Jurnal Ilmu Kefarmasian Indonesia
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
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<![CDATA[Aktivitas Sitotoksik Ekstrak Metanol Benalu Batu (Begonia sp.): Ethnomedicine Suku Wana Sulawesi Tengah ]]>
<![CDATA[MUHAMMAD SULAIMAN ZUBAIR]]>;
<![CDATA[SYARIFUL ANAM]]>;
<![CDATA[YULIET .]]>;
<![CDATA[AGUS RITNA]]>;
<![CDATA[FIRMANITA DWIMURTI]]>;
<![CDATA[DEWI RISMAYANTI]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 1 (2014): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Benalu batu (Begonia sp.) is used as traditional medicine by Wana tribe in Central Sulawesi to treat various diseases, including cancer. In an effort to search potential anticancer drugs from natural sources, investigation was conducted on the cytotoxic activity of Begonia sp. methanol extract against cervic cancer cells (HeLa) and breast cancer cells (T47D) and identification of the chemical compound groups in methanol extract that is responsible for the anticancer activity. Investigations including the extraction of Begonia sp. dried herb by soxhletation using methanol, followed by evaporation on rotary vapor until viscous extract gained. The cytotoxic test were carried out by tetrazolium bromide (MTT) method. The concentration series of Begonia sp. methanol extract were 250, 125, 62.5 and 31.25 μg /mL. Results showed that the Begonia sp. methanol extract inhibited the growth of cervic cancer cells (HeLa) (IC50 = 70.97 μg/mL) stronger than inhibition on breast cancer cells (T47D) (IC50 = 122.21 μg/mL). Analysis of chemical compound groups in the methanol extract using thin-layer chromatography (TLC) method indicated that polyphenolic flavonoid might be the main compound responsible for the anticancer activity]]>
<![CDATA[Aktivitas Isolat Actinomycetes dari Rumput Laut (Eucheuma cottonii) sebagai Penghasil Antibiotik terhadap Staphylococcus aureus dan Escherichia coli ]]>
<![CDATA[NANIK SULISTYANI]]>;
<![CDATA[ACHMAD NURYADIN AKBAR]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 1 (2014): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Actinomycetes are microbial group of the most widely produced bioactive compound as antibiotics.This study was intended to isolate Actinomycetes from seaweed Eucheuma cottonii and to identify the activity of isolated Actinomycetes as antibiotic producer against Staphylococcus aureus and Escherichia coli. Furthermore, the research was aimed to know the spots on thin-layer chromatography(TLC) which has antibacterial activity against S. aureus and E. coli. Isolation of Actinomycetes from E. cottonii was carried out with a spread plate method. The activity test of Actinomycetes as antibiotic producer against S. aureus and E. coli was performed by cup plate method. TLC bioautography was done with stationary phaseof silica gel GF254 and mobile phase of n-hexane : ethylacetate (2:3). The results showed that RL 6 and RL 12 isolate produced antibiotic against S. aureus and E. coli.The TLC bioautography result of ethyl acetate extracts of RL 6 and RL 12 cultures against S. aureus and E. coli showed a inhibition zone at Rf 0.05 and 0.22, respectively.]]>
<![CDATA[Potensi Ekstrak Rimpang Kunyit Sebagai Prebiotik Pemacu Pertumbuhan Lactobacillus plantarum Secara In Vitro ]]>
<![CDATA[MIN RAHMINIWATI]]>;
<![CDATA[SAEPUDIN RAHMATULLAH]]>;
<![CDATA[IRMANIDA BATUBARA]]>;
<![CDATA[SUMINAR S. ACHMADI]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 1 (2014): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Turmeric contains curcumin which has antibacterial and anti-inflammatory activities. In addition, turmeric contain also carbohydrates that has potency as a prebiotic agent. Research on turmeric extract that was obtained by maceration in variety of solvent, temperatures and time have been carried out to get the most potent prebiotic extract of turmeric to stimulate L. plantarum growth. Maceration with water at 28oC for 1 hour resulted in extract which can enhance the growth of L. plantarum approximately is higher than controls at a concentration of 1 ppm. L. plantarum growth rate increases with increasing concentration of extract. Sugars content of oligosaccharide in the extract were stakiosa, sucrose and lactose of 3014, 164, and 82 ppm respectively. It is concluded that oligosaccharide in turmeric extract is potential as prebiotic agent to increase L. plantarum growth.]]>
<![CDATA[Aktivitas Antioksidan Ekstrak Daun Sirih Merah (Piper crocatum) Hasil Optimasi Pelarut Etanol-Air ]]>
<![CDATA[AGATHA BUDI SUSIANA LESTARI]]>;
<![CDATA[YOHANES DWIATMAKA]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 1 (2014): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Red bettle (Piper crocatum) is one of the plants which is extensively explored and has many biological activity. In this research, it is done the optimization of 96% ethanol and water composition as solvents in the process of extraction of red bettle leaves in percentage ratio of 100:0 (P1), 75:25 (P2), 50:50 (P3), 25:75 (P4), and 0:100 (P5) using Simplex Lattice Design (SLD). The aim of this research were to find the optimum composition of solvent which can obtain extract with the highest antioxidant activity. The antioxidant activity of red bettle leaves extract was measured by radical scavenging method using DPPH (diphenylpicryl hydrazyl), and assessed using parameter of EC50. The result showed that red bettle leaves extract which produced with ethanol-water as a solvent in percentage (%) of 75:25 (P2) has the higest antioxidant activity, with the smallest EC50’s value of 301,10 μg/ml.]]>
<![CDATA[Metode Kromatografi Cair Kinerja Tinggi Menggunakan Kolom Oktil Silika Fully Endcapped Residual Silanol pada Pemisahan Kotinin dan 3-Hidroksikotinin dalam Sampel Urin ]]>
<![CDATA[CHRISTINE PATRAMURTI]]>;
<![CDATA[SUDIBYO MARTONO]]>;
<![CDATA[SUGIYANTO SUGIYANTO]]>;
<![CDATA[ARIEF NURROCHMAD]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 1 (2014): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Cotinine (COT) and 3-hydroxycotinine (3-HCOT) are nicotine metabolite excreted in urine. Mediated by the enzyme cytochrome P450 2A6 (CYP 2A6), nicotine will be metabolized to COT and 3-HCOT. The activity of CYP 2A6 can be predicted from the ratio 3-HCOT to the COT, therefore the ratio of 3-HCOT and COT can be used as phenotyping and polymorphism studies of the enzyme. In this study, isolation COT and 3-HCOT of urine samples was carried out by liquid-liquid back extraction. Simultaneous analysis of COT and 3-HCOT using High Performance liquid Chromatography (HPLC) was performed by a reversed-phase octyl silica column (C8; Shimadzu 250 × 4.6 mm, 5 μm) fully endcapped residual silanol. The internal standard solution (SI) was acetanilide. The mobile phase which separate COT, 3-HCOT and SI was methanol : ammonium acetate 5 mM (50:50) at a flow rate 0.8 mL/min. Retention time (tR) of the three compounds was less than 10 minutes, with peak tailing factor (tf) was less than 2. The resolution (Rs) 3-HCOT to COT was 2.67, while the Rs COT to SI was 8.836.]]>
<![CDATA[Aktivitas Sitotoksik Ekstrak Metanol Benalu Batu (Begonia sp.): Ethnomedicine Suku Wana Sulawesi Tengah ]]>
<![CDATA[MUHAMMAD SULAIMAN ZUBAIR]]>;
<![CDATA[SYARIFUL ANAM]]>;
<![CDATA[YULIET YULIET]]>;
<![CDATA[AGUS RITNA]]>;
<![CDATA[FIRMANITA DWIMURTI]]>;
<![CDATA[DEWI RISMAYANTI]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 1 (2014): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Benalu batu (Begonia sp.) is used as traditional medicine by Wana tribe in Central Sulawesi to treat various diseases, including cancer. In an effort to search potential anticancer drugs from natural sources, investigation was conducted on the cytotoxic activity of Begonia sp. methanol extract against cervic cancer cells (HeLa) and breast cancer cells (T47D) and identification of the chemical compound groups in methanol extract that is responsible for the anticancer activity. Investigations including the extraction of Begonia sp. dried herb by soxhletation using methanol, followed by evaporation on rotary vapor until viscous extract gained. The cytotoxic test were carried out by tetrazolium bromide (MTT) method. The concentration series of Begonia sp. methanol extract were 250, 125, 62.5 and 31.25 μg /mL. Results showed that the Begonia sp. methanol extract inhibited the growth of cervic cancer cells (HeLa) (IC50 = 70.97 μg/mL) stronger than inhibition on breast cancer cells (T47D) (IC50 = 122.21 μg/mL). Analysis of chemical compound groups in the methanol extract using thin-layer chromatography (TLC) method indicated that polyphenolic flavonoid might be the main compound responsible for the anticancer activity.]]>
<![CDATA[Uji Toksisitas Akut, Aktivitas Antioksidan In Vitro dan Efek Rebusan Bunga Kemboja Merah (Plumeria rubra L.) terhadap Kadar Malondialdehid ]]>
<![CDATA[NI MADE DWI SANDHIUTAMI]]>;
<![CDATA[LESTARI RAHAYU]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 1 (2014): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Antioxidants are substances that may inhibit free radical reactions in the body. The purpose of this research is to identify lethal dose, in vitro antioxidant activity and effect of kemboja merah flowers decoction (Plumeria rubra L.) on MDA level. Lethal dose was measured by Weil method. Antioxidant activity assays was performed in vitro by DPPH method and in vivo by measuring MDA plasma level. The level of MDA was conducted using the thiobarbituric acid reactivity test. In the test, 30 mices were divided into 6 groups: normal, negative control, positive control and 3 group treated with variation dose of kemboja merah flowers decoction. LD50 of decoction kemboja merah flowers is > 15 g/kg of body weight. In vitro, antioxidant activity showed the IC50 value of decoction kemboja merah flowers is 36.96 μg/mL.The antioxidant activity of decoction kemboja merah flowers is smaller than vitamin C (IC50 5.89 μg/mL). In vivo antioxidant activity showed levels of MDA on normal group is 1.66 nmol/mL, negative control group is 5.67 nmol/mL, positive control group is 1.45 nmol/mL, treated group which was given by decoction kemboja merah flowers at dose 0.39 g/kg of body weight is 4.32]]>
<![CDATA[Peningkatan Kelarutan Andrografolid dalam Fraksi Etil Asetat Herba Sambiloto (Andrographis paniculata Nees) Melalui Mikroenkapsulasi dengan Metode Semprot Kering ]]>
<![CDATA[IDAH ROSIDAH]]>;
<![CDATA[WAHONO SUMARYONO]]>;
<![CDATA[SILVIA SURINI]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 1 (2014): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Sambiloto (Andrographis paniculata Nees) is one of a medicinal plants containing andrographolide as its primary bioactive component, which is able to inhibit breast cancer cell proliferation. Andrographolide is a diterpene lacton that is sparingly soluble in water. The aim of this study is to improve the solubility of andrographolide in A. paniculata herbs ethyl acetate fraction by microencapsulation method prepared using spray drying. The ethyl acetate fraction of A.paniculata herbs was microencapsulated using PVP K30 and HPMC as the coating polymer in different ratios of ethyl acetat fraction and polymer (1:5; 1:7,5 and 1:10). Microspheres containing ethyl acetate fraction of A.paniculata herbs were evaluated their saturation solubility and in vitro dissolution in aquadest, pH 6.8 phosphate and pH 1.2 chloride medium. The result showed that the microencapsulation could increase the saturation solubility and dissolution rate of andrographolide as compared to the ethyl acetate fraction and andrographolide standard. Compared to the solubility of andrographolide from A. paniculata ethyl acetate fraction, the solubility of andrographolide on ethyl acetate fraction microspheres in aquadest, pH 6.8 phosphate and pH 1.2 chloride medium were increased approximately 23.42-39.34, 19.92-34.83 and 24.56-38.25 folds respectively. Moreover, compared to the solubility of andrographolide standard, the solubility of andrographolide on ethyl acetate fraction microspheres in aquadest, pH 6.8 phosphate and pH 1.2 chloride medium were increased approximately 16.99-28.53, 19.76-34.54 and 17.26-26.87 folds respectively.]]>
<![CDATA[Konstruksi dan Validasi Protokol Skrining Virtual Berbasis Struktur dengan Kode PDB 3MQE, 3NTG, dan 3LN0 untuk Penemuan Inhibitor Siklooksigenase-2 (COX-2) ]]>
<![CDATA[ESTI MUMPUNI]]>;
<![CDATA[ARGUN WIDARSA]]>;
<![CDATA[YANTI SUSILAWATI]]>;
<![CDATA[OISAN OISAN]]>;
<![CDATA[ARIEF NURROCHMAD]]>;
<![CDATA[HARNO DWI PRANOWO]]>;
<![CDATA[UMAR ANGGARA JENIE]]>;
<![CDATA[ENADE PERDANA ISTYASTONO]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 1 (2014): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Cyclooxygenase-2 (COX-2) inhibitors are high demand drugs in the market. However, available COX-2 inhibitors nowadays have many side effects. Therefore, there is still a need to develop more potent selective COX-2 inhibitors and one of the method that has been prove the effectivity and eficiency for new drugs research is in silico. Structure-based virtual screening (SBVS) protocols were developed to find COX-2 inhibitors using the Protein-Ligand ANT System (PLANTS) docking software, SPORES, BKChem and Open Babel. The directory of useful decoys (DUD) dataset for COX-2 was used to validate the protocols retrospectively; the DUD consist of 426 known COX-2 inhibitors and 13289 decoys. Based on criteria value of EF20% and EFmax used in the article from Huang et al (2006) and Yuniarti et al (2011), two validated protocol, AYO_COX2_v.1.1 and AYO_COX2_v.1.2 , showed good results]]>
<![CDATA[Penelusuran Potensi Kapulaga, Temu Putri dan Senggugu sebagai Penghambat Pembentukan Biofilm ]]>
<![CDATA[TRIANA HERTIANI]]>;
<![CDATA[SINTAYU PUTRI WANDAN SARI]]>;
<![CDATA[FERRY RAHMA PUSPITA]]>;
<![CDATA[NURI IRIYANI]]>;
<![CDATA[SYLVIA UTAMI TUNJUNG PRATIWI]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 1 (2014): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Kapulaga fruit, temu putri rhizome and sengugu bark have been reported as antibacterials, suggesting potency to be developed as antibiofilm agents. This research has investigated the inhibition activity on biofilm formation of Methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli. Following petroleum ether extraction, the remaining biomass was macerated in ethanol 70 %. After solvent evaporation, the ethanol extract was partitioned to yield hexane, ethyl acetate and water fractions. The inhibition activities of ethanol extracts, hexane, ethyl acetate and water fractions of samples were carried out in vitro on microplates flexible U-bottom 96 wells using crystal violet staining and were recorded at λ 595nm. Phytochemical identification were performed by thin layer chromatography. Results showed that extract or fraction samples which have the highest biofilm inhibition activity toward MRSA were hexane fraction of kapulaga IC50 0.23±0.01 mg/mL, temu putri IC50 0.45±0.03 mg/mL and the ethyl acetate fraction of senggugu IC50 0.35±0.022 mg/mL. Biofilm inhibition activity toward E. coli, were shown by the ethyl acetate fractions of kapulaga IC50 0.32±0.17 mg/mL, temu putri IC50 0.46±0.03 mg/mL and senggugu IC50 0.39±0.02 mg/mL.]]>
