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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 741 Documents
 71   72   73   74   75 
Natural deep eutectic solvents (NaDES) improves extraction and antioxidant activity of stem bark of Garcinia cowa Roxb. Fahleni, Fahleni; Mun'im, Abdul; Saputri, Fadlina Chany; Surini, Silvia
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1722

Abstract

Garcinia cowa Roxb. ex DC. is a plant belonging to the Clusiaceae family, and commonly dicovered in Southeast and South Asia. This study aimed to assess the efficiency of eight natural deep eutectic solvents (NaDES) in extracting total xanthones and phenolic compounds from the stem bark using ultrasound-assisted extraction as there is limited research on the use of NaDES in this plant extraction process. The study also examined their antioxidant properties. The NaDES were synthesized with choline chloride and betaine as hydrogen-bond acceptors, accompanied by various acids, alcohols, and glucose as hydrogen-bond donors. In comparison, ethanol was used as standard solvent. The NaDES exhibited higher densities than water, ranging from 1.059 to 1.244 g/cm³, with density increasing according to the number of hydroxyl groups present in the constituents. The total phenolic content (TPC) varied from 22.82 to 28.73 mg GAE/g extract, with NaDES1 (a combination of choline chloride, 1,2-propanediol, and water in a ratio of 1:3:1) showing the highest TPC at 28.73±0.18 mg GAE/g extract. It also exhibited significant antioxidant activities, as demonstrated by DPPH (28.98±0.03 µg/mL) and FRAP assays (43.66±1.51 mmol trolox/g dw). A significant negative correlation was observed between total xanthone, total phenolic content, and IC50 values. These findings suggest that NaDES, particularly NaDES1, have considerable advantages in extracting phenolic compounds and xanthones from G. cowa stem bark, resulting in enhanced antioxidant properties.This highlights the potential of NaDES as eco-friendly and effective solvents for the extraction of bioactive compounds from plant materials.
Identification and antibiotic sensitivity test of isolated aerobic bacteria from acne vulgaris Lily Suciati; Iman Santoso; Qonita Gina Fadhilah; Sogandi Sogandi
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 1 (2026): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i1.1589

Abstract

Acne vulgaris is an inflammatory skin condition caused by various factors, including bacteria in the sebaceous glands of the dermis. Inflammation in acne vulgaris can lead to the formation of purulent papules, known as acne papulopustulosa. Treatment options for acne vulgaris include topical antibiotics, such as clindamycin, and oral antibiotics, such as tetracycline, minocycline, and doxycycline. This study aimed to isolate and identify aerobic bacteria associated with acne vulgaris and assess their susceptibility to commonly used antibiotics. Aerobic bacteria from the papulopustules of six patients were isolated using the quadrant streak method on Mueller Hinton Agar (MHA) and Mannitol Salt Agar (MSA). Twelve isolates were obtained, characterized using Gram staining, catalase, and oxidase tests, and identified by 16S rRNA sequencing. The most common bacteria were Staphylococcus spp. (five patients), followed by Klebsiella sp. (two patients), Enterobacter sp. (one patient), and Citrobacter sp. (one patient). Sensitivity testing was conducted with tetracycline, minocycline, doxycycline, and clindamycin, following the Clinical Laboratory Standards Institute (CLSI) guidelines. The results showed that the effectiveness of tetracycline was 50.0%, minocycline 58.3%, and doxycycline 58.3%, while all isolates were resistant to clindamycin. Due to the small sample size, the findings should be interpreted as preliminary and descriptive, providing exploratory insight into the diversity of aerobic bacteria in acne lesions and their antibiotic susceptibility.
Adherence and blood pressure control in hypertensive patients: a cross-sectional study Intan Sukma Larasati; Eva Nurinda; Ari Susiana Wulandari; Nurul Kusumawardani; Sofyan Indrayana; Danang Prasetyaning Amukti
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 1 (2026): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i1.1641

Abstract

In 2023, the prevalence of hypertension in the Special Region of Yogyakarta was  31.8%, with 24% of patients inconsistent adherence to therapy. This study was a cross-sectional study which examined the link between adherence to medication and lifestyle changes with blood pressure control among 120 hypertensive patients in the Hypertension Class Program at Bambanglipuro Primary Health Center using an adherence questionnaire. Most participants exhibited low adherence to both medication (54.2%) and lifestyle interventions (73.3%). The cut-off point for grouping respondents into low and high adherence is based on the median value of the respondents' questionnaire scores (because the data is not normally distributed). Uncontrolled blood pressure was prevalent, with a mean systolic pressure of 151.95±11.45 mmHg and a mean diastolic pressure of 87.14±10.45 mmHg. Spearman's rho analysis revealed a statistically significant relationship between adherence and blood pressure control (p<0.001), with a strong negative correlation observed for medication adherence (r = -0.530) and a moderate negative correlation for lifestyle adherence (r = -0.404). Furthermore, low adherence was associated with a substantially increased risk of uncontrolled blood pressure, with odds ratios of 11.30 (95% CI: 4.70–27.21) for medication adherence and 6.82 (95% CI: 2.77–16.80) for lifestyle adherence. These findings underscore the critical importance of improving patient adherence to both pharmacological and non-pharmacological management strategies to achieve optimal blood pressure control.
Socio-demographic determinants and prevalence of traditional medicine product use in Bali: implications for healthcare integration Ni Made Umi Kartika Dewi; Sri Sulistyawati Anton; Dewi Puspita Apsari; Luh Seri Ani; Agung Wiwiek Indrayani; Pande Putu Januraga
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 1 (2026): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i1.1672

Abstract

Traditional medicine products (TMPs) are integral to Balinese cultural practices. This study examined the socio-demographic determinants of TMP use through a cross-sectional survey of 440 households across all districts and cities in Bali province. A multistage cluster sampling method was applied, and data were collected using a structured questionnaire validated by expert review and tested for reliability (Cronbach’s alpha = 0.82). The results showed that 76.1% of the respondents used TMPs. The key predictors included age, gender, income, and residence. Middle-aged adults (46–55 years) had the highest odds of TMP use (OR = 5.667), followed by urban residents (OR = 4.999), individuals with no income (OR = 4.681), those earning below the provincial minimum wage (OR = 2.496), and women (OR = 1.838). These trends may be linked to cultural familiarity, financial barriers, caregiving roles, and increased product availability in urban areas. These findings underscore the need to integrate TMPs into Bali’s healthcare system through policy regulation, clinical guidelines, community education, and interprofessional training. Integration efforts must also address challenges such as regulatory oversight, product standardization, and patient safety. This study provides a foundation for developing culturally informed public health strategies to ensure the safe and effective use of TMP.
Antidiabetic, antioxidant activities and bioactive compound profile of extracts and fractions of tawar seribu root (Bauhinia purpurea) Rizka Mulya Miranti; Yulianita Pratiwi Indah Lestari; Nurul Fajeriyati
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 1 (2026): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i1.1703

Abstract

Diabetes mellitus is a global health challenge that requires innovative solutions. This study aimed to evaluate the antidiabetic and antioxidant potentials of the root extract and its fractions of Bauhinia purpurea (Tawar Seribu). Extraction was performed using 95% ethanol as a solvent through the maceration method, followed by stepwise fractionation with n-hexane, ethyl acetate, and water. The biological activities were evaluated using the α-glucosidase enzyme inhibition assay for antidiabetic activity and the DPPH assay for antioxidant activity. The results revealed that The aqueous fraction exhibited the strongest α-glucosidase inhibitory activity (IC50 = 26.61 ppm), whereas the ethyl acetate fraction exhibited the highest antioxidant activity (IC50 = 36.73 ppm). GC-MS analysis revealed the presence of bioactive compounds such as 24-norursa-3,12-diene, olean-12-en-3-ol acetate, and lupeol, which support these biological activities. This study concludes that tawar seribu root holds great potential as a natural alternative for managing diabetes and oxidative stress, paving the way for further development as an effective and safe herbal medicine.
Barriers and facilitators of medication reconciliation through the Consolidated Framework for Implementation Research (CFIR): a systematic review Fathul Muin; Akbar Eka Nugraha
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 1 (2026): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i1.2026

Abstract

Medication reconciliation (MedRec) is an intervention that ensures patient safety during healthcare transitions. The Consolidated Framework for Implementation Research (CFIR) was applied to deduce the contextual factors that impact the adoption of MedRec. This systematic review aimed to synthesize evidence on MedRec or pharmacist-led transition-of-care interventions that applied CFIR. A systematic review was conducted according to the PRISMA guidelines. Searches were performed in PubMed, Scopus, and ScienceDirect for studies published between 2000 and 2025 that employed Boolean operators (AND/OR) with keywords (“medication reconciliation” OR “pharmacist-led transition” OR “Pharmacist Discharge Care”) AND (“Consolidated Framework for Implementation Research” OR “CFIR” OR “Implementation Research”). Eligible studies were peer-reviewed, mixed-methods, or implementation research that applied the CFIR to evaluate MedRec. A total of 690 studies were identified and screened by title and abstract, followed by a full-text assessment. Six studies were considered for inclusion after full-text screening. Data were extracted and synthesized narratively, and the findings were mapped across the five CFIR domains. Key facilitators were primarily related to Intervention Characteristics, including adaptability and perceived value, and Inner Setting, including leadership engagement and a supportive organizational culture. The characteristics of individuals included clinical expertise and commitment to medication safety, while effective interprofessional communication supported the implementation across settings. Common barriers were identified within the Inner Setting and Process domains, including limited resources, unclear professional roles, insufficient training, and poor integration of MedRec into existing work flows. The Outer Setting was less frequently reported but reflected patient needs and broader system-level influences. Overall, the CFIR provides a comprehensive framework for understanding the determinants affecting the implementation of MedRec.
Optimization of red algae (Kappaphycus alvarezii) lozenges: formulation design and antioxidant evaluation Putriana Rachmawati; Brian Tinanto; Mathias Lourdion Kusnaman; Pretty Falena Atmanda Kambira
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 1 (2026): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i1.2027

Abstract

Red algae (Kappaphycus alvarezii) are a marine resource containing bioactive compounds, such as flavonoids and carotenoids, with potential antioxidant properties. This study aimed to develop lozenge formulations of red algae powder using direct compression, optimize the excipient composition, and evaluate the physicochemical properties and antioxidant activity. Red algae powder was characterized microscopically and by LC–MS, confirming the presence of quercetin, rutin, kaempferol, and astaxanthin in the powder. Five lozenge formulations (F1–F5) were prepared using varying concentrations of hydroxypropyl methylcellulose (HPMC) and starch. In-process evaluation included flow rate, angle of repose, loss on drying, and particle size distribution, while post-compression testing covered organoleptic properties, weight variation, hardness, friability, surface abrasion, and disintegration time. Antioxidant activity was determined using the DPPH radical scavenging assay, with quercetin as the standard. All formulations met the pharmacopeia standards, with hardness ranging from 74.3–111.1 N, friability 0.61–0.98%, and disintegration times 6.61–15.88 min. Optimization using a Simplex Lattice Design identified Formula 3 (3.5% HPMC and 10.5% starch) as the most desirable composition. The red algae powder and lozenge exhibited weak antioxidant activity, with IC₅₀ values of 5,969 ppm and 6,854 ppm, respectively. These findings demonstrate that lozenges containing red algae powder can be successfully produced with acceptable physical properties; however, improvement of raw material standardization or enrichment is required to enhance antioxidant efficacy.
Effect of Stichopus hermanii extract on interleukin-6 levels in a high-fat diet-induced rat model of inflammation Diah Purwaningsari; Sihning Endah J. Tehupuring; Nita Pranitasari; Lestari Dewi
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 1 (2026): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i1.2030

Abstract

Atherosclerosis is a major contributor to cardiovascular diseases and is increasingly recognized as a chronic low-grade inflammatory disorder involving oxidative stress and immune-mediated mechanisms. Interleukin-6 (IL-6) is a key proinflammatory cytokine that links oxidative stress and immune responses and has been widely associated with the progression of inflammation-related vascular conditions and the acceleration of atherosclerosis. The adverse effects of current pharmaceuticals have driven interest in herbal alternatives with fewer side effects. Sea cucumbers are recognized as potent biomedical resources with bioactivities against atherosclerotic pathways. This study aimed to identify the effects of Stichopus hermanii extract on IL-6 levels in a rat model of atherosclerosis induced by a high-fat diet. An experimental in vivo study utilizing a post-test-only control group design was performed on 32 Wistar rats, categorized into four groups: negative control (standard diet), positive control (high-fat diet), and two treatment groups administered Stichopus hermanii extract at dosages of 35 mg and 40 mg per 200 g body weight. IL-6 concentrations were markedly increased in rats subjected to a high-fat diet compared to those in the conventional diet group (p<0.05). Stichopus hermanii extract at both dosages markedly diminished IL-6 concentrations compared to the positive control group. The 40 mg dose reinstated IL-6 levels to those similar to the negative control group, signifying a dose-dependent anti-inflammatory effect. The extract of Stichopus hermanii successfully regulated IL-6 levels in rats with atherosclerosis induced by a high-fat diet, indicating its potential as a natural anti-inflammatory and cardioprotective agent for managing atherosclerosis.
Comparative evaluation of magnetic stirrer and homogeniser on globules characterization and stability of red palm oil submicroemulsion prepared by d-phase emulsification method Elsa Fitria Apriani; Tommy Julianto Bustami Effendi; Windy Keumala Budianti; Mahdi Jufri
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 1 (2026): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i1.2042

Abstract

Red palm oil (RPO) contains antioxidants due to its carotenoid and vitamin E content. However, the lipophilicity and instability of these two compounds may reduce RPO's bioavailability and efficacy of RPO. This study aimed to develop RPO submicroemulsions and evaluate the effects of magnetic stirrer (M) and homogeniser (H) on their characteristics and physical stability. A submicroemulsion was developed using the D-phase emulsification method. Formulas with globule sizes less than 200 nm, polydispersity index (PDI) less than 0.4, and zeta potential less than -30 mV were tested for stability at room temperature for 3 months and analysed for Ostwald ripening rates. The homogenizer method produced smaller globule sizes and lower PDI (p<0.05). Ten formulations from both the magnetic stirrer and homogeniser methods met the initial globule requirements. After 3 months, F4H and F9H showed the best physical stability with globule sizes of 181.23±0.96 and 175.23±1.88 nm, PDI of 0.077±0.034 and 0.035±0.023, and zeta potential of -33.80±0.56 and -30.57±0.15 mV (p>0.05). However, F9H had a lower Ostwald ripening rate than F4H, namely 2.54×105 and 6.04×105 nm3/month, respectively. In conclusion, the homogeniser produced more stable RPO submicroemulsions than the magnetic stirrer. 
Formulation and evaluation of antioxidant activity of lip moisturizing serum containing dragon fruit pulp extract (Selenicereus monacanthus (Lem.) D.R.Hunt) and avocado pulp oil (Persea americana Mill.) Ade Irfan; Shelly Taurhesia; Kosasih
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 1 (2026): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i1.2054

Abstract

This study aimed to formulate and evaluate a lip moisturizing serum containing dragon fruit extract (Selenicereus monacanthus (Lem.) D.R.Hunt) and avocado oil (Persea americana Mill.) with a focus on antioxidant activity, moisturizing efficacy, irritation potential, and physical stability. The combination of both ingredients was optimized at a 2:1 ratio of extract to oil, which exhibited the highest antioxidant activity. Based on this ratio, three serum formulations were developed: F0 (placebo), F1 (100×), and F2 (200×). The formulations were evaluated for their physicochemical properties, antioxidant capacity, moisturizing performance, irritation response, and stability using a cycling test. The results demonstrated that the antioxidant activity decreased after formulation but remained strong for F1 and F2 after formulation. Among all formulations, F2 exhibited optimal characteristics - strong antioxidant effect, high moisturizing ability, stable physicochemical properties, and no signs of irritation. These findings indicate that the 2:1 combination of dragon fruit extract and avocado oil can be successfully developed into a stable, effective, and antioxidant-rich natural lip-moisturizing serum.

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