood, but has not found information on chemical content and biological activity. Therefore, this study was carried out to Isolation and evaluation of the antioxidant activity of the phenolic constituent of the G. sizygiifolia. A 30.0 g portion of ethyl acetate extract of the stembark G. sizygiifolia were separated by column chromatography method using silica G 60 F254 (230-400 mesh), eluted gradient polarity mixtures of n-hexane-ethyl acetate were collected and sorted into fractions. Fraction F 1 (5.2 g) were separated and purified again by chromatography method until pure compound obtained. The structure of the isolated compound was determined using UV, IR, and NMR spectroscopy. The antioxidant activity was tested by DPPH method. The isolated pure compound was a yellow solid with melting point 148-149 oC. Base on spectroscopy data and by comparison with data from the literature, isolated compound is a known compound 2,4-dihydroxyphenylethanone. The compound exhibited antioxidant activity with IC50 96 µg/mL against DPPH.

POTENSI HUMIN HASIL ISOLASI TANAH HUTAN DAMAR BATURRADEN DALAM MENURUNKAN KESADAHAN AIR Tien Setyaningtyas; Roy Andreas; Kapti Riyani
Molekul Vol 3, No 2 (2008)
Publisher : Universitas Jenderal Soedirman

The hardness water is not good for consumption because can resulted kidney disease One of the method which can be used to degrade rodamin B is adsorption use humin. Humin is biggest fraction of humat materials that insoluble in acid, alcohol and base. The ability of humin for adsorp Ca2+ and Mg2+ caused by the existence of OH phenolic and carboxylic functional group which can interacted with metal ion. The aim of this study is to recognize humin characteristic from the soil of Baturraden resin forest, and ability of humin from the soil of Baturraden resin forest for decreasing the hardness water.Humin was isolated from the Baturraden resin forest and purified use mixture of HCl:HF. Purified humin is characterised such as identify of functional group of humin, stipulating of water content, stipulating of dust content, obstetrical stipulating of total acidity content, carboxylic and OH phenolic functional group. Decreasing of hardness water was analysed with variation time 0, 10, 30, 60, 180, 300, 600, 900, 1200 dan 1440 minute.Humin that isolated from Baturraden resin forest have characteristic such as water content 16.6199 %; dust content 9.2050 %; total acidity content 475 cmol / Kg; carboxylic rate 200 cmol/Kg, and OH phenolic rate 275 cmol/Kg. Decreasing of hardness water in Darmakradenan, Ajibarang subdistrict, Banyumas regency was 54,745 % with equlibrium time at 600 minute (10 hours).

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Editorial Address Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

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Contact Name
Amin Fatoni

Contact Email
aminfatoni@unsoed.ac.id

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Journal Mail Official
j.molekul@gmail.com

Editorial Address
Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location
Kab. banyumas,

Jawa tengah

INDONESIA