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Journal Syifa Sciences and Clinical Research (JSSCR)
Published by Universitas Negeri Gorontalo
ISSN : 26568187     EISSN : 26569612     DOI : 10.37311/jsscr
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Journal Syifa Sciences & Clinical Research (JSSCR) is a national journal intended as a communication forum for scientists from many practitioners who use Pharmacology Development in research.
Arjuna Subject : -
Articles 196 Documents
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Komparasi Daya Adsorpsi Silika Dari Abu Sekam Padi dan Ampas Tebu Terhadap Adsorpsi Pb2+ Hanandayu Widwiastuti; Riska Yudhistia Asworo
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14910

Abstract

Heavy metals are the main pollutants which numbers are increasing . PB is a heavy metal that has high toxicity when it enters the human body. This is indicated by the LD value of 50 Pb which is 500 mg / kg body weight. Based on Government Regulation No. 82 of 2001, the maximum permissible concentration of Pb2 + in waters is 0.03 mg / L. Therefore, the presence of Pb2 + in the waters needs to be controlled so that pollution in the waters can be reduced. The purpose of this study was to determine the silica adsorption capacity of rice husks and sugarcane bagasse against Pb2 + adsorption. In this study the characterization of each adsorbent was carried out to determine the active functional groups in the bonds that occur. The maximum adsorption capacity of Pb (II) in Si-husk is 126 mg / g at 0.6 g of mass of the adsorbent while the maximum adsorption capacity of Pb (II) in Si-sugarcane is 109.69 mg / g at 0.8 g of adsorbent.
Evaluasi Penggunaan Antibiotik untuk Terapi Infeksi Saluran Kemih (ISK) pada Pediatri di Instalasi Rawat Inap Rumah Sakit Sermila Wulandari; Nera Umilia Purwanti; Ressi Susanti
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14796

Abstract

Urinary tract infection (UTI) is infection caused by the presence of microorganism in the urinary tract that multiply. Treatment of urinary tract infection can use antibiotic therapy andi if not done properly can cause resistance. This study aimed was to evaluate the use of antibiotics for the treatment of urinary tract infections in pediatrics at the Sultan Syarif Mohamad Alkadrie Inpatient Installation in January 2019-December 2020. This study is a descriptive observational research with a retrospective approach. The sampling technique used purposive sampling  and the number of samples that met the inclusion criteria was 76 patients. Data obtained from  medical records analyzed using Microsoft Excel based on 4T criteria ( right indication , right patient , right medicine , and right dose) refers to Guidelines On Urological Infections from European Association Of Urology Year 2015, Pediatric Dosage Handbook (PDH), and Guidelines for Medical Services of the Indonesian Pediatrician Association in 2009. The result showed that the evaluation the use of antibiotics was based on the right indications 100% (very good), right patient 100% (very good), right medicine 100% (very good), and right dose 55,3%  (pretty good). The use of antibiotics for UTI patients at Sultan Syarif Mohamad Alkadrie Hospital still needs increased again , especially in terms of administering antibiotic dose.
Analisis Persistensi Penggunaan Obat Antihipertensi Terhadap Pencapaian Tekanan Darah Optimal pada Pasien di Puskesmas Serli Andini; Nurmainah Nurmainah; Mohammad Andrie
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15370

Abstract

Persistence of the use of antihypertensive drugs in hypertensive patients is very necessary considering the main outcome of hypertension therapy is to prevent cardiovascular disease events such as myocardial infarction and stroke which can lead to death. This study aims to analyze the relationship between characteristic factors and drug use factors with the persistence of antihypertensive drug use and to determine the average blood pressure of outpatient hypertension patients at Sungai Raya Dalam Public Health. This study uses a retrospective cohort study design and uses secondary data sources for outpatient hypertension patients at Sungai Raya Dalam Public Health Center, Kubu Raya Regency. Persistence measurement method is the gaps between refill method with a grace period of 14 days for taking the drug. Data were analyzed using chi square test. The number of subjects who took part in this study were 402 hypertensive patients who used antihypertensive drugs (diagnostic index date 1 June 2020 to 30 June 2021). The results showed that the majority of the characteristics of hypertensive patients who visited the Sungai Raya Dalam Public Health Center tended to be 45 years old (57.7%), female (58.7%), patients with monotherapy therapy regimens (73.9%), and patients with CCB therapy (66.9%). Only (36.3%) patients had persistent use of antihypertensive drugs. Chi square analysis showed that there was no significant relationship between age (p=0.715) and gender (p=0.786), statistically there was a statistically significant relationship between therapy regimen (p=0.000) and type of therapy (p=0.029). The conclusion from the research is that the persistence of drug use is influenced by the regimen and type of hypertension therapy.
Studi in silico : Hubungan Kuantitatif Struktur-Aktivitas Antivirus SARS-COV2 Pada Senyawa Turunan N-4-benzoil-N’-(4-fluorofenil) tiourea Anindi Lupita Nasyanka; Diah Ratnasari; Janatun Na’imah; Dini Kesuma
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.15119

Abstract

Specific therapies for the SARS-CoV2 virus are still being developed in several countries countries in the world. One of the suspected molecular targets specific to SARS COV2 is the 3CLpro or main protease of the COVID-19 virus. Based on the target of this work, there are similarities between the compounds  N-4-benzoyl-N'-(4-fluorophenyl)thiourea derivatives with their inhibitors. This study aims to develop derivative compounds N-4-benzoyl-N'-(4-fluorophenyl)thiourea as a potential drug candidate inhibiting SARS-CoV2 viral protein using the HKSA method in silicon. Based on the results of the analysis, the best equation for the development of anti-virus SARS-CoV2 was Log 1/C = 0.269 Log P2 – 2.776 Log P + 0.221 cMR +3.195 (n= 8; R = 0.949 S= 0.11399; F=12,119;Sig=0,018). The role of the lipophilic and -containing groups steric can increase its activity as an anti-virus SARS-CoV2 In silico on the modification of the derivative.
Analisis Perbedaan Tekanan Darah Pada Akseptor Pengguna Kontrasepsi Suntik Depo Medroxyprogesterone Acetate Ardiyani Istiwardani; Nurmainah Nurmainah; Ressi Susanti
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14794

Abstract

The most widely used contraceptive method in controlling the Indonesian population is a three-month injection KB called Depo Medroxyprogesterone Acetate. Three-month injection KB has a side effect in the form of an increase in blood pressure in the acceptor of the user. The purpose of this study was to analyze the average blood pressure of acceptors and to analyze the relationship between duration of use of DMPA injectable contraceptives and the increase in blood pressure of DMPA injectable contraceptive acceptors at the Pontianak City Health Center. The method used in this research is an analytic observational study with a cohort research design. Sampling was done by purposive sampling, namely sampling based on inclusion and exclusion criteria. Data analysis was performed using univariate (microsoft excel) and bivariate with Chi-square analysis. The results showed an increase in the average blood pressure in the age group of 9.9-10.5 mmHg (systolic) and 3.7-6.2 mmHg (diastolic). The average increase in blood pressure in the long-term use group was 9.2-10.7 mmHg (systolic) and 3.0-5.3 mmHg (diastolic). Chi-square analysis showed that there was no relationship between duration of use and the risk of hypertension in acceptors of DMPA injection contraceptive users at the Pontianak City Health Center (p = 0.176; RR = 1.582; 95% CI = 0.795-3.149)
Faktor yang Mempengaruhi Kepatuhan Pasien DM Tipe 2 di Rumah Sakit Dita Arisa Ratnasari; Nurmainah Nurmainah; Mohammad Andrie
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14790

Abstract

Non-adherence to drug use in patients with diabetes mellitus has an impact on the low clinical impact, risk of complications, low quality of life, and mortality. This study aims to analyze the level of adherence to the use of oral antidiabetic drugs and the factors that influence adherence to the use of antidiabetic drugs in outpatients with type 2 diabetes mellitus in RSUD dr. Rubini, Mempawah Regency. This research is an observational analysis research with a cohort study design. Data collection was carried out retrospectively using medical records of outpatient diabetes mellitus patients from January 2019 to December 2019. The number of samples that met the inclusion and exclusion criteria were 90 patients. Compliance with drug use was measured using the Medication Possession Ratio (MPR) method. Analysis of the relationship between compliance with patient characteristics using the chi square test. The results showed that the characteristics of patients who visited RSUD dr. Rubini tended to be 45 years old (92.2%), female (51.26%), combination therapy regimen (55.6%), uncontrolled blood sugar level (58.9%), and only 12.2% patients who adhere to oral antidiabetic drugs. Chi-square analysis showed that there was no significant relationship between age (p=0.171), gender (p=0.751), therapy regimen (p=0.749) on patient compliance in using antidiabetic drugs. From this study it can be concluded that age, gender, and treatment regimen have no effect on adherence to oral antidiabetic use in patients with type 2 diabetes mellitus.
Analisis Persistensi Penggunaan Obat Antidiabetik Terhadap Pencapaian Gula Darah Optimal Pada Pasien di Puskesmas Shinta Bella; Nurmainah Nurmainah; Mohammad Andrie
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15371

Abstract

DM sufferers in Indonesia lack awareness of using drugs regularly and continuously or in clinical terms known as persistence. The persistence of using antidiabetic drugs for 1 year is known to be low (65%). This study aims to analyze the relationship between patient characteristics, patient therapy factors and drug factors used by patients that can affect the persistence of antidiabetic drug use in outpatient type 2 diabetes mellitus patients at Sungai Raya Dalam Public Health Center, Kubu Raya Regency. This study uses a retrospective cohort study design and uses secondary data sources for outpatient type 2 diabetes mellitus patients at Sungai Raya Dalam Public Health Center, Kubu Raya Regency. The persistence measurement method used is the gaps between refill method with a grace period of 14 days for taking the drug. Data were analyzed using chi square test. The number of subjects used were 206 patients with type 2 diabetes mellitus who used antidiabetic drugs (June 2020-June 2021). The results showed that the majority of the characteristics of patients with type 2 diabetes mellitus who visited the Sungai Raya Dalam Public Health Center tended to be 40-60 years old (68.4%), female (54.9%), patients with monotherapy therapy regimen (76.7%). %), patients with metformin (72.3%) and patients with uncontrolled blood sugar (67.5%). Only (43.2%) of patients persistently used antidiabetic drugs. Chi square analysis showed that there was a significant difference between the age factor (p = 0.036), there was no significant difference between gender (p = 0.425), treatment regimen (p = 0.452) and type of therapy (P = 0.121). The conclusion of this study is that the persistence of drug use is influenced by the therapeutic regimen and the type of antidiabetic drug given.
Formulasi Sediaan Sabun Padat Herbal Dari Serbuk Kulit Buah Pisang Ambon (Musa paradisiaca var. sapientum L.) Muthmainna B
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.15214

Abstract

Most of the soaps in the market are chemical soaps. Chemical soap is a soap that uses Sodium Laurat Sulposphat (SLS) as its main raw material. Ambon banana is a type of banana that is widely consumed by the people of Indonesia. Ambon banana (Musa paradisiaca var. sapientum (L.) Kunt.) are also known to contain saponin, glycoside, tannin, alkaloid, and flavonoid. Ambon banana peel has a higher antioxidant activity than the pulp. The purpose of this study was to evaluate the formula of herbal solid soap from Ambon banan peel powder. This type of research is experimental using a simple formula design. The activity stage includes sample processing, product manufacture, and product quality analysis testing. The test includes an organoleptic test where the results of the data obtained are brown yellow solid soap, greentea lily scent, smooth texture, and rectangular shape, the pH test has an alkaline pH of 9, foam height test has a foam height of 125 mm, 15% water content test, and irritation test that does not cause irritation to the skin of the panliests. From the results of the research that has been done, it can be concluded that the soap formula used meets the requirements of the SNI standard which is safe and good for use on human skin.
Hubungan Tingkat Kepatuhan Minum Obat Pasien Tuberkulosis Terhadap Efek Samping Obat Anti Tuberkulosis (OAT) Berly Afilla Christy; Ressi Susanti; Nurmainah Nurmainah
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14830

Abstract

One of the causes of failure in tuberculosis treatment therapy is the incidence of side effects of anti-tuberculosis drugs (OAT) which can affect drug adherence in tuberculosis patients. The purpose of this study was to evaluate the relationship of OAT side effects to patient medication adherence at the Sungai Betung Public Health Center, Bengkayang Regency. The method in this research is an observational study with a cross sectional study design . The study design was a non-experimental epidemiological study. Data was collected by collecting medical record data and questionnaires containing 11 questions related to OAT side effects and drug compliance. The results showed the characteristics of the majority of patients of productive age as much as 71.42%, male sex of 82.85% and the average being undergoing a category 1 treatment regimen. Distribution of OAT side effects, as many as 51.43% of patients responded well to side effects. OAT and the remaining 48.57% of patients did not respond well to OAT side effects, while the distribution of patient compliance in taking drugs was 65.71% of patients had high adherence and 34.29% of patients had low adherence. The results of statistical tests to determine the relationship between OAT side effects on adherence using the Chi-square test showed p value0.05 (p value= 0.024) then Ho was accepted. The conclusion is that there is a significant relationship between OAT side effects and adherence to medication for pulmonary tuberculosis patients at the Sungai Betung Public Health Center, Bengkayang Regency.
Analisis Kepatuhan Penggunaan Obat Antihipertensi Pasien Hipertensi Rawat Jalan Usia Geriatri Terhadap Tekanan Darah Novi Tartila Akri; Nurmainah Nurmainah; Mohammad Andrie
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14793

Abstract

Medication adherence is an important factor in controlling blood pressure in hypertensive patients. The purpose of this study was to analyze the correlation between therapy adherence and control of blood pressure factors, as well as to analyze the correlation between gender and gender on the adherence of geriatric patients in undergoing antihypertensive treatment. The method used is analytical observational method by designing a cohort study research. Data was collected retrospectively, manual and electronic data collection (medical records). Measurement of compliance using the Medication Possession Ratio (MPR) method. Data analysis used Chi-Square test with SPSS. The results showed that patients who visited the Outpatient Installation of RSUD dr.Rubini tended to be female (60.6%), patients with monotherapy regimen (50.7%), frequency of drug administration 1x1 a day (90.1%), and patients with uncontrolled blood pressure (73.2%). As many as 18.3% of patients adhered to antihypertensive treatment. Chi-square analysis showed that there was a significant relationship between gender (p=0.05) and blood pressure control (p=0.032), while the results of therapy analysis were not statistically significant with p-values of 0.387 and 1,000 ( 0, 05). It was concluded that there was a correlation between gender and blood pressure control on patient compliance in undergoing treatment.

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