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INDONESIA
ISM (Intisari Sains Medis) : Jurnal Kedokteran
Published by Universitas Udayana
ISSN : 25033638     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Intisari Sains Medis is published by Medical Scientific Community, Indonesia. Intisari Sains Medis is an international, multidisciplinary, peer-reviewed, open access journal accepts papers for publication in all aspects of Science Digest, Medical Research Development, Research Medical Field and Theory. We also publish cases from third world country, that is considered very rare and special cases.
Arjuna Subject : -
Articles 1,063 Documents
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Perbedaan kadar antitrombin III pada sepsis neonatal kultur darah positif dan kultur darah negatif Prima Indah Siridian; Ricke Loesnihari; Guslihan Dasa Tjipta
Intisari Sains Medis Vol. 10 No. 1 (2019): (Available online 1 April 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (307.811 KB) | DOI: 10.15562/ism.v10i1.335

Abstract

Background: Fetal and neonatal hemostatic systems are dynamic. Coagulation and inhibitors of coagulation factors are progressively synthesized by the fetus which begins after 34 weeks of pregnancy and at the initial hours after birth. The neonatal hemostatic system generally shifts towards hypercoagulability. During sepsis, this hypercoagulability is exacerbated by an imbalance of coagulation and inhibitors of coagulation factors including antithrombin III. This study aimed to determine differences of antithrombin III levels in neonatal sepsis positive blood cultures (proven sepsis) and negative blood cultures (unproven sepsis).Methods: The subjects of this study were 26 patients of neonatal sepsis, which consisted of 13 positive blood cultures and 13 negative blood cultures. Levels of antithrombin III were examined by chromogenic methods. Examination of blood cultures of gram-positive bacteria using manual method and gram-negative bacteria using semiautomatic method. Data analysis uses an independent t test.Results: Antithrombin III levels in neonatal sepsis patients positive blood culture (73,23 ± 21,62) didn’t differ significantly compared to negative blood cultures (65,63 ± 20,81) with p = 0,370 (p> 0,05). The bacterial pattern that caused neonatal sepsis were Staphylococcus sp. (84,6%), CoNS (81,8%), Staphylococcus aureus (18,2%)}, Salmonella spp (7,7%) and Klebsiella pneumoniae ssp pneumoniae (7,7%). The sensitivity pattern of Staphylococci to cefoxitin to determine resistence, found 5 Methicillin-resistant Staphylococci (MRS) and 1 Meticillin-resistant Staphylococcus aureus (MRSA). Conclusion: There were no significant differences of antithrombin III levels in neonatal sepsis positive blood cultures and negative blood cultures.
Deteksi gen Gtf-B Streptococcus mutans dalam plak dengan gigi karies pada siswa di SD N 29 Dangin Puri I Gusti Agung Dyah Ambarawati; I Dewa Made Sukrama; I Wayan Putu Sutirta Yasa
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (828.452 KB) | DOI: 10.15562/ism.v11i3.337

Abstract

Background: Bacteria situated in the formation of dental plaque as a leading cause of caries is Streptococcus mutans. Streptococcus mutans use glycosyltransferase enzymes to convert saccharose saliva into an extracellular polysaccharide (PSE) through glycosylation process. One of the virulence factors of Streptococcus mutans is the gtf-B gene.Aim: This study aims to detect gtf-B gene in plaque with dental caries on students of SD Negeri 29 Dangin Puri.Method: The design of the study was descriptive observational research involved 51 carries children as a sample in SD Negeri 29, Dangin Puri. Bacterial culture was applied to detect colonies of Streptococcus. Additional gram staining and catalase test were also conducted to distinguish Streptococcus against Staphylococcus. After it revealed negative catalase test, PCR was continued optimally about 517 bp in size and 585 bp gtf B gene in size.Result and Conclusion: Streptococcus mutans are as many as 19 samples from 51 samples (37.25%). Three samples from 19 isolates of Streptococcus mutans were detected by gtf-B gen (16%). Bakteri yang berperan penting dalam pembentukan plak gigi sebagai penyebab karies adalah Streptococcus mutans. Streptococcus mutans memiliki enzim glikosiltransferase yang dapat mengubah sakarosa saliva menjadi polisakarida ekstraseluler (PSE) melalui proses glikosilasis. Salah satu faktor virulensi bakteri Streptococcus mutans sebagai penyebab karies gigi adalah gengtf-B Streptococcus mutans. Tujuan: Penelitian ini bertujuan untuk mendeteksi gen gtf-B Streptococcus mutans dalam plak dengan gigi karies pada anak di SD Negeri 29 Dangin Puri.Metode: Penelitian ini menggunakan 51 sampel anak di SD Negeri 29 Dangin Puri yang mengalami karies. Kultur bakteri digunakan untuk mendeteksi koloni Streptococcus Sp. kemudian dilakukan pengecatan gram, uji katalase untuk membedakan Streptococcus dengan Staphylococcus. Hasil uji katalase negatif dilakukan proses PCR Streptococcus Mutans dengan ukuran 517 bp dan gen gtf B Streptococcus mutans dengan ukuran 585 bp.Hasil dan Simpulan: ditemukan bakteri streptococcus mutans sebanyak 19 sampel dari 51 sampel (37,25%). Tiga sampel dari 19 isolat bakteri streptococcus mutans terdeteksi gen gtfB streptococcus mutans (16%).  
The sensitivity and specificity of neutrophil lymphocyte count ratio in diagnosing sepsis patients at Dr. Saiful Anwar General Hospital, Malang, Indonesia Agustin Iskandar; Yeni Ayu Prihastuti; Muhammad Anshory
Intisari Sains Medis Vol. 10 No. 1 (2019): (Available online 1 April 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (369.737 KB) | DOI: 10.15562/ism.v10i1.338

Abstract

Background: Sepsis is the most severe manifestation of acute infection which can cause death in 30-50% of cases. Rapid and accurate diagnosis of sepsis is a challenge for clinicians and laboratories. Neutrophil Lymphocyte Count Ratio is a potential index to detect the occurrence of sepsis. This examination is easy, fast and cheap. Procalcitonin is currently widely used as a newer indicator in diagnosing pre-shock but is rarely done because of its cost. This study aims to compare the diagnostic value of Neutrophil Lymphocyte Count Ratio with procalcitonin as a marker in septicpatients.Method: A Case-control analytic research was conducted from March to June 2018. Examination of neutrophils and lymphocytes using Sysmex XN-1000 while procalcitonin examination used Elecsys BRAHMS PCT using ECLIA method. Diagnostic values are analyzed using the ROC curve, and the cut-off value is determined. The sensitivity, specificity, positive predictive value, negative predictive value, accuracy are calculated with 2x2 tables.Result: The subjects of the study were 60 patients who hospitalized and examined for procalcitonin with 30 patients diagnosed based on clinical symptoms and SOFA score ≥ two by clinicians as sepsis patients and also 30 control patients. ROC analysis with procalcitonin cut-off values of 2,24 ng / mL obtained a sensitivity of 93%, specificity of 86,7%, PPV of 86,9%, and NPV of 92,4%.. At the cut-off value of Neutrophil Lymphocyte Count Ratio 5,06, there was a sensitivity of 80%, specificity of 76,7%, PPV of 76,9%, and NPV of 79,1%.Conclusion: Procalcitonin has a better diagnostic value than Neutrophil Lymphocyte Count Ratio in diagnosing sepsis.
Laparoscopic pyelolithotomy in treating extra-renal pelvic calculi at Sanglah General Hospital: a case series Made Kurniawan AS; Kadek Budi Santosa
Intisari Sains Medis Vol. 10 No. 1 (2019): (Available online 1 April 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1013.256 KB) | DOI: 10.15562/ism.v10i1.339

Abstract

Background: This study aims to describe our initial experience in treating extra-renal pelvic calculi using retroperitoneal laparoscopic pyelolithotomy techniques in Urology Division, Department of Surgery, Sanglah hospital, Bali.Case Description: There were seven patients enrolled with extra-renal pelvic calculi in this study whereas two of them accompanied by calyx inferior secondary stones. All the patients underwent retroperitoneal laparoscopic pyelolithotomy with DJ Stent applied. The operating time was improving in each procedure, with average time was 110 minutes, VAS at the first day post-operative was 1-2, a drain was removed on the second day, one of them was extended until the sixth day, most patients was discharged on postoperative day 3. All patients were stented for 3 to 4 weeks; The stents were removed with office cystoscopy. All patients were stone free on follow-up imaging.Conclusion: Retroperitoneal laparoscopic pyelolithotomy is a safe alternative for the management of pelvic renal calculi with minimal post-operative pain and shorter length of stay.
Validitas nilai CA 19-9 praoperatif dalam memprediksi resektabilitas pada kejadian karsinoma pankreas Kadek Adi Wiguna; Ketut Sudartana; Nyoman Golden
Intisari Sains Medis Vol. 10 No. 1 (2019): (Available online 1 April 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (281.929 KB) | DOI: 10.15562/ism.v10i1.340

Abstract

Latar Belakang: Karsinoma pancreas adalah penyakit dengan median survival rate yang rendah dengan angka resectabilitas yang juga rendah. pasien dengan stadium lanjut hanya kurang dari 10 % dapat di reseksi dengan kriteria margin nol setelah sebelumnya dinyatakan dapat di reseksi dari pemeriksaan CT scan. Tujuan dari penelitian ini untuk mengetahui validitas dari CA 19-9 sebagai prediktor derajat invasive karsinoma pancreas. Metode: rancangan penelitian ini adalah kasus kontrol dengan retrospektif, menelusuri kebelakang data data pasien di rekam medik di RSUP Sanglah Denpasar mulai agustus 2015 sampai agustus 2017. Didapatkan 18 pasien yang memenuhi kriteria inklusi. Hasil: rata rata responden dengan karsinoma pancreas berumur 52 tahun, Kanker pancreas di nyatakan unresectable berdasarkan analisis curva Receiver Operating Characteristic (ROC) AUC (Area Under Curve) sebesar 83,8% (CI 95%: 54,4% - 100, %) Titik potong dari kurva AUC kadar CA 19-9 yaitu 126,76 dengan sensitifitas sebesar 76, 9 % dan spesifitas 80 %. Secara statistic didapatkan CA 19-9 valid sebagai penentu unresektabilitas dengan sensitivitas sebesar 76,9%. Kesimpulan: CA 19-9 merupakan tumor marker yang dapat memprediksi derajat invasi suatu kanker pancreas sehingga diharapkan tindakan lebih tepat dapat segera diambil bila kita mengetahui nilai dari tumor marker ini
Uji korelasi leukosit esterase dan nitrit dengan kultur urin pada infeksi saluran kemih Ursula Nauli Malau; Purwanto Adipireno
Intisari Sains Medis Vol. 10 No. 1 (2019): (Available online 1 April 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (419.733 KB) | DOI: 10.15562/ism.v10i1.343

Abstract

Background: Urinary tract infection (UTI) is a condition where the urinary tract is infected by pathogens, causing microorganisms in urine. The gold standard examination for UTI is urine culture. Urine culture has some weaknessess. It takes around two days to get result and requires quite expensive cost. Leukocyte esterase and nitrite are relatively inexpensive, less-time consuming and easy to do laboratory tests that can detect UTI.Aim: To explore the correlation of leukocyte esterase and nitrite with urine culture in UTI patients.Methods: A cross sectional study of 42 UTI adult patients which treated at Dr. Kariadi hospital Semarang in September until October 2018. Combur dipstick using colorimetry method and urine culture using convensional method. Correlation test analyze using contingency coefficient.Results: The correlation analysis showed there was a positive correlation between urine esterase leukocytes with urine culture (p = 0.044 and r = 0.152) and there was no correlation between urine nitrite with urine culture (p = 0.272),.Conclusion: There was a correlation between urine leukocyte esterase and urine culture and there was no correlation between the urine nitrite to urine culture. However further researches are needed to analyze factors that affecting the UTI diagnostic.
Perbedaan parameter analisa gas darah (AGD) pada mixing sampel sesuai dan tidak sesuai standar Clinical and Laboratory Standards Institute (CLSI) Diah Ayu Kusuma; Banundari Rachmawati
Intisari Sains Medis Vol. 10 No. 1 (2019): (Available online 1 April 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (297.016 KB) | DOI: 10.15562/ism.v10i1.344

Abstract

Pendahuluan: Analisis Gas Darah (AGD) merupakan bagian penting untuk mendiagnosis dan mengelola status oksigenasi dan keseimbangan asam basa pasien. Instalasi Gawat Darurat (IGD) dan perawatan intensif (ICU) menggunakan AGD sebagai bagian tak terpisahkan dari penilaian status klinis pasien. Dalam pemeriksaan AGD khususnya, pengumpulan dan penanganan spesimen darah arteri yang tidak tepat dapat menghasilkan hasil yang keliru. Pada pemeriksaan AGD salah satu kesalahan pra-analitik adalah mixing sampel yang tidak sesuai standar. Tujuan penelitian ini adalah membuktikan adanya perbedaan hasil parameter AGD antara sampel yang dilakukan mixing sesuai dengan standar Clinical and Laboratory Standards Institute (CLSI) dan yang tidak sesuai standar CLSI.Metode: Ini merupakan studi observasional analitik potong lintang. Subjek penelitian adalah pasien usia 25-50 tahun yang dirawat di ICU RSUP Dr. Kariadi Semarang dan dilakukan pemeriksaan AGD. Analisis statistik menggunakan paired T-test dan Wilcoxon test. Dikatakan terdapat perbedaan bermakna apabila nilai p < 0.05.Hasil: Terdapat perbedaan bermakna pada parameter pO2 (p < 0.001), SO2 (p      < 0.001),  dan natrium (p = 0.038) antara sampel yang dilakukan mixing sesuai standar CLSI dan tidak sesuai standar CLSI. Tidak terdapat perbedaan bermakna pada parameter pH, pCO2, Hb, Hct, HCO3-, dan BE antara sampel yang dilakukan mixing sesuai standar CLSI dan tidak sesuai standar CLSI.Simpulan: Terdapat perbedaan bermakna pada parameter untuk menilai status oksigenasi antara mixing sampel sesuai dengan CLSI dan tidak sesuai CLSI. Mixing sampel yang benar diperlukan untuk mendapatkan hasil yang dapat dipertanggungjawabkan.
Hubungan resting metabolic rate (RMR) dan komposisi tubuh dengan kadar HbA1c pada obesitas Inggrid Lovita; Meita Hendrianingtyas; Ria Triwardhani
Intisari Sains Medis Vol. 10 No. 1 (2019): (Available online 1 April 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (304.499 KB) | DOI: 10.15562/ism.v10i1.345

Abstract

Background: Obesity occurs due to an imbalance intake and energy expenditure. The cause of obesity is low energy expenditure whereas the resting metabolic rate (RMR) is the largest component of energy expenditure of the body. The factors that influence RMR are body composition, age, sex and hormonal status. Body composition measured as fat mass and free fat mass (FFM). Body fat increase in obesity can cause insulin resistance which will increase blood glucose levels. This study aims to determine the correlation between RMR and body composition (fat mass and FFM) with HbA1c levels increase as a parameter of diabetes mellitus in obesity.Methods: Cross sectional study design to 38 subjects young adults obese. Resting metabolic rate and body composition (fat mass and FFM) measured with Omron Karada scan HBF 375. HbA1c measured with ion-exchange HPLC method. Statistical analysis using the Spearman’s correlation test (p<0.05)Result: HbA1c mean of 5.4% is still a normal value of HbA1c. There were no correlation between RMR and HbA1c (p = 0.768), fat mass with HbA1c (p = 0.102) and FFM with HbA1c (p = 0.843).Conclusion: RMR and body composition (fat mass and FFM) are not associated with HbA1c levels in obese young adults.
Perbedaan kadar ureum, natrium, kalium dan klorida pra dan pasca hemodialisa pada pasien dengan penyakit ginjal kronik Syaiful Anwar; Ariosta Ariosta
Intisari Sains Medis Vol. 10 No. 1 (2019): (Available online 1 April 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (256.382 KB) | DOI: 10.15562/ism.v10i1.346

Abstract

Background: Chronic Kidney Disease (CKD) is a progressive and irreversible damage to kidney function (GFR < 60 ml / minute / 1.73 m2). The function of the kidneys is to maintain stability, electrolyte level, osmolarity of extracellular fluid and excrete products such as urea, uric acid, and creatinine. CKD disrupts electrolyte fluid balance and uremia, thus requiring renal replacement therapy in the form of dialysis or kidney transplantation. Different levels of urea, sodium, potassium, and chloride pre- and post-hemodialysis can be a consideration for the management of hemodialysis in CKD patients. This study aimed to determine the difference in urea, sodium, potassium, and chloride pre- and post-hemodialysis in CKD patients.Method: This was a cross-sectional analytical observational study of pre- and post hemodialysis conducted from September to October 2018. Normally distributed data were analyzed using the paired t-test, while data that were not normally distributed were analyzed using the Wilcoxon test. It was considered significant when the p-value was < 0.05.Results: There was a total of 50 patients consisting of 30 males (60.0%) and 20 females (40.0%). The mean age of the patients was 51.10 ± 7.48 years. The level of pre-hemodialysis urea (161.96 ± 53.80 mg / dL) was significantly different from post-hemodialysis (120.70 ± 40.84 mg / dL). The level of pre-hemodialysis sodium (134.5 mmol / L) was significantly different from post-hemodialysis (140 mmol / L). The level of pre-hemodialysis potassium (5.6 mmol / L) was significantly different from post-hemodialysis (4.6 mmol / L). The level of pre-hemodialysis chloride (100 mmol / L) was significantly different from post-hemodialysis (96 mmol / L). Conclusion: There was a significant difference in urea, sodium, potassium, and chloride between pre- and post-hemodialysis (p < 0.05).
Hubungan petanda inflamasi dan hemoglobin pada obesitas di Fakultas Kedokteran Universitas Diponegoro periode Mei-September 2018 Emelia Wijayanti; Dwi Retnoningrum; Meita Hendrianintyas
Intisari Sains Medis Vol. 10 No. 1 (2019): (Available online 1 April 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (407.818 KB) | DOI: 10.15562/ism.v10i1.347

Abstract

Introduction: Obesity is one of global epidemic health problems. Obesity has been suggested to be associated with a state of chronic low-grade inflammation, which is characterized by abnormal cytokine production, increased acutephase reactants and activation of inflammatory signaling pathways. NLR (neutrofil to lymphocyte ratio) a simple and reliable indicator of inflammation, have been reported to be associatied with metabolyc syndrom, insulin resitence, and obeity in more study. Ferritin is a marker of inflammation contribute in obesity, and have been reported that ferritin is a marker of inflammation rather than iron status in overweight and obese people. Relationship between anemia and obesity may be due to fat a ccumulation and chronic inflammation in adipose tissue can be decreased iron absorbtion.Methods: Cross-sectional study of 50 obesity subject, based on Riskesdas criteria, on Mei – September 2018. Marker of inflammation is ferritin serum was measured by ELISA (enzyme linked immunosorbent assay), and NLR and haemoglobin was perfomed from haematology analyzer. Spearman test was perfomed for analyzing data with p <0,05 was significantResults: No correlation between NLR and haemoglobin, r= 0,067 and p= 0,642, and significant strong positive correlation between ferritin and haemoglobin, r= 0,630 and p < 0,000.Conclusion: There was no correlation between NLR and haemoglobin, and there was significant strong positive correlation between ferritin and haemoglobin in obesity. Future research need to observe with evaluate hepcidin, other iron status parameter and marker of inflammation.

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