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Jurnal Ilmu Kefarmasian Indonesia

jifi
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Published by Universitas Pancasila

ISSN : 16931831 EISSN : 26146495 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 18 Documents

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Search results for , issue "Vol 16 No 2 (2018): JIFI" : 18 Documents clear

Analisis Ramuan Obat Tradisional untuk Wasir di Pulau Jawa; Studi Etnofarmakologi RISTOJA 2015 Peristiwan R Widhi Astana; Ulfatun Nisa
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

The using of traditional medicine among community has being accepted and become huge potency to be developed by our country. One of disease which is often treated with traditional medicine is hemorrhoid or in bahasa as known as “wasir”. According to the result of ethopharmacology research of traditional medicine and jamu (RISTOJA) 2015 in java island, there are several formulas used by traditional healers to treat hemorrhoid. In order to fi nd potential formulas to be developed, a descriptive study was conducted involving identifi cation of medicinal plant and also literature study about its benefi t and toxicity evidences. The plants which named in formula’s ingredient were analized to see how important and utility value for hemorrhoid treatment. Literature study was conducted to assess potential benefi t and toxicity. The result said there were 37 species of medicinal plant in 25 family used in traditional medicine formula for hemorrhoid. Based on Frequency Citation(FC), Utility Value (UC) and literature study, Graptophyllum pictum (L.) Griff ., Curcuma longa L., Aloe vera (L.) Burm.F, and Musa balbisiana have enough scientifi c evidence to be studied further development.

Sintesis Senyawa N-(2-Klorobenzoil)-N’-Fenilurea dan Uji Aktivitas Anti Kanker Terhadap Sel HeLa Bambang Tri Purwanto
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Research in the search for cancer drug compounds continue to be developed given the lack of specific anticancer compounds. Some urea derived compounds are also continuously being developed in search of potent anticancer compounds with minimal side effects. In relation to the above, we want to develop an urea derivative of N-phenylurea compound which will be reacted with benzoyl chloride derivative that is 2-chlorobenzoyl chloride so that N-(2-chlorobenzoyl) -N'phenylurea will be obtained. Synthesis of N- (2-chlorobenzoyl) -N'phenylurea was done by modified Schotten-Baumman method, then purity test was performed with thin layer chromatography using 3 different solvents. The next step is structural characterization using UV and IR spectrophotometry method, then 1H-NMR and MS spectrometry, so that the structure of N- (2-chlorobenzoyl) -N'phenylurea will be obtained. An anticancer activity test is performed on HeLa cells using MTT assay method and IC50 value will be obtained. Compounds that have been successfully synthesized are compound of N- (2-chlorobenzoyl) -N'phenylurea, with yield of 80.47% in the form of white needle crystal. The purity test of the N- (2-chlorobenzoyl) -N'phenylurea compound was performed by thin layer chromatography with 3 different solvents (hexan: ethyl acetate: methanol = 2: 3: 1; Hexan: acetone = 4: 2; Hexan: ethylacetate = 4: 2) a single stain is obtained which is different from the Rf value compared to the N-phenylurea origin compound. The Melting Point of the compound is 149oC so it is seen that the compound has been formed and different from the origin compound of N-phenylurea. The anticancer activity test after performed with MTT assay method using HeLa cells line, has an IC50 2100 mg / ml or 8,52 mM for the N- (2-chlorobenzoyl) -N'phenylurea and higher than hydroxy urea as standard compound which has the activity as 7537 mg / ml or 99,10 mM. Conclusion: N- (2-chlorobenzoyl) -N'phenylurea compound has been successfully synthesized and can be further developed as an anticancer compound. Keywords: Synthesis; N-(2-chlorobenzoyl)-N'phenylurea; anticancer activity; HeLa cells.

Efek Serbuk Eestrak Etanol Kelopak Bunga Rosella (Hibiscus sabdariffa L.) Terhadap Jumlah Sel CD4 Pada Sukarelawan Sehat Dini Mardhiyani; Endang Darmawan; Akrom Akrom
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Roselle flower (Hibiscus sabdariffa L.) is beneficial as an immunostimulant because of its antioxidant property. Antioxidants in roselle flower are hibiscus anthocyanin, quercetin, L-ascorbic acid and protocatechuic acid. Any potential plants for pytopharmacy should be proven beneficial and safe through preclinical and clinical trial. The purpose of this clinical trial was to determine the effect of ethanol extract of roselle (Hibiscus sabdariffa L.) to lymphocyte and CD4 cell count in healthy volunteer for 30 days. This study used pre-post treatment design. A total of 21 healthy volunteer were chosen according to inclusion and exclusion criteria and filled informed consent. Healthy volunteer were given 500 mg roselle ethanol extract powder every day for 30 days. Lymphocyte and CD4 cell count was conducted using hematology analyzer and flowcytometer. Results were analyzed using paired t test, if the distribution is not normal than Wilcoxon test will be used on 95% confidence interval. Results showed that there was no significant effect (p>0,05) of CD4 cell absolute count and there was a significant effect of CD4 percentage (p<0,05). Results on day 45 (14 days after the treatment was interrupted) showed no significant effect (p>0,05) of CD4 cell absolute count and CD4 cell percentage. The effect of CD4 cell percentage on day 31 was in normal range. This study concluded that 500 mg roselle petal ethanol extract powder (Hibiscus sabdariffa L.) given everyday for 30 days showed some effect on d increasing CD4 cell percentage.

Efek Gel Putih Telur terhadap Penyembuhan Luka Bakar pada Tikus Putih (Rattus novergicus) Lucia Hendriati; Iwan Sahrial Hamid; Teguh Widodo; Chintya Wandasari; Putu Mirah Risata
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Egg whites traditionally used for the treatment of burns. In this research, egg white was formulated as gel dosage form for easy to use and covered unpleasant odor. The aim of the study was to determined effectivity of egg white in gel dosage form against the healing of superficial partial thickness burns (second degree) on white rats (Rattus novergicus) Wistar strain with parameters were macrophages, fibroblasts, collagen deposit density and wound healing. Research subject were male white rats aged 3 months. Second degree burns on the back of rat with a diameter of 2 cm were made by using a hot coin with temperature 80 ° C for 20 seconds. 18 white rats divided into 3 groups of treatment that is negative control using 0.9% NaCl, positive control using Bioplacenton®, and 40% egg white gel as treatment. Based on the experimental results, white egg gel given topically decreased the number of macrophages and increase the number of fibroblasts, increase the density of collagen deposits and speed up wound healing on second degree burns. White egg gel had significantly difference with negative control of NaCl 0.9% and no significantly difference with Bioplasenton as positive control.

Pengaruh Suplementasi Vitamin A pada Pengobatan Pasien TB Paru terhadap Percepatan Konversi Dahak pada Fase Intensif Di Wilayah Kerja Puskesmas Kecamatan Medan Kota Alexander Marpaung; Parluhutan Siagian; Dina Keumala Sari
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Indonesia is the second rank for the most TB (Tuberculosis) cases in the world after India. It’s estimated there are a million cases per year in Indonesia. The objective of the research was to find out the influence of Vitamin A supplementation in the medication of pulmonary TB on the acceleration of sputum conversion time at intensive phase in the Working Area of Puskesmas in Medan Kota Subdistrict. This research applied clinical testing design with experimental approach and Experimental Quasi method. The samples were 30 newly diagnosed pulmonary TB patients consisting of 15 patients in the treatment group and 15 patients in the control group. They were ≥ 18 years old, regularly consumed category I OAT with BMI ≥ 18.5. The statistical data were analyzed by Mann-Whitney statistical testing at reliability rate 95% (p < 0.05). The results of the research on the treatment group discovered that they were mostly 18-27 years old 40.0%, male 73.3%, mostly university students 26.7%, had BTA conversion in the second week 80.0%; and the sputumconversion time was 2.4 weeks in average. The results of the research on the control group demonstrated that they were mostly 18-27 years old 33.3%, male 80.0%, mostly university students and entrepreneurs 20.0%, had BTA conversion in the second week 80%; and the sputum conversion time was 4.1 weeks in average. Vitamin A supplementation in the medication of pulmonary TB patients had some influence on the acceleration of sputum conversion at intensive phase (p = <0.001) < (alpha = 0.05). Vitamin A supplementation in the medication of pulmonary TB patients had some influence on the acceleration of sputum conversion at intensive phase in the Working Area of Puskesmas in Medan Kota Subdistrict. speed up wound healing on second degree burns. White egg gel had significantly difference compared to negative control of NaCl 0.9% and no signifi cantly difference compared to Bioplacenton as positive control.

Uji Efektifitas Ekstras Etanol Buah Naga Putih (Hylocereus undatus) Terhadap Penurunan Kadar Asam Urat Darah Pada Mencit (Mus musculus) Mellova Amir; Juliana Irem Adriana Purukan
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Buah naga putih (Hylocereus undatus) mengandung flavonoid yang dapat menghambat kerja enzim xantin oksidase yang dapat mengurangi kadar asam urat. Penelitian bertujuan untuk mengetahui efektivitas ekstrak etanol buah naga putih dalam menurunkan kadar asam urat darah pada mencit yang diinduksi kafein secara oral dengan dosis 0,39 mg/25 g BB. Sampel buah naga putih diambil saat berumur 50-55 hari setelah muncul bunga. Pada uji efektifitas, hewan coba mencit dibagi menjadi lima kelompok perlakuan dan diinduksi dengan kafein yaitu kelompok kontrol negatif yang hanya diinduksi kafein, kelompok kontrol positif diberikan allopurinol 0,26 mg/25 g BB, kelompok dosis 0,455 mg/25 g BB, kelompok dosis 0,91 mg/25 g BB, kelompok dosis 1,82 mg/25 g BB ekstrak etanol buah naga putih. Pengukuran kadar asam urat darah dilakukan sebelum induksi (hari ke 1), sesudah induksi atau sebelum pemberian ekstrak (hari ke 6) dan sesudah pemberian ekstrak pada (hari ke 9, 12 dan 15). Hasil penelitian menunjukkan bahwa ekstrak etanol buah naga putih dosis 1,82 mg/25 g BB dapat menurunkan kadar asam urat darah pada mencit secara bermakna dibandingkan dengan dosis 0,455 mg dan dosis 0,91 mg/25 g BB, tetapi tidak berbeda bermakna dengan kontrol positif (allopurinol) dengan presentase penurunan sebesar 92,16%. Kata kunci: Ekstrak buah naga putih, asam urat darah, kafein, allopurinol.

Pharmacoeconomic Analysis Of Using Cephalosporin Group In Appendicitis Prophylactic In Rumah Sakit Umum Daerah Subang Yulia Wardati; Dytha Andri Deswat; Zainal Muttaqin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

The administration of cephalosporin group antibiotics in patients with post-surgical appendicitis is necessary to prevent postoperative wounds. This pharmacoeoconomic study was conducted retrospectively in the period of 1 January to 31 December 2015 in RSUD Subang for the purpose of determining the effectiveness of drugs and the cost of antibiotic use of ceftriaxone, cefotaxime, and ceftizoxime injection by Cost Effectiveness Analysis method. The subject of the patient was 78 people. Based on Average Cost Effectiveness Ratio (ACER), the smallest value is ceftriaxone Rp 729.124 / day, while the result of Cost Effectiveness plane with cefotaxime as standard drug, ceftriaxone occupies quadrant IV and ceftizoxime occupies quadrant I. The result of Incremental Cost Effectiveness Ratio (ICER) calculation obtained by difference of value equal to Rp 106.347 / day hence can be concluded that antibiotic injection of cefotaxime as standard injection antibiotics used by RSUD Subang can be replaced by antibiotic injection of ceftizoxim by adding cost Rp 106.347 / day but need attention to resource especially funds owned and should be selected if sufficient resources are available.

Efek Anti Diabetes Spirulina Platensis Terhadap Analisis Kadar, Gambaran Histopatologi, Ekspresi Insulin dan Glucose Transpoter 4 Pada Tikus Putih Wistar yang Diinduksi Streptozopin Kintoko Kintoko; Rifqi Ferry Balfas; Nura Ustrina; Sitarina Widyarini; Lintang Cahya Saputri; Anandita Nurwijayanti; Fajar Slamet Riana; Neni Tri Anggraini
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Based on Basic Health Research, in Yogyakarta the incidence of diabetes mellitus based on doctor's diagnosis is 2.6% and symptoms will increase with age, but will decrease from age> 65 years. In the treatment of diabetes mellitus there are several treatments with synthetic drugs and natural ingredients for natural ingredients such as Spirulina platensis. Spirulina platensis is one of the microalgae that contains the natural spectrum of carotene and xantophyll pigment mixtures, and with fikocyanin has antioxidant activity, and Spirulina platensis can show a decrease in blood sugar. The type of research conducted is an experimental study. Spirulina platensis is made with several doses of 36 mg, 72 mg, and 144 mg. Rats were divided into 6 groups, 5 groups of streptozotosin induced at a dose of 45 mg / kgBW until the mice had DM were characterized by high KGD yield, then given spirulina suspension, measured in sugar levels on days 0-28. After that the mice in the blood and then analyzed the effect of Spirulina platensis on creatinine and urea in blood. The results were analyzed using SPSS ANOVA and Post Hoc Test methods with 95% confidence level. The results of the analysis of levels in various groups showed that in the induction of streptozotocin treated with spirulina plantesis various doses there was improvement in each analysis of the levels obtained, and also at the dose STZ+SP 36 in each analysis can improve the level of analysis. While on histopathology result and insulin expression in pancreas and histology and expression of glucose transporter 4 and histopathology on kidney and liver showed good change at various treatment dose group especially in STZ+SP 36 group. So at STZ+SP 36 dose showing the change both in this study.

Aktivitas Antibiotik Isolat Bakteri Kp13 dan Analisa Kebocoran Sel Bakteri Escherichia coli Alfian Syarifuddin; Nanik Sulistyani; Kintoko Kintoko
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

A bacterium is one of microorganisms that can produce secondary metabolite, such as antibiotic. KP13 isolate is a bacterium isolated from Melaleucaleuca dendron L rhizosphere. The aim of this study is to know the eff ect of the most active fraction antibacterium of KP13 isolate toward Escherichia coli bacterium and the ability to caused cell leakage. Extraction of antibiotic was conducted by ethyl acetate. Extract is fractioned with a n-heksan-etilacetate solvent gradient another uses a solvent methanol. Each fraction is done by KLT and grouped based on RF value. A fraction group is compare by inhibition eff ectiveness. Then, the Minimum Inhibitory Concentration (MIC) from the most active group is tested. Cell leakage analysis was performed using UV spectrophotometry to detect the release of nucleic acid and protein. Atomic Absorption Spectrophotometry (AAS) was used to detect ion release of K+ and Ca2+ from. cell of bacteria. The results showed that the most active fraction against Escherichia coli was the fraction number 1 with MIC value of 5% and inhibition zone of 7.33±0.58 mm.

Peranan Kebijakan Obat dalam Memperbaiki Keterjangkauan Obat Yusi Anggriani
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Medicine is a pharmaceutical product that has imperfect market characteristics. This affects affordability to the community, and therefore it is necessary for the government to regulate medicine prices. Medicine prices can be regulated in the medicine supply chain by the industry, importers, distributors and health facilities such as pharmacies, hospitals and medicine sellers. Developed and high income countries generally regulate the prices of medicines and are part of a health insurance system. In contrast with the situation in developed countries, medicine pricing regulation in developing countries and Lower Middle Income Countries is not well established. The regulation of mark-ups in distribution channels is the most common strategy used by LMIC. Small country with only a few pharmaceutical facilities has a weak bargaining position, generally the government cannot set prices. The application of cost-plus pricing is quite effective if it is implemented in a small country. In developing countries with a large market segment and adequate pharmaceutical industry facilities the price competition method is an effective strategy option to get lower prices. In practice, the application of medicine pricing policy is dynamic. The medicine pricing system in a country can be changed or combined with other methods if the evaluation does not provide optimal results or generates unintended impacts.

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Syafira Dwi Cahyani

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Editorial Office: Lenteng Agung St, Srengseng Sawah District, Jagakarsa Regency, Jakarta Selatan, Special Region of Jakarta 12640, Indonesia.

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INDONESIA

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Home Page

OAI Link

Editorial Team

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Reviewer

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Contact Name Syafira Dwi Cahyani

Contact Email adminjifi@univpancasila.ac.id

Phone +6287780957284

Journal Mail Official syafira.ffup@univpancasila.ac.id

Editorial Address Editorial Office: Lenteng Agung St, Srengseng Sawah District, Jagakarsa Regency, Jakarta Selatan, Special Region of Jakarta 12640, Indonesia.

Location Kota adm. jakarta selatan, Dki jakarta INDONESIA

Abstract

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Abstract

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Abstract

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Abstract

Contact Name
Syafira Dwi Cahyani

Contact Email
adminjifi@univpancasila.ac.id

Phone
+6287780957284

Journal Mail Official
syafira.ffup@univpancasila.ac.id

Editorial Address
Editorial Office: Lenteng Agung St, Srengseng Sawah District, Jagakarsa Regency, Jakarta Selatan, Special Region of Jakarta 12640, Indonesia.

Location
Kota adm. jakarta selatan,

Dki jakarta

INDONESIA