Jurnal Ilmu Kefarmasian Indonesia
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
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<![CDATA[Peningkatan Laju Difusi Allisin dalam Sistem Fitosom Ekstrak Bawang Putih ]]>
<![CDATA[Anisa Amalia]]>;
<![CDATA[Rahmah Elfiyani]]>;
<![CDATA[Adesi Chenia]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 1 (2021): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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DOI: 10.35814/jifi.v19i1.842
<![CDATA[Garlic (Allium sativum L) contains allicin which has the property of reducing blood sugar levels. In previous studies, methanol extract of garlic can reduce blood sugar levels in mice at a dose of 400 mg/kg BW. Penetration of allicin can be increased by formulating extracts in the phytosome system. In this study, it will be observed the effect of making a phytosome system on the diffusion rate of allicin. Garlic extract phytosome was made using a thin layer hydration method which was then evaluated for its physicochemical properties which included testing of entrapment efficiency, density, particle size, index polydispersity, and zeta potential. Determination of the value of the diffusion rate of allicin in the extract and in the phytosome system was carried out using a modified diffusion cell for 420 minutes. The phytosome system formed has an entrapment efficiency value of 64.8789% with a density of 1.0051 g/mL, the particle size of 270 nm, the zeta potential of -32.55 mV and polydispersion index of 0.571. Diffusion rate testing indicates the diffusion rate of the phytosome system can increase the diffusion rate of allicin when compared to the diffusion rate of allicin in garlic extract.]]>
<![CDATA[Formulasi dan Aktivitas Antibakteri Gel Ekstrak Daun Murbei (Morus alba L.) terhadap Staphylococcus aureus ]]>
<![CDATA[Akbar Rino Pamuladiman]]>;
<![CDATA[Lina Widiyastuti]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 1 (2021): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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DOI: 10.35814/jifi.v19i1.941
<![CDATA[Mulberry leaves (Morus alba L.) contain quercetin, a flavonoid compound with antibacterial activity against Staphylococcus aureus. For convenience, dosage accuracy, and hygiene, a gel formulation with a mixture of carbopol and propylene glycol is required. This study aimed to determine the right concentration of carbopol and propylene glycol to obtain a gel with good physical properties and antibacterial activity on Staphylococcus aureus. Mulberry leaf extract was obtained by maceration method. A factorial design method was used to optimize carbopol and propylene glycol concentrations. The parameters of gel physical properties were the viscosity, spreadability, adhesion, and pH test. The optimal area was determined by creating a contour plot of the parameters test result. Validation of the optimum formula was by comparing the prediction result to the actual research result. The data were analyzed using SPSS with a 95% confidence level. The results showed that the concentration of carbopol and propylene glycol was 1.04% and 7.85%, 1832.42 ± 62.48 cP viscosity, 5.96 ± 0.08 cm spreadability, 64.63 ± 0.97 seconds of adhesion, and pH 5.26 ± 0.03. The antibacterial test showed an inhibitory power with 28.67 ± 0.76 mm. From the teat result, it can be concluded that the gel had antibacterial activity and good physical properties.]]>
<![CDATA[Isolasi Fungi Tanah Kabupaten Situbondo serta Skrining Aktivitas Antibakteri Terhadap Pseudomonas Aeruginosa ]]>
<![CDATA[Fawwas Batio Putra Pamungkas]]>;
<![CDATA[Bawon Triatmoko]]>;
<![CDATA[Ari Satia Nugraha]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 1 (2021): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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DOI: 10.35814/jifi.v19i1.750
<![CDATA[Bacterial resistance to antibiotics is a serious concern. The search for new antibacterial compoundsfrom medicinal plants can result in overexploitation of natural ingredients. Therefore, it is necessary to search for new alternative sources. This study was aimed to fi nd new antibacterial agents derived from soil fungi isolated from swampy soil in the Pasir Putih Beach area of Situbondo Regency in inhibiting Pseudomonas aeruginosa (P. aeruginosa). Isolation was carried out using Potato Dextrose Agar (PDA) dissolved in sea water. The isolation results showed that 5 isolates fungi. The fungi IS-STB-III-4 and IS-STB-III-5 have the potential to inhibit bacterial using antagonist tests. Potential soil fungi were fermented for 14 days and extracted with ethyl acetate as a solvent. The extraction results were dissolved in 10% DMSO with a concentration series of 1000 μg /mL, 2000 μg/mL, 4000 μg/mL, 6000 μg/mL, 8000 μg/mL which will be used for antibacterial activity test using the disc diff usion method. The extract activity test showed results that were directly proportional to the extract concentration. The analysis and profi ling of the extract using High Performance Liquid Chromatography (HPLC) instrument showed that the extract contained alkaloids which were then isolated and identifi ed by HPLC.]]>
<![CDATA[Efek Ekstrak Etanol Kulit Petai (Parkia speciosa) Terhadap Fungsi Hepar Rattus norvegicus yang Terpapar Minyak Goreng Bekas ]]>
<![CDATA[Fafa Nurdyansyah]]>;
<![CDATA[Dyah Ayu Widyastuti]]>;
<![CDATA[Andita Ayu Mandasari]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 1 (2021): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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DOI: 10.35814/jifi.v19i1.795
<![CDATA[The use of cooking oil repeatedly is one of liver damage trigger which usually be marked byenhancement of SGPT and SGOT level. The objective of this study is to know the eff ect of P. speciosa peelethanolic extract in used cooking oil exposed Wistar rats (R. norvegicus). The indicator are SGPT and SGOTconcentration. Parkia speciosa peel was extracted then use to antioxidant source. Rattus norvegicus was divided into 4 group. Group 1 with no treatment, group 2 with 1 ml used cooking oil 118 mek/kg and 100 mg/l extract, group 3 with 1 ml used cooking oil 118 mek/kg and 200 mg/l extract, and group 4 as positive control with 1 ml used cooking oil 118 mek/kg. Each group serum sample was analyzed for SGPT and SGOT. The result showed that 200 mg extract treatment is signifi cantly bring lower SGPT and SGOT concentration compared to positive control. The higher dose of ethanolic extract of P. speciosa peel is highly prevent liver damage which indicated by the lower SGPT and SGOT concentration in serum. The ethanolic extract of P. speciosa peel has potential to ward off free radicals which caused by used cooking oil exposed. That fact was be marked by SGPT and SGOT decreasing persentage.]]>
<![CDATA[Uji Aktivitas Ekstrak Etanol 70% Daun Kaliandra Merah (Calliandra calothyrsus Meisn.) sebagai Penurun Kadar Glukosa Darah pada Tikus Hiperglikemia ]]>
<![CDATA[Dwitiyanti Dwitiyanti]]>;
<![CDATA[Hayati Hayati]]>;
<![CDATA[Sindi Anggraeni]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 1 (2021): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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DOI: 10.35814/jifi.v19i1.916
<![CDATA[Diabetes mellitus (DM) is an increase in blood glucose levels due to impaired metabolism of carbohydrates, fats, and proteins. Red kaliandra leaf (Calliandra calothyrsus Meisn.) contains tocopherol, carotenoid, flavonoid, saponin, and tannin compounds are natural sources of non-enzymatic antioxidants. The active compound has inhibitory activity against the α-glucosidase enzyme so that it can be potential as an antidiabetic. This study aims to determine the activity of 70% ethanol extract of red calliandra leaves on the decrease in blood glucose levels in male white rats Sprague Dawley hyperglycemia strain. Test animals were divided into 6 groups consisting of normal controls (standard feed), negative controls (alloxan induction), positive controls (metformin HCL dose 51.38 mg/kg), group I dose (50 mg/kg), dose II (100 mg/kg), and dose III (200 mg/kg). Data were analyzed using one way ANOVA and continued by Tukey test. The results showed that doses 1, 2, and 3 can reduce blood glucose. Dose 3 had a decrease in the percentage of 58.08% which was comparable to a positive control (metformin HCl dose 51.38 mg/kg) of 63.85%.]]>
<![CDATA[Efek Ekstrak Daun Sambung Nyawa (Gynura procumbens) untuk Mengurangi Ketombe pada Kulit Kepala ]]>
<![CDATA[Neneng Siti Silfi Ambarwati]]>;
<![CDATA[Rita Susesty]]>;
<![CDATA[Devi Sulastiowati]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 1 (2021): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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DOI: 10.35814/jifi.v19i1.942
<![CDATA[Gynura procumbens is a medicinal plant commonly used in Asian countries such as China, Thailand, Indonesia, Malaysia, and Vietnam. G. procumbens content flavonoids and glycosides and have bacteria activity and anti-fungal activity such as Candida albicans and Aspergillus niger. The purpose of this study was to obtain empirical data about the effect of using the G. procumbens leaves extract on reducing dandruff on the scalp. The extract was obtained by the maceration method using 70% ethanol solvent. The phytochemical compound content is determined with spectrophotometry ultraviolet. Two observers observe the scalp by using observation sheets and grating instruments assisted by a skin and hair analyzer. The reduction of scalp dandruff was the difference between the initial the results and the final test (after treatment). The sample was selected using a purposive sampling technique totaling ten people and divided into two groups (experimental and control groups). The results showed that the calculation of hypothesis testing after analyzing the data obtained a value of t count (5.817)>t table (1.86). This showed an effect of using the G. procumbens leaves extract as a shampoo for reducing dandruff on the scalp. The use of G. procumbens leaves extract as shampoo can reduce dandruff.]]>
<![CDATA[Formulasi dan Uji Inhibitor Tirosinase Masker Peel-Off Ekstrak Etanol 96% Kulit Buah Jeruk Nipis (Citrus aurantifolia) ]]>
<![CDATA[Ari Widayanti]]>;
<![CDATA[Rini Prastiwi]]>;
<![CDATA[Kartika Tiara Wijayanti]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 1 (2021): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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DOI: 10.35814/jifi.v19i1.764
<![CDATA[Tyrosinase is an enzyme that is widely distributed in microorganisms, plants and animals. Tyrosinaseis the main enzyme involved in the biosynthesis of melanin. Melanin has a very important role in skin protection, especially against exposure to ultraviolet rays which are harmful to the skin. This study aims to test the tyrosinase inhibitor in the peel-off mask of lime peel extract (Citrus aurantifolia). Lime peel extract is formulated into a peel-off mask with extract content of 0% (F1), 15% (F2) and 25% (F3) respectively and with the gelling agent PVA (Polyvinyl alcohol). The physical stability test was carried out by measuring the pH, the results obtained were F2 pH 6.85 and F3 pH 6.78. The analysis of tyrosinase inhibitor activity was carried out using a UV-Vis spectrophotometer and seen from the percent inhibition value obtained. The percent inhibition results obtained from the peel-off mask of lime extract were 17.89% (F2) and 18.86% (F3). Lime peel has the potential as a tyrosinase inhibitor.]]>
<![CDATA[Formulasi Self Nano Emulsifying Drug Delivery System (SNEDDS) Minyak Biji Jinten Hitam dengan Surfaktan Tween 80 dan Kosurfaktan Sorbitol ]]>
<![CDATA[Iis Wahyuningsih]]>;
<![CDATA[Yenni Latief]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 1 (2021): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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DOI: 10.35814/jifi.v19i1.945
<![CDATA[Black cumin seed oil has many benefits. One of which is as an anticancer, it can be used as an opportunity to develop drugs that utilizes the black cumin seed oil. A method to improve the stability and absorption of the drug in the body is within the formulation of Self Nano Emulsifying Drug Delivery System (SNEDDS). This study aims to determine whether the black cumin seed oil can be made into SNEDDS formula with tween 80 and sorbitol as a surfactant and cosurfactant along with the establishment for the optimal formula. SNEDDS formula of black cumin seed oil was optimized using SLD method by DX.10 software. SNEDDS formula was made using tween 80 as surfactant and sorbitol as cosurfactant. Previously carried out with the manufacturing of a trial formula to determine the lower and upper value of each component, then 14 formulas were made based on DX.10. The formula were evaluated for transmittance percentage in 650 nm wavelength and emulsification time of 37oC. Results of the tests included in DX10 is to obtain the optimal formula. The optimal formula was validated by t-test and evaluated for droplet size, zeta potential, and stability test of nanoemulsion in artificial gastric fluid (AGF) and artificial intestinal fluid (AIF) for 4 hours. The results showed that the proportion of 13% black cumin seed oil, 60% tween 80 and 27% sorbitol is able to establish the optimal SNEDDS formula of black cumin seed oil. Transmittan value of the optimal formula was 92% with the emulsification time of 56 seconds, SNEDDS black cumin seed oil droplet size of 21.5 nm, zeta potential value -31.5 mV and nanoemulsion stable in the AIF and AGF.]]>
<![CDATA[Evaluasi Fitokimia dan Antioksidan dari Piper hispidum Sw. yang dikoleksi dari Desa Gunung Malang pada Vegetasi yang Berbeda ]]>
<![CDATA[Vivi Anggia]]>;
<![CDATA[Rindita Rindita]]>;
<![CDATA[Fauziah Ulfa Ramadhany]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 1 (2021): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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DOI: 10.35814/jifi.v19i1.926
<![CDATA[Jamaican pepper (Piper hispidum Sw.) is a wild plant, member of Piperaceae family and invasive plant species reported used to heal wounds and treat symptoms of skin leishmaniasis. This study aims to explore phytochemicals of Piper hispidum, especially phenolic content and antioxidant capacity, in two different abiotic condition of the forest, shaded and open area. Exploration of P. hispidum was conducted in Gunung Malang Village, Halimun Salak Mountain National Park (TNGHS). The sample was extracted with the ultrasonic method. The phenolic level and antioxidant activity were determined with Folin Ciocalteu and DPPH method where gallic acid was used as a standard. The total phenolic content assay showed 70% ethanol extract of P. hispidum Sw. leaves from the shaded and open forest were 17.4775 mg GAE/g and 12.6137 mg GAE/g of sample respectively. The antioxidant activity assay showed that IC50 of the sample from shaded and open forest were 94.8414 and 94.3412 ppm and gallic acid was 7.9817 ppm. This study showed that differences in vegetation and environmental abiotic factor may contributed in the amount of chemical compounds where open vegetation exposed to the sunlight had lower values than shaded but not significantly affected the antioxidant value.]]>
<![CDATA[Efek Penurunan Kadar Glukosa Darah Rebusan Asparagus (Asparagus offi cinalis L.) Pada Mencit yang Diinduksi Aloksan ]]>
<![CDATA[Rika Sari Dewi]]>;
<![CDATA[Lestari Rahayu]]>;
<![CDATA[Ni Made Dwi Sandhiutami]]>;
<![CDATA[Sondang Khairani]]>;
<![CDATA[Isti Atika]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 1 (2021): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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DOI: 10.35814/jifi.v19i1.956
<![CDATA[Diabetes mellitus characterized by hyperglycemia whereas the condition for high blood glucose. InIndonesia, there are a lot of medicinal plants that used as antidiabetic treatment. Medicinal plants are known have relatively few side eff ects compared to chemical based drugs. Asparagus (Asparagus offi cinalis L.) was reported to have fl avonoids and saponins compounds that could be functioned as antidiabetic. The aim of this research was to fi nd out the eff ect of boiled asparagus on blood glucose level in mice induced by Alloxan. This research used 30 male DDY strained mice, which were classifi ed into 6 groups, and each group consisted of 5 mice. These 6 groups were: normal control, negative control, positive control (Acarbose), the boiled asparagus with dose of 280, 560, and 840 mg/kgBW for 14 days. Blood glucose level of mice were observed on day-0, 8, 15, and 22. The results showed that Alloxan injection increased the level of blood glucose. Another result showed that boiled asparagus with dose of 280, 560 and 840 mg/kgBW reduced the level of blood glucose and the eff ect showed treatment groups doses of 560 dan 840 mg/kgBW had no signifi cantly diff erent with positive control group (Acarbose).]]>
