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Muhammad Taupik, M.Sc
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Journal Syifa Sciences and Clinical Research (JSSCR)
Published by Universitas Negeri Gorontalo
ISSN : 26568187     EISSN : 26569612     DOI : 10.37311/jsscr
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Journal Syifa Sciences & Clinical Research (JSSCR) is a national journal intended as a communication forum for scientists from many practitioners who use Pharmacology Development in research.
Arjuna Subject : -
Articles 199 Documents
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Service Quality Dimensions and Impact on Purchasing Decisions: A Case Study at Cuan Farma Pharmacy, Jakarta Subagya, Guruh; Nur Tanty, Herty; Dwi, Meiana; Syafira, Syafira
Journal Syifa Sciences and Clinical Research Vol 7, No 3 (2025): Volume 7 Number 3 2025
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v7i3.33883

Abstract

In Indonesia’s increasingly competitive pharmacy market, driven by the growth of online platforms and large pharmacy chains, service quality has become a decisive factor in attracting and retaining customers. This study examined how the five SERVQUAL dimensions influence purchasing decisions at Cuan Farma Pharmacy in East Jakarta. A cross-sectional quantitative design was applied with 287 respondents selected through systematic random sampling. Service quality was measured using a validated and reliable questionnaire (Cronbach’s Alpha = 0.94) and analyzed with multiple linear regression. The results showed that tangibles, reliability, responsiveness, and empathy had significant positive effects on purchasing decisions (p 0.05), with empathy emerging as the strongest driver. Assurance, however, was not significant (p 0.05), suggesting that customers perceive it as a basic expectation rather than a differentiating factor. Together, service quality dimensions explained 47.2% of the variance in purchasing decisions, while the remainder was influenced by other factors such as price, location, and product availability. These findings underscore the importance of enhancing empathy and responsiveness, supported by reliability and tangible aspects, to strengthen customer loyalty and competitiveness in the pharmacy sector.
Formulation and Stability Evaluation of Carrot Extract (Daucus carota L.) Scrub Lotion as a Natural Moisturizer Mahardika, Muladi Putra; Okta Riyan, Putri; Vera Vero Nika, Melinda
Journal Syifa Sciences and Clinical Research Vol 7, No 3 (2025): Volume 7 Number 3 2025
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v7i3.33398

Abstract

Carrots contain bioactive compounds such as beta-carotene and vitamin E that protect the skin against oxidative stress, maintain hydration, and delay premature aging. This study aimed to formulate and evaluate scrub lotions containing Daucus carota L. extract at concentrations of 2%, 4%, and 6%. The formulations were tested for physicochemical stability (organoleptic properties, pH, homogeneity, adhesion, and spreadability), moisturizing effect, and consumer acceptability. All formulations were stable, homogeneous, and within the safe pH range. The 6% formulation (Formula III) showed the most pronounced effect, significantly increasing skin hydration to 35% after 12 days of application (p 0.05). These findings demonstrate the potential of Daucus carota L. extract as a natural, safe, and effective active ingredient for moisturizing and anti-aging cosmetic products. To the best of our knowledge, this is among the first studies to systematically evaluate the stability and moisturizing efficacy of carrot extract scrub lotion, although further clinical investigations are required to confirm long-term safety and performance.
Sweet Potato Leaf Extract Gummy Candy as an Antioxidant-Rich Functional Food for Stunting Prevention in Children Udayani, Ni Nyoman Wahyu; Gelgel Wirasuta, I Made Agus; Nindya Kartika, Dewa Ayu Kintan; Anggreni, Ayu Putu Puspa
Journal Syifa Sciences and Clinical Research Vol 7, No 3 (2025): Volume 7 Number 3 2025
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v7i3.33862

Abstract

Stunting remains a major public health concern linked to oxidative stress and micronutrient deficiencies. This study aimed to develop and evaluate gummy candy formulations containing sweet potato leaf extract (Ipomoea batatas L.) as a functional food candidate for stunting prevention in children. The extract was obtained by maceration, and the formulation was evaluated through phytochemical screening, sensory evaluation, weight uniformity, antioxidant activity using the DPPH method, and mineral content analysis with atomic absorption spectrophotometry (AAS). Phytochemical analysis confirmed the presence of flavonoids, tannins, and saponins. Sensory evaluation by 30 panelists indicated observable differences between formulations: F0 (control) was preferred in terms of color and taste, while F1 (with extract) presented a darker green-purple appearance and a slightly bitter aftertaste, though texture remained similar in both. Weight uniformity results met pharmacopeial standards, with coefficient of variation values below 5%. Antioxidant activity testing revealed strong radical scavenging potential of the extract (IC₅₀: 29.263 ppm), moderate activity in the F1 gummy (IC₅₀: 108.245 ppm), and very weak activity in F0 (IC₅₀ 200 ppm), compared to ascorbic acid as a positive control (IC₅₀: 6.426 ppm). Mineral analysis of F1 showed iron content of 168.94 ppm and zinc content of 28.05 ppm, contributing significantly to daily nutritional requirements. In conclusion, the incorporation of sweet potato leaf extract into gummy candy provides bioactive compounds with antioxidant activity and essential minerals, while maintaining acceptable sensory quality. These findings support its potential development as a functional food to contribute to stunting prevention strategies in children.
Phylogenetic Analysis of Selected Chrysanthemum Species Using matK Gene Sequences: An In Silico Approach Wilapangga, Anjas; Rakhmad Noordam, Errol; Yudianto, Dian
Journal Syifa Sciences and Clinical Research Vol 7, No 3 (2025): Volume 7 Number 3 2025
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v7i3.31516

Abstract

This study evaluated the effectiveness of the matK gene as a molecular marker for identifying and establishing phylogenetic relationships among species within the genus Chrysanthemum. DNA sequence data were retrieved from the NCBI database and analysed using MEGA X software with the UPGMA method and 1000 bootstrap replicates. The resulting phylogenetic tree showed clear species differentiation, with strong clustering between C. indicum and C. × morifolium, and distinct divergence among other species such as C. zawadskii, C. chanetii, and C. lucidum. These findings confirm that matK is a reliable DNA barcoding marker for systematic and taxonomic studies of Chrysanthemum, particularly in addressing the limitations of morphological identification caused by phenotypic variation and hybridisation. However, this study was limited to a single marker, and future research should incorporate additional loci or genomic approaches to obtain a more comprehensive understanding of Chrysanthemum phylogeny.
Antihypertensive Therapy Patterns in Prolanis Patients at North Gorontalo City Health Centre, Indonesia Tuloli, Teti Sutriyati; Reski Manno, Mohamad; Tungadi, Robert; Nurrohwinta Djuwarno, Endah
Journal Syifa Sciences and Clinical Research Vol 7, No 3 (2025): Volume 7 Number 3 2025
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v7i3.34245

Abstract

Hypertension is a chronic condition characterized by persistent elevation of blood pressure above normal limits, which increases morbidity and mortality risk. A systolic blood pressure ≥140 mmHg reflects pressure during cardiac contraction, while a diastolic blood pressure ≥90 mmHg reflects pressure during cardiac relaxation. This study aimed to evaluate the use of antihypertensive drugs in Prolanis patients with persistent hypertension at the North Gorontalo City Health Centre. An observational design was applied using secondary data from medical records of 42 patients who received antihypertensive therapy between January and June 2025. Amlodipine was the most commonly prescribed agent in monotherapy, while combinations of two to five drugs were frequently used. The evaluation revealed that drug selection was appropriate (100%), dosage accuracy was 86%, and adherence to usage rules reached 98%, although some inappropriate dosages and usage instructions were still identified. These findings underscore the need for systematic monitoring, regular prescription audits, strengthened verification processes, laboratory monitoring, and patient education to enhance the safety and effectiveness of hypertension management in primary care.
Clinical Outcomes of Antihypertensive Therapy in Chronic Kidney Disease: A Literature Review Candraningrat, I Dewa Agung Ayu Diva; Ayu Sri Handani, Dewa; Vyra Ginanti Putri, Ni Putu; Dirga Mega Buana, Komang
Journal Syifa Sciences and Clinical Research Vol 7, No 3 (2025): Volume 7 Number 3 2025
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v7i3.34331

Abstract

Chronic kidney disease (CKD) carries high cardiovascular risk, and optimal antihypertensive therapy is central to slowing progression. This review synthesized randomized controlled trials from the past 10 years in adults with CKD identified via PubMed, focusing on estimated glomerular filtration rate (eGFR) decline, albumin/protein excretion, and cardiovascular outcomes; study selection followed PRISMA. Renin–angiotensin system inhibitors (RASi) consistently lowered blood pressure, reduced albumin/protein excretion, and attenuated eGFR decline versus comparators. In a crossover trial, azilsartan produced greater reductions in urine protein-to-creatinine ratio and faster blood-pressure control than candesartan. Among calcium channel blockers, benidipine (T/L-type) decreased urinary albumin excretion and improved vascular surrogates versus amlodipine (L-type), suggesting class-specific renal effects. Nifedipine GITS combined with candesartan improved blood-pressure control in high-risk subgroups. Adding spironolactone can further reduce albuminuria but increases hyperkalemia risk; co-administration of patiromer enables RASi/MRA intensification under biochemical monitoring. Overall, RASi remain first-line—particularly in albuminuric CKD—while selected combinations with a dihydropyridine calcium channel blocker or a mineralocorticoid receptor antagonist (with a potassium binder when needed) may augment renoprotection. Treatment should be individualized to CKD stage, comorbidities, and laboratory follow-up.
Performance Verification of the LOCMEDT C200 Automatic Biochemistry Analyzer Using Routine Clinical Samples Abas Suherli; Anjas Wilapangga
Journal Syifa Sciences and Clinical Research Vol 8, No 2 (2026): Volume 8 Number 2 2026
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v8i2.37251

Abstract

Analytical verification is an essential prerequisite before implementing a new automated biochemistry analyzer in routine clinical laboratories to ensure reliability, accuracy, and compliance with recognized quality standards. This study aimed to verify the analytical performance of the LOCMEDT C200 Automatic Biochemistry Analyzer in accordance with CLSI and ISO 15189 principles by evaluating precision, accuracy (bias), and method comparison against an established routine analyzer using CLIA allowable error limits as performance benchmarks. Precision was assessed using a modified CLSI EP15-A3 approach with two levels of internal quality control materials to determine within-run and between-day coefficients of variation (CV%). Accuracy and method comparison were evaluated according to CLSI EP09-A3 by analyzing 40 patient serum samples in duplicate across clinically relevant concentration ranges. Statistical analyses included correlation assessment, percentage bias, and paired significance testing, with interpretation based on CLIA total allowable error criteria. The LOCMEDT C200 demonstrated acceptable analytical precision for most parameters, with between-day CV values largely within CLIA limits. Method comparison showed very strong correlation between the LOCMEDT C200 and the reference analyzer across all analytes. Most parameters, including glucose (3.58%), urea (4.06%), creatinine (7.07%), triglycerides (7.28%), and HDL (1.85%), showed bias within CLIA allowable limits. However, AST (32.30%) and total cholesterol (22.32%) exceeded CLIA total error thresholds, indicating systematic bias that requires further technical evaluation. Although statistically significant differences were observed for albumin and total protein (p 0.05), the mean deviations remained within clinically acceptable limits. Overall, the LOCMEDT C200 demonstrated acceptable analytical performance for routine clinical chemistry testing, although targeted calibration assessment is recommended for analytes with elevated bias.
Drug-Drug Interactions in Adult Acute Respiratory Infections Prescriptions at the Gorontalo Police Clinic: A Six-Month Retrospective Study Fika Nuzul Ramadhani; Teti Sutriyati Tuloli; Tesalonika Tudja
Journal Syifa Sciences and Clinical Research Vol 8, No 2 (2026): Volume 8 Number 2 2026
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v8i2.32403

Abstract

Acute respiratory infection (ARI) is one of the most common conditions managed in primary care, and its treatment often involves multiple medications that may increase the risk of potential drug–drug interactions (DDIs). This study aimed to identify medication use patterns and to determine the frequency, severity, and mechanisms of potential DDIs in adult ARI prescriptions at the Gorontalo Police Clinic. This observational cross-sectional study used a retrospective approach based on outpatient medical record and prescription data collected from July to December 2023. A total of 110 eligible adult patients were included in the analysis. Potential DDIs were screened using the Drugs.com Interaction Checker and further reviewed with Stockley’s Drug Interactions as a reference. Data were analyzed descriptively. The results showed that the median number of medications per patient was 4 (IQR 3–6), while polypharmacy was identified in 11 patients (10.0%). Potential DDIs were found in 2 of 110 patients (1.82%). All identified DDIs were moderate in severity, with no minor or major interactions detected. The interaction mechanism was exclusively pharmacodynamic, and both cases involved the combination of amoxicillin and chloramphenicol, indicating a potential antagonistic effect. In conclusion, potential DDIs in adult ARI prescriptions at the Gorontalo Police Clinic were uncommon but clinically relevant. Routine screening is needed to prevent potentially inappropriate antibiotic combinations in primary care practice.
Antioxidant Activity and Effects of Kedayan (Aristolochia sp.) Stem Extract on HSC-3 Human Oral Cancer Cells Komariah Komariah; Rahmi Amtha; Fiqie Amaliah Jusman; Yoli Sidarta; Rezky Anggraeni; M. Orliando Roeslan
Journal Syifa Sciences and Clinical Research Vol 8, No 2 (2026): Volume 8 Number 2 2026
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v8i2.35713

Abstract

Medicinal plants are a promising source of bioactive compounds with potential therapeutic applications, including antioxidant and anticancer-related activities. This study aimed to identify secondary metabolites in the stem extract of Aristolochia sp. and to evaluate its antioxidant activity and effects on the viability of HSC-3 human oral cancer cells. The stem extract was prepared by maceration with 95% ethanol and screened qualitatively for phytochemical constituents. Antioxidant activity was assessed using the DPPH assay, whereas cell viability was evaluated using the CCK-8 assay. The extract contained several secondary metabolites, including flavonoids, phenolic compounds, saponins, and tannins. In the DPPH assay, the extract showed an IC₅₀ value of 138.34 ± 12.14 µg/mL, indicating moderate antioxidant activity. In the HSC-3 viability assay, the extract reduced cell viability in a concentration-dependent manner; however, the IC₅₀ was not reached within the tested concentration range and was therefore reported as 50 µg/mL. The greatest reduction in HSC-3 cell viability was observed at 50 µg/mL, with a corresponding cell mortality rate of 39.90%, which differed significantly from the control groups (p 0.05). In conclusion, the stem extract of Aristolochia sp. demonstrated moderate antioxidant activity and reduced HSC-3 cell viability within the tested concentration range. These findings provide preliminary evidence of bioactivity; however, further studies using a wider concentration range and additional mechanistic and safety evaluations are required before anticancer potential can be inferred.

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