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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 742 Documents
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Comparative study of DOTS treatment outcomes among pulmonary tuberculosis patients at Bondongan and East Bogor primary health centers Sondang Khairani; Reise Manninda; Lusiana Ariani; Sabina Radya Harumi
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 1 (2026): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i1.2105

Abstract

Tuberculosis (TB) remains a major infectious disease and a significant public health concern in Indonesia. The Directly Observed Treatment Short-course (DOTS) strategy has been widely implemented to improve treatment adherence and outcomes among patients with TB. This study aimed to compare the treatment outcomes of patients with pulmonary tuberculosis undergoing DOTS therapy at Bondongan Primary Health Center and East Bogor Primary Health Center. This study used a descriptive and inferential research design with retrospective data collection conducted in 2024. A total of 159 patients with pulmonary TB were included in the study. Data were analyzed based on patient characteristics, including age, sex, comorbidities, type of diagnosis, duration of treatment, and treatment outcomes. The results showed that the majority of patients at Bondongan Primary Health Center were aged 38–47 years (30.13%), whereas most patients at East Bogor Primary Health Center were aged 18–27 years (36.03%). Female patients accounted for 54.10% of the total population. Most patients received six months of treatment (84.91%), were bacteriologically confirmed (76.10%), and all patients received fixed-dose combination (FDC) therapy. At Bondongan Primary Health Center, the comorbidity status of diabetes mellitus (DM) was largely unknown (80.82%), whereas most patients at East Bogor Primary Health Center had no DM comorbidity (87.21%). The treatment success rates were 83.56% and 97.67% at the Bondongan and East Bogor Primary Health Centers, respectively. Statistical analysis indicated that patient characteristics were not significantly associated with treatment success (p≥0.05).
Ficus septica Burm. f.: A comprehensive review of its ethnomedicinal uses, phytochemistry, and pharmacological properties Tazkiyatan Isria; Berna Elya; Roshamur Cahyan Forestrania; Muhammad Hanafi
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 1 (2026): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i1.2033

Abstract

Ficus septica Burm. f. is a significant medicinal plant within the Moraceae family, recognized for its extensive ethnomedicinal application throughout Southeast Asia, including Indonesia, the Philippines, and Papua New Guinea. It has been used to treat various conditions, from dermatological infections and fever to digestive disturbances. This review aimed to compile and critically evaluate the existing scientific literature on the botany, ethnomedicine, phytochemistry, and pharmacological potential of F. septica. A systematic literature search and selection process was conducted following the PRISMA guidelines to ensure transparency and reproducibility, supported by a narrative synthesis approach. Phytochemical investigations have consistently demonstrated that this species is abundant in diverse secondary metabolites, notably phenanthroindolizidine alkaloids (such as antofine, tylophorine, and ficuseptine), which serve as primary chemical markers. In conjunction with other flavonoids, terpenoids, and phenolic compounds, these compounds are responsible for many scientifically validated bioactivities. Pharmacological evidence highlights its anticancer capabilities, including apoptosis induction, cell cycle arrest, and anti-metastatic activity. Furthermore, it exhibits broad-spectrum antimicrobial activity, including antibacterial, antifungal, antiviral, and antiprotozoal effects. Its antioxidant, anti-inflammatory, and wound-healing properties have been extensively documented. This review affirms that contemporary scientific findings substantiate the traditional utilization of F. septica and underscores its potential as a valuable source for developing novel therapeutic agents, particularly in oncology and infectious disease management.
Analysis of predisposing factors affecting community antibiotic use behavior in Mampang Village Depok City Sherly Tandi Arrang; Najwa Arumiyati Abella; Hadiyanto; Evi Ulina Margareta
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 1 (2026): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i1.2034

Abstract

Antibiotic misuse remains prevalent in Indonesia, including behaviors such as storing antibiotics and using them without a doctor's prescription. Despite this widespread issue, no prior studies have specifically examined antibiotic use behavior in Mampang Village in Depok City. This study aimed to analyze the relationship between predisposing factors, namely age, sex, education level, occupation, and knowledge level and antibiotic use behavior among the local population. An analytical observational design with a cross-sectional approach was applied to 110 respondents. Knowledge levels were assessed using a structured questionnaire, and the relationships between predisposing factors and behavior were analyzed using multivariate logistic regression. The findings revealed that the majority of respondents had good knowledge (43%) and exhibited appropriate antibiotic-use behavior (52%). Statistical analysis indicated a significant association between knowledge and antibiotic use behavior (p < 0.001). In contrast, age (p = 0.166), sex (p = 0.938), education level (p = 0.340), and occupation (p = 0.365) were not significantly associated with the knowledge score. These results suggest that knowledge is a key predisposing factor influencing antibiotic use behavior in the Mampang Village community.
Validation of HPLC for identification of captopril, enalapril, and lisinopril in traditional Indonesian herbal medicine Liliek Nurhidayati; Mawarni Tobing; Elvi Rahmayuni
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 1 (2026): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i1.2041

Abstract

Traditional Indonesian herbal medicine (Jamu) is widely used for health maintenance and disease  prevention. The addition of medicinal chemicals to Jamu is not in accordance with quality and safety requirements. The purpose of this study was to develop a valid HPLC method for the identification of captopril, lisinopril, and enalapril in Jamu for hypertension. In this study, they were identified using high-performance liquid chromatography with a photodiode array detector. The stationary phase was a C18 YMC column (length 250 mm, diameter 4.6 mm, particle size 5 μm), methanol - 0.1 % phosphoric acid (45:55) as the mobile phase with isocratic elution, a flow rate of 1.0 mL/min, a column temperature of 40 °C, an injection volume of 20 μL, and detection at  210 nm. The results showed that this method fulfilled the specificity requirement, with detection limits of captopril, enalapril, and lisinopril of 0.715, 0.795, and 1.403 ppm, respectively. This HPLC method can be used for the identification of captopril, enalapril, and lisinopril in commercial Jamu.
Impact of SNEDDS formulation variables on physical characterization, drug release, and anti-inflammatory activity: a review Rodhia Ulfa; Benni Iskandar; Gressy Novita; Deni Anggraini; Wira Noviana Suhery; Prima Aulia Putra
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 1 (2026): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i1.2050

Abstract

Self-nano-emulsifying drug delivery systems (SNEDDS) address the challenges of poor solubility and bioavailability in oral drug delivery. These challenges lead to poor therapeutic results and an increased frequency of dosing. This review assesses the challenges of oral drug delivery due to poor solubility and absorption and the potential of Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) to deliver poorly water-soluble drugs. This also entails an assessment of the formulation components of SNEDDS, particularly oils, surfactants, and co-surfactants, and their influence on the physicochemical properties, release profile, stability, and anti-inflammatory activity of the formulation. A thorough assessment of 25 of the most recent primary studies revealed the significant influence of formulation design on the size and distribution of droplets and their subsequent emulsification, drug release, and bioavailability. Oils that are easier to solubilize, along with high HLB surfactants and co-surfactants, such as PEG 400 and Transcutol, are instrumental in producing smaller, stable emulsions that facilitate permeability. Nevertheless, human pharmacokinetic data are lacking, and challenges remain in the large-scale production of solid dosage forms from liquid SNEDDS. This problem is further complicated by the variability of the excipients. The review highlights the need for standardized predictive models and more refined plans for in vivo validation and excipient development. What is unique is the integration of specific information from formulation optimization with translational pharmacological outcomes. This integration has the potential to greatly improve the design and utilization of SNEDDS, thereby expanding its therapeutic benefits.
Analysis of  potential drug interaction in children under 10 years of age with acute respiratory tract infections at  RSIA Sitti Khadijah hospital in Makassar Nurhikma Awaluddin; Tenry Wahyuni; Dwi Yulianti Alifah; Astika Ekawati Putri; Ghina Ramadhani
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 1 (2026): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i1.2058

Abstract

Acute Respiratory Tract Infection (ARI) is one of the most prevalent diseases, triggered by various factors such as microorganisms and air pollution. This study aimed to analyze the risk of drug interactions in pediatric ARI patients under 10 years of age at RSIA Sitti Khadijah Makassar from July to December 2024. A non-experimental retrospective design was applied using data collected from outpatient medical records.The findings indicated that 75% of patients having potential drug interactions predominantly in the moderate category with a pharmacodynamic mechanism. The primary factor contributing to these interactions was the concurrent use of multiple drugs. Such interactions can alter therapeutic effectiveness by either enhancing or reducing drug effects; therefore, early identification and appropriate management of drug interactions are essential to optimize treatment outcomes and minimize adverse effects. Greater attention to potential drug interactions in pediatric ARI therapy is crucial to ensure treatment safety and effectiveness.
Predictors of drug-related problems among psychiatric patients with anxiety disorders: a systematic review Andi Ayulestari; Atika Wahyu Puspitasari; Nadia Farhanah Syafhan
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 1 (2026): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i1.2080

Abstract

Anxiety disorders are a major component of mental health conditions and are commonly managed with long-term pharmacotherapy, including the use of antidepressants and anxiolytics. The complexity of these regimens increases the risk of drug-related problems (DRPs), which may compromise treatment effectiveness, patient safety, and adherence to medication. This systematic review aimed to identify and synthesize the risk factors associated with DRPs in patients with anxiety disorders. A comprehensive systematic search was conducted across electronic databases according to the PRISMA guidelines. Observational studies were included to reflect real-world clinical practice, and the methodological quality of the included studies was assessed using the Newcastle-Ottawa Scale (NOS). Studies published between 2016 and 2026 were considered; however, only eligible studies published between 2022 and 2025 were included in the final analysis. Ten studies involving 151,331 participants from inpatient and outpatient settings were analyzed. Polypharmacy was the most consistently reported predictor of DRPs (7/10 studies). Other commonly identified risk factors included comorbidities (7/10), older age (6/10), use of multiple psychotropic medications (6/10), longer treatment duration or hospitalization (5/10), poor medication adherence (5/10), and inappropriate dosing (4/10). Patients with anxiety disorders are at considerable risk of DRPs, with polypharmacy being the most critical predictor. These findings highlight the importance of targeted pharmaceutical care interventions, including medication reviews, deprescribing, and adherence optimization, as well as the key role of pharmacists in improving pharmacotherapy outcomes.
Potential of bioactive compounds Piper betle L. as angiotensin converting enzyme inhibitors: molecular docking study and in silico analysis evaluation of physicochemical properties, drug-likeness, and toxicity Agus Kurniawan; Ernawati Sinaga; Muhammad Hanafi; Puspa Dewi Narrij Lotulung; Syamsudin Abdillah
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 1 (2026): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i1.2083

Abstract

Hypertension remains a major global health burden, with angiotensin converting enzyme (ACE) representing a central therapeutic target in blood pressure regulation via the RAAS. Although synthetic ACE inhibitors are clinically effective, their long-term use is frequently associated with adverse effects, motivating the search for safer alternative agents. Piper betle L. is a medicinal plant rich in diverse bioactive phytochemicals with reported cardiovascular benefits. This study aimed to systematically evaluate the ACE inhibitory potential of Piper betle leaf constituents using an integrated in silico approach. A total of 43 compounds were docked against human ACE (PDB ID: 1UZF) using the PLANTS algorithm, with protocol validation performed by captopril redocking. Binding affinities and key interactions were analyzed, followed by prediction of physicochemical properties, drug-likeness, and toxicity using ADMETlab 3.0 and ProTox-3.0. Docking results revealed that several compounds, including cerebrosides, lignans, and long-chain esterified phenolics, exhibited strong predicted binding to ACE. However, many high-affinity ligands showed unfavorable physicochemical characteristics, low quantitative estimates of drug-likeness, and multiple medicinal chemistry rule violations. In contrast, Piperenamide A and Piperenamide B demonstrated a balanced profile, combining stable ACE binding with favorable physicochemical properties, compliance with Lipinski’s Rule of Five, and low predicted toxicity. Simple phenolic compounds displayed good safety profiles despite moderate binding affinity. Overall, this integrative in silico analysis highlights compounds derived from Piper betle L. leaves as a promising natural source of ACE-inhibitory scaffolds and provides a rational framework for subsequent experimental validation and lead optimization in antihypertensive drug discovery.
Incompatibility of IV Admixture Administration among Hospitalized Patient at Referral Hospital in Banyumas Regional Erza Genatrika; Wahyu Utaminingrum; Tsabita Maryam Afurisac
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 1 (2026): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i1.2085

Abstract

Drug administration to inpatients in referral hospitals is generally performed using intravenous (IV) admixtures. IV admixtures can cause incompatibility problems that can affect the stability and bioavailability of the drugs. This study aimed to determine the potential for incompatibility problems in administering IV admixtures to inpatients in referral hospitals in the Banyumas region. This was a descriptive observational study. Data collection was carried out prospectively with the inclusion criteria of non-cytostatic IV admixtures administered to inpatients from March to May 2024. The potential for incompatibility in IV admixtures was determined based on visual observations and pH values ​​carried out in the laboratory. In addition, we analyzed the Handbook of Injectable Drugs. The results of the study showed that 1516 IV admixtures were obtained within 3 months. Of the 1516 IV admixtures, 40 different IV admixtures had different characteristics. The characteristics of IV admixtures obtained at this referral hospital consisted of IV admixtures-small volume parenteral (36%), IV admixtures-large volume parenteral (5%), and reconstitution (59%). The solvents used included water for injection (94.65%), NaCl 0.9%, and RingerLactate (1.39%). Incompatibility occurred in a mixture of Sodium Phenytoin 50 mg/mL with NaCl 0.9% at concentrations as high as 0.264% (4 occurrences out of 1516 IV mixtures), characterized by the formation of crystals after mixing. From this study, it can be concluded that the administration of IV admixtures to inpatients at the Banyumas Referral Hospital has a low potential for incompatibility (0.264%). However, the mixture of sodium phenytoin with 0.9% NaCl has been proven to cause crystal formation due to a decrease in pH, thus requiring special attention in the practice of mixing intravenous drugs.
Dissolution and pharmacokinetics profile of acetylsalicylic acid in rabbit plasma following oral ingestion of acetylsalicylic acid microcapsules Faizatun; Ni Made Dwi Sandhiutami
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 1 (2026): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i1.2092

Abstract

Acetylsalicylic acid (80 mg) suppresses thromboxane A2 (TXA-2) formation, thereby reducing platelet aggregation and is used as an antiplatelet agent. Oral administration of acetylsalicylic acid causes gastrointestinal bleeding; therefore, acetylsalicylic acid microcapsules have been developed, which are less soluble in stomach acid but dissolve in intestinal fluid. This study aimed to evaluate the concentration, dissolution, and bioavailability of acetylsalicylic acid (ASA) microcapsules. Microcapsules were prepared using the microencapsulation method with an alginate crosslinking technique, with calcium chloride as the crosslinker. The concentration of acetylsalicylic acid and the dissolution of microcapsules were determined in vitro. The bioavailability of 80 mg acetylsalicylic acid microcapsules was studied in rabbits that were orally administered of 80 mg. Blood sampling was carried out at 0, 0.5, 1, 2, 4, 6, 8, 8.5, 9, 9.5, 10, 12, 14, 16, 24, and 30 h. In this study, the percentage of acetylsalicylic acid in the microcapsules was 24.08±0.59%. The dissolution test at the acid stage showed that acetylsalicylic acid was still released at 40.09% in 90 min. In the bioavailability test, a lag time of absorption of less than 1 h was obtained, peak plasma levels of 2.06 μg/mL were achieved within 9.16 h after microcapsule administration, and the area under the curve was 15.98 μg · h/mL. It can be concluded that the release of acetylsalicylic acid from microcapsules in the acidic medium indicates incomplete entrapment, and there is a lag time, indicating inhibition of drug release due to the microencapsulation process.

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