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ISM (Intisari Sains Medis) : Jurnal Kedokteran

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Published by Universitas Udayana

ISSN : 25033638 EISSN : - DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

Intisari Sains Medis is published by Medical Scientific Community, Indonesia. Intisari Sains Medis is an international, multidisciplinary, peer-reviewed, open access journal accepts papers for publication in all aspects of Science Digest, Medical Research Development, Research Medical Field and Theory. We also publish cases from third world country, that is considered very rare and special cases.

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Articles 1,063 Documents

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The correlation between serum magnesium level and blood pressure in patient with chronic kidney disease Maulida Devi Yanti; Lisyani Budipradigdo Suromo
Intisari Sains Medis Vol. 10 No. 1 (2019): (Available online 1 April 2019)
Publisher : DiscoverSys Inc.

Background: Increased blood pressure is one of the complications from hemodialysis in Chronic Kidney Disease (CKD) patients. Magnesium is an electrolyte which is a calcium antagonist in regulating blood pressure. This study aims to prove the correlation of serum magnesium level with blood pressure in CKD patientsMethods: A cross-sectional study was conducted on 30 CKD patients in Dr. Kariadi Hospital, Semarang during Septemberâ€“October 2018. The serum magnesium level was measured with spectrophotometry method, blood pressure with a sphygmomanometer. Statistical analysis used Pearson and Spearman correlation test.Result: There is a significant correlation between serum magnesium level and systolic blood pressure with p< 0,001 and r=-0,737 and correlation between serum magnesium level and diastolic blood pressure with p=0,011 and r=-0,457Conclusion: There is a strong negative correlation of serum magnesium level with systolic blood pressure and moderate negative correlation of serum magnesium level with diastolic blood pressure in this study. Further studies are needed to analyze the influential factors of blood pressure.

Analisis hubungan Rasio Trombosit Limfosit (RTL) dengan derajat keparahan stenosis pada pasien Coronary Artery Disease (CAD) Zahra Inayah Kasim; Sulina Yanti Wibawa; Darmawaty E. Rauf
Intisari Sains Medis Vol. 10 No. 2 (2019): (Available online: 1 August 2019)
Publisher : DiscoverSys Inc.

Background: Atherosclerosis in CAD is marked by formation of plaque inside the arterial lumen. Platelet plays a role on formation and development of atherosclerosis. Adhesion of platelets to the endothelial cells followed by releasing platelet granules caused inflammation of endothel. Lymphocytes also play a role in atherosclerosis and atherotrombosis. T lymphocyte was the first to be recruited inside atheromas and gathered along inside an unstable plaque. The severity of stenosis can be calculated using Gensini score. The Aim of this study is to analyze the correlation between PLR and degree of stenosis in CAD.Methods. This study is a retrospective study by collected 110 patients with CAD that had undergone coronary Angiography. Platelets and lymphocyte count were measured by automatic haematologycal analyzer. PLR was measured by dividing trombocyte count with absolute lymphocyte. Angiography findings were calculated using Gensini score and later devided into 3 groups according to degree of severity.Results. 110 patients retrospectively assesed, 80% were male and 20% female. The most age found was 50-59 years (35.5%). Using Anova test there is a significant differences onÂ PLR between 3 groups of lesions (p<0.05). Continued with Posthoc test, the only significant finding was PLR between moderate and severe lesion. By Spearmanâ€™s Correlation test, there is a positif colleration between PLR and severity of stenosis (p<0.048), with R value 0.189 (3.6%).Conclusions. There was a poor correlation between PLR and degree of stenosis severity in CAD. A prospective study needed to assess PLR as predictor of mortality and morbidity in CAD.

Turnaround time pelayanan darah rujukan di bank darah RSUP Dr. Wahidin Sudirohusodo sebelum dan sesudah implementasi sistem informasi manajemen darah Erika Rosaria Simbolon; Rachmawati Muhiddin; Mansyur Arif
Intisari Sains Medis Vol. 10 No. 1 (2019): (Available online 1 April 2019)
Publisher : DiscoverSys Inc.

Background: Blood Information Management System or SIMERAH is the system information which allows blood bank officers at Dr. Wahidin Sudirohusodo hospital to check blood supply in Blood Transfusion Unit. Before SIMERAH implementation, referral blood service was done by directly giving the patientâ€™s family a blood request form to PMI without blood supply information. Referral blood service after SIMERAH implementation requires blood bank officers to order blood before referring patients to PMI. This study aims to compare Turnaround Time (TAT) of referral blood before and after SIMERAH implementation.Methods: The population of this study has been all patients receiving referral blood service to PMI since January 2017 to June 2017 (before SIMERAH implementation) and January 2018 to June 2018 (after SIMERAH implementation). Statistical analysis conducted were descriptive statistics and paired t-test.Results: The average TAT at Dr. WahidinSudirohusodo Hospitalâ€™s Blood Bank before SIMERAH implementation was 6,10 hours. The average TAT after SIMERAH implementation was 4,37 hours. There was 25,2 % decrease of average TAT after SIMERAH implementation at Dr. Wahidin Sudirohusodo Hospitalâ€™s Blood Bank. There were significant decreases of TAT in January, February, March, May, and June (p<0.05). There was a decrease of TAT in April but not statistically significant (p>0.05).Conclusion: SIMERAH was significantly decrease TAT in Dr. Wahidin Sudirohusodo Hospitalâ€™s Blood Bank.

Analisis rasio netrofil limfosit dan rasio platelet limfosit terhadap penanda gangguan ginjal pada penyakit systemic lupus erythematosus di RSUP dr. Wahidin Sudirohusodo tahun 2017-2018 Evi Andriyani Lauddin; Asvin Nurulita; Darwati Muhadi
Intisari Sains Medis Vol. 10 No. 1 (2019): (Available online 1 April 2019)
Publisher : DiscoverSys Inc.

Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease that causes damage to several organ systems including the kidneys. The neutrophil-lymphocyte ratio (NLR) and the platelet-lymphocyte ratio (PLR) continue to be developed as a marker of SLE disease activity. This study aimed to assess NLR and PLR for markers of kidney disorders in SLE.Method: A retrospective study evaluated NLR and PLR with routine urine results including proteinuria, hematuria, and casts from 40 subjects of SLE patients at Dr.Wahidin Sudirohusodo Hospital Makassar from July 2017 - July 2018. Descriptive statistical analysis, frequency distribution and Mann-Whitney statistical test.Results: NLR values were significantly higher in positive hematuria than negative hematuria, which was 7.44 compared to 3.80 (p <0.05).Conclusion: A significant relationship between increased NLR values and hematuria can be used as a marker of early occurrence of lupus nephritis even though no manifestations or signs of other kidney disorders are found.

Efek latihan kesamaptaan terhadap kadar D-Dimer pada anggota militer Kodam I Bukit Barisan R. Prathama Wiradharma; Nizam Zikri Akbar; Adi Koesoema Aman
Intisari Sains Medis Vol. 10 No. 2 (2019): (Available online: 1 August 2019)
Publisher : DiscoverSys Inc.

Background: Several reports and experiences show that when doing heavy exercise often occur complaints which direct the diagnosis towards Venous Thrombo-Embolism (VTE) in the form of painful and swollen feet. This was due to hypercoagulation and resulted in VTE. The D-dimer level is a measure of clot formation and lysis resulting from the breakdown of fibrinogen and fibrin during fibrinolysis. Therefore this study aimed to see an increase in D-Dimer which is a marker of increased fibrinolysis.Method: This study took a sample of blood from 30 soldiers who were declared healthy. The sample was checked for D-Dimer 1 hour before and after the test. The physical readiness test is a standard for assessing the readiness of soldiers in carrying out tasks. The sample was evaluated whether there was an increase after the test. Examination using Coatron machine with the Immuno Turbidimetric Assay method.Result: 30 people are men with an average age of 19-22 years. D-Dimer showed a significant difference with a mean of 92.83 Â± 49.62 SD before the test and after the test found a mean of 127.53 Â± 57.75 SD with p = 0.001 (p <0.05).Conclusion: The increase in D-Dimer shows an increase in blood coagulation processes and fibrinolysis and can occur in individuals who often carry out heavy activities. D-Dimer and Dopler ultrasound screening should be carried out on a periodic check before carrying out the physical readiness test.

Analisis Corrected Count Increment (CCI) pada penderita post transfusi trombosit apheresis di RSUP Dr. Wahidin Sudirohusodo, Makassar, Indonesia Lisdiana Amin Asri; Sri Juliani; Rachmawati Muhiddin
Intisari Sains Medis Vol. 10 No. 2 (2019): (Available online: 1 August 2019)
Publisher : DiscoverSys Inc.

Background: Platelet refractoriness is a problem in the implementation of platelet transfusion. It is a lack of increased platelets after platelet transfusion. This study aimed to analyze the increase in platelet counts of patients who received apheresis platelet transfusion by using Corrected Count Increment (CCI) formula at Dr. Wahidin Sudirohusodo General Hospital Makassar.Methods: This was an observational cross sectional study with 242 thrombocytopenia patients. The success of platelet transfusion was calculated using the CCI formula with CCI values after transfusion of 4.5 x 109/L at 24 hours post transfusion. Statistical analysis used chi square, t-independent, and spearmenâ€™s correlation test, with significant test results if p-value was < 0.05.Results: An average increase of platelet counts was 28.5 x 109/L. Successful thrombocyte transfusion was found in 107 subjects (44.2%) and unsuccessful in 135 subjects (55.8%). The proportion of successful transfusion was found to be higher in men (45.5%) than women (43.2%), however, it was not significant (p > 0.05). There was a significant relationship between young age and successful thrombocyte transfusion (p < 0.001). Unsuccessful transfusion rate was high in cases of malignancy, infection, bleeding, and metabolic disease (p < 0.05).Conclusions: There was a significant negative correlation between age and CCI, older age presented lower value of CCI. Characteristics of disease affected the successful of apheresis thrombocyte transfusion.

Efektivitas ekstrak metanol akar pandan wangi (Pandanus amaryllifolius Roxb.) Sebagai antimalaria terhadap jumlah limfosit dalam darah mencit (Mus musculus) yang diinfeksi Plasmodium berghei Danang Mustofa; Muhammad Ibnu Kahtan; Diana Natalia; Mistika Zakiah; Ari Widiyantoro
Intisari Sains Medis Vol. 10 No. 2 (2019): (Available online: 1 August 2019)
Publisher : DiscoverSys Inc.

Malaria is a infectious disease cause by protozoa with genus Plasmodium that is transmitted by female Anopheles mosquito. Our immune system which is role by lymphocyte works specifically when body infected by Plasmodium. The secondary metabolites of Pandan Wangi roots (Pandanus amaryllifolius Roxb.) Â possess as antimalaria. The purpose of this research to know the activity of methanol exctract from roots of Pandan Wangi (Pandanus amaryllifolius Roxb.) as antimalaria on white male mice (Mus muscullus) lymphocyte count infected by Plasmodium berghei. This is a true experimental in vivo with completely randomized design. Antimalaria effect test used methanol extract from roots of Pandan Wangi with concentration 6.5%, 13% and 26%. Positive control group was given 3.74 mg/mL DHP (Dihydroartremisinin-Piperaquin), normal control group was not given any intervention, negative control group was given aquadest. Results of this research show extract with concentration 6.5%, 13% and 26% have the antimalaria effect show by the decrease of parasitemia percentage. In addition, concentration of 26% extract can increase the number of lymphocytes significantly. Extract of Pandan Wangi Roots have antimalaria effect and can increase the number of lymphocytes with the best concentration of 26%. The decreasing number of parasitemia level is not directly related to the increasing of lymphocyte

Faktor risiko yang mempengaruhi length of stay pasien kanker solid dengan febrile neutropenia pasca kemoterapi neoadjuvant/terapeutik di Ruang Isolasi RSUP Sanglah, Bali Ronald Natawidjaja; Ida Bagus Tjakra Wibawa Manuaba; Putu Anda Tusta Adiputra
Intisari Sains Medis Vol. 10 No. 1 (2019): (Available online 1 April 2019)
Publisher : DiscoverSys Inc.

Background. Febrile neutropenia is a common complication in patient undergoing chemotherapy. Length Of Stay (LOS) is an important marker for disease severity and use of medical resources in febrile neutropenia. This study was done to find the risk factor affecting length of stay in solid cancer patients with febrile neutropenia post neoadjuvant/therapeutic chemotherapy.Method. This is a case control study without matching. Age â‰¥ 60 years, (Absolute Neutrofil Count) ANC level < 1,5 Î¼L , comorbid,Â Hb level <10 gr/dl, and albumin < 3 gr/dl, were related to LOS ( â‰¤ 5 days and > 5 days). Univariate (chi square) and multivariate (logistic regression) were used to analyse the statistic.Results. Forty six patients met inclusion-exclusion criteria were included in this study. ANC level in all patients were < 1,5 Î¼L (100%). Hb level <10 gr/dl is statistically significant (P<0.05), whereasÂ age â‰¥ 60 years, and comorbid, albumin level < 3 gr/dl were not is statistically significant (P>0.05).Conclusion. Hb level < 10 gr/dl is the risk factor for LOS > 5 days in solid cancer patients with febrile neutropenia post neoadjuvant/therapeutic chemotherapy.

Interferensi sampel lipemik pada bayi dengan lipemia retinalis dikarenakan primary mixed hyperlipidemia: laporan kasus Andi Munawirah; Habibah S. Muhiddin; Liong Boy Kurniawan; Ruland DN Pakasi
Intisari Sains Medis Vol. 10 No. 2 (2019): (Available online: 1 August 2019)
Publisher : DiscoverSys Inc.

Background: Interference is a condition of which sample components cause an error in the analyte measurement in the analyzer.Â The most common cause of interference is lipemic sample. Lipemic sample is characterized by turbidity of the serum or plasma caused by an accumulation of lipoprotein particles. Primary mixed hyperlipidemia (PMH) is a cause of primary hypertrigliseridemia with lipemia manifestation.Case report: A three month-old baby boy was admitted to a hospital, having white spots in his black eyes. The spots were seen clearer at light exposure, and ophthalmologic examination indicated lipemia retinalis. Patientâ€™s sample was lipemic and its laboratory analysis resulted in as follow: WBC 13.103/Î¼L, Hb 15.6 gr/dL, RBC 2.99 106/Î¼L, triglyserida 10.435 mg/dL, total cholesterol 631 mg/dL, HDL 12 mg/dL, LDL 195 mg/dL, and apoprotein B 196 mg/dL. Due to a significant interference, SGOT, SGPT, ureum and creatinin were not obtained. Immunologic serum analysis of the patient and his mother showed an increasing of antibody IgG CMV: 28 dan 20 IU/ml, respectively.Conclusion: Lipemic samples could directly affect most of laboratory examination methods. Laboratory results with such lipemia interferences shoud be interpretated critically and accurately to produce precise diagnosis, and in turn, monitoring of patient with lipemia.

Nilai rasio netrofil limfosit dan rasio trombosit limfosit pada pasien chronic kidney disease sebelum dan setelah hemodialisa Nelly Nelly; Yuyun Widaningsih; Fitriani Mangarengi
Intisari Sains Medis Vol. 10 No. 2 (2019): (Available online: 1 August 2019)
Publisher : DiscoverSys Inc.

Background: CKD is a world health problem with an increasing incidence, having a poor prognosis and requiring expensive treatment costs. Cardiovascular disease is the cause of high mortality rates in CKD patients due to inflammation. Neutrophil to lymphocytes ratio (NLR) and platelet to lymphocyte ratios (PLR) are considered as inflammatory markers that are cheap, fast and easily calculated from the routine blood examination. This study aimed to know the value of RNL and RTL in CKD patients before and after HD as the initial marker of inflammation. Method: Eighty-eight patients with CKD were divided into three groups before HD, after the first HD, and after the third HD. The neutrophil-lymphocyte ratio and platelet-lymphocyte ratio are calculated based on the results of routine blood tests. Data distribution was tested with Kolmogorov-Smirnov and analyzed by appropriate data testing.Results: RNL and RTL values in CKD patients after HD increased compared to before HD (p <0.05). There is a weak correlation between RNL values and serum urea levels. However, the RTL value only correlates with urea before hemodialysis.Conclusion: There are differences in RNL and RTL values in CKD patients before HD, after the first HD and third HD. There is a correlation between the RNL value and the state of uremia that is aggravated by HD

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