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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 721 Documents
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Evaluation of the combination patch of betel leaf extract (Piper sp.) - ultrasonic assisted extraction as a transdermal delivery system on fibroblast cell formation and collagen density Valencia, Regina; Trinovita, Elsa; Shinta, Herlina Eka; Toemon, Angeline Novia; Ysrafil, Ysrafil
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1687

Abstract

The combination of red betel (Piper crocatum) and green betel (Piper betle L.) leaves is believed to act synergistically in enhancing wound healing. Transdermal patches offer advantages over conventional topical forms due to their sustained drug release, ease of application, and prolonged therapeutic effect. This study evaluated the histopathological effects of a combination patch containing betel leaf extracts for incision wound treatment in Wistar rats. The studies used an true experimental post-test-only control group design, five groups were tested: a blank patch (K−), a povidone-iodine patch (K+), and combination extract patches at concentrations of 7.5% (K1), 15% (K2), and 30% (K3), applied over 14 days with six animals per group. Patch characteristics were assessed through organoleptic tests, thickness, weight uniformity, folding endurance, and pH, while wound healing was evaluated through histological analysis of fibroblast cell counts and collagen density. Statistical analysis was conducted using the Kruskal-Wallis test followed by Mann-Whitney post-hoc tests. The 30% combination patch (K3) showed the most significant healing effect, with fibroblast counts exceeding 50 cells and dense collagen formation scoring +3. These results indicate that a transdermal patch combining Piper crocatum and Piper betle L. extracts effectively promotes wound healing by enhancing fibroblast proliferation and collagen synthesis.
PENGARUH EDUKASI E-POSTER TERHADAP PENGETAHUAN DAN SIKAP TERKAIT NYERI MUSKULOSKELETAL PADA CALON JEMAAH HAJI DI KOTA BATU Fitrah Shaliha, Khansa; Taurhesia, Shelly; Finotory Swandiny, Greesty
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1688

Abstract

Excessive free radicals accelerate skin degradation by causing oxidative damage to keratinocytes and fibroblasts, leading to structural protein breakdown (collagen, elastin, keratin), lipid peroxidation, and DNA damage. This process compromises skin barrier integrity, reduces elasticity, and promotes premature aging. Antioxidants play a crucial role in protecting the skin by neutralizing reactive oxygen species (ROS) and preventing lipid peroxidation. This study aimed to develop a topical cream containing jujube (Ziziphus mauritiana L.) and perilla (Perilla frutescens L. Britton) leaf extracts and evaluate its antioxidant activity and dermal safety. Extracts were obtained through kinetic maceration using 70% ethanol and formulated into oil-in-water creams at two concentration levels. The creams were assessed for physical characteristics (organoleptic properties, cream type, pH, homogeneity, spreadability, rheology, viscosity), stability under room and accelerated conditions (40°C for 4 weeks), antioxidant activity via DPPH assay, and irritation potential using albino rabbits. All formulations exhibited good physical properties, stability, and homogeneity. Irritation testing showed no erythema or edema, confirming the cream’s safety for topical application. Antioxidant testing revealed strong free radical scavenging activity, with IC50 values of 119.705 ppm (F1) and 66.938 ppm (F2). Accelerated storage slightly reduced antioxidant activity, while higher extract concentrations enhanced antioxidant effects compared to the base formulation. These findings indicate that jujube (Ziziphus mauritiana L.) and perilla (Perilla frutescens L. Britton) leaf extracts synergistically enhance antioxidant activity in a safe topical cream formulation, demonstrating potential as a natural preparation for skin protection against oxidative damage.
Analisis Waktu Tunggu Pelayanan Resep dan Faktor-Faktor yang Mempengaruhi di Rumah Sakit Pemerintah, Surabaya Thesa Ghozali, Muhammad; Jean Rassyifa, Aloina; Faradiba, Faradiba; Septiani Damanik, Ferina; Sari, Seftika; Satibi, Satibi; Fortwengel, Gerhard
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1693

Abstract

Electronic Medical Records (EMRs) are increasingly recognized as vital tools for enhancing the efficiency, accuracy, and quality of healthcare delivery. Despite regulatory mandates in Indonesia, the adoption of EMRs remains uneven, particularly in rural healthcare settings. This study applied the Unified Theory of Acceptance and apply of Technology (UTAUT) to investigate the behavioral intention of healthcare professionals working in private hospitals to use electronic medical records. A quantitative, cross-sectional design was implemented involving 90 participants selected through purposive sampling in an Indonesian hospital. The study's data were gathered between October 2024 and January 2025 using a validated 18-item UTAUT-based questionnaire. Data analysis was conducted with SPSS and SmartPLS software. Results indicated that all four UTAUT construct – Performance Expectancy (β = 0.200, p = 0.016), Effort Expectancy (β = 0.353, p < 0.001), Social Influence (β = 0.291, p < 0.001), and Facilitating Conditions (β = 0.262, p = 0.008 – had statistically significant positive effects on Behavioral Intention. The model demonstrated moderate explanatory power (R² = 0.655) and strong predictive relevance (Q² = 0.512). These results validate the UTAUT model's suitability in this context and provide practical insights for strengthening EMR implementation strategies. Future research should consider longitudinal approaches and multi-site comparisons to enhance generalizability and policy relevance.
Evaluation of the rationality of drugs use inpatient patients with type 2 diabetes mellitus of 2023 at Hospital Y Depok Khairani, Sondang; Manninda, Reise; Wijayanti, Bitya Aulia
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1694

Abstract

Diabetes mellitus is a chronic disease caused by failure to control blood glucose levels. Type 2 Diabetes Mellitus (T2DM) is a condition of hyperglycemia caused by the failure of insulin to maintain balanced blood sugar levels. If T2DM is not treated it will cause complications. One way to control T2DM is the rational use of antidiabetic drugs. This study aims to look at the demographic data of inpatients with T2DM, patterns of drug use, rationality for drug use, and the relationship between the rationality of drug use and therapeutic outcomes in inpatients with T2DM at Hospital Y Depok for the period 2023. The outcome evaluated is a random blood sugar test. The research method was carried out descriptively and inferentially with a cross-sectional design. There were 122 samples that met the inclusion criteria, women predominantly suffered from type 2 diabetes mellitus (50.89%). The most common age range was 46-65 years (64.56%). As many as 84.31% of patients used the JKN payment method. The most widely used class of type 2 diabetes mellitus medication is insulin. In evaluating the rationality of using type 2 diabetes mellitus drugs, the rationality results were 99.49% correct drug, 100% correct dose, and 98.73% correct administration. The results of statistical tests show that there is a correlation between the rationality of drug use and clinical outcomes p-value 0.001.
Gastroprotective effect test of ekor naga leaves extract (Rhaphidophora pinnata (L.f) Schott) on male white rats Sani K, Fathnur; Putri, Kresentia; Elisma, Elisma; Lestari, Uce; Maharini, Indri; Yuliawati, Yuliawati
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1698

Abstract

Rhaphidophora pinnata leaves are one of the herbal plants that have pharmacological effects. Previous research has shown that ekor naga leaves contain secondary metabolites with tonic pharmacological effects, including the ability to heal cut wounds, as well as antihyperglycemic and antidiabetic properties. This research aims to demonstrate the potential of ekor naga leaf extract as a gastroprotective agent. The extract was evaluated using standard methods, including determination of water content, ash content, phytochemical screening, and compound identification by LC-MS. Gastroprotective testing was carried out by dividing the treatment group into six groups, including the Group 1: normal group, Group 2: negative control (Sodium CMC 0.5%),  Group 3: positive control (Sucralfate), Group 4: 125mg/KgBW extract, Group 5: 250 mg/KgBW extract, and Group 6: 500mg/KgBW extract. The results of the observations were in the form of gastric ulcer severity scores and histological images of the gastric organs. Gastroprotective testing revealed significant differences between the treatment groups and the negative control group (p<0.05). The 500 mg/kgBW extract exhibited the most effective gastroprotective effect, with a 42.5% inhibition rate and minimal inflammation observed both macroscopically and microscopically. These results suggest that ethanol extract from ekor naga leaves may serve as an alternative or complementary therapy for gastritis.
Molecular docking and pharmacokinetic prediction of isoniazid and curcumin compounds against N-acetyltransferase 2 (NAT2) protein Simanullang, Gayatri; Rahayyu, Annisa Maulidia; Nabila, Novrilia Atika; Hammami, Akmal; Wardani, Intan Kusuma
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1699

Abstract

NAT2 serves as the key enzyme responsible for metabolizing the INH compound, with its expression and functional activity significantly contributing to the risk of hepatotoxicity. Due to the possible inhibitory role of curcumin on NAT2, it is important to assess its effect on the metabolic processing of INH and to examine the enzyme-related interactions that may occur between drugs. Molecular docking studies demonstrated that curcumin can localize in the hydrophobic pocket and form a strong bond with NAT2. The aim of this study was to predict the potential interaction of the isoniazid and curcumin compounds against NAT2 protein. In this study, NAT2 protein (PDB ID: 2PFR) was used as a receptor. The results obtained showed the binding energies of native ligand, isoniazid, and curcumin were -5.78, -4.47, -8.35 kcal/mol, respectively. The findings of this research suggest that curcumin is capable of suppressing NAT2 activity, thereby affecting the pharmacokinetics of INH. These results may offer insights into minimizing INH-related liver toxicity and enhancing its effectiveness through co-administration with curcumin.
Adverse events among pulmonary drug-resistant tuberculosis patients in Banten, Indonesia Restinia, Mita; Siddiqa, Alyya; Sari, Wulan Purnama
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1704

Abstract

Drug-resistant Tuberculosis (DR-TB) treatment requires an extended duration, making adverse events (AEs) a common concern. This study aimed to assess the frequency of AEs, time to events, and their association with treatment outcomes among DR- pulmonary TB patients. A retrospective cohort study was conducted on patients aged >18 years at one of public hospitals at Tangerang, Banten, Indonesia, from March 2021 to May 2023. Bivariate analysis was used to analyze the association between AEs and treatment outcomes. Among 53 patients included in the study, all experienced at least one AEs. Number of AEs mean ± SD; 9.724±4.86. Mild AEs were reported in 100% of patients, while 75.5% experienced moderate AEs, and 81.1% experienced severe AEs. The most common AEs included nausea (90.6%), anemia (73.6%), vomiting (62.3%), decreased appetite (60.4%), and joint pain (60.4%). The AEs were frequently reported during intensive phase (4-6 months). AEs have association with treatment outcome (P<0.05). The frequency of AE among DR-TB patients was high. Early detection and effective management of AEs are essential to improving treatment outcomes for DR-TB patients.
Optimization of oil-based liquid lipstick formula from sesame seed oil (Sesamum indicum L.) and antibacterial activity test against Staphylococcus aureus Miksusanti, Miksusanti; Wijaya, Dina Permata; Kovalina, Yosi; Sari Wardana, Mutia; Herlina, Herlina
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1712

Abstract

Liquid lipstick is a type of lip color cosmetic that consumers highly favor. However, repeated use of liquid lipstick can promote the growth of Staphylococcus aureus (S. aureus) bacteria. The formulation of liquid lipstick involves several components, including a mixture of wax, oil, and other additives. Sesame seed oil (Sesamum indicum L.), incorporated into the formulation, serves as both a base and preservative due to its fatty acid content, which is expected to inhibit the growth of S. aureus bacteria. Microcrystalline wax is added to achieve a good texture and enhance the adhesion properties of the formulation. This study aimed to determine the optimum formula and evaluate the antibacterial activity of the liquid lipstick formulation. The formula was developed using a 2² factorial design method, with sesame seed oil and microcrystalline wax as variables. The optimum formula was analyzed using Design Expert® 13 software based on parameters such as viscosity, spreadability, and adhesion. The final optimum formula consisted of 70% sesame seed oil and 5% microcrystalline wax. The formulation demonstrated good stability during the cycling test, maintaining red color, vanilla and sesame-like aroma, liquid texture, and pH 5. The viscosity was 11797.51 cP, the spreadability was 6.06 cm, and the adhesion time was 64 seconds. Antibacterial activity, assessed using the disk diffusion method, yielded an inhibition zone diameter of 15±1.322 mm, indicating a strong inhibition zone. Based on the research findings, it was concluded that the optimum sesame seed oil-based liquid lipstick formula exhibited good product characteristics, stability, and strong antibacterial activity.
Optimization of hand sanitizer gels containing soursop (Annona muricata L.) leaf extract using simplex lattice design method Kosasih, Kosasih; Lismawati, Dita; Adinugroho, Rifael Satrio
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1717

Abstract

Soursop (Annona muricata L.) is a plant whose leaf extract contains alkaloids, flavonoids, saponins, and tannins and can be antibacterial. Based on the compounds it contains, soursop leaf extract can be an active substance in hand sanitizer gel preparations. This study aims to determine the characteristics of the resulting hand sanitizer gel and the optimum concentration of the base combination that can produce a qualified hand sanitizer gel. This study used a Simplex Lattice Design experimental method with two factors (carbomer 940 and HPMC). Three hand sanitizer gels were prepared, with a ratio of carbomer 940: HPMC for F1 (1%:0%), F2 (0.5%:0.5%), and F3 (0%:1%). Tests conducted on hand sanitizer gel preparations included organoleptic, homogeneity, spreadability, adhesion, pH, and viscosity. The results of physical properties tests (spreadability, adhesion, and viscosity) were analyzed using Design Expert 11. The results showed that carbomer 940 and HPMC could increase viscosity and adhesion but could decrease spreadability. Ethanol extract of soursop leaves (Annona muricata L.) could be formulated and optimized into hand sanitizer gels. The optimum formula contained carbomer 940 0% and HPMC 1%, obtained in Formula 3 with a desirability value of 0.986.
Smoking as a risk factor for dyslipidemia: study among type 2 diabetes mellitus patients on private hospital in Yogyakarta Patramurti, Christine; Maria Virginia, Dita
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1720

Abstract

Smoking behavior is known to be a significant factor that has adverse effects on people with type 2 diabetes (T2DM). Nicotine in cigarettes stimulate adrenoreceptors and promotes lipolysis, leading to the synthesis of free fatty acids, which in turn increase the susceptibility to dyslipidemia and the development of cardiovascular disorders. This study aimed to examine the relationship between smoking status and the occurrence of dyslipidemia in patients with T2DM in a private hospital in Yogyakarta.  A total of 107 T2DM patients participated in this cross-sectional observational study. Through live interviews, we collected smoking status conducted using the Fagerström Test for Nicotine Dependence (FTND) questionnaire.  The fasting blood samples taken from participants were used to analyze the lipid profiles, including triglycerides (TG), total cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL). The chi-square test revealed a significant association between smoking status and the risk of dyslipidemia among the participants, with χ²(2) = 13.463, p = 0.001. The findings suggest that smoking increases the risk of dyslipidemia among T2DM patients. These results highlight the importance of smoking cessation as a preventive measure to reduce metabolic complications in individuals with T2DM. 

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