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Journal Syifa Sciences and Clinical Research (JSSCR)
Published by Universitas Negeri Gorontalo
ISSN : 26568187     EISSN : 26569612     DOI : 10.37311/jsscr
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Journal Syifa Sciences & Clinical Research (JSSCR) is a national journal intended as a communication forum for scientists from many practitioners who use Pharmacology Development in research.
Arjuna Subject : -
Articles 196 Documents
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Swamedikasi : Pengaruh Perilaku Terhadap Tingkat Pengetahuan Common Cold Pada Mahasiswa Baru Farmasi Syifa Nafisa Musyafak; Muhammad Akib Yuswar; Nera Umilia Purrwanti
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15374

Abstract

Self-medication is a person's attempt to treat himself, usually to overcome a mild disease, one of which is the common cold . Self-medication will have a negative impact if self-medication is carried out incorrectly due to lack of knowledge about drug information. The purpose of this study was to determine the relationship between knowledge level and common cold self-medication behavior in Pharmacy students batch 2021 at the Faculty of Medicine, Tanjungpura University. The method used is cross sectional and the total sampling method with of samples used in this study was 60 samples. The instrument used in this research is a questionnaire that has been tested for validity and reliability. Data analysis was carried out by using the Spearman rank test using SPSS. There is a strong relationship with the P value = 0.000 and positive (+) with a correlation coefficient of 0.556 between knowledge level and self-medication behavior Common cold on Pharmacy students batch 2021, Faculty of Medicine, UNTAN .
Uji Aktivitas Antioksidan Sediaan Salep Ikan Gabus (Channa Striata) Kombinasi Vitamin C dan Madu Kelulut (Heterotrigona Itama) Risma Dwi Anugerah; Wintari Taurina; Mohamad Andrie
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15271

Abstract

Based on the results of research, snakehead fish extract and kelulut honey have properties to make wounds heal faster. Ointment with an active formulation of snakehead fish extract and extract of kelulut honey showed an oxidation process that could make the preparation rancid. The addition of BHA and Vitamin C is expected to prevent the oxidation process so that the preparation does not become rancid. This study aims to determine the effect of adding Antioxidant BHA and Vitamin C in preventing the oxidation process of the ointment in the aqueous phase of extracts of snakehead fish (Channa Striata)and of kelulut honey (Heterotrigona Itama) at 28 days storage. Stability was accelerated at a temperature of 40 ± 20ºC and a RH of 75 ± 5%. Variations in the concentration ofiBHA and Vitamin C used were BHA.0.02. : Vitamin C 0.1, BHA 0.02 : Vitamin C 0.01, BHA 0.005 : Vitamin C 0.01, and BHA 0.005 : Vitamin C 0.1 then tested the physical properties of the ointment, namely through organoleptic test, homogeneity test, spreadability test, adhesion test, protection test and acid number test which were then analyzed by SPSS. Based on the analysis of the scattering power showed a significant difference between F0, F1, and F3. The results of the adhesion analysis showed that there were significant differences in each formula. Furthermore, the results of the stability test showed that all formulas had good physical stability. Conclusion: F1 is a very good formula to prevent oxidation in the preparation as evidenced by a decreased acid number, which is 9.62 mg KOH/g.
Efektivitas Penurunan Kadar Glukosa Darah Daun Lamtoro (Leucaena leucocephala L.) Pada Mencit Jantan (Mus muscullus L.) Juliyanty Akuba; Endah Nurrohwinta Djuwarno; Faramita Hiola; Mahdalena Sy. Pakaya
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.14913

Abstract

Diabetes mellitus (DM) is defined as a disease or metabolic disorder characterized by high blood glucose levels. The management of diabetes mellitus therapy in the community is diverse, ranging from synthetic drugs to herbal medicines. Many people assume that herbal medicines are relatively cheaper and safer compared to synthetic drugs. One of the plants commonly used as herbal medicine is Lamtoro. This research aimed to determine the effectiveness of Lamtoro leaves (LeucaenaleucocephalaL) on decreasing blood glucose levels on lab mice (Mus musculus L). This study used 27 male house mice divided into nine groups; each group consisted of three male house mice, i.e., glucose control (group I), negative control Na-CMC 1% w/v (group II), Positive control of chlamyd Gliben 1.56% w/v (group III), administered N-Hexan extract of Lamtoro leave 1% w/v (group IV), the extract of N-Heksan Lamtoro leaf 2.5% w/v (group V),  the extract of N-Heksan Lamtoro leaf 5% w/v (group VI), ethanol extract of Lamtoro leaf 1% w/v (group VII), ethanol extract of Lamtoro leaf 2.5% b/v (group VIII), and ethanol extract of Lamtoro leaves 5% w/v (group IX). The results were analyzed using the One Way ANOVA test. It showed that N-Hexane and Ethanol extract of Lamtoro leaves with a concentration of 1% w/v, 2.5% w/v and 5% w/v was able to reduce the blood glucose levels. The extract which had the best activity in reducing blood glucose levels was found in ethanol extract 96% at a concentration of 5% w/v with a decrease in the percentage by 59%. This was because the 96% ethanol extract contained a number of secondary metabolite compounds, i.e., flavonoids, alkaloids and tannins as blood glucose levels reducer
Karakteristik Dan Penggunaan Obat Pasien Dispepsia Rawat Inap Di Rumah Sakit Maura Zettira Shabrina; Nurmainah Nurmainah; Mohammad Andrie
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14791

Abstract

The 2006 Indonesian health data profile states that dyspepsia ranks 10th out of the top 10 most hospitalized diseases in all Indonesian hospitals with 34,029 cases (1.52%). This study aims to describe the characteristics of inpatient dyspepsia patients, determine the presentation of dyspepsia drug use, and describe comorbidities in inpatient dyspepsia patients at RSUD dr. Rubini Kabupaten Mempawah. The sampling method used purposive sampling and data were taken from medical records with a total of 110 patients. Data collection used medical record for inpatient dyspepsia patients at dr. Rubini Hospital, Mempawah Regency for the January-December 2020 period. The results in this study were dyspepsia patients who were hospitalized at dr.Rubini Hospital, Mempawah Regency, the dominant gender was female (74.55%), patients with the majority age ranged 46-55 years (23.63%), housewife work (52.72%) with a senior high school education (42.37%). Dyspepsia patients with marital status (77.28%), patients with the majority of non-smoking habits (82.73%), and patients with 3 days of hospitalization (27.27%). The most widely used drug use in RSUD dr. Rubini, Mempawah Regency, namely omeprazole injection (26.90%) and the most common combination treatment for dyspepsia is PPI + Cytoprotective + Antiemetic (49.10%). The most dominant comorbidities in inpatient dyspepsia patients at RSUD dr. Rubini, Mempawah Regency are hypertension and vertigo.
Formulasi Salep Ekstrak Ikan Gabus (Channa striata) dan Madu Kelulut (Heterotrigona itama) sebagai Antioksidan Ely lisnawati; Wintari Taurina; Mohamad Andrie
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15270

Abstract

Kelulut honey and snakehead fish extract have been demonstrated to improve wound healing, hence the two active components are combined in ointment formulations. Adeps lanae is a base that is included in the oil phase that undergo an oxidation process that causes rancidity in the ointment preparation, so in this study BHA and BHT antioxidants were added to suppress the oxidation process. The ointment was made with 5 concentrations consisting of 1 control group and 4 treatment groups which were given variations of BHA and BHT antioxidants. Organoleptic testing, homogeneity, adhesion, dispersion, protection, and acid numbers were all evaluated. SPSS 24 is used to test data related to adhesion, and dispersion. Results: The addition of antioxidants BHA and BHT based on acid number tests revealed that the higher the combination of antioxidants employed, the less the increase in acid numbers on day 28. The organoleptic test, homogeneity, protection, and adhesion on the preparation fulfilled the test criteria, whereas the adhesion test revealed significant differences in F1, F2, and F4 when compared to the control group. The optimum formula is F4, which fits the test parameters and has the minimum rise in acid number (9.22 mg KOH/g).
Kromatografi Lapis Tipis (KLT): Pendekatan Pola Kromatogram Untuk Mengkonfirmasi Rhodamin B Pada Perona Pipi Sania Puspita Sari; Retno Ikayanti; Elok Widayanti
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14865

Abstract

Blusher is a decorative cosmetic whose purpose is to beautify the face and emphasize the shape of the cheekbones. Rhodamine B is a synthetic dye in the form of a crystalline powder which is prohibited from being used in cosmetics according to the regulation by Head of The Indonesian Food and Drug Administration No. 18 of 2015 concerning Technical Requirements for Cosmetic Materials, because they are dangerous if contact with the skin. The purpose of this study was to determine rhodamine B in blusher which is traded in Kandat Market, Kediri Regency. In this study, five samples were used, namely sample A, sample B, sample C, sample D, and sample E. The qualitative analysis method used was Thin Layer Chromatography (TLC). In this method, the eluent N-butanol:ethyl acetate:ammonia is used in the ratio (55: 20: 25). TLC results showed visually in pink color, then when viewed under UV light 254 nm was yellow fluorescence. From the five samples, the Rf value was 0.52; 0.56; 0.61; 0.52 and 0.57, while the average Rf of the standard solution of rhodamine was 2.1. So that from the five samples it can be seen that they do not contain rhodamine B dye.
Penapisan Virtual Basis Data Senyawa Tanaman Afrodisiak Asal Family Rutaceae Sebagai Inhibitor α-Amylase ADRIANI ADRIANI
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14752

Abstract

The family Rutaceae has plants with worldwide aphrodisiac effects, but their activity as an antidiabetic has not been widely reported. This study aims to predict the -amylase activity of aphrodisiac plant compounds from the Rutaceae family based on virtual screening. The -amylase receptor (PDB ID: 1XD1) was prepared using Pymol while the ligand was prepared using Pyrx. Virtual screening using Autodoct vina in Pyrx with acarbose as a control drug. The results of virtual screening were analyzed using Discovery Studio software to get potential compounds. Prediction of a potential compound target protein using Swiss Prediction Target while pharmacokinetic analysis is based on The lipinski rule. The results showed that lunamarine had the highest inhibitory activity (-8.9 Kcal/mol) against -amylase receptors and was close to acarbose control (-9.7 Kcal/mol). Lunamarine complies with the Lipinski rule and has a high probability of target protein. The study concludes that compounds from aphrodisiac plants from the family Rutaceae have antidiabetic activity. Lunamarin has the highest activity as an -amylase inhibitor compared to other compounds.
Rasionalitas Penggunaan Obat Pada Pasien GERD di Instalasi Rawat Jalan Rumah Sakit Nurul Aisiyah; Muhammad Akib Yuswar; Nera Umilia Purwanti
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15364

Abstract

The prevalence of Gastroesophageal Reflux Disease (GERD) is increasing every year. Inaccuracy of indication, drug, dose, route of administration, and time interval of administration can lead to failure of therapy. The purpose of this study was to evaluate the rationality of drug use in GERD patients in the outpatient installation of RSUD dr. Soedarso Pontianak. This research method is descriptive observational with cross sectional design. Data collection was carried out retrospectively by looking at the medical records and prescriptions of GERD patients for the period 2020-2021. The samples used in the study were 60 samples that met the inclusion criteria. The results showed that the percentage of rationality in patients without comorbidities was based on 100% correct indication, 93,33% correct drug, 100% correct dose, 100% correct route of administration, and 100% right time interval for administration and with comorbidities based on correct indication 100%, 40% right drug, 100% right dose, 100% right route of administration, and 100% right time interval for administration.
Pola Penggunaan Obat Diare Akut Pada Balita di Rumah Sakit Sofia Futria Wulandari; Muhammad Akib Yuswar; Nera Umilia Purwanti
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15445

Abstract

The prevalence of diarrhea in Indonesia based on the diagnosis of health workers reached 6.8% in 2018. Generally attacks toddlers under the age of 5 years because the toddler's immune system is still in the weak category, making them more susceptible to exposure to bacteria that cause diarrhea. The most cases of diarrhea in Indonesia are cases of acute diarrhea. This study aims to determine the pattern of use of acute diarrhea medication in toddlers at Sultan Syarif Mohamad Alkadrie Hospital Pontianak in 2020. This study used a descriptive observational method with a cross-sectional research design. Retrospective data collection using purposive sampling method. The results showed that the characteristics of patients by gender who suffered the most from acute diarrhea were women (55%), the most age group was 0-1 year (30%), the type of diarrhea that most suffered was acute diarrhea without dehydration (51, 25%) and the most felt clinical symptoms were liquid defecation and fever (44.20% and 20.99%). The most widely prescribed drug to treat acute watery diarrhea was zinc (27.97%). The conclusion in this study is that the most widely prescribed drug to treat acute diarrheal disease in toddlers is zinc.
Pola Penggunaan Obat Antihipertensi Pada Pasien Hipertensi di Instalasi Rawat Jalan Rumah Sakit Umi Khairiyah; Muhammad Akib Yuswar; Nera Umilia Purwanti
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15446

Abstract

Hypertension is a condition of a person experiencing an increase in blood pressure above normal, namely systolic blood pressure 140 mmHg and or diastolic blood pressure 90 mmHg. The purpose of this study was to determine the pattern of use of antihypertensive drugs in hypertensive patients in the outpatient installation of RSUD Sultan Syarif Mohamad Alkadrie Pontianak in 2020. The method used was descriptive observational method with a cross sectional design. Data collection was carried out retrospectively through searching medical record data and patient prescription data for the period January-December 2020. The results showed that the characteristics of patients based on age who suffered the most from hypertension were in the age range of 56-65 years, the sex being the most female, and most hypertensive patients suffer from stage 2 hypertension. The most widely used single antihypertensive drug is amlodipine with a percentage of 50%, the most combined antihypertensive drug is a combination of amlodipine and candesartan at 58.06%. The conclusion of this study is that the most widely prescribed antihypertensive drug as a single antihypertensive is amlodipine and as a combination antihypertensive drug, namely amlodipine and candesartan.

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