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Perbandingan Insidensi Hipotensi Saat Induksi Intravena Propofol 2 Mg/Kg Bb Pada Posisi Supine dengan Perlakuan dan Tanpa Perlakuan Elevasi Tungkai Beni Indra; Untung Widodo; Yunita Widyastuti
Jurnal Kesehatan Andalas Vol 5, No 1 (2016)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v5i1.476

Abstract

Abstrak          Penggunaan Propofol untuk induksi pada general anestesi dapat menyebabkan  hipotensi akibat vasodilatasi arteri dan vena terutama vena kapasitan ditungkai. Manuver elevasi tungkai dapat mempertahankan stabilitas hemodinamik dengan meningkatkan aliran balik vena ke jantung dan mengurangi penumpukan darah di vena kapasitan tungkai. Penelitian ini dirancang dengan menggunakan cara Open Randomized Control Trial. Subyek penelitian adalah 184 sampel pasien dewasa ASA I-II yang menjalani operasi elektif dengan menggunakan general anestesi dengan induksi propofol. Kelompok sampel penelitian dibagi dalam dua kelompok masing-masing berjumlah 92 orang. Setelah prabeban cairan RL 10 cc/kgbb dan pemberian fentanyl 2 mcg/kgbb dan midazolam 0,05 mg/kgbb maka kelompok A dilakukan elevasi tungkai 45º satu menit sebelum induksi propofol dan dipertahankan sampai penelitian selesai. Sedangkan kelompok B tidak dilakukan elevasi tungkai. Data yang dikumpulkan dianalisa dengan uji t tes. Untuk data proporsi dilakukan analisa dengan tes chi-square. Dari data demografi tidak didapatkan perbedaan yang bermakna secara statistik (p>0,05) antara kedua kelompok penelitian kecuali untuk BMI (p<0,05). Insidensi hipotensi  menit pertama pasca induksi propofol pada kelompok A (elevasi tungkai) secara signifikan lebih rendah (12%) dibanding kelompok kontrol B  (27,2%) (p=0,016; p < 0,05). Pada menit ketiga pasca induksi juga didapatkan insidensi hipotensi kelompok A  (15,2%) signifikan lebih rendah dibanding kelompok B (23,9%) (p= 0,014; p < 0,05). Elevasi tungkai 45 derajat efektif dalam menurunkan insidensi hipotensi pasca induksi propofol.  Kata kunci: propofol, hipotensi, elevasi tungkai AbstractThe induction of general anaesthesia with propofol may induce of considerable degree of hypotension that has been atributed to decrease in systemic vascular resistance  caused by combination of venous and arterial vasodilatation. It will produce a shifting  of blood to venous reservoir, especially capacitance venule of legs. Leg elevation can provide hemodynamic stability by increases cardiac preload and recruits blood contained in the venous reservoir. This is Open Randomized Control Trial include 184 elective surgery patients with American Society of Anaesthesiologist (ASA) physical status I and II. Anesthesia  was induced with propofol. Patients were randomly allocated into two groups with 92 patients in each. All the patients received Ringer’s Lactate (10 ml/kg) and premedicated with fentanyl (2 mcg/kg) and midazolam (0,05 mg/kg) before induction of anesthesia. Group A was performed passive leg raising 45 degree 1 minute before injection of propofol until  the end of study and group B (control) did not receive any maneuver. Parametric data were analyzed with t-test and categorical data was done by using Chi-square test. A p value of less than 0,05 was consider significant. Demografic characteristics (age, sex, body weight and height) and  baseline haemodynamic parameters of the patients were similar in two groups (p > 0.05) except for BMI (p < 0.05) . The incidence of hypotension was significantly lower in group A (12 %, ) than group  B (27,2%) at the first minute after propofol  injection, p value = 0.016 (p < 0,05). In the third minute, incidence of hypotension was also significantly lower in group A (15,2%) than group B (23,9%), p value = 0,014 (p < 0,05). Leg elevation maneuver 45º significantly decrease incidence of hypotension after propofol induction. Keywords: Propofol, hypotension, leg elevation
Identifikasi Kandungan Rhodamin B pada Perona Pipi yang Terdaftar dan Tidak Terdaftar dalam BPOM dari Produk yang Beredar di Kecamatan Lubuk Begalung Kota Padang Tessa Tamara Novhadi; Elmatris Elmatris; Beni Indra
Jurnal Ilmu Kesehatan Indonesia Vol 2 No 3 (2021): September 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v2i3.316

Abstract

Latar Belakang: Perona pipi merupakan kosmetik yang banyak digunakan oleh wanita, salah satu bahan berbahaya yang dapat terkandung dalam perona pipi adalah Rhodamin B yang digunakan pada industri tekstil, kertas, dan cat. Paparan secara langsung Rhodamin B pada kulit dapat menghambat proliferasi fibroblas sehingga kulit menjadi kering dan penyerapan secara sistemik dapat menyebabkan gangguan pada hepar. Objektif: Mengidentifikasi kandungan Rhodamin B pada perona pipi yang beredar di Kecamatan Lubuk Begalung Kota Padang. Metode: Identifikasi kualitatif kandungan Rhodamin B dilakukan menggunakan Rapid Test Kit Rhodamin B yang dilakukan di Laboratorium Biokimia Fakultas Kedokteran Universitas Andalas. Hasil: Hasil penelitian ini menunjukkan dari 13 sampel perona pipi yang beredar di Kecamatan Lubuk Begalung Kota Padang lebih dari separuh sampel (61,5%) merupakan perona pipi yang terdaftar dalam BPOM dan kurang dari separuh (38,5%) merupakan perona pipi yang tidak terdaftar dalam BPOM. Kesimpulan: Dari penelitian ini disimpulakan hanya satu sampel yang positif mengandung Rhodamin B yaitu dari sampel perona pipi yang terdaftar dalam BPOM.
Gambaran Risiko Post-Traumatic Stress Disorder (PTSD) pada Penyintas COVID-19 di Rumah Sakit Universitas Andalas Wahyuni, Sri; Widya Murni, Arina; Indra, Beni; Gusya Liza, Rini; Koerniati, Isnindiah; Sauma, Eldi
Jurnal Penyakit Dalam Indonesia Vol. 10, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction. The COVID-19 pandemic has a negative impact on life where sufferers can experience emotional problems such as despair, deep sadness, helplessness, anxiety, and depressive symptoms. Especially in hospitalized COVID-19 survivors, there are sequelae in the form of anxiety, depression, and Post-traumatic Stress Disorder (PTSD). PTSD experienced by COVID-19 survivors will affect the patient’s quality of life in the future. This study aimed to assess the risk of PTSD in COVID-19 survivors who had been hospitalized at Andalas University Hospital. Methods. A cross-sectional descriptive study was conducted among COVID-19 survivors aged ≥15 years who had been hospitalized at Andalas University Hospital. Samples were selected by using total sampling method with inclusion criteria included experiencing mild, severe, or critical clinical symptoms during COVID-19 infection, being discharged from Andalas University Hospital for six months or more, and willing to participate in the study by signing an informed consent. Samples who have met the inclusion criteria completed the Bahasa Indonesia version of PCL-5 (PTSD Checklist for DSM-5) questionnaire which has been tested for its validity and reliability. Respondents were categorized as having PTSD risk if the questionnaire results showed a score of ≥23. The collected data were subsequently analyzed using univariate analysis. Results. A total of 75 respondents were included in the study, of which 9.3% (7) were found to be potentially or at risk of PTSD. The group of respondents who were at risk of PTSD was mostly comprised of females, and all of them experienced the four PTSD symptoms (intrusion/re-experiencing, avoidance, negative alterations in cognition and mood, and hyperarousal). The most common trigger that causes PTSD among respondents was the experience of a previous life-threatening traumatic event (71.43%). In addition, the most frequent clinical symptoms of COVID-19 in the PTSD risk group were severe clinical symptoms (71.43%). Conclusions. COVID-19 survivors who have the potential to experience PTSD are predominantly female survivors with severe clinical symptoms, experiencing all four PTSD symptoms, and having a traumatic life-threatening experience during COVID-19 hospitalization. Keywords: COVID-19 survivors, hospitalization, risk of PTSD
Hubungan Rasio Neutrofil-Limfosit dengan Derajat Keparahan COVID-19 pada Pasien Diabetes Zahara Findi; Beni Indra; Netti Suharti; Muhammad Zulfadli Syahrul; Roza Mulyana; Elfira Yusri
Jurnal Ilmu Kesehatan Indonesia Vol 4 No 2 (2023): Juni 2023
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v4i2.1072

Abstract

Latar Belakang: Corona Virus Disease 2019 (COVID-19) merupakan penyakit yang disebabkan oleh SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus 2). Peningkatan kasus COVID-19 di Indonesia cukup cepat dan menyebar ke berbagai wilayah di Indonesia. Diabetes Melitus merupakan salah satu komorbiditas yang berkaitan dengan infeksi berat COVID-19, gagal napas akut, dan peningkatan mortalitas pasien COVID-19. Oleh karena itu, diperlukan penanda klinis yang ekonomis, cepat, dan bersifat sensitif dan spesifik. Peningkatan rasio neutrofil-limfosit merupakan biomarker peradangan yang mudah dianalisis untuk memprediksi risiko COVID-19 dan menilai keparahan COVID-19. Objektif: Tujuan dari penelitian ini adalah untuk menganalisis hubungan antara rasio neutrofil-limfosit dengan derajat keparahan COVID-19 pada pasien diabetes. Metode: Jenis penelitian adalah kohort retrospektif dengan teknik convenience sampling. Sampel pada penelitian ini adalah 84 pasien diabetes yang terkonfirmasi COVID-19 pada bulan April 2020 hingga Agustus 2021 di RS Universitas Andalas. Data dianalisis menggunakan uji Chi-square dan Independent group t-test. Hasil: Hasil penelitian didapatkan derajat keparahan COVID-19 paling banyak pada derajat berat (32,1%). Terdapat hubungan yang signifikan antara rasio neutrofil-limfosit dengan derajat keparahan COVID-19 (p = 0,00). Gula darah sewaktu pada kasus severe (291.82 mg/dL) lebih tinggi dibandingkan dengan kasus non severe (272.33 mg/dL), tetapi secara statistik tidak signifikan (p = 0,389). Kesimpulan: Kesimpulan dari penelitian ini adalah terdapat hubungan yang signifikan antara rasio neutrofil-limfosit dengan derajat keparahan COVID-19 pada pasien diabetes. Peningkatan rasio neutrofil-limfosit ini dapat digunakan sebagai penanda awal yang mempengaruhi derajat keparahan COVID-19 pada pasien diabetes.
Deteksi Resistensi Piretroid Secara Bioassay dan Mutasi Gen kdr pada Aedes aegypti dan Aedes albopictus Puti Reno Diandra K.; Hasmiwati Hasmiwati; Beni Indra; Selfi Renita Rusjdi; Wirsma Arif Harahap; Nice Rachmawati Masnadi
Majalah Kedokteran Andalas Vol 46, No 7 (2023): Supplementary December 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i7.p1217-1228.2023

Abstract

Objective: The aim of this study is to detect the insecticide resistance by bioassay test and to detect the kdr mutation in Aedes aegypti and Aedes albopictus.Methods: This study was a narrative review that evaluated various articles related to detection of pyrethroid resistance by bioassay and mutation of the kdr gene in Ae. aegypti and Ae. albopictus sourced from PubMed, Google Scholar, and ProQuest database.Results: The results of the study review show that almost the entire population of Ae. aegypti and Ae. albopictus is already resistant to pyrethroid insecticide based on the bioassay detection using the WHO Susceptibility Test and CDC Bottle Assay protocols, and several variations of the kdr gene allele have been found, especially the V1016G, F1534C, and S989P genesConclusion: Ae. aegypti is resistant to pyrethroid insecticides, especially to deltamethrin and permethrin groups, Ae. albopictus are generally still in the susceptible status, and mutations in kdr gene are mostly found in the population of Ae. aegypti. The genotypes of the kdr that experienced many mutations are V1016G, F1534C, and S989P.
Original Research The Effect of Yoga or Nonpharmacotherapy on Dysmenorrhore in Medical Students of Andalas University, Indonesia Rifqah Wardah Astarini; Muhammad Zulfadli Syahrul; Mustafa Nour; Beni Indra; Aladin Aladin; Miftah Irramah
Jurnal sosial dan sains Vol. 4 No. 9 (2024): Jurnal Sosial dan Sains
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jurnalsosains.v4i9.1522

Abstract

Background: Dysmenorrhea is a menstrual pain that is often experienced by young women, with a global prevalence of 16.8-81%. In Indonesia, the prevalence reaches 54.89%, with adolescent girls being the largest group. Treatment generally uses analgesics, but it has side effects. Yoga as a non-pharmacological therapy can reduce pain through muscle relaxation. Purpose: Analyzing the effect of yoga therapy on the intensity of the degree of dysmenorrhea in female students of the Class of 2018 Undergraduate Medical Education Study Program, Faculty of Medicine, Andalas University. Methods: This research uses a pure experimental design with a pre-test, post-test, and only group design, with a sample size of 32 people. The research instrument used in the study was a pre-test and post-test questionnaire, which contained VAS scores and guidelines regarding yoga movements. The questionnaire contains a Visual Analog Scale (VAS), which consists of a vertical scale from 0 to 10 cm. Results:  The results showed there were no differences related to age. As many as 18% of respondents usually took analgesics, while 81.3% did not take analgesics to treat dysmenorrhea before yoga therapy. Meanwhile, after yoga therapy, 5 out of 6 respondents who usually consumed analgesics in previous menstrual cycles no longer consumed analgesics, and one respondent still consumed analgesics. Bivariate analysis showed a value of p=0.00 (p<0.05), which means there is a relationship between the provision of yoga therapy and the degree of dysmenorrhea. Where providing yoga therapy can reduce the intensity of pain in respondents who experience dysmenorrhea. Conclusion: This research concludes that there is a significant relationship between the provision of yoga therapy and the degree of dysmenorrhea.
Vitamin D levels in nasopharyngeal carcinoma of the Minangkabau ethnic group Rahman, Sukri; Ali, Hirowati; Indra, Beni
Oto Rhino Laryngologica Indonesiana Vol. 53 No. 1 (2023): VOLUME 53, NO. 1 JANUARY - JUNE 2023
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v53i1.613

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Background: The etiology of nasopharyngeal carcinoma (NPC) is not yet known with certainty, but is suspected to be an interaction of multiple factors. Nasopharyngeal carcinoma is closely related to Epstein-Barr virus (EBV) infection which interacts with genetic susceptibility and environmental factors. Various studies have reported the relationship of vitamin D with the risk of various cancers, but very little research has a relationship with NPC. Objective: This study was conducted to analyze the association of vitamin D levels with nasopharyngeal carcinoma in the Minangkabau ethnic group. Methods: This study was a cross-sectional study comparing plasma levels of vitamin D (25(OH)D) in new patients with NPC of the Minangkabau ethnic who were treated at Dr. M. Djamil Padang with healthy control plasma. Result: This study found that the average vitamin D level in the NPC group was higher than the control group. Vitamin D levels in this study varied in both cases and controls. In the NPC group, vitamin D levels varied from 14.64 to 75.56 ng/ml. Most of the NPC group had normal vitamin D levels (69.6%), and in controls, vitamin D levels also varied from 6.06 to 73. .96 ng/ml, and most of them were also with normal levels (52.2%). There was no statistically significant difference between cases and controls (p>0.05). Conclusion: This study found no association between the level of vitamin D and the incidence of nasopharyngeal carcinoma in the Minangkabau ethnic group.
Efektivitas Edukasi dan Pelatihan Early Warning System (EWS) untuk Meningkatkan Kesiapsiagaan Tenaga Kesehatan Rumah Sakit Kurnia, Dedy; Indra, Beni; Effendi, Rinal; Rustini, Rini; Usman, Elly; Aulia, Apif
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 5 (2025): JURNAL LOCUS: Penelitian & Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i5.4011

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Pelatihan Early Warning System (EWS) memiliki peran penting dalam kesiapsiagaan prabencana, terutama bagi tenaga kesehatan yang berperan sebagai garda depan dalam situasi darurat. Penelitian ini bertujuan untuk mengevaluasi efektivitas pelatihan EWS dalam meningkatkan pengetahuan petugas kesehatan di Rumah Sakit Dr. Adnaan WD Payakumbuh. Sebanyak 40 petugas kesehatan mengikuti pelatihan ini, yang terdiri dari sesi pre-test, pelatihan, dan post-test menggunakan 20 pertanyaan pilihan ganda untuk mengukur tingkat pengetahuan peserta sebelum dan sesudah pelatihan. Hasil penelitian menunjukkan bahwa sebelum pelatihan, sebagian besar peserta berada pada kategori pengetahuan kurang (75%) dan cukup (25%), tanpa ada peserta yang mencapai kategori baik. Setelah pelatihan, terjadi peningkatan signifikan, dengan 40% peserta mencapai kategori baik, 60% berada dalam kategori cukup, dan tidak ada lagi peserta dalam kategori kurang. Secara keseluruhan, terdapat peningkatan pengetahuan sebesar 62% setelah pelatihan, yang menegaskan efektivitas metode pelatihan berbasis kuliah dan simulasi langsung. Pelatihan EWS terbukti dapat meningkatkan kesiapan tenaga kesehatan dalam menghadapi situasi prabencana. Implementasi pelatihan ini secara rutin dan meluas, didukung dengan penggunaan teknologi simulasi modern, dapat semakin memperkuat kesiapsiagaan prabencana dalam menghadapi berbagai ancaman bencana di masa depan.
The Use of Dexmedetomidine, Midazolam, and Ketamine in Prevention of Emergence Agitation in Pediatric Patients Undergoing Surgery Under General Anesthesia Syilfana, Hanifah; Indra, Beni; Welan, Rahmani; Effendi, Rinal; Rustam, Erlina
Indonesian Journal of Anesthesiology and Reanimation Vol. 6 No. 2 (2024): Indonesian Journal of Anesthesiology and Reanimation (IJAR)
Publisher : Faculty of Medicine-Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijar.V6I22024.116-124

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Introduction: Emergence agitation (EA) is a problem that often occurs in pediatric patients during recovery from anesthesia. The cause of EA remained unclear, but the combination of etiologies increases the risk of postoperative agitation. The researchers use various drugs such as ketamine, midazolam, and dexmedetomidine to prevent and treat EA. Objective: This review aims to determine the effectiveness of dexmedetomidine, midazolam, and ketamine in preventing emergence agitation in pediatric patients undergoing surgery under general anesthesia. Method: This literature review is a narrative review that looks at the outcomes of randomized controlled trials (RCT) studies that tested how well dexmedetomidine, midazolam, and ketamine worked at keeping pediatric patients from becoming agitated during emergence. Literature was collected through Google Scholar and PubMed using the keywords Pediatric, Children, Dexmedetomidine, Ketamine, Midazolam, Emergence Agitation, Emergence Delirium, Postoperative Agitation, and Postoperative Delirium and published within the last ten years (2011–2021) in English or Indonesian. The researchers excluded articles that were not available in full, as well as literature reviews. Results: Based on the specified database and keywords identified, there were 695 articles. This literature study included thirteen articles that met the inclusion criteria. Ten articles examined the effectiveness of dexmedetomidine, four reviewed the effectiveness of midazolam, and three examined the effectiveness of ketamine. Conclusion: According to the ten reviewed articles, administering dexmedetomidine or ketamine reduced the incidence of emergence agitation in children. However, the administration of midazolam yielded inconsistent results. To evaluate the optimal dosage, route, and timing of dexmedetomidine, midazolam, and ketamine in preventing EA, further studies are necessary.
Hubungan Laju Endap Darah (LED) dengan Kejadian Syok pada Pasien Multisystem Inflammatory Syndrome in Children (MIS-C) Rahmi, Yannisa Mutiara; Ihsan, Indra; Indra, Beni; Yani, Finny Fitry; Rofinda, Zelly Dia
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 1 (2024): Maret 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i1.1094

Abstract

Latar Belakang: Multisystem Inflammatory Syndrome in Children (MIS-C) merupakan respon inflamasi yang melibatkan > 2 organ pasca infeksi SARS-CoV-2. Pemeriksaan marker inflamasi dapat membantu klinisi dalam menegakkan diagnosis dan memprediksi luaran buruk, seperti kejadian syok. Laju endap darah (LED) merupakan marker inflamasi yang murah dan mudah dilakukan di layanan primer yang memiliki keterbatasan fasilitas. Objektif: Mengetahui hubungan LED dengan kejadian syok pada pasien MIS-C yang dirawat di RSUP Dr. M. Djamil Padang. Metode: Jenis penelitian ini adalah analitik retrospektif dengan menggunakan data rekam medis pasien yang memenuhi kriteria inklusi dan eksklusi. Penelitian dilakukan di RSUP Dr. M. Djamil Padang pada pasien yang didiagnosis MIS-C sesuai kriteria World Health Organization (WHO). Data kemudian dianalisis dengan uji Mann-Whitney. Hasil: Penelitian ini mendapatkan median LED adalah 25,5 (1-117) mm/jam pada pasien MIS-C. Sebanyak 43,8% pasien mengalami syok. Uji statistik Mann-Whitney menunjukkan bahwa tidak terdapat perbedaan yang signifikan antara nilai LED pada pasien MIS-C yang mengalami syok dengan yang tidak (p = 0,055). Kesimpulan: Median LED pada pasien MIS-C ditemukan meningkat melebihi batas normal. Pasien MIS-C yang mengalami syok memiliki median nilai LED yang lebih tinggi jika dibandingkan dengan yang tidak (43 vs. 19,5 mm/jam), namun tidak terdapat hubungan yang signifikan antara nilai LED dengan kejadian syok pada pasien MIS-C. Pemeriksaan LED tidak dianjurkan untuk digunakan dalam memprediksi kejadian syok pada pasien MIS-C. Kata kunci: Laju Endap Darah, Luaran, MIS-C, SARS-CoV-2, Syok