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Syafira Dwi Cahyani
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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 9 Documents
 1 
Search results for , issue "Vol 8 No 1 (2010): JIFI" : 9 Documents clear
Penggunaan Obat Herbal pada Pasien Kanker Serviks MAKSUM RADJI; HENDRI ALDRAT; YAHDIANA HARAHAP; COSPHIADI IRAWAN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 8 No 1 (2010): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Herbal medicines have widely been used to treat many type of diseases despite the advance of standard or conventional therapy. In fact, many people in Indonesia use medicinal plant as their customary part of life. Therefore, it is necessary to further explore the use of herbal medicines through modern perception. ln this study we would like to know the frequency and species of herbal medicines used among cervical cancer patients in National Cancer Hospital Dharmais, Jakarta, Indonesia and also to assess the relationship between age, education, jobs, stage of cancer, and payment status of the patients. The results were 61,8% patients used herbal medicines. The herbal medicines used most were mahkota dewa (Phaleria macrocarpa Scheetf Boerl.) 35.3%, temu putih (Curcuma zedoaria Rosc.) 32.4%, and buah merah (Pandanus conoideus Lam) 17,6%. There was a significant relationship (p=0,039) between the use of herbal medicines and stage of cancer but no relationship between age, education, occupation, income and payment status with the use of herbal medicines.
Sinergisme Fraksi Butanol Metabolit Sekunder Kapang Endofit 1.3.11 dengan Doxorubicin dalam Modulasi Daur Sel T47D dan MCF-7 SHIRLY KUMALA; EDY MEIYANTO; MUTHI IKAWATI; RIRIS ISTIGHFARI JENIE
JURNAL ILMU KEFARMASIAN INDONESIA Vol 8 No 1 (2010): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

The synergic effects of n-butanolic fraction of secondary metabolite of endophytic fungus 1.3.11 (FB) and doxorubicin (Dox) on cell cycle regulation and the expression of Bcl-2 gene expression were investigated on MCF-7 and T47-D cells by iiow cytometry and immunocytochemical techniques respectively. The results showed that after 12 hours of incubation period with FB at its IC50 dose, MCF-7 cell cycle was inhibited at G1 phase while Dox inhibited the cell cycle at G2/M phase. Similar results were observed in T47-D cells when incubated with Dox and FB individually under the same treatment condition. Further treatment was then performed to these cells where both Dox and FB were combined at their IC50 and lC50 dose and added to incubate with the cells over 12 hours period. Interestingly, the modified treatment combination showed that MCF-7 and T47-D cell cycle regulation were inhibited at G2/M phase. Our immunocytochemical study also showed no significant inhibition suppression of Bel-2 gene expression in both MCF-7 and T47-D cells when compared with their corresponding positive control after treatment with FB and Dox or both combined FB and Dox at 1C50 and IC50 dosage over 15 hours incubation.
Sintesis Hidrogel Superabsorben Polietilen Oksida-Alginat dengan Teknik Radiasi Gamma dan Karakterisasinya ERIZAL ERIZAL; I WAYAN REDJA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 8 No 1 (2010): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Abstract: In order to develop the applications of radiation for biomaterial preparation, a non-toxic superabsorbent has been synthesized. A series of superbasorbent hydrogel were prepared from aqueous solution containing 5% polyethylene oxide (PEO) with different concentration of alginate (0.5-2.0%) were irradiated at the doses of 20, 30, and 40 kGy by gamma radiation.The gel fraction, swelling kinetics and the equilibrium degree of swelling (EDS) of the hydrogels were studied, It was found that the incorporation of even 2% alginate (sodium salt) increased the EDS of the hydrogels from 20g/g to 320 g/ g. At a dose of 20 kGy, PEO-alginat hydrogels with high gel fraction ( ̴ 8O%) and very high EDS ( ̴ 320 g/g) were obtained. The hydrogels were also found to be sensitive to the ionic solution of NaCl. The PEO-alginate hydrogels could be considered as candidate biomaterials in health care.
Isolasi Senyawa Aktif dari Ekstrak Hipokotil Sarang Semut (Myrmecodia pendens Merr. & Perry) sebagai Penghambat Xantinoksidase PARTOMUAN SIMANJUNTAK; FANNY FANNY; MUHAMMAD AHKAM SUBROTO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 8 No 1 (2010): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Medicinal plant called “sarang semut”, Myrmecodia pendens Merr. & Perry (Rubiaceae), is an epiphyt plant traditionally used in Papua for healing various diseases such as hyperuricemia, rheumatic, and cancer. A chemical compound recognized as xanthinoxidase inhibitor has been isolated from n-buthanol fraction of the plant extract. The isolation was carried out by column chromatography (SiO2, CHCI3-MeOH = 5:1-1:1) and the purification Was conducted using high pressure liquid chromatography (RP, C-18; MeOH-water = 5 : 1). The activity test for Xanthinoxidase inhibitor Was performmed by using modilied Noro method. The pure compound showed xanthinoxidase inhibitor activity of IC50 at 79,77%.
Aktivitas Sitotoksik Ekstrak Etanol Daun Aglaia elliptica Blume terhadap Galur Sel Kanker Serviks (HeLa) WAHONO SUMARYONO; AGUN ERU WIBOWO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 8 No 1 (2010): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Cytotoxicity tests on ethanol extract of Aglaia elliptica Blume leaves and its fractions on cervical cancer cell line (HeLa) were carried out. Dried powder of Aglaia elliptica leaves was extracted using ethanol andthen fractionated by n-hexane, ethyl acetate, and buthanol solvents. The cytotoxicity tests using MTT method (prolipheration inhibiton test) on HeLa cell lines were conducted for ethanol extract, n-hexana, ethyl acetate, and buthanol lractions.The results showed that the ethanol extract of Aglaia elliptica and its fractions have inhibition effect against HeLa cell line with IC50 of 282.44 ppm, 177.64 ppm, 16.03 ppm, 211.77 ppm, 181.33 ppm for ethanol extract, n-hexane, ethyl acetate, buthanol, and Water fractions respectively.
Pengaruh Lupene-ol dan Lupene-on dari Aegle marmelos Correa terhadap Pelepasan Enzim β-hexoaminidase dari Sel Mast AGUNG ENDRO NUGROHO; SUGENG RIYANTO; MOHAMAD ASPOLLAH SUKARI; KAZUTAKA MAEYAMA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 8 No 1 (2010): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

20(29)-lupene-3α-ol and 20(29)-lupene-3-on are pentacyclic triterpenes isolated from Aegle marmelos Correa collected in Yogyakarta, Indonesia. Their molecular structures were confirmed in Universiti Putra Malaysia. These compounds were obtained from petroleum ether extract of the plant’s stem bark. This study investigated the effects of the compounds on the β -hexoaminidase enzyme release from mast cell culture (RBL-2H3 cell line). DNP24-BSA was used as immunologic inducer for the β -hexoaminidase release from the mast cells. The enzyme release was determined by colorimetric methods with a substrate, p-nytrophenyl-2-acetamydo-2-deoxy- β -D-gluko-pyranocide, and a microplate reader at 405 nm. lt was found that treatment with 20 µg/ml DNP24-B SA could stimulate the release of β -hexoaminidase from RBL-ZH3 cells by 3O.83 ± 1.10%. Lupene-ol and lupene-on showed inhibitory effects on the β -hexoaminidase release from RBL-2H3 cells induced by DNP24-BSA in dose-dependent manner. At the dose of 100 µM, lupene-ol and lupene-on inhibited the β -hexoaminidaserelease by 35.69i4.7 5% and 39.19 9.56%, respectively. The ICN values of their effects on DNP24-BSA experiments were 59.40 µM and 72.51 µM. The results suggested that the inhibitory effect of lupene-ol and lupene-on on the β-hexoaminidase release involved mechanisms related to the interaction of IgE on the RBL-2H3 cells surface or intracellular signal transductions found in the mast cell degranulation. Key words: Aegle marmelos Correa, lupene-ol, lupene-on, mast cells, β -hexoaminidase enzyme.
Penandaan Falerin dengan Iodium-131 dan Uji Biodistribusi pada Mencit yang Diinduksi Inflamasi WIDYASTUTI WIDJAKSANA; AGUS ARIYANTO; GINA MONDRIDA; ARINA KUSUMAWARDANI; AS' ARI NAWAWI; ABDUL MUTALIB
JURNAL ILMU KEFARMASIAN INDONESIA Vol 8 No 1 (2010): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Phalerin is an active component of mahkota dewa (Phaleria macrocarpa (Scheff) Boerl) proven to have an anti-inflammation effect. The labeling of phalerin with gamma emitting radionuclides was aimed to study its pharmacokinetic behavior and particularly to trace its metabolites. The labeling with 131I was caried out using iodogen as oxidator. Radiolabeled compound was characterized by high performance liquid chromatography (HPLC) using C- 18 column eluted with methanol 70% and detected with UV detector (λ=291 nm) and by thin layer chromatography (TLC) using silica gel strips eluted with chloroform-methanol (9:2), and labeling efficiency was determined using the same TLC system. Purification of radiolabeled product Was carried out using size exclusion chromatography (Sephadex G-25 column) eluted with 0.05 M phosphate buffer pH 7.4. Biodistributions of 131l-phalerin in various organs of normal and inilammation-induced mice were observed at 1, 4, and 24 hours post-intravenous injection. Radiochemical purity of 131l-phalerin was 90.2 ± 2.8% and increased to 96.0 ± 0.4% after purification. Radioactivities in inflamed tissue at 1, 4, and 24 hours post-injection were respectively 1.6 times, 1.4 times, and 1.3 times higher than that in normal tissue, The results showed a significant uptake of radiolabeled phalerin in inflamed tissue.
Formulasi Edible Film Ekstrak Daun Sirih (Piper betle L.) sebagai Antihalitosis MOCH FUTUCHUL ARIFIN; LILIEK NUR HIDAYATI; SYARMALINA SYARMALINA; RENSY RENSY
JURNAL ILMU KEFARMASIAN INDONESIA Vol 8 No 1 (2010): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Halitosis (bad breath) is the most complained problem among mouth and teeth health. The source of halitosis are volatile sulfur compounds produced by Streptococcus mutans from degradation of food debris. Sirih leaves (Pqaer betle L.) are traditionally used as mouth antiseptic for its volatile oil. The aim of this research was to formulate sirih extract into an edible film. The leaves were macerated with 96% ethanol for 24 hours, resulting to an extract with minimum inhibitory concentration (MIC) on Streptococcus mutans of 8.49x10-3 g/ml. The extract with strength quadruple of the MIC, or equal to 0.92% povidone iodine, was formulated using 23 factorial design. Com starch, hydroxypropyl methylcellulose (HPMC) and sorbitol were independent variables and drying time, moisture, hlm thickness, disintegrating time, and iilrn strength were the dependent ones. The results showed that HPMC significantly fastened the drying time, decreased the moisture, and lengthened the disintegrating time. Sorbitol significantly lengthened the drying time, increased the moisture, and strengthened the film, while corn starch decreased the moisture and lengthened the disintegrating time. Optimation of the formula ingredients using contour plot superimposed cannot be determined due to edible film disintegrating time that was out of comparative interval.
Uji Sitotoksisitas Ekstrak Etanol Herba Ceplukan (Physalis angulata Linn.) terhadap Sel T47D secara In Vitro IRA DJAJANEGARA; PRIYO WAHYUDI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 8 No 1 (2010): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Cutleaf groundcheny (Physalis angulata Linn.) is a popular traditional medicine. This experiment was conducted to investigate the possible role of the herbal extract as an anticancer agent using T47D breast cancer cell line. Cytotoxicity assay was caried out by direct counting method. Breastcancer T47D cell lines Were treated with 70% ethanol extract from cutleaf groundcherry fruit with serial dilution of 2000, 1000, 500, 250, 125, 62.5, and 31.25 µg/ml for 24 hours of incubation at 37°C As a positive control doxorubicin was also tested on the breast cancer T47D cell lines with serial dilution of 20, 10, 5, 2.5, 1.25, 0.625, 0.312, and 0.156 µg/ml for 24 hours of incubation at 37°C The amount of living cells were observed and counted, death percentage was then determined and probit analysis was used to determine the LC50 value. The LC50 value for ethanol extract from the fruits was 28,02 µg/ml While doxorubicin as the positive control was 0,113 µg/ml. It is concluded that the cutleaf groundcherry (Physalis angulata) fruits have a cytotoxic activity toward T47D (breast cancer) cell lines which confirmed previous toxicity experiment using brine shrimp lethality test (BSLT) method.

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