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INDONESIA
ISM (Intisari Sains Medis) : Jurnal Kedokteran
Published by Universitas Udayana
ISSN : 25033638     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Intisari Sains Medis is published by Medical Scientific Community, Indonesia. Intisari Sains Medis is an international, multidisciplinary, peer-reviewed, open access journal accepts papers for publication in all aspects of Science Digest, Medical Research Development, Research Medical Field and Theory. We also publish cases from third world country, that is considered very rare and special cases.
Arjuna Subject : -
Articles 1,063 Documents
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Karakteristik amplitudo akomodasi mata pada anak sekolah dasar dengan kelainan refraksi di Kabupaten Badung, Bali, Indonesia Luh Gede Anggasari Dewi; Ariesanti Tri Handayani; Ida Bagus Putra Manuaba; Anak Agung Mas Putrawati Triningrat
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (513.438 KB) | DOI: 10.15562/ism.v11i3.789

Abstract

Background: Amplitude of Accommodation (AA) is the maximum amount of accommodation of a person's response when looking closely. Decreased accommodation capability indicates functional abnormalities, including refractive disorders. This study aims to determine the characteristics of accommodative amplitude in elementary school children with refractive abnormalities in Badung Regency, Bali.Methods: This study was an analytic cross-sectional observational research. Data were collected prospectively based on the results of examinations and observational records of students in four elementary schools. Data were presented in frequency, percentage, and bivariate tests. Data were analyzed by SPSS version 20 for Windows.Results: Most of the study respondents were 7 years old (25.7%), female (52.7%), not wearing glasses (91.2%), bilateral myopia correction (43.2%), and having sharp vision before correction of 0.3 (0.2-0.5) diopters. There was a significant difference in binocular eye accommodation based on the comparison of Subject AA with the Expected Value (p = 0.001). However, there was no significant difference in the comparison of students' refractive errors with the amplitude of monocular accommodation (p> 0.05).Conclusion: The measurement of monocular AA decreased with age and in this study, there was no AA result that was lower than the expected value or the minimum value according to the Hofstetteer formula. AA measurement results are not affected by refractive errors. It is necessary to screen for refractive errors early in children to reduce the number of amblyopia.  Latar Belakang: Amplitudo akomodasi (AA) adalah jumlah maksimum akomodasi dari respon seseorang saat melihat dekat. Penurunan kemampuan akomodasi menunjukkan adanya kelainan fungsional antara lain  berupa kelainan refraksi. Tujuan penelitian ini untuk mengetahui karakteristik amplitudo akomodatif pada anak sekolah dasar dengan kelainan refraksi di Kabupaten Badung, Bali.Metode: Penelitian ini merupakan observasional dengan pendekatan studi potong lintang analitik. Data dikumpulkan secara prospektif berdasarkan hasil pemeriksaan dan pencatatan hasil observasi pada anak-anak di empat sekolah dasar. Data ditampilkan dalam bentuk frekuensi, persentase, dan analisis bivariat. Data dianalisis dengan SPSS versi 20 untuk Windows.Hasil: Sebagian besar responden penelitian berusia 7 tahun (25,7%), berjenis kelamin perempuan (52,7%), tidak menggunakan kacamata (91,2%), koreksi kacamata myopia bilateral (43,2%), dan memiliki tajam pengelihatan sebelum koreksi sebesar 0,3 (0,2-0,5) dioptri. Terdapat perbedaan yang bermakna akomodasi mata binokular berdasarkan perbandingan AA Subjek dengan Expected Value (p=0,001). Akan tetapi tidak terdapat perbedaan bermakna pada perbandingan kelainan refraksi siswa dengan amplitudo akomodasi monokular (p>0,05).Kesimpulan: Pengukuran AA monokular menurun sesuai usia dan pada penelitian ini, tidak terdapat hasil AA yang lebih rendah dibandingkan dengan expected value maupun nilai minimal menurut formula Hofstetteer. Hasil pengukuran AA tidak dipengaruhi oleh kelainan refraksi. Perlu dilakukan skrining kelainan refraksi lebih awal pada anak-anak untuk mengurangi jumlah ambliopia.
Association between age, urine pH, and urinary stone incidence in Kardinah Tegal General Hospital, Indonesia Zulfikar Ali; Stevano Lucianto Hotasi
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (320.973 KB) | DOI: 10.15562/ism.v11i3.790

Abstract

Introduction: An increase in the incidence of urolithiasis at age> 15 years in Indonesia provides increased morbidity and medical costs. The study aims to determine the association between age, urine pH, and urinary stones incidence in Kardinah Tegal General Hospital, Indonesia.Method: There were 240 subjects from July to August 2019, with urolithiasis in Kardinah Tegal General Hospital who never received any previous treatment for urolithiasis. Subjects were divided into 120 subjects in case group and 120 subjects in control group. Medical records were assessed and reviewed for age, gender, urinalysis (including urine pH), urinary tract infection (UTI), and urinary stones incidence. Kolmogorov-Smirnov was used to assess data distribution of age and urine pH, and Chi-square test was used to evaluate the association between each age category and urinary pH.Results: Subject’s mean age between urolithiasis and non-urolithiasis groups were 47.68 ± 11.74 and 55.49 ± 15.72 years old, respectively There are no significant differences in stone incidence according to urinary pH in both groups. Stone incidence was found to be highest in age group of 50-59 years old in acidic urinary pH. No age group and urinary pH were associated with stone incidence. The odds of urinary stones occurrence would be 0.689 times more likely to happen with the increase of urinary pH,Conclusion: There was significant difference of age between urolithiasis and non-urolithiasis groups. No age group and urinary pH were found associated with stone incidence, however the increase of age and urinary pH, increase the odds of developing urinary stones.
Ekspresi tenascin-C yang tinggi pada ligamentum sakrouterina sebagai faktor risiko terjadinya prolaps uterus derajat III-IV di RSUP Sanglah Denpasar, Bali-Indonesia I Wayan Megadhana; Riza Firman Satria; Ketut Suwiyoga; I Gusti Putu Mayun Mayura; Putu Doster Mahayasa; I Nyoman Bayu Mahendra
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (442.813 KB) | DOI: 10.15562/ism.v11i2.791

Abstract

Introduction: Uterine prolapse is the descent of the uterus into the vagina or out of the vagina as a result of the failure of the ligament as a pelvic support. Uterine prolapse has multifactorial risk factors, but in every case of uterine prolapse, weakness is found in the pelvic floor supporting tissues, including the sacrouterine ligament. Childbirth is direct trauma that cause damage and weakness of levaor ani muscle, which leads to stretch of sacrouterine ligament that plays important role in maintaining uterus in its normal position. The main structure of the sacrouterine ligament consists of cells and extracellular matrix such as collagen, elastin, glycoproteins (fibronectin, tenascin, link protein, fibromodulin and dan osteopontin) and proteoglycans (agrecan, versican, biglican, dan perlecan). Tenascin is a major oligomeric glycoprotein found in the extracellular matrix. Tenascin has an important role not only during development but also when there are pathological conditions in adulthood such as tissue injury and tumorigenesis. Based on the current research, there are four tenascin groups, that are: tenascin-C, tenascin-R, tenascin-X, tenascin-Y and tenascin-W. If there is an expression of tenascin-C disturbance  in the sacrouterine ligament, it will cause uterine prolapse. The purpose of this study was to prove the high expression of tenascin-C in the sacrouterine ligament as a risk factor for stage III-IV uterine prolapse.Method: This research is an observational study with case control design. Forty four cases was included in this study. Twenty-two cases of III-IV degree uterine prolapse as study group and another 22 non-prolapse cases as a control group. This research was carried out in Sanglah General Hospital and Patobiology Laboratory of the Faculty of Veterinary Medicine UNUD. Samples were taken from the sacrouterine ligament of grade III-IV uterine prolapse patients and uterine non-prolapse patients, that had been performed total hysterectomy.Result: The results showed that high tenascin-C expression was a risk factor for stage III - IV uterine prolapse by 5.9 times (OR = 5.9; IK 95% = 1.59-22.32; p = 0.006).Conclusion: It can be concluded  that high expression of tenascin-C in the sacrouterine ligament is a risk factor of III-IV degree uterine prolapse.  Latar Belakang: Prolaps uterus adalah turunnya uterus ke dalam liang vagina atau keluar liang vagina sebagai akibat gagalnya ligmentum penyokong dasar panggul. Prolaps uterus memiliki faktor risiko yang bersifat multifaktorial, namun pada setiap  kasus prolaps uterus, selalu ditemukan kelemahan pada jaringan penyangga dasar panggul, termasuk ligamentum sakrouterina. Trauma langsung pada jalan lahir yang mengakibatkan kerusakan dan kelemahan otot levaor ani sehingga mengakibatkan ligamentum sakrouterina meregang untuk mempertahankan uterus dalam posisi normal. Struktur utama ligamen sakrouterina terdiri dari sel dan matriks ekstraseluler seperti kolagen, elastin, glikoprotein (fibronectin, tenascin, link protein, fibromodulin ) dan proteoglikan (agrecan, versican, biglican, dan perlecan). Tenascin merupakan suatu glikoprotein oligomerik utama yang terdapat pada matriks ekstraseluler. Tenascin memiliki peranan penting tidak hanya pada masa perkembangan tetapi juga saat terjadi kondisi patologis pada usia dewasa  seperti cedera jaringan dan tumorigenesis. Berdasarkan penelitian saat ini,  dikenal empat kelompok tenascin yaitu : tenascin-C, tenascin-R, tenascin-X, tenascin-Y dan tenascin-W. Apabila terjadi gangguan dalam ekspresi tenascin-C pada ligamentum sakrouterina akan menyebabkan terjadinya prolaps uterus. Tujuan penelitian ini adalah untuk membuktikan ekspresi tenascin-C yang tinggi pada ligamentum sakrouterina sebagai faktor risiko terjadinya prolaps uterus derajat III-IV.Metode: Penelitian ini merupakan rancangan observasional dengan kasus kontrol. Terdapat  22 kasus prolaps uterus derajat III-IV sebagai kelompok kasus dan 22 kasus non prolaps sebagai kelompok kontrol. Penelitian ini dikerjakan di RSUP Sanglah dan Laboratorium Patobiologi FKH UNUD. Sampel diambil dari ligamentum sakrouterina pasien prolaps uterus derajat III-IV dan  non-prolaps uterus yang telah dilakukan histerektomi total.Hasil: Hasil penelitian didapatkan bahwa ekspresi tenacin-C yang tinggi merupakan faktor risiko terjadinya prolaps uterus derajat III - IV sebesar 5,9 kali (OR =5,9; IK 95% =1,59-22,32; p =0,006).Simpulan: Sehingga dapat disimpulkan bahwa ekspresi tenascin-C yang tinggi pada ligamentum sakrouterina sebagai faktor risiko terjadinya prolaps uterus derajat III-IV.
Karakteristik epidemologi ibu hamil dengan infeksi human immunodeficiency virus di RSUP Sanglah Denpasar periode Januari 2014 - Desember 2017 Komang Juni Artawan; I Wayan Artana Putra
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (386.666 KB) | DOI: 10.15562/ism.v11i2.792

Abstract

Introduction: The cumulative rate of AIDS in pregnant women in the world is reported to increase dramatically, giving the consequent increase in morbidity and mortality from mothers and children. The purpose of this study is to provide a descriptive picture of pregnant women with HIV in Sanglah Hospital Denpasar during the period January 2014 to December 2017.Methods: This study used a descriptive retrospective design in the population of pregnant women with HIV in Sanglah Hospital Denpasar during the period January 2014 to December 2017.Results: During the study period a total of 218 cases of mothers with HIV were obtained in Sanglah Hospital Denpasar, with the majority characteristics being 20-29 years (56.80%), with the most dominant parity being 1 (48.16%), multipartner husband risk factors (56.43), housewife occupation (63.76%), origin of the area found in Jebmbrana Regency (20.64%), referral origin of Jembrana Regional Hospital (24.31%), age >28 weeks of pregnancy (47.70%), duration of antiretroviral therapy ≥6 months (55.51%), clinical stage I (79.35%), birth method of caesarean section (70.22%), birth weight of children >2500 grams (82.58% ), experienced mild anemia (Hb 9.5 to 10.9 g/dL) (84.12%), an undetectable viral load (66.7%), and a CD4 count of 200-500 / mm3 (49.08%) .Conclusion: HIV prevalence in pregnant women which has an increasing trend in Bali requires more attention from all lines, not only from health workers, but government involvement and public education are needed to prevent new cases of pregnant women with HIV infection.  Pendahuluan: Angka kumulatif AIDS pada wanita di dunia dilaporkan meningkat secara dramatis, memberikan konsekuensi peningkatan akan morbiditas dan mortalitas dari ibu dan anak. Tujuan dari penelitian ini adalah memberikan gambaran deskriptif pada ibu hamil dengan HIV di RSUP Sanglah Denpasar selama periode Januari 2014 hingga Desember 2017.Metode: Penelitian ini menggunakan rancangan retrosepktif deskriptif pada populasi ibu hamil dengan HIV di RSUP Sanglah Denpasar selama periode Januari 2014 hingga Desember 2017.Hasil: Selama periode studi didapatkan total 218 kasus ibu dengan HIV di RSUP Sanglah Denpasar, dengan karakteristik mayoritas berupa 20-29 tahun (56,80%), dengan paritas paling dominan adalah para 1 (48,16%), faktor risiko suami multipartner (56,43), pekerjaan ibu rumah tangga (63,76%), asal daerah ditemukan Kabupaten Jebmbrana (20,64%), asal rujukan RSUD Jembrana (24,31%), usia >28 minggu kehamilan (47,70%), lama terapi ARV ≥6 bulan (55,51%), stadium klinis I (79,35%), metode kelahiran seksio caesaria (SC) (70,22%), berat lahir anak >2500 gram (82,58%), mengalami anemia ringan (Hb 9,5- 10,9 g/dL) (84,12%), viral load tidak terdeteksi (66,7%), dan hitung CD4 200-500 /mm3 (49,08%).Simpulan: Prevalensi HIV pada ibu hamil yang memiliki tren semakin meningkat di Bali membutuhkan perhatian lebih dari segala lini, tidak hanya dari tenaga kesehatan, namun keterlibatan pemerintah serta edukasi masyarakat sangat dibutuhkan untuk mencegah timbulnya kasus baru ibu hamil dengan infeksi HIV.
Ekspresi sel fibroblas yang rendah pada ligamentum sakrouterina sebagai faktor risiko terjadinya prolaps uterus derajat III-IV di RSUP Sanglah Denpasar, Bali-Indonesia Yosevangelika Hutabarat; I Wayan Megadhana; Ketut Suwiyoga; Nyoman Mantik Astawa; Arthawan Arthawan
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (283.008 KB) | DOI: 10.15562/ism.v11i2.793

Abstract

Introduction: Uterine prolapse is the fall of the uterus into the vaginal due to the failure of the pelvic floor supporting ligaments. Uterine prolapse has multifactorial risk factors, but in every case of uterine prolapse, weakness in the pelvic floor, including the sacrouterine ligament, is always found. The strength of the sacrouterine ligament is determined by fibroblasts and extracellular matrix. Fibroblasts are the most cells making up the ligament, where the ligament is a connective tissue consisting of most collagen fibers that provide a structure with high tensile strength. Women with POP have a picture of changes that occur in the supporting tissues, where the extracellular matrix plays an important role because of accelerated remodeling in POP patients caused by biochemical changes in extracellular matrix such as collagen, elastin and stromal cells. Myofibroblasts play an important role in extracellular matrix remodeling and its regulation by matrix cell regulators such as metalloprotease (MMP) matrix, transformation growth factor (TGF) -β, and thrombospondin (TSP)-1. The purpose of this study was to prove the low expression of fibroblast cells in the sacrouterine ligament as a risk factor for stage III-IV uterine prolapse.Method: This study was an observational design with case control. There were 22 cases of grade III-IV uterine prolapse as a group of cases and 22 cases of non-prolapse as a control group. This research was carried out at Sanglah General Hospital and the Integrated Biomedical Laboratory of Faculty of Medicine, Universitas Udayana. Samples were taken from sacrouterine ligament of uterine prolapsed patients with stage III-IV and uterine non-prolapse who had performed total hysterectomy at Sanglah Hospital.Results: The results showed that low expression of fibroblasts became a risk 9 times higher of uterine prolapse grade III-IV compared to high level of fibroblast expressin (OR = 9.1; IK95% = 2.3-35.7; p = 0.001).Conclusion: From the results of this study it can be concluded that the low expression of fibroblasts in the sacrouterine ligament is a risk factor for stage III-IV uterine prolapse. Pendahuluan: Prolaps uterus adalah turunnya uterus ke dalam liang vagina atau keluar liang vagina sebagai akibat gagalnya ligamentum penyokong dasar panggul. Prolaps uterus memiliki faktor risiko yang bersifat multifaktorial, namun pada setiap kasus prolaps uterus, selalu ditemukan kelemahan pada jaringan penyangga dasar panggul, termasuk ligamentum sakrouterina. Kekuatan ligamentum sakrouterina ditentukan oleh fibroblas dan matriks ekstraselular. Fibroblas adalah sel terbanyak penyusun ligamentum, dimana ligamentum merupakan jaringan ikat yang terdiri dari sebagian besar serat kolagen yang menyediakan struktur dengan daya tarik yang tinggi. Wanita dengan POP memiliki gambaran perubahan yang terjadi pada jaringan penyokong, dimana matriks ekstraseluler memegang peranan penting karena akselerasi remodeling pada pasien POP yang disebabkan oleh perubahan biokimia pada matriks ekstraseluler seperti kolagen, elastin dan sel stromal. Miofibroblas berperan penting dalam remodeling matriks ekstraseluler dan pengaturannya oleh regulator sel matriks seperti matriks metalloprotease (MMP), transformation growth factor (TGF)-β, dan thrombospondin (TSP)-1. Tujuan penelitian ini adalah untuk membuktikan ekspresi sel fibroblas yang rendah pada ligamentum sakrouterina sebagai faktor risiko terjadinya prolaps uterus derajat III-IV.Metode: Penelitian ini merupakan rancangan observasional dengan kasus kontrol. Terdapat 22 kasus prolaps uterus derajat III-IV sebagai kelompok kasus dan 22 kasus non prolaps sebagai kelompok kontrol. Penelitian ini dikerjakan di RSUP Sanglah dan Laboratorium Biomedik Terpadu FK Universitas Udayana. Sampel diambil dari ligamentum sakrouterina pasien prolaps uterus derajat III-IV dan non-prolaps uterus yang telah dilakukan histerektomi total di RSUP Sanglah.Hasil: Hasil penelitian didapatkan bahwa ekspresi fibroblas yang rendah menjadi risiko terjadinya prolaps uterus derajat III-IV sebesar 9 kali (OR=9,1; IK95%=2,3-35,7; p=0,001).Simpulan: Dari hasil penelitian ini dapat disimpulkan bahwa ekspresi fibroblas yang rendah pada ligamentum sakrouterina menjadi faktor risiko terjadinya prolaps uterus derajat III-IV.
Lower Urinary Tract Obstruction (LUTO) pada fetus: laporan kasus Rey Jauwerissa; I Nyoman Hariyasa Sanjaya; Endang Sri Widiyanti; Ryan Saktika Mulyana; Evert Solomon Pangkahila
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (795.836 KB) | DOI: 10.15562/ism.v11i3.796

Abstract

Background: Lower fetal urinary tract obstruction (LUTO) is an abnormality observed during an ultrasound test in the antenatal period in the form of an enlarged fetal bladder. Oligohydramnios, renal cortex dilation, and pulmonary hypoplasia may be caused by obstruction of the lower urinary tract. In the management of LUTO, early diagnosis and assessment as early as possible are very important. The insertion of a shunt from the fetal bladder to the amniotic cavity is one of the therapies for fetal LUTO (vesicoamniotic shunt). This case study aims to determine the management of LUTO in fetuses at Sanglah Hospital, Bali, Indonesia. Case Presentation: A 39-year-old female G3P2002 was referred to the obstetrics and gynecology clinic of Sanglah Hospital with suspected fetal LUTO for 18-19 weeks. There were no complaints or risk factors for LUTO in the past. Physical examination and obstetric examinations were within normal limits. On ultrasound examination, there was a hypohyperechoic image measuring 4.3 x 5.3 cm with the impression of the enlarged bladder, key-hole appearance, oligohydramnios, and bilateral hydronephrosis. Double pigtail installation on the fetus, amnioinfusion, and amniosynthesis was performed for karyotyping. Ten weeks after double pigtail placement, the patient developed premature labor and subsequently gave birth to a baby boy, LBW 1,800 gram, with severe asphyxia, Potter facies, abdominal distension, and leg deformities. Unfortunately, the baby eventually died 1 hour postpartum.Conclusion: Overall, infants have a poor prognosis for fetal LUTO cases. In assessing the effectiveness of treatment, early diagnosis, assessment, and early intervention are very critical. Latar Belakang: Lower Urinary Tract Obstruction (LUTO) pada fetus merupakan suatu kelainan pada periode antenatal berupa pembesaran kandung kemih fetus yang ditemukan pada pemeriksaan USG. Sumbatan saluran kemih bagian bawah tersebut dapat menyebabkan oligohidramnios, pelebaran korteks ginjal, hingga hipoplasia paru. Diagnosis awal dan evaluasi sedini mungkin sangat penting dalam penanganan LUTO. Salah satu penanganan fetal LUTO adalah dengan pemasangan shunt dari vesika urinaria fetus ke rongga amnion (vesicoamniotic shunt). Laporan kasus ini bertujuan untuk mengevaluasi penanganan LUTO terhadap fetus di RSUP Sanglah, Bali, IndonesiaPresentasi Kasus: Seorang perempuan 39 tahun G3P2002 18-19 minggu dirujuk ke poliklinik kebidanan dan kandungan RS Sanglah dengan kecurigaan fetal LUTO. Pada anamnesis tidak didapatkan keluhan maupun faktor risiko LUTO. Pemeriksaan fisis dan pemeriksaan obstetri dalam batas normal. Pada pemeriksaan USG didapatkan gambaran hipohiperekoik berukuran 4,3 x 5,3 cm dengan kesan vesika urinaria membesar, key-hole appearance, oligohidramnios dan hidronefrosis bilateral. Dilakukan tindakan pemasangan double pigtail pada fetus, amnioinfusion serta amniosintesis untuk pemeriksaan karyotyping. Sepuluh minggu setelah pemasangan double pigtail, pasien mengalami partus prematurus imminens dan selanjutnya melahirkan bayi lelaki, BBL 1.800 gram, dengan asfiksia berat, Potter facies, distensi abdomen dan deformitas tungkai. Sayangnya, bayi akhirnya meninggal 1 jam pasca-persalinan.Kesimpulan: Secara keseluruhan kasus fetal LUTO memiliki prognosis yang kurang baik bagi bayi. Diagnosis awal, evaluasi dan intervensi sedini mungkin sangat penting dalam menentukan keberhasilan terapi.
Hitung trombosit metode otomatis dikonfirmasi dengan Hapusan Darah Tepi (HDT) tanpa pewarnaan dan dengan pewarnaan giemsa di RSUP Sanglah, Bali, Indonesia Ivan Master Worung; Ni Nyoman Mahartini; Sianny Herawati
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1141.859 KB) | DOI: 10.15562/ism.v11i3.799

Abstract

Background: The platelet count calculation is a basic hematological examination, which is indispensable due to laboratory tests that are important for making clinical decisions. However, in practice, it was found that several methods of examining the platelet count showed inconsistent results. Therefore, this study aims to determine the platelet count's suitability on the peripheral blood smear with staining, without staining, and automatic platelet count using the flowcytometry method.Methods: This study used an observational method on 36 samples. A blood smear without staining and staining was made, read on a microscope with a magnification of 1,000 times, then compared with the platelet count results by the flowcytometry method. The data were then performed statistical tests using the One-Way ANOVA test, followed by the post-hoc test. Data were analyzed using SPSS version 17 for Windows.Results: Most of the respondents were female (55.56%) and had a mean age of 42.37 ± 20.90 years. From the One-Way ANOVA test, it was found that there was no difference in the platelet count between groups of the calculation method used (p = 1,000). The post-hoc test also showed that the results of the calculation of the automatic tool flowcytometry method were compatible with the stained and non-stained peripheral blood smear (p> 0.05).Conclusion: There is an agreement between the unstained method, staining, and flowcytometry. Latar Belakang: Perhitungan jumlah trombosit merupakan pemeriksaan hematologi dasar dimana sangat diperlukan sebagai hasil pemeriksaan laboratorium yang penting untuk membuat keputusan klinis. Akan tetapi dalam pelaksanaannya ditemukan bahwa beberapa metode pemeriksaan jumlah trombosit menunjukkan hasil yang tidak sesuai. Oleh karena itu penelitian ini bertujuan untuk mengetahui kesesuaian antara hitung trombosit pada hapusan darah tepi dengan pewarnaan, tanpa pewarnaan dan hitung trombosit otomatis dengan metode flowcytometry.Metode: Penelitian menggunakan metode observasional pada 36 sampel. Dibuat hapusan darah tepi tanpa pewarnaan dan dengan pewarnaan, dibaca pada mikroskop dengan pembesaran 1.000 kali, kemudian dibandingkan dengan hasil hitung trombosit dengan metode flowcytometry. Data kemudian dilakukan uji statistik dengan menggunakan uji One-Way ANOVA dilanjutkan dengan uji post-hoc. Data dianalisis menggunakan SPSS versi 17 untuk Windows.Hasil: Sebagian besar responden berjenis kelamin perempuan (55,56%) dan memiliki rerata usia 42,37±20,90 tahun. Dari uji One-Way ANOVA ditemukan tidak terdapat perbedaan hitung trombosit diantara kelompok metode perhitungan yang digunakan (p=1,000). Uji post-hoc juga menunjukkan terdapat kesesuaian hasil perhitungan alat otomatis metode flowcytometry dengan metode hapusan darah tepi dengan pewarnaan dan tanpa pewarnaan dengan (p>0,05).Kesimpulan. Terdapat kesesuaian antara metode hitung trombosit tanpa pewarnaan, dengan pewarnaan dan dengan hitung otomatis metode flowcytometry.
Rasio Monosit-High Density Lipoprotein (RMH) sebagai prediktor independen kejadian kardiovaskular mayor selama rawat inap pada pasien Infark Miokard Akut (IMA) yang menjalani intervensi koroner perkutan di RSUP Sanglah, Bali, Indonesia Ni Made Dharma Laksmi; I Gusti Ngurah Putra Gunadhi; Hendy Wirawan; Rani Paramitha Iswari Maliawan
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (396.73 KB) | DOI: 10.15562/ism.v11i3.800

Abstract

Background: Several inflammatory cell markers have been addressed in recent studies and one of them is the Ratio of Monocyte-High Density Lipoprotein (RMH) as a new predictor and prognostic indicator of cardiovascular disease. There is, however, still little evidence to relate RMH parameters to the severity of coronary lesions in patients with Acute Myocardial Infarction (AMI). In order to determine whether RMH was a predictor of Major Cardiovascular Events (MACE) in AMI patients who underwent percutaneous coronary intervention at the Sanglah General Hospital during hospitalization, this analysis was carried out.Methods: This study was an observational study design with a cohort study approach. The selection of study subjects was carried out by consecutive sampling, with a total of 60 patients. AMI patients who underwent percutaneous coronary intervention were included in the affordable population and met the inclusion and exclusion criteria during the study period. Data were analyzed with SPSS version 23 for Windows.Results: An independent measure of the occurrence of MACE during hospitalization in AMI patients is a high RMH value (RR = 1.459; p = 0.046; 95 percent CI = 1.028–25.366). In addition, it was found that independent predictors of mortality were smoking (RR = 1.555; p = 0.039; 95% CI = 1.131-116.058), diabetes mellitus type 2 (DM-2) (RR = 1.507; p = 0.036; 95% CI = 1.133-45,368) and high TIMI (RR = 1.512; p = 0.026; 95% CI = 1.268-43.772).Conclusion: In acute myocardial infarction patients, the high RMH value is an independent indicator of major cardiovascular events during hospitalization. Other variables such as diabetes mellitus, smoking, and the TIMI score were also found as predictors of major cardiovascular events during treatment in patients with acute myocardial infarction.  Latar Belakang: Berbagai studi terakhir, banyak membahas tentang penanda dari sel inflamasi, dan salah satunya Rasio Monosit-High Density Lipoprotein (RMH) sebagai prediktor baru dan indikator prognosis dari penyakit kardiovaskular. Namun masih sedikit data yang menghubungkan parameter RMH terhadap derajat keparahan lesi koroner pada pasien Infark Miokard Akut (IMA). Studi ini dilakukan untuk mengetahui apakah RMH merupakan prediktor terhadap Kejadian Karviovaskular Major (KKM) pada pasien IMA yang menjalani intervensi koroner perkutan selama rawat inap di Rumah Sakit Umum Pusat Sanglah.Metode: Penelitian ini merupakan rancang studi observasional dengan pendekatan studi kohort. Pemilihan subjek penelitian dilakukan secara consecutive sampling dengan total 60 pasien. Pasien IMA yang menjalani intervensi koroner perkutan yang masuk populasi terjangkau dan memenuhi kriteria inklusi maupun eksklusi selama periode penelitian. Data dianalisis dengan SPSS versi 23 untuk Windows.Hasil: Nilai RMH yang tinggi (RR=1,459; p=0,046; 95% IK=1,028–25,366) merupakan prediktor independen terhadap kejadian KKM selama rawat inap pada pasien IMA. Selain itu didapatkan bahwa merokok (RR=1,555; p=0,039; 95% IK=1,131-116,058), Diabetes Mellitus Tipe 2 (DM-2) (RR=1,507; p=0,036; 95% IK=1,133-45,368), dan TIMI yang tinggi (RR=1,512; p=0,026; 95% IK=1,268-43,772) merupakan prediktor independen terhadap mortalitas.Kesimpulan: Nilai RMH yang tinggi merupakan prediktor indedepnden terhadap kejadian kardiovaskular mayor selama rawat inap pada pasien infark miokard akut. Didapatkan juga faktor lain seperti diabetes mellitus, merokok, dan skor TIMI sebagai prediktor terhadap kejadian kardiovaskular mayor saat perawatan pada pasien infark miokard akut.
Fenomena raynaud sekunder pada seorang penderita kanker kolon I Gusti Agung Indra Adi Kusuma; Gede Kambayana
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (421.144 KB) | DOI: 10.15562/ism.v11i3.801

Abstract

Introduction: Secondary Raynaud's phenomenon (RP) is a transient microvascular spasm associated with other etiologies with clinical features of triphasic manifestations. Malignancy is a rare cause of secondary RP. Case Report: A man, 46 years, came to Sanglah General Hospital with secondary RP and colorectal malignancy. Discoloration white at the distal digits of the right manus and digits 3-5 left and sometimes accompanied thick at the fingertips, involved proximal to the medial phalanges. Laboratory examination showed albumin 2.55 g / dL, globulin 2.12 g / dL, LDH 323 IU / L, CRP 6.5 mg / dL, CEA 5.83 ng / mL plain abdominal radiograph impression of thickening on the part of the wall and show colitis appearance, be suspected ileus in the upper left abdominal region. Base on histopathological examination, ascending colon presents well-differentiated adenocarcinoma, and abdominal CT shows liver metastases. Management of patients with secondary RP with lifestyle and pharmacological interventions and chemotherapy for colorectal adenocarcinoma as the underlying cause. Pharmacological therapy of RP with intraoral amlodipine Conclusion: Malignancy in this patient as a cause of RP and management is carried out to treat primary disease and Raynaud's  Pendahuluan:    Fenomena Raynaud (RP) sekunder merupakan vasokontriksi transien pada mikrovaskular dikaitkan dengan etiologi lain dengan gambaran manifestasi trifasik. Keganasan menjadi kausa yang jarang pada RP sekunder.Laporan Kasus: Seorang laki-laki, usia 46 tahun, datang ke RSUP Sanglah dengan RP sekunder dan keganasan kolorektal. Dengan pucat  pada distal digiti manus dekstra dan digiti 3-5 sinistra dan disertai kadang tebal di ujung jari, meliputi proksimal sampai  medial falang. Pemeriksaan laboratorium menunjukkan albumin 2,55 g/dL, dan globulin 2,12 g/dL, LDH 323 IU/L, CRP  6,5 mg/dL, CEA 5,83 ng/mL dengan foto polos abdomen kesan penebalan pada sebagian dinding usus menunjukkan suatu gambaran kolitis yang diduga ileus pada regio abdomen kiri atas, kolon asenden dengan gambaran well differentiated adenokarsinoma  pada hasil biopsi histopatologi dan CT abdomen menunjukkan metastasis pada hepar. Penatalaksanaan pasien RP sekunder dengan intervensi gaya hidup dan farmakologis serta kemoterapi untuk adenokarsinoma kolorektal sebagai penyebab dasar. Terapi farmakologis RP dengan pemberian amlodipin intra oral.Simpulan: Kondisi keganasan pada pasien sebagai kausa dari RP dan tatalaksana  pengobatan spesifik RP. 
Analisis dampak trauma Kekerasan Dalam Rumah Tangga (KDRT) terhadap kecerdasan emosional anak di Desa Beraban, Tabanan, Bali I Made Gede Widyatmika; Lely Setyawati Kurniawan; Ni Ketut Putri Ariani
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (272.164 KB) | DOI: 10.15562/ism.v11i3.804

Abstract

Background: Domestic violence is significantly affecting children's growth and development. To recover their physical and mental, they need optimal and psychological and educational treatments continuously, but nobody can guarantee that they will be improved well after therapy. This study aims to describe the interpretation of domestic violence towards emotional intelligence in children.Methods: This quantitative research uses a retrospective descriptive study with a cross sectional study design, and the sampling technique is proportional stratified random sampling. Data were analyzed using SPSS version 17 for Windows.Results: The results showed that most forms of domestic violence were in the form of mild physical violence (93.9%), mild psychological violence (87.8%), mild sexual violence (83.7%), and mild neglect (93.9%). Based on emotional intelligence, most respondents have high self-awareness (93.9%), high emotional management (98.0%), high self-motivation (95.9%), high empathy (95.9%), and social skills. high (95.9%). There is a significant relationship between domestic violence (KDRT) and emotional intelligence (KE) in children (p <0.05).Conclusion: Domestic violence has a significant effect on children's emotional intelligence in Beraban Village, Bali, Indonesia. Latar Belakang: Kekerasan Dalam Rumah-Tangga (KDRT) sangat mempengaruhi pertumbuhan dan perkembangan seorang anak. Dibutuhkan penanganan psikologis dan edukatif secara optimal dan berkesinambungan, untuk pemulihan fisik dan mental mereka, meskipun tidak ada suatu jaminan bahwa kondisi mereka akan sepenuhnya pulih setelah menjalani proses terapi. Penelitian ini bertujuan untuk dapat menggambarkan serta menginterpretasikan pengaruh KDRT terhadap kecerdasan emosional pada anak.Metode: Penelitian kuantitatif ini menggunakan pendekatan deskriptif retrospektif dengan desain penelitian potong lintang (cross sectional) dan teknik pengambilan sampel secara proportionate stratified random sampling. Data dianalisis dengan SPSS versi 17 untuk Windows.Hasil: Hasil penelitian menunjukkan bahwa sebagian besar bentuk KDRT dalam bentuk kekerasan fisik ringan (93,9%), kekerasan psikis ringan (87,8%), kekerasan seksual ringan (83,7%), dan penelantaran ringan (93,9%). Berdasarkan kecerdasan emosional, sebagian besar responden memiliki kesadaran diri tinggi (93,9%), pengelolaan emosi tinggi (98,0%), motivasi diri tinggi (95,9%), empati tinggi (95,9%), dan keterampilan sosial tinggi (95,9%). Terdapat hubungan yg bermakna antara kekerasan dalam rumah tangga (KDRT) dan kecerdasan emosional (KE) anak (p<0,05).Kesimpulan: Kekerasan dalam rumah tangga memiliki pengaruh yang bermakna terhadap kecerdasan emosional anak di Desa Beraban, Bali, Indonesia.

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