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Molekul: Jurnal Ilmiah Kimia

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Published by Universitas Jenderal Soedirman

ISSN : 19079761 EISSN : 25030310 DOI : -

Core Subject : Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry

MOLEKUL is a peer-reviewed journal of chemistry published by the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Soedirman University, Indonesia. Publishing frequency 2 issues per year, on May and November. This Journal encompasses all branches of chemistry and its sub-disciplines including Pharmaceutical, Biological activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry.

Arjuna Subject : -

Articles 331 Documents

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PEMODELAN SENYAWA TURUNAN ASAM KARBAMAT SEBAGAI SENYAWA ANTIKANKER MENGGUNAKAN METODE SEMIEMPIRIS AM1 Senny Widyaningsih; Purwati Purwati; Riyadi Riyadi
Molekul Vol 2, No 2 (2007)
Publisher : Universitas Jenderal Soedirman

4-N-carbamic acid-4’-dimetylpipodopylotoxin and its derivatives are compounds which are synthesized from etoposide (VP 16). These compounds are used as anticancer medicine because they inhibit DNA topoisomerase II enzyme. The enzyme participates in controlling breaking process of DNA double helix bounding in cancer cell. It makes cancer growing cease and dies because cell can not replicate. However, the compound insoluble in water, make a medicine resistant, inhibit metabolism system and poison. It needs to design a modification of new compounds from carbamic acid derivatives which have higher activity. Structure modification was done using Quantitative Structure Activity Relationship (QSAR) which was a computational chemistry application in medicine design process. This research used semiempiris AM1 method to determine the best QSAR equation based on multilinear regression analysize, with log 1/IC50 as dependent variable and independent variables were atomic net charge of qN29, qC30, qO31, qO32, dipole moment, n-octanol-water coefficient partition (Log P), and polarity. The best QSAR equation in this research was : Log 1/IC50 = 4.871 + 12.738 qN29 + 33.183 qC30 + 28.015 qO31 – 3.6 x 10-2 polarity, with N = 13, r =0.907, SE = 0.13025, Fcount/Ftable = 1.901, PRESS = 0.1357. Based on the best QSAR equation, the prediction compounds were 1, 2, 3, 8, and 22 with each IC50 theoretical value were 0.032, 0.034, 0.036, and 0.098 µM.

BIOSORPSI TIMBAL OLEH BIOMASSA DAUN KETAPANG Reza Mulyawan; Asep Saefumillah; Foliatini Foliatini
Molekul Vol 10, No 1 (2015)
Publisher : Universitas Jenderal Soedirman

Limbah yang mengandung logam berat timbal (Pb) sangat berbahaya bagi lingkungan. Proses pengolahan telah diperkenalkan untuk mengolah limbah, dari proses pengendapan, hingga menggunakan resin penukar ion. Daun ketapang telah di gunakan sebagai media pengolahan air yang digunakan untuk akuarium. Para peneliti telah menunjukkan daun ketapang berpotensi sebagai pengolah air limbah. Penelitian ini bertujuan untuk mengetahui potensi biosorpsi daun ketapang pada limbah yang tercemar logam berbahaya, dengan mempelajari karakteristik biosorpsi, kesetimbangan, kinetika dan termodinamika. Kondisi optimum seperti pH, dosis daun ketapang, waktu kontak dan suhu akan diamati pada penelitian ini. Hasil Penelitian biomassa daun ketapang berpotensi sebagai biosorben, dengan perlakuan asam atau basa daun ketapang ini masih berpotensi sebagai biosorben. Penyerapan sangat dipengaruhi oleh pH, konsentrasi ion Pb, massa adsorben, waktu kontak dan suhu, yang berurutan nilai maksimum nya adalah pH 3, konsentrasi ion Pb 5 mg/L, massa adsorben 0,5 gram, waktu kontak 4 jam, dan suhu 40 ºC. Laju reaksi berjalan pada orde satu dan memenuhi kaidah isotermal Langmuir. Daun ketapang memiliki energi aktivasi yang rendah sehingga cocok untuk dijadikan adsorben alternatif penyerapan logam Pb dari limbah yang mengandung logam Pb.

KAJIAN SIFAT MAGNETIK DARI PASIR BESI PANTAI LOGENDING KABUPATEN KEBUMEN Bilalodin Bilalodin
Molekul Vol 5, No 2 (2010)
Publisher : Universitas Jenderal Soedirman

Study on magnetic properties of iron sand on the Logending beach sand has been done. The research aims to identify the mineral content and characterization of magnetic properties on the Logending beach sand. The irond sand samples taken from the Logending beach with several lokation. Sand then dried, determined density and magnetic content is separated using a permanen magnet. The iron sand were analyzed using XRD ( X-ray difraction) and characterization of magnetic properties using the VSM (Vibrating sample magnetometer). The research shows that minerals are contained hematit (Fe2O3), with a value of susceptibility is 0.43 x10-6 m3/kg. The main magnetic mineral of iron sand from logending beach is paramagnetic.

Hemostatic Effect of Ethanol Extract of Piper betle, Linn Leaves to Male Mice Sadakata Sinulingga; Subandrate Subandrate; Bebbi Arisya Kesumaputri; Galuh Anggraini
Molekul Vol 12, No 1 (2017)
Publisher : Universitas Jenderal Soedirman

Hemorrhage occurs in most of the dental care. Untreated hemorrhage could cause excessive blood loss, hypotension, and cyanosis. A Natural resource that reported has an hemostatic effect is ethanol extract of betel leaves (Piper betel, Linn).The aim of this study is to find the minimum concentration of ethanol extract of betel leaves which capable of shortening the bleeding time in mice. The experimental study used pretest-posttest with control group design was conducted on 35 mice that divided into 7 group which are negative control, positive control (feracrylum 1%), the ethanol extract of betel leaves 1%, 5%, 10%, 15%, and 20%. All mice were injected heparin intravenously. Miceâs tail was cut at diameter 3 mm and pretest bleeding time was counted. Miceâs tail was recut at diameter 4 mm, given treatment for 5 seconds and posttest bleeding time was counted. Results of paired t-test showed that reduction of bleeding time between pretest and posttest was significant (p<0,050). The enhancement of ethanol extract of betel leaves concentration leads to better hemostatic effect. Results of ANOVA test showed that comparison of posttest bleeding time among groups was significant (p<0,050). The minimum concentration of ethanol extract of betel leaves which capable of shortening the bleeding time in mice is 5%.

OPTIMASI PENURUNAN COD, BOD, DAN TSS LIMBAH CAIR INDUSTRI ETANOL(vinasse) PSA PALIMANAN DENGAN METODE MULTI SOIL LAYERING (MSL) Irmanto Irmanto; Suyata Suyata; Zusfahair Zusfahair
Molekul Vol 8, No 2 (2013)
Publisher : Universitas Jenderal Soedirman

Industri etanol merupakan salah satu industri yang menimbulkan pencemaran terhadap lingkungan khususnya sistem perairan. Banyaknya limbah cair etanol yang dibuang serta senyawa-senyawa organik dapat menyebabkan rusaknya ekosistem di perairan. Untuk mengatasi pencemaran limbah cair etanol, digunakan metode Multi Soil Layering (MSL) sebagai salah satu metode alternatif. MSL adalah suatu metode pengolahan limbah cair yang meningkatkan fungsi tanah untuk pemurnian limbah cair. Penelitian ini menggunakan metode MSL untuk mengolah limbah cair industri etanol sebelum dibuang ke perairan. Metode MSL merupakan suatu sistem pengolahan limbah yang menggunakan beberapa material seperti tanah, zeolit, dan arang tempurung kelapa yang dibentuk dalam suatu susunan pola bata bertingkat. Faktor yang diteliti adalah kecepatan pengisian yang terdiri dari 5 tahap yaitu: 160, 320, 480, 640, dan 800L.m-2hari-1, kemudian ditentukan efesiensi sistem MSL dalam menurunkan kadar COD, BOD, dan TSS limbah cair industri etanol (vinasse) PSA Palimanan menggunakan kecepatan pengisian optimum. Penentuan kadar COD ditentukan dengan metode refluks, penentuan kadar BOD menggunakan metode Winkler dan penentuan kadar TSS ditentukan dengan menggunakan gravimetri. Hasil penelitian menunjukkan bahwa pengolahan limbah cair industri etanol (vinasse) PSA Palimanan dengan metode MSL dapat menurunkan kadar COD, BOD, dan TSS pada kecepatan pengisian optimum 320 L.m-2hari-1. Efisiensi sistem MSL dalam menurunkan kadar COD, BOD, dan TSS masing-masing sebesar 80,85%; 94,68%; dan 83,99%.

Density Functional Study on Benzene, Toluene, Ethylbenzene and Xylene Adsorptions on ZnO(100) Surface Nugraha Nugraha; Adhitya Gandaryus Saputro; Mohammad Kemal Agusta; Fiki Taufik Akbar; Aditya Dimas Pramudya
Molekul Vol 14, No 1 (2019)
Publisher : Universitas Jenderal Soedirman

We study the interaction between benzene, toluene, ethylbenzene and xylene (BTEX) molecules with ZnO(100) surface by means of density functional theory-based calculations. We find that these interactions result in the physical adsorptions of BTEX gases with adsorption distances larger than 2 Å. These adsorptions are governed by the van der Waals interaction instead of the covalent interaction. We also find that the trend of the strength of BTX adsorptions on ZnO(100) surface is in line with the experimental trend of sensitivity of ZnO material towards BTX gases (benzene < tolune < xylene). We explain this relation by using one of the sensing mechanism within the ionosorption model. By using this relation, we also predict that the response of ZnO towards ethylbenzene will be similar to the response towards toluene since these two molecules have similar adsorption energies on ZnO(100) surface.

Modification of Screen Printed Carbon Electrode (SPCE) with Fe3O4 for the Determination of Nitrite (NO2-) in Squarewave Voltammetry Erica Marista Rosida; Ani Mulyasuryani; Rachmat Triandi Tjahjanto
Molekul Vol 12, No 2 (2017)
Publisher : Universitas Jenderal Soedirman

Nitrite is one of the food preservatives that the government permits, but on the use of over limits can cause endanger health, so it is necessary to control the content of nitrite in the food. Modification of electrodes on a screen printed carbon electrode (SPCE) with Fe3O4 has been successfully done for determination of nitrite. Modification of the electrode has been done by electrodeposition with cyclic voltammetry. Electrodeposition successfully performed with an electrolyte solution of FeCl3 in ethanol. Selection of the optimum drying temperature modified electrode obtained based on the respond of the solution of nitrite in Britton Robinson buffer pH 8. The result of the modification electrode used for the determination of nitrite with squarewave voltammetry method. Reaction between Fe3+ with nitrite a basis for determining nitric indirectly measured so that the peak current is the peak current of Fe3+ of about 0,55 V vs Ag/AgCl. The results showed nitrite measurements with this method has a detection limit of 1.3 x 10-8 M.

THE CHARACTERISTICS OF BIOACTIVE PEPTIDES AND ANTIBACTERIAL ACTIVITY OF HONEY BEE (Apis nigrocincta) SMITH VENOM, ENDEMIC TO SULAWESI Mokosuli Yermia Semuel; Rudi Alexander Repi
Molekul Vol 10, No 2 (2015)
Publisher : Universitas Jenderal Soedirman

Apis nigrocincta Smith is a species of honey bee cavity nesting, endemic to Sulawesi. Research that aims to find the composition of the bioactive content of peptides and antibacterial activity of honey bee venom A. nigrocincta Smith has been conducted. Honey bee venom composition was analyzed using Sodium Dodecyl Sulphate Polyacrylamide Gel Electrophoresis (SDS-PAGE) Method and Spectrophotometer UV-Vis Method. Analysis of antibacterial activity, was conducted using a modified agar diffusion method. The results showed that the venom of the honey bee Apis nigrocinctaSmith has five bands of molecules with a molecular weight i.e. 33.54kDa; 21 kDa and 15.43 kDa. The peptide detected were hyaluronidase, fosfolipase A, mellitin, lysofosfolipase or antigen 5. Antibacterial activity was higher than the control ampisilin and antibiotic streptomycin.

KARAKTERISASI KATALIS Pt-Pd/ZEOLIT ALAM REGENERASI PADA REAKSI HIDRODENITROGENASI PIRIDIN Dina Asnawati
Molekul Vol 9, No 1 (2014)
Publisher : Universitas Jenderal Soedirman

Telah dilakukan penelitian tentang Karakterisasi Katalis Pt-Pd/Zeolit Alam Regenerasi pada Reaksi Hidrodenitrogenasi Piridin. Tujuan dari penelitian ini adalah untuk mempelajari karakter katalis Pt-Pd/zeolit alam baru, bekas dan hasil regenerasi pada hidrodenitrogenisasi piridin. Katalis Pt-Pd/zeolit alam terdeaktivasi diregenerasi dengan cara dioksidasi dengan gas O2 pada temperatur 350oC selama 2 jam, dan direduksi dengan gas H2 pada temperatur 400oC selama 1 jam. Karakterisasi katalis baru (fresh), terdeaktivasi dan terregenerasi meliputi penentuan luas permukaan, volume pori dan rerata jejari pori dengan alat Gas Sorption Analyzer NOVA-1000 berdasarkan adsorpsi gas N2 serta penentuan keasaman dengan metode adsorpsi gas amoniak. Hasil penelitian menunjukkan bahwa deaktivasi katalis menyebabkan penurunan luas permukaan spesifik, volume total pori dan keasaman katalis, sedangkan proses regenerasi pada katalis bekas dengan metode oksidasi dan reduksi meningkatkan luas permukaan spesifik, volume total pori, rerata jejari pori dan keasaman katalis.

Caryophyllene-Type Sesquiterpenoids from the Stembark of Aglalia harmsiana and Their Cytotoxic Activity Against MCF-7 Breast Cancer Cells Hersa Milawati; Desi Harneti; Rani Maharani; Nurlelasari Nurlelasari; Ace Tatang Hidayat; Mohamad Nurul Azmi; Yoshihito Shiono; Unang Supratman
Molekul Vol 14, No 2 (2019)
Publisher : Universitas Jenderal Soedirman

Sesquiterpenoid is a class of terpenoid compounds that have the most abundant diversity of structures and biological activitiesthat can be found in natural resources. Tropical plants are main source of sesquiterpenoid compounds such as Aglaiagenus belong to Meliaceae family. A. harmsianais a species from Aglaiathat only has few previous researchs. Therefore, the purpose of this study was to isolate and determine the structure of sesquiterpenoid compounds from stem barkA. harmsianaalong withtheir cytotoxic activity against MCF-7 breast cancer cells. The isolation process begins by extracting powder from A. harmsianastembark using n-hexane, ethyl acetate and methanol. All extracts were evaluated for their cytotoxic activity against MCF-7 breast cancer cells, and n-hexane extractsshowed significant cytotoxic activitywith IC50values of 117.86 µg/mL. Therefore, n-hexane extracts were further separated and purified by various chromatographic techniquesto obtain compounds 1and 2. Compounds 1and 2were elucidated their chemical structures by spectroscopic methods includingIR, NMR, and MS as well as bycomparison of data with literatures and identified ascaryophyllene-typesesquiterpenoids, β-caryophylleneoxide (1) and senecrassidiol (2). Compounds 1and 2were submitted for cytotoxic eveluation on MCF-7 breast cancer cells and as a result, β-caryophyllene oxide (1) showed the stronger activity compared to senecrassidiol (2). These finding indicatedthat the cytotoxic activity of caryophyllene-typesesquiterpenoid areinfluenced by the presence of double bonds and configuration of methyl groups.

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Home Page

OAI Link

Editorial Team

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Contact Name Amin Fatoni

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Editorial Address Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location Kab. banyumas, Jawa tengah INDONESIA

Abstract

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Abstract

Contact Name
Amin Fatoni

Contact Email
aminfatoni@unsoed.ac.id

Phone
-

Journal Mail Official
j.molekul@gmail.com

Editorial Address
Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location
Kab. banyumas,

Jawa tengah

INDONESIA