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ISM (Intisari Sains Medis) : Jurnal Kedokteran

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Published by Universitas Udayana

ISSN : 25033638 EISSN : - DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

Intisari Sains Medis is published by Medical Scientific Community, Indonesia. Intisari Sains Medis is an international, multidisciplinary, peer-reviewed, open access journal accepts papers for publication in all aspects of Science Digest, Medical Research Development, Research Medical Field and Theory. We also publish cases from third world country, that is considered very rare and special cases.

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Articles 1,063 Documents

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Hubungan jenis packed red cell (PRC) yang ditransfusikan dengan reaksi transfusi febrile non haemolytic transfusion reaction (FNHTR) Dinda Kamilah; Dian Widyaningrum
Intisari Sains Medis Vol. 10 No. 1 (2019): (Available online 1 April 2019)
Publisher : DiscoverSys Inc.

Background: One of the components of blood cells are often used for transfusions is Packed Red Cell (PRC). Blood components transfusion may continues with rapid or delayed transfusion ractions. The most transfusion reactionsÂ was fever (55%) or febrile non haemolytic transfusion reaction (FNHTRs). The cause of these events is associated with allogenic leucocytes (the ability to differentiate self cells and non-self cells based on the human leukocyte antigen (HLA) on the cell surface) and release of proinflammatory cytokines such as IL-1, IL-6, IL-8, TNFÎ±, Cell-free DNA (cfDNA), histone and the duration of blood storage. Methods: Cross-sectional study on 41.177 patients who received a PRC transfusion with the FNHTR transfusion reaction in Hospital Blood Bank Dr. Kariadi Semarang, duringÂ January 2017 to July 2018. Pearson Chi Square test for expected frequency more than 5. The Kolmogorov smirnov and Shapiro-wilk test were used to evaluate normality of the data. Mann-Whitney test to analyze the difference, p < 0,05 was considered as significant.Results: The incidence of FNHTR was lower in patients who received leukodepleted PRC (11 patients) than non leukodepleted PRC (124 patients). There were differences in body temperature in the incidence of FNHTR between the two groups 38.10 C (38-39) VS 38.40 C (38 â€“ 39.2) with p = 0,046.Conclusions:There were relationship between the incidence of FNHTR with the transfusion with leukodepleted PRC and non leukodepleted PRC.

Karakteristik kasus faringitis akut di Rumah Sakit Umum Daerah Wangaya Denpasar periode Januari â€“ Desember 2015 Darryl Alby Triadi; I Made Sudipta
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Background: Acute pharyngitis is an infection of the pharynx caused by viruses or bacteria, which is characterized by the presence of a sore throat, exudate, hyperemia, fever, lymph nodes enlargement of the neck, and malaise. The most common etiology are the germs of Streptococci Î²-haemolyticus, Streptococcal viridans, and Streptococci pyogenes. It can also be caused by viral infections such as influenza and adenovirus. Acute pharyngitis can be transmitted through contact by nasal or droplet infection of people suffering pharyngitis.Aim: The study aimed to report acute pharyngitis in the Wangaya General Hospital in the period January - December 2015.Method: This study was an observational study using a descriptive cross sectional design for patients with acute pharyngitis in the Wangaya General Hospital in the period January - December 2015.Result and Conclusion: Proportion of acute pharyngitis patients based on age at Wangaya General Hospital were the highest in the age group 0-14 years as many as 47 people (55.9%). The lowest proportion is in the age group > 50 years, 16 people (19%). By its sex proportion, the highest was among women, 48 people (57.2%) as against 36 people (42.8%) for men. Based on clinical symptoms proportion in Wangaya General Hospital, throat pain as many as 57 people (67.9%), followed by difficulty of swallowing as many as 47 (55.9%), fever 19 (22.6%), vomiting 18 (21.4%), malaise 17 (20.2%), lymph nodes enlargement 13 (15.5%), and those with a headache 4 (4.8%)Â Faringitis akut adalah infeksi pada faring yang disebabkan oleh virus atau bakteri, yang ditandai oleh adanya nyeri tenggorokan, faring eksudat dan hiperemis, demam, pembesaran limfanodi leher dan malaise. Penyebab terbanyak radang ini adalah kuman golongan Streptokokus Î²-haemolyticus, Streptoccocus viridans dan Streptoccocus pyogenes. Penyakit ini juga dapat disebabkan oleh infeksi virus seperti virus influenza dan adenovirus. Faringitis akut dapat menular melalui kontak dari sekret hidung dan ludah (droplet infection) dari orang yang menderita faringitis.Tujuan: untuk mengetahui gambaran tentang penyakit faringitis akut di Rumah Sakit Umum Daerah (RSUD) Wangaya Denpasar periode Januari â€“ Desember 2015.Metode: Penelitian ini merupakan penelitian observasional yang menggunakan rancangan desktiptif cross sectional terhadap penderita penyakit faringitis akut di RSUD Wangaya Denpasar periode Januari - Desember 2015.Hasil dan Simpulan: Proporsi penderita Faringitis Akut berdasarkan umur di RSUD Wangaya Denpasar yang tertinggi dijumpai pada pada kelompok umur 0-14 tahun, yaitu 47 orang (55,9%). Proporsi terendah terdapat pada kelompok umur >50 tahun, yaitu 16 orang (19,0%). Proporsi penderita Faringitis Akut berdasarkan jenis kelamin di RSUD Wangaya Denpasar yang tertinggi adalah pada perempuan yaitu 48 orang (57,2%). Sedangkan pada laki-laki yaitu 36 orang (42,8%). Proporsi penderita Faringitis Akut berdasarkan gejala klinis yang dialami di RSUD Wangaya yang tertinggi adalah nyeri tenggorok sebanyak 57 orang (67,9% ), diikuti sulit menelan sebanyak 47 orang (55,9% ), demam 19 orang (22,6% ), muntah 18 orang (21,4% ), malaise 17 orang ( 20,2%), kelenjar limfa bengkak 13 orang (15,5% ), dan yang disertai nyeri kepala 4 orang (4,8%)

Uji efektivitas ekstrak kunyit (Curcuma longa) terhadap daya hambat pertumbuhan bakteri Streptococcus mutans I Nyoman Candra Kumara; I Gusti Agung Sri Pradnyani; I Gusti Ayu Fienna Novianthi Sidiarta
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Background: Dental caries is a multifactorial disease characterized by dental tissue damage caused by the production of bacterial acids. The bacteria play the most role in the occurrence of caries is Streptococcus mutans. Turmeric extract (Curcuma longa) has been studied can inhibit bacterial growth because it contains essential oils and curcumin. The purpose of this study was to determine the inhibitory power of turmeric extract 5%, 10%, 20%, and 40% on the growth of Streptococcus mutans bacteria.Methods: Studies with true experimental design using a post test only control group design have been carried out on Streptococcus mutans bacteria. Turmeric extract was made by maceration method into 96% ethanol so that the required concentration was obtained (5%, 10%, 20%, dan 40%). The inhibition testing is done by the disk-diffusion method. Data were analyzed using the Kruskal-Wallis test on SPSS version 20 due to the data were not normally distributed.Results: The results showed that phytochemical assessment of turmeric extract showed positive results on phenol, essential oil, saponins, tannins, and flavonoids. The average value of the inhibitory zone diameter of Streptococcus mutans bacteria formed in turmeric extract concentrations of 5%, 10%, 20%, and 40% is 0 mm where there are significant differences compared to positive controls (P < 0.05)Conclusion: Various doses of turmeric extract couldnâ€™t inhibit the growth of Streptococcus mutans bacteriaÂ

Aktivitas secara in vitro dan in vivo kombinasi ekstrak daun kelor (Moringa oleifera lam.) dan pegagan (Centella asiatica (l.). Urb.) sebagai gel anti jerawat Ninik Setya Hastuti; Shelly Taurhesia; Agung Eru Wibowo
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Background: Acne is a skin problem that is common in everyday life. Expressions of acne can cause psychological problems because of appearance. Moringa leaf extract and herbs contain alkaloid compounds, flavonoids, saponins, tannins and phenolics that can be used as antibacterial, reduce inflammation, reduce sebum glands and moisturize the skin. The purpose of this study was to conduct an in vitro and in vivo analysis of gel activity in combination of Moringa Oleifera L. leaf extract and Centella asiatica (L.). Urb.) Herb or KEKP gel as an anti-acne gel.Method: Activities carried out in vitro with an antibacterial effect on P. acnes, in vivo are carried out by clinical observation and measurement of sebum secretion. The gel contains the same combination of extracts. Twelve volunteers who met the inclusion and exclusion criteria followed the in vivo test to determine the safety and benefits of KEKP gel.Results: At a concentration of 0.78% dilution shows a diameter of 10.4 mm inhibitory power. Medikline as a positive control gives better results compared to KEKP gel with a minimum inhibition diameter of 16.6 mm. Clinical improvement was assessed by reduced signs of inflammation, the number of papules, pustules, nodules and changes in sebum levels measured using a skin analysis tool.Conclusion: The results showed that KEKP antifungal gel invitro had antibacterial activity, and in vivo showed real clinical differences

The oxidative-stress level determine patientâ€™s outcomes with a severe head injury at Sanglah General Hospital, Denpasar, Indonesia I Made Bagus Wirawan; I Nyoman Golden; I Wayan Niryana
Intisari Sains Medis Vol. 10 No. 1 (2019): (Available online 1 April 2019)
Publisher : DiscoverSys Inc.

Background: In secondary brain injury, oxidative stress will occur due to a balance disorder between pro-oxidants with antioxidants. The antioxidant activity that is often used to assess oxidative stress, such as malondialdehyde (MDA), is superoxide dismutase (SOD) and glutathione peroxidase (GPx). This study aims to evaluate the level of oxidative stress, reflected by the MDA serum level and SOD level to determine the outcomes of patients with severe head injury.Method: A cross-sectional analytic study was conducted among 40 patients with severe head injury within 24 hours post-trauma at Emergency Ward, Surgery Department, Sanglah General Hospital Denpasar from January - June 2017. MDA and SOD levels were assessed using ELISA at Clinical Pathology Laboratory, Sanglah General Hospital. Data were analyzed using SPSS ver. 16 software. Results: This study found significant differences on elevated MDA levels (p-value < 0.05) in patients who died or had a persistent vegetative state, patients with severe disability and those with a good recovery/moderate disability. The statistical analysis also found a significant difference in MDA serum levels among patient with severe disability and patients with a good recovery/moderate disability (P=0,028). Meanwhile, there was no significant correlation between SOD serum levels and patients outcome (P>0.05).Conclusion: Increased MDA serum levels is a significant factor in predicting outcomes of patients with severe head injury.

Hubungan antara Chronic Kidney Disease (CKD) dengan hipotiroid di RSUP Dr. Kariadi Semarang, Indonesia I Gede Ardy Surya Dharmanta; Indranila Kustarini Samsuria
Intisari Sains Medis Vol. 10 No. 1 (2019): (Available online 1 April 2019)
Publisher : DiscoverSys Inc.

Background: Thyroid hormone in many previous studies have been linked to chronic kidney disease (CKD). There are several interactions between renal dysfunction and thyroid hormones that influence each other. The aim of this study was to see the effect of CKD on the thyroid.Methods: Cross sectional studies on subject data taken retrospectively by looking at medical records on a single center Dr. Kariadi Semarang Hospital during the period 1 June 2017 â€“ 1 June 2018 to then observe the correlation effect of CKD on thyroid hormones by comparing serum urea and creatinine with T3, T4 andTSH.Results: There was a significant correlation of CKD on T3 and TSH levels with ureum (p = 0.020 and p = 0,0,25), and there was a significantly weak correltaion with creatinin (p = 0,081), but there was no significant correlation in T4 (p=0,102; p = 0,108).Conclusion: The results of this study can be concluded that there is a significant correlation between Chronic Kidney Disease (CKD and hypothyroidism, especially the correltation effect of T3 with ureum and creatinine, and TSH with ureum.

Perbedaan rerata kadar protein-C pada sepsis neonatorum dengan kultur positif dan negative di RSUP H. Adam Malik Medan tahun 2018 Jeffry Nugraha; Ricke Loesnihari; Guslihan Dasa Tjipta
Intisari Sains Medis Vol. 10 No. 2 (2019): (Available online: 1 August 2019)
Publisher : DiscoverSys Inc.

Background: First ten months from conception is a period of susceptibility to infection. Diagnostic testing for disease must be conducted as quickly as possible for antimicrobial administration. Blood culture, the 'gold standard' for diagnosis, is full of shortcomings. Decreasing protein C levels are characteristic of sepsis due to an increase in consumption, degradation, or decreased synthesis, so that the onset of protein C deficiency may occur before the diagnosis of sepsis.Aim: The study aimed to determine the difference in mean serum C protein levels in septic neonatorum in which positive cultures compared with negative culturesMethods: The sample in this study were septic neonatorum patients in the perinatology unit of H. Adam Malik General Hospital Medan by consecutive sampling technique. The blood was incubated in BACTEC 9050 and identified with gram staining, gram-positive identified by catalase, coagulase and MSA tests, while gram-negative with API 20E. Protein C was examined with Coatron A4. A bivariate analysis determined differences in protein C in septic neonatorum with positive and negative cultures.Result: The prevalence of positive culture sepsis was 36.1%. The most common pathogens were Staphylococci epidermidis (19.4%). There was no significant difference in protein C levels between the septic neonatorum with positive and negative cultures (p = 0.166). Positive culture sepsis is a risk factor associated with protein C decreasing with p = 0.011. Positive culture sepsis had a higher risk of reducing protein C levels by 7.536 times compared to negative culture sepsis.Conclusion: There were no significant differences in protein C levels between septic neonatorum with positive and negative cultures, but sepsis was significantly associated with a decrease in C protein levels.

Hubungan kadar leptin terhadap parameter trombosit pada pasien dengan obesitas Dwi Fajaryani; Meita Hendrianingtyas; Dwi Retnoningrum
Intisari Sains Medis Vol. 10 No. 1 (2019): (Available online 1 April 2019)
Publisher : DiscoverSys Inc.

Background: Obesity is excessive and abnormal fat accumulation thus harmful to health. Increase in body mass index (BMI) in obesity, also accompanied by increase hormon which synthesized and released by adipose tissue informs the brain for controlling hunger and food intake that is Leptin. Leptin plays a role in chronic inflammatory process of obesity. Leptin receptor was detected in human platelets and high concentration of leptin reported to promote platelet aggregation. The platelet parameters examination is a cheap, easy, and routinly done in daily basis, which consist of platelet counts, mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (PLCR), plateletcrit (PCT), which indicates platelet proliferation. The aim of research was to look the relationship of leptin with thrombocyte parameter in obesity people.Methods: Cross sectional study of 45 obese adults, based on RISKESDAS criteria Â with Â BMI>27, on Mei-September 2018 was done. Venous blood collected in EDTA and plain tube. The EDTA sample was used for complete hematological examination to obtain platelet parameters by Hematology analayzer with impendace method. Serum from plain tube used for leptin examination was measured by ELISA. Data were analyzed by Pearson and Spearman correlation test. P-value < 0,05 was consideres as significant.Results: There is no correlation between leptin and platelet count (r=0,051, p=0,740), MPV (r=0,021, p=0,891), PDW (r=-0,093, p=0,541),Â P-LCR (r=0,082,Â p=0,593), and PCTÂ (r=0,079, p=0,605).Â Conclusion: There is no correlation between leptin and platelet parameters in obesity. Further studies need to be done with adding another characteristic such as inflammation markers, metabolic syndrome parameters and platelet activation

Gambaran pengetahuan, sikap, dan perilaku tentang vaginal hygiene terhadap kejadian keputihan patologis pada siswi kelas 1 di SMA Negeri 1 Denpasar periode Juli 2018 Ida Ayu Cintya Pradnyandari; I Gede Ngurah Harry Wijaya Surya; Made Bagus Dwi Aryana
Intisari Sains Medis Vol. 10 No. 1 (2019): (Available online 1 April 2019)
Publisher : DiscoverSys Inc.

Introduction: Leucorrhea was a prolonged problem that has been experienced by women, especially teenagers. Teenagers are part of a population that are at risk. Pathological leucorrhea which is not prevented and handled properly can cause various disease and have a fatal end. This research aimed to know how were the knowledge, attitudes, and behavior of vaginal hygiene towards pathological leucorrhea phenomenon on first grade female students in 1 Senior High School of Denpasar City. Method: This research was a descriptive study with cross-sectional method. The research subject was 106 first grade female students in 1 Senior High School of Denpasar City. The data were collected on 26th of July 2018. This research used primary data from the questionnaire that had been filled out.Result: The results showed that the level of knowledge about vaginal hygiene was 99,9% good and 0,1% bad. The level of attitudes about vaginal hygiene was 100% good. The level of behavior about vaginal hygiene was 98,2% good and 1,8% bad.Conclusion: Most of the student in Senior High School 1 Denpasar have a good level of knowledge, attitude, and behavior towards vaginal hygiene.

Analisis kadar fetuin-A pada pasien dengan sirosis hati di RSUP Haji Adam Malik, Medan, Indonesia Yuni Aflah Lubis; Zulfikar Lubis; Ilhamd Ilhamd
Intisari Sains Medis Vol. 10 No. 2 (2019): (Available online: 1 August 2019)
Publisher : DiscoverSys Inc.

Background: Serum Fetuin-A is produced by hepatocytes in adults and its concentration decreases during acute phase reactions in patients with liver disease. Due to it is synthesized in the liver, in some chronic liver diseases the Fetuin A levels decrease as in hepatic cirrhosis. This study aims to determine the difference between Fetuin-A levels in each severity degree in liver cirrhosis patients (Child-Pugh Score).Methods: The study was conducted in the FK USU Clinical Pathology Department / RSUP H. Adam Malik Medan in collaboration with the Gastro Entero Hepatology Division of the Internal Medicine Department FK-USU / RSUP. H. Adam Malik, Medan for the period January to April 2018. An cross-sectional observational analytic method was conducted. There were 33 people with liver cirrhosis and based on Child pugh criteria consisted of 11 cirrhosis patients with liver cirrhosis, 11 class B people, 11 class C people fulfilling the criteria inclusion. The study sample was examined by Fetuin-A and analyzed using SPSS version 17.Results: There were significant differences in fetuin A levels between groups, namely in class A liver cirrhosis of 273.87 Â± 15.77 pg / ml, class B 247.43 Â± 4.69 and in class C 191 Â± 10.99 with a p-value was <0.000. In addition, there was a significant difference between the gender with the degree of liver cirrhosis (P <0.05) but not significantly different from the mean age and degrees of liver cirrhosis (P> 0.05)Conclusion: There were significant differences in Fetuin-A levels between patients in liver cirrhosis in all three groups based on Child-Pugh criteria. However, there was no significant difference in age between the three groups based on Child-Pugh criteria.

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