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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 742 Documents
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Anti-acne activity and nanoemulsion formulation of a combination of lime peel (Citrus aurantifolia (Christm.) Swingle) extract and essential oil Muhammad Aqsyal; Yesi Desmiaty; Siti Umrah Noor
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 1 (2026): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i1.2102

Abstract

Acne is a common skin disorder closely associated with bacterial infection, particularly Cutibacterium acnes and Staphylococcus epidermidis. Lime peel contains flavonoids, saponins, phenolics, tannins, and essential oils that exhibit antibacterial potential. This study aims to evaluate the anti-acne activity of a combination of lime peel extract and essential oil and to formulate it into a nanoemulsion dosage form. An experimental study was conducted using the disk diffusion method to assess anti-acne activity. The inhibition zone was measured after 24-hour incubation at 37 °C. Nanoemulsions were then prepared through ultrasonic processing and characterised using PSA and TEM. The results demonstrated that the extract–essential oil combinations at ratios 1:1, 1:2, and 2:1 produced greater inhibition zones than the single agents, indicating a synergistic effect. The nanoemulsion formulated with Alkamuls CRH 40, glycerin, and VCO produced particles <100 nm with a polydispersity index of 0.072–0.141, although the zeta potential values (−14.1 to −16.7 mV) indicated suboptimal stability. Overall, the combination of lime peel extract and essential oil exhibited significant anti-acne activity and has the potential to be developed as a topical nanoemulsion-based preparation.
Optimation of meniran (Phyllanthus niruri L.) leaf extract using natural deep eutectic solvent basis choline chloride-glycol on antioxidant Marybet Tri Retno Handayani; Yulianita Yulianita; Bina Lohitasari; Rieke Fitria P
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 22 No. 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1561

Abstract

Phyllanthus niruri L. has many benefits because it is known that meniran leaves contain secondary metabolites in the form of alkaloids, flavonoids, tannins, saponins and phenolics. The content of phenol compounds which are constituent compounds for antioxidant activity. This research was conducted to determine the combination of Natural Deep Eutectic Solvents (NADES) which can produce extracts with strong antioxidant activity. The preliminary stage determines the best combination of NADES with choline chloride as the Hydrogen Bond Acceptor and the type of sugar as the Hydrogen Bond Donor. The NADES screening obtained the best combination of choline chloride: glycerol, then the optimization stage was carried out using the RSM method with a Central Composite Design. Three variables used were temperature (25°, 40°, 60°C), time (10, 30, 60 minutes) and the ratio of NADES usage (50%, 70% and 90%). Antioxidant activity was determined with the value of in Meniran extract with positive control of vitamin C. The best NADES combination was choline chloride-glycerol (1:1) with an value of 18.039 ppm. Optimization with variations in temperature time and ratio variables obtained optimal conditions at temperature of 60°C with an extraction time of 44 minutes and ratio of 90% NADES obtained values IC50 values of 8.040 ppm and positive control of vitamin C obtained values IC50 values of 4.307 ppm. The best results for antioxidant activity are at a temperature of 60°C gives an value of 8.050 ppm was obtained and the average is 8.075 ppm.

Page 75 of 75 | Total Record : 742

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