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INDONESIA
ISM (Intisari Sains Medis) : Jurnal Kedokteran
Published by Universitas Udayana
ISSN : 25033638     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Intisari Sains Medis is published by Medical Scientific Community, Indonesia. Intisari Sains Medis is an international, multidisciplinary, peer-reviewed, open access journal accepts papers for publication in all aspects of Science Digest, Medical Research Development, Research Medical Field and Theory. We also publish cases from third world country, that is considered very rare and special cases.
Arjuna Subject : -
Articles 1,063 Documents
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Perbedaan jenis kuman pada pasien Diabetes Mellitus Tipe-2 (DM-2) dengan infeksi saluran kemih dan bakteriuria asimtomatik di RSUP H. Adam Malik, Medan, Indonesia Deby Novayanti; Ricke Loesnihari; Muzahar Muzahar
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (474.229 KB) | DOI: 10.15562/ism.v11i1.569

Abstract

Background: Patients with Diabetes Mellitus Type-2 (DM-2) have a high probability of suffering from urinary tract infections (UTIs) and asymptomatic bacteriuria (AB). AB is the presence of significant bacteriuria > 105 cfu/ml in urine cultures without clinical symptoms (asymptomatic). This study aims to find out the different types of the pathogen in DM-2 patients with urinary tract infections and bacteriuria asymptomatic at H. Adam Malik Hospital, Medan, Indonesia. Methods: A total of 18 DM-2 patients with UTIs and 18 patients with AB who met the criteria were included in this study from H. Adam Malik Hospital, Medan, Indonesia. Fasting blood glucose and blood glucose levels in 2 hours postprandial were examined. The middle portion of urine sample using a sterile container was conducted for urinalysis test using dipstick (Combur10 Test M, Roche Mannheim, Germany) and a Cobas U 411 ROCHE urine analyzer. Urine leukocytes were evaluated using leukocyte esterase. The urine culture for identification of bacterial and antibiotic sensitivity tests was conducted if leukocytes count > 5 / LPB. Data were analyzed using SPSS version 17 for Windows. Results: Most of the DM-2 respondents were females in both Urinary Tract Infection (UTI) group (77.8%) and Asymptomatic Bacteriuria (AB) group (88.9%). The age group of 39-50 years was predominant in the UTIs group (50.0%) compared with AB group in age 51-62 years old group (44.4%). Data were normally distributed between types of bacterial infection on both groups (p=0.945). However, based on the sensitivity and resistance of antibiotics, no significant difference was found between both groups (P>0.05) except for cefixime (p=0.018) from the Chi-square test.  Conclusion: There were no differences in the types of pathogen in UTIs and AB among DM-2 patients. Besides, no significant difference for bacterial sensitivity and resistance found between groups except in cefixime.  Latar Belakang: Pasien Diabetes Mellitus Tipe-2 (DM-2) memiliki kemungkinan tinggi menderita Infeksi Saluran Kemih (ISK) dan Bakteriuria Asimptomatik (BAS). BAS adalah adanya bakteriuria yang signifikan >105 cfu/ml dalam kultur urin tanpa gejala klinis (asimptomatik). Penelitian ini bertujuan untuk mengetahui berbagai jenis patogen pada pasien DM-2 dengan infeksi saluran kemih dan bakteriuria asimptomatik di Rumah Sakit H. Adam Malik, Medan, Indonesia.Metode: Sebanyak 18 pasien DM-2 dengan ISK dan 18 pasien dengan BA yang memenuhi kriteria dimasukkan dalam penelitian ini dari Rumah Sakit H. Adam Malik, Medan, Indonesia. Glukosa darah puasa dan kadar glukosa darah dalam 2 jam post-prandial diperiksa. Bagian tengah sampel urin menggunakan wadah steril diambil untuk menjalani tes urinalisis menggunakan dipstick (Combur10 Test M, Roche Mannheim, Jerman) dan alat analisis urin Cobas U 411 ROCHE. Leukosit urin dievaluasi menggunakan leukosit esterase. Kultur urin untuk identifikasi tes sensitivitas bakteri dan antibiotik dilakukan jika jumlah leukosit > 5/LPB. Data dianalisis menggunakan SPSS versi 17 untuk Windows.Hasil: Sebagian besar responden DM-2 adalah perempuan dalam kelompok Infeksi Saluran Kemih (ISK) (77,8%) dan kelompok Bakteriuria Asimtomatik (BAS) (88,9%). Kelompok usia 39-50 tahun dominan pada kelompok ISK (50,0%) dibandingkan dengan BA pada kelompok usia 51-62 tahun (44,4%). Data terdistribusi secara normal terhadap jenis infeksi bakteri pada kedua kelompok (p = 0,945). Namun, berdasarkan sensitivitas dan resistensi antibiotik, tidak ada perbedaan bermakna yang ditemukan antara kedua kelompok (P> 0,05) kecuali untuk sefiksim (p = 0,018) dari uji Chi-square.Kesimpulan: Tidak ada perbedaan dalam jenis patogen pada ISK dan AB pada pasien DM-2. Selain itu, tidak ada perbedaan bermakna untuk sensitivitas dan resistensi bakteri yang ditemukan antara kelompok kecuali pada sefiksim.
Perbedaan kadar serum feritin dengan dan tanpa infeksi Soil – Transmitted Helminth (STH) pada anak sekolah dasar di Pesantren Hidayatullah Tanjung Morawa, Kabupaten Deli Serdang, Sumatera Utara, tahun 2018 Noffrizal Noffrizal; Ricke Loesnihari; Muzahar Muzahar
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (361.335 KB) | DOI: 10.15562/ism.v11i1.570

Abstract

Background: Worm infections caused by Soil-Transmitted Helminths (STH) currently remains a public health problem in the world, especially Indonesia. STH infection is a risk factor for iron deficiency and eventually reaches the stage of iron deficiency anaemia in chronic infections. Serum ferritin levels were measured as early detection of loss of iron reserves in the body to prevent anaemia. This study aims to compare serum ferritin levels in elementary school/ibtidaiyah children with and without STH infection.Method: A cross-sectional study was conducted among 60 children at Pesantren Hidayatullah Tanjung Morawa in 2018. About 30 children infected with STH and 30 children not-infected with STH, who fulfilled the inclusion and exclusion criteria were included in this study. Every child was examined for faeces with the Kato-Katz Method and serum ferritin levels with Cobas e411 (Electrochemiluminescence immunoassay). The results obtained were analyzed by Mann Whitney's test by SPSS version 17 for Windows.Result: Serum ferritin levels in the group with STH infection were 10-281 ng/ml, whereas, in the group that did not suffer from STH infection, the values were 15 - 283 ng/ml. The median rank between groups was 5.26 (>5), so clinically, there were significant differences between the two groups. But statistically, there was no significant difference between serum ferritin levels between the two groups (p = 0.24), with the significance value of the Mann-Whitney test p <0.05.Conclusion: The study showed no significant difference between serum ferritin levels between groups of children who had STH infection and groups of children who did not have STH infection. Pendahuluan: Infeksi cacing yang disebabkan Soil Transmitted Helminths (STH) saat ini tetap menjadi permasalahan kesehatan masyarakat di dunia khususnya Indonesia. Infeksi STH merupakan salah satu faktor resiko terjadinya defisiensi besi dan akhirnya mencapai tahapan anemia defisiensi besi pada infeksi kronis. Kadar serum feritin diukur sebagai deteksi dini hilangnya cadangan zat besi dalam tubuh untuk mencegah terjadinya anemia. Tujuan penelitian ini adalah untuk untuk membandingkan kadar serum ferritin pada anak sekolah dasar/ ibtidaiyah dengan dan tanpa infeksi STHMetode: Sebuah penelitian potong lintang dilakukan terhadap 60 anak pada Pesantren Hidayatullah Tanjung Morawa pada tahun 2018. Sekitar 30 anak terinfeksi STH dan 30 anak tidak terinfeksi STH dimana telah memenuhi kriteria inklusi dan ekslusi terlibat dalam penelitian ini. Setiap anak dilakukan pemeriksaan tinja dengan Metode Kato-Katz serta kadar serum ferritin dengan alat Cobas e411 (Electrochemiluminescence immunoassay). Hasil yang didapat dianalisa dengan uji Mann-Whitney menggunakan SPSS versi 17 untuk Windows.Hasil: Kadar serum feritin pada kelompok dengan infeksi STH adalah 10 – 281 ng/ml sedangkan pada kelompok yang tidak menderita infeksi STH di peroleh nilai 15 – 283 ng/ml. Rank median antar kelompok 5,26 (>5), maka secara klinis terdapat perbedaan bermakna antara kedua kelompok. Tetapi secara statistik tidak terdapat perbedaan yang bermakna antara kadar serum feritin antara kedua kelompok (p = 0,24).Kesimpulan : Penelitian menunjukkan tidak terdapat perbedaan yang bermakna antara kadar serum feritin antara kelompok anak yang mengalami infeksi STH dan kelompok anak yang tidak mengalami infeksi STH.
Perbedaan nilai Neutrophil Lymphocyte Ratio (NLR) terhadap pemeriksaan kultur darah dalam mendiagnosis sepsis pada pasien peritonitis di RSUP Sanglah, Bali, Indonesia I Putu Gede Sudiartha; I Ketut Wiargitha; Tjokorda Gde Bagus Mahadewa
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (537.4 KB) | DOI: 10.15562/ism.v11i1.571

Abstract

Background: Sepsis is a leading cause of death worldwide. A delayed or missed diagnosis of sepsis could increase its morbidity and mortality. The abdomen is the most common source of sepsis, which known as peritonitis-induced-sepsis. Peritonitis leads to an inflammatory and anti-inflammatory response. This study aims to elaborate on the role of Neutrophil Lymphocyte Ratio (NLR) as an easy, fast and inexpensive infection marker compared to blood culture, which known as the gold standard of sepsis in peritonitis patients. Methods: This is a diagnostic study which combined secondary data taken at Sanglah Hospital Medical Record Department and new cases of generalized peritonitis patients with sepsis who came to Surgical Emergency Unit of Sanglah Hospital as the subjects. A total of 86 subjects, complete blood count analysis was done to calculate NLR. Besides, 2-sided blood culture was tested to see whether the results were positive or negative. Data were analyzed using Stata/SE version 12.1Results: We found that sensitivity of NLR compared to blood culture was 80% (CI:63.1-91.6), with specificity of 88.2% (CI:76.1-95.6), positive predictive value of 82.4% (CI:65.5-93.2), negative predictive value of 86.5% (74.2-94.4), accuracy of 84.9% and likelihood ratio (LR) positive value of 6.8>1. Our results showed that NLR has an enormous value in predicting the occurrence of sepsis in patients with generalized peritonitis. Conclusion: NLR can be used as a screening tool for sepsis in generalized peritonitis patients because it has better sensitivity and accuracy, but it has to confirmed by blood culture as the gold standard. Latar belakang: Sepsis merupakan penyebab kematian diseluruh dunia. Keterlambatan atau kesalahan dalam mendiagnosis dapat menyebabkan peningkatkan morbiditas dan mortalitas. Abdomen merupakan sumber penyebab paling sering terjadinya sepsis yang disebut dengan sepsis diinduksi peritonitis (peritonitis-induced sepsis). Penelitian ini bertujuan untuk menguji kemampuan Neutrophil Lymphocyte Ratio (NLR) sebagai marker infeksi yang mudah, cepat dan murah dibandingkan kultur darah yang merupakan standar baku dalam mendiagnosis sepsis pada pasien peritonitis.Metode: Rancangan penelitan yang digunakan dalam penelitian ini adalah uji diagnostik dengan subjek penelitian  merupakan gabungan antara data sekunder yang diambil di Instalasi Rekam Medis RSUP Sanglah serta identifikasi kasus baru yaitu pasien sepsis pada peritonitis generalisata yang datang ke IRD Bedah RSUP Sanglah sehingga jumlah total sampel 86 orang. Pasien kemudian diambil darah lengkap untuk nilai NLR dan kultur darah 2 sisi apakah hasilnya positif atau negatif. Data dianalisis menggunakan Stata/SE versi 12.1Hasil:   Dari penelitian ini didapatkan sensitifitas NLR dibandingkan dengan kultur darah adalah sebesar 80% (CI: 63,1-91,6) dengan spesifitas 88,2% (CI: 76,1-95,6), nilai prediktif positif 82,4% (CI: 65,5-93,2), nilai prediktif negatif 86,5% (CI: 74,2-94,4) dan akurasi 84,9%, serta nilai likelihood ratio (LR) positif didapatkan 6,8>1. NLR mempunyai nilai yang besar dalam meprediksi terjadinya sepsis pada pasien peritonitis generalisata.Simpulan: NLR dapat digunakan sebagai skrinning pasien sepsis pada peritonitis generalisata karena memiliki sensistifitas dan akurasi yang lebih baik tetapi tetap dikonfirmasi dengan kultur darah sebagai standar baku.
Faktor – faktor yang berhubungan dengan kejadian anemia pada anak usia 6-59 bulan di RSUD Wangaya, Denpasar, Bali, Indonesia tahun 2019 Elien Yuwono; I Wayan Bikin Suryawan; Anak Agung Made Sucipta
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (286.421 KB) | DOI: 10.15562/ism.v11i1.572

Abstract

Background: Anemia is one of the four micronutrient problems in Indonesia. Based on Global Prevalence on Anemia, the Southeast Asian region is one of the areas with the highest prevalence of anemic populations, more than 53.8% of children aged 6-59 months were classified as mild anemia, and 3.6% of them are severe anemia. In the first 1000 day birth gold period, anemia was associated with delays and developmental disorders, both motor and intellectual, which may be irreversible. This study aims to analyze the risk factors for the incidence of anemia to optimize child development.Objective: To analyze the relations of the risk of age under two years old, low birth weight, underweight, short stunting, and not exclusive breastfeeding, to the incidence of anemia in children aged 6-59 months in Kaswari Room, Wangaya General Hospital, Denpasar in 2019.Methods: Observational analytic epidemiology design with case-control study. The research subjects were determined by consecutive sampling method and fulfilled the inclusion criteria with a comparison of case and control groups, namely 1: 1. Data were analyzed bivariate by chi-square statistical test and Odds Ratio (OR) at the significance limit of α=5%, and multivariate analysis was performed with logistic regression test. Data was processed using the Statistical Package for Social Science (SPSS) version 23 for Windows program.Results: The research subjects were 62 samples, consisting of 31 anemia samples, and 31 samples had no anemia. The results showed that there was no significant relationship between the risk of low birth weight and the incidence of anemia (95% CI = 0.80 - 22.29; p: 0.073), the risk of malnutrition with the incidence of anemia (95% CI = 0.81 - 63.85; p: 0.052), and the risk of not exclusive breastfeeding with the incidence of anemia (95% CI = 0.21 - 1.63; p: 0.440). However, there was a significant relationship between the risk of age <2 years with the incidence of anemia (OR 3.870; 95% CI = 1.34 - 11.17; p: 0.022) and the risk of short stature with the incidence of anemia (OR 7.686; 95% CI = 1, 92 - 30.70; p: 0.002). Logistic regression test results obtained significant results in short stature variables (sig 0.020; OR 5.379).Conclusion: age <2 years and short stature (stunting) have a significant relationship with the incidence of anemia in children aged 6-59 months in Kaswari Room, Wangaya Hospital, Denpasar in 2019. Latar belakang : Anemia merupakan salah satu dari empat masalah gizi mikro masyarakat Indonesia. Berdasarkan Global Prevalence on Anaemia, regio Asia Tenggara menjadi salah satu kawasan dengan prevalensi tertinggi populasi anemia, lebih dari 53,8% anak usia 6-59 bulan diklasifikasikan anemia ringan, serta 3,6% di antaranya adalah anemia berat1. Pada periode emas 1000 HPK, anemia berhubungan dengan keterlambatan dan gangguan perkembangan baik motorik maupun intelektual yang mungkin irreversible2. Penelitian ini bertujuan untuk menganalisis faktor-faktor risiko kejadian anemia sebagai langkah mengoptimalkan tumbuh kembang anak.Tujuan : Menganalisis hubungan risiko usia  < 2 tahun, berat badan lahir rendah, gizi kurang (underweight), perawakan pendek (stunting), dan tidak ASI eksklusif, terhadap kejadian anemia pada anak usia 6-59 bulan di Ruang Kaswari, RSUD Wangaya, Denpasar tahun 2019.Metode : Rancangan epidemiologi analitik observasional dengan desain studi case control. Subyek penelitian ditentukan dengan metode consecutive sampling, serta memenuhi kriteria inklusi dengan perbandingan kelompok kasus dan kontrol yaitu 1:1. Data dianalisis bivariat dengan  uji statistic chi-square dan Odds Ratio (OR) pada batas kemaknaan α 5%, serta dilakukan analisis multivariat dengan uji regresi logistic. Data diproses menggunakan program Statistical Package for Social Science (SPSS) versi 23 for Windows.Hasil : Subjek penelitian sejumlah 62 sampel, terdiri dari 31 sampel anemia dan 31 sampel tidak anemia. Hasil penelitian menunjukkan bahwa tidak didapatkan hubungan bermakna antara risiko berat badan lahir rendah dengan kejadian anemia (95% CI = 0,80 – 22,29; p:0,073), risiko gizi kurang dengan kejadian anemia (95% CI = 0,81 – 63,85; p:0,052),  serta risiko tidak ASI eksklusif dengan kejadian anemia (95% CI = 0,21 – 1,63; p:0,440). Namun didapatkan hubungan bermakna antara risiko usia < 2 tahun dengan kejadian anemia (OR 3,870; 95% CI = 1,34 – 11,17; p:0,022) dan risiko perawakan pendek dengan kejadian anemia (OR 7,686; 95% CI = 1,92 – 30,70; p:0,002). Hasil uji regresi logistic, didapatkan hasil bermakna pada variabel perawakan pendek (sig 0,020; OR 5,379).Kesimpulan:  usia < 2 tahun dan perawakan pendek (stunting) memiliki hubungan bermakna dengan kejadian anemia pada anak usia 6-59 bulan di Ruang Kaswari, RSUD Wangaya, Denpasar tahun 2019.
Plasmodium falciparum Serine Repeat Antigen 5 (PfSERA5): current vaccine candidate for Plasmodium falciparum malaria Ayuti Bulaan; W. Riski Widya Mulyani; Agung Nova Mahendra; I Wayan Sumardika
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (853.556 KB) | DOI: 10.15562/ism.v11i1.573

Abstract

Background: Most of the malaria cases are caused by Plasmodium falciparum infection. The prevalence of cases and high mortality rates due to malaria should be watched out globally. However, currently, efforts to prevent and treat malaria suffer obstacles due to resistance to insecticides and antimalarial drugs. For these reasons, other preventive measures are needed, such as vaccines. This study aims to review the Plasmodium falciparum Serine Repeat Antigen 5 (PfSERA5) as a potential candidate for Plasmodium falciparum malaria vaccine development. Methods: Of the 65 journals reviewed, 51 journals were found to be suitable as references for this paper. The keywords included in selected search engines are "malaria" "PfSERA5", "Plasmodium falciparum", and "malaria vaccine". Search results and studies show that the erythrocytic phase of the vaccine can fight malaria parasites that escape the liver stage while reducing or eliminating clinical symptoms. Data were analyzed and written in a narrative form.Results: PfSERA5 is an asexual erythrocytic stage antigen that accumulates in the parasitophorous vacuole. The PfSERA5, SE47 and SE36 (modified SE47) domains can induce the formation of antibodies that protect against falciparum malaria infection in vivo and in vitro. This protective mechanism, caused by PfSERA5 (anti-SE47 and anti-SE36) specific antibodies, occurs through inhibition of parasite growth and merozoite lysis. PfSERA5 also does not show antigenic variations and has limited polymorphism, so the probability of resistance can be reduced. Conclusion: Based on this, PfSERA5 has great potential as an effective erythrocytic phase vaccine candidate. However, further studies are needed regarding the toxicological and pharmacological properties of PfSERA5, both in vivo and in clinical settings.
Self-foreign omphalitis in adult: a case report Daniel Ardian Soesilo; April Baby
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (976.991 KB) | DOI: 10.15562/ism.v11i1.574

Abstract

Introduction: Severe omphalitis in adults is rare and can be caused by both congenital and acquired etiologies. We are reporting an impacted self-foreign-body in omphalitis case induced by accumulated keratin fragments.Case: A 28-year-old overweight male presented with a 3-day history of persistent purulent umbilical discharge with a remittent fever a few days before, constant abdominal tenderness with edema and erythema around navel area. There were no other GIT-related symptoms. He was given oral antibiotics, which showed no improvement. Upon surgery, we examined deep umbilical cavity without urachal connection to the navel. From the umbilical cavity scooped out multiple polypoid umbolith debris. Histopathologic examination revealed pyogenic granuloma with numerous keratin fragments without any foreign bodies.Conclusion: An impacted and infected self-foreign-body may be a cause of omphalitis in adults and could lead to severe and wide-spread infection if left untreated.
Gambaran prediktor perforasi pada penderita apendisitis di Rumah Sakit Umum Ari Canti Gianyar, Bali, Indonesia tahun 2018 Cokorda Bagus Nurparma Putra; Sang Nyoman Suryana
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (290.045 KB) | DOI: 10.15562/ism.v11i1.575

Abstract

Background: Acute appendicitis is one of the most common acute abdomen disease. Morbidity and mortality increased when the complications occur. The most severe complication is perforation which can cause peritonitis and sepsis. So it needs to be known as early as possible to prevent deterioration. This study aims to determine the predictor factors of perforation in appendicitis.Method: This study was retrospective cross sectional design using secondary data from medical records of appendicitis patients treated at Aricanti Hospital, Gianyar in 2018. Total samples are 96 and they were selected by consecutive technique sampling. Data about age, sex, Total Leukocyte Count (TLC), and symptoms duration of appendicitis patients were collected and analyzed using the Chi-square test.Result: From 96 samples, 33 (34.4%) were perforated appendicitis and 63 (65.6%) were acute appendicitis. Chi-square test results showed that the predictor factors associated with perforated appendicitis were age under 10 and above 49 years (PR = 2.0; X2 = 5.474; p <0.05), male more affected than females (X2 = 8.800; p < 0.05), TLC more than 18000/mm3 (PR = 3.3; X2 = 20.862; p <0.05) and symptoms duration above 24 hours (PR = 4.1; X2 = 24.834; p<0.05 ).Conclusion: Age, sex, TLC, and symptoms duration can be used as predictors for perforated appendicitis. These predictor factors should be evaluated in appendicitis patients to prevent the occurrence of perforation or to provide immediate treatment in cases of perforation. Latar Belakang: Apendisitis akut merupakan salah satu akut abdomen yang paling sering dijumpai. Peningkatan morbiditas dan mortalitas terjadi bila terjadi komplikasi. Komplikasi yang terberat adalah perforasi apendiks yang dapat menyebabkan peritonitis dan sepsis. Sehingga perlu diketahui sedini mungkin untuk mencegah perburukan. Penelitian ini bertujuan untuk mengetahui faktor prediktor perforasi pada kasus apendisitis.Metode: Penelitian ini berdesain retrospektif cross sectional dengan menggunakan data sekunder berupa rekam medis pasien apendisitis yang dirawat di RSU Aricanti Gianyar tahun 2018. Sampel pada penelitian ini berjumlah 96 yang dipilih secara consecutive sampling. Data mengenai usia, jenis kelamin, Total Leukosit Count (TLC), dan symptoms duration pasien apendisitis dikumpulkan dan dianalisa menggunakan uji Chi-square.Hasil: Dari 96 sampel, sebanyak 33 (34,4%) merupakan apendisitis perforasi dan 63 (65,6%) merupakan apendisitis akut. Hasil uji Chi-square menunjukan faktor prediktor yang berhubungan dengan apendisitis perforasi adalah usia dibawah 10 dan diatas 49 tahun (PR=2,0; X2= 5,474; p<0,05), jenis kelamin laki laki (X2=8,800; p<0,05), TLC lebih dari 18000/mm3 (PR=3,3; X2=20,862; p<0,05) dan symptoms duration diatas 24 jam (PR=4,1; X2=24,834; p<0,05).Simpulan: Berdasarkan hasil uji statistik tersebut dapat disimpulkan bahwa usia, jenis kelamin, TLC, dan symptoms duration dapat dijadikan faktor prediktor terjadinya apendisitis perforasi. Faktor prediktor ini sebaiknya diperhatikan untuk mencegah kejadian perforasi pada pasien apendisitis ataupun memberikan penanganan yang lebih cepat pada kasus perforasi.
Three-Port Laparoscopic Sleeve Gastrectomy: Serial Cases Report Gede Eka Rusdi Antara; Maria Yustina
Intisari Sains Medis Vol. 10 No. 2 (2019): (Available online: 1 August 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (806.375 KB) | DOI: 10.15562/ism.v10i2.576

Abstract

Background: Laparoscopic sleeve gastrectomy is the procedure of choice for bariatric surgery. It is a minimally invasive procedure that giving good outcome and less complication compared to other procedures. The multiport sleeve gastrectomy technique is usually described by using 4 to 6 ports and an additional port for a liver retractor. Single-incision laparoscopic sleeve gastrectomy was reported, but not widely adopted.  Objective: To describe a convenient and applicable modified technique of three ports laparoscopy for sleeve gastrectomy that may give better outcome and cosmetic.Cases: Four patients were diagnosed with obese class II and III. Upper GI study was performed before surgery. We performed three ports laparoscopic sleeve gastrectomy. The 15 mm port was placed in the umbilical, for the camera. The second 12 mm port was placed in the right side of the umbilical for the stapler, and the third port, 5 mm was placed in the right hypochondrium midclavicular line. During the surgery, we used endoscope as guidance during gastric stapling and also for evaluation the stapler line and the size of the stomach. The postoperative condition was uneventful, the patients have less scar and less length of stay.Conclusion: Three ports laparoscopic sleeve gastrectomy is easy to perform, convenient and applicable, consume less time and also give excellent results for the patient's recovery. 
Berat badan lahir lebih dari 4000 gram merupakan faktor risiko kejadian mikropenis pada bayi baru lahir di Denpasar tahun 2019 I Gusti Bagus Dharma Prakasa Musti; Gede Wirya Kusuma Duarsa; Tjok Gde Mahadewa; Gede Wirata
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (326.915 KB) | DOI: 10.15562/ism.v10i3.577

Abstract

Background: Standard values related to age for penis size can help for early diagnosis and treatment of potential diseases. Rapid changes in growth and interindividual differences can occur during infancy and puberty. Therefore, micropenis data during newborns are beneficial for clinical evaluation and prognosis.Aim: This study aims to find out whether birth weight > 4000 grams and testis size <0.52 cm are risk factors for micropenis prevalence in newborns.Methods: This study used a descriptive-analytical cohort study involving 85 research subjects, namely healthy newborn boys who did not experience hypospadias, severe chordae, ambiguous penises. Respondents contributed to physical examinations and investigations following the standard procedure in the analysis of the weight, gestational age, and size of the testis. The study also evaluated the risk factors for micropenis in the form of a history of maternal hormonal birth control.Results: The micropenis was categorised to be <1.8 cm, which was obtained from <2.5 SD mean where the size of penis length in this study was achieved with a mean of 2.08 cm. The results of the multi-variate test showed that birth weight> 4000 grams was the most dominant risk factor causing micropenis. The positive B value with a value of 5.13, which means birth weight> 4000 grams has a positive relationship with the incidence of micropenis. The newborn weight was obtained about p = 0,000 (95%CI: 11,29-2558,17) with OR 170 which mean that there was an effect of birth weight on the incidence of micropenis where birth weight> 4000 grams had a chance of micropenis by 170 times.Conclusion: Weight> 4000 grams became the most dominant risk factor for micropenis having probabilities for a micropenis approximately 170 times.
Iron-deficiency anemia: a review of diagnosis and management Putu Amanda Widiada
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (463.76 KB) | DOI: 10.15562/ism.v11i1.578

Abstract

Background: Anemia is the most common medical problem encountered in daily practice. It is a significant health problem, especially in developing countries that have a high prevalence. Iron-deficiency anemia (IDA) is anemia that arises due to decrease in iron supply for erythropoiesis regarded with lack of iron storage that consequently leads to reduced haemoglobin formation.Aim: This literature review aims to review diagnosis to the management of IDA.Conclusion: IDA has severe and detrimental health effects. Complete history taking, physical examination, and laboratory test need to be done thoroughly to be able to establish the diagnosis of IDA as well as to determine its cause. Currently used therapies include oral iron therapy which is the first-line therapy, intravenous iron therapy, and blood transfusion. 

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