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Journal Syifa Sciences and Clinical Research (JSSCR)
Published by Universitas Negeri Gorontalo
ISSN : 26568187     EISSN : 26569612     DOI : 10.37311/jsscr
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Journal Syifa Sciences & Clinical Research (JSSCR) is a national journal intended as a communication forum for scientists from many practitioners who use Pharmacology Development in research.
Arjuna Subject : -
Articles 196 Documents
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Isolasi dan Karakterisasi Bakteri Endofit dari Akar Pare (Momordica charantia L.) Mahdalena Sy. Pakaya; Julianty Akuba; Dizky Ramadani Putri Papeo; Andi Makkulawu; Ade Ari Puspitadewi
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.15536

Abstract

Endophytic bacteria are microbes that grow on plant tissue and can form a colony on plant tissue without producing a negative effect on the host. The endophytic bacteria have the potential to have the same activity and produce secondary metabolite as their host. The root of bitter melon (momordica charantia L.) has been known to have antibacterial activity, thus enabling the presence of endophytic bacteria, which also have antibacterial potential.This present research aims to isolate and characterize endophytic bacteria found in bitter melon (Momordica charantia L. The method used in the isolation stage is direct lanting so that the endophytic bacteria are obtained from plant tissue; macroscopic and microscopic characterization stage; inhibition test stage; inhibition test stage using disc method (Kirby-Bauer). In accordance with the results of macroscopic and microscopic characterization, the two bacteria indicate different characteristics.
Gambaran Praktik Five Moment Cuci Tangan Pada Perawat Di Puskesmas Hilmawaty Susanthy Kue Paudi
Journal Syifa Sciences and Clinical Research Vol 2, No 2 (2020): Volume 2 Edisi 2 2020
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v2i2.15453

Abstract

The prevalence of nosocomial infections around the world is a serious concern for all health services, especially in hospitals. One of the contributing factors is non-compliance in the implementation of handwashing procedures in accordance with standard operating procedures. The study aims to determine the level of compliance of nurses in the implementation of the five-moment Handwashing at the Dungingi Health Center in 2020. The design used is obsevasional descriptive with a cross sectional approach. The total sample was 97 people taken by purposive sampling . The data analysis carried out in this study is univariate data analysts. The results of the study found that most respondents had a compliance rate of less than 69.1%, moderate compliance as much as 18.6% and good compliance as much as 12.4%. It is recommended that all nurses be more concerned about the importance of implementing the five-moment hand hygiene standard procedure, and the Puskesmas provides rewards to nurses who are obedient in implementing these standards.
Formulasi Dan Evaluasi Fisik Sediaan Mouthwash Ekstrak Etanol Kulit Buah Matoa (Pometia Pinnata) Nur Ain Thomas; Mahdalena Sy. Pakaya; Ariani H. Hutuba; Yayah Rachmatiyah
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.15538

Abstract

Matoa peels contained phenolic, saponin, tannin, flavonoid and terpenoid which functions as anti-bacterias to Streptococcus mutans that can cause dental caries and active ingridients for mouthwash preparations. Mouthwash is a solution to be used as a cleansing agent that can improve mouth hygiene, esthetics and breath freshness. This study aimed to identify the etanol extract of Matoa peels to be formulated mouthwash preprations and its physical evalutions. This study employed methods that includes peels extraction, extract phytochemical screening, mouthwash preparation productions and mouthwash preparations evluations consisting of organoleptic, pH and viscosity test. The testing was conducted in day 0, 7, 14, 21 and 28. The findings revealed formula 2 as the best formula with 10% of glycerin concentration.
Identifikasi Cemaran Zat Pewarna Berbahaya Rhodamin B Pada Beberapa Produk Lipstik Siti Cholifah; Lukky Jayadi
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15408

Abstract

Rhodamine B is a synthetic dye used in industries such as paper and textile dyes. Rhodamine dye is prohibited from being used in cosmetic preparations because rhodamine is carcinogenic and can cause irritation and cancer in long-term use. This study aims to determine the presence of harmful dyes in lipstick cosmetic preparations. The method used in this research is using concentrated HCl reagent and 10% NaOH, this method is used as a test for the alleged presence of rhodamine in the sample. Positive results of the presence of rhodamine content were indicated by a change in the color of the sample which became dark orange after concentrated HCl was added and turned blue after 10% NaOH was added. Then continued by using the UV-Vis spectrophotometry method to determine the rhodamine levels in the sample. The samples used were 5 red lipsticks, from 5 samples that were tested, 1 sample was indicated which was indicated to contain rhodamine b because it changed color to orange when given concentrated HCl and blue when given 10% NaOH. Positive samples were samples with code C, after measuring with spectrophotometry, the results showed that the levels of Rhodamine in the sample were 0.009% in replication 1; 0.012% at replication 2 and 0.008 at replication 3.
Gambaran Tingkat Kepatuhan Berobat Antiretroviral Pada Pasien HIV/AIDS Anggie Maulida; Muhammad Akib Yuswar; Nera Umilia Purwanti
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15444

Abstract

Antiretroviral use can reduce the amount of virus in the body and increase the CD4 cell count in people infected with HIV. The success of HIV treatment can be achieved by increasing adherence to taking antiretroviral drugs. The aim of this study was to describe the level of adherence of HIV/AIDS patients undergoing antiretroviral treatment at dr. Agoesdjam Ketapang. The research method used is descriptive research with cross sectional design. Sampling was done by purposive sampling technique with a sample of 45 respondents. Research data were collected through the administration of the Morisky 8-Item Medication Adherence Questionnaire (MMAS-8) questionnaire to HIV/AIDS patients in RSUD dr. Agoesdjam Ketapang. The results showed that the characteristics of HIV/AIDS patients undergoing antiretroviral treatment at VCT Bougenville RSUD dr. Agoesdjam Ketapang is dominated by male patients (78%), patients aged 25-49 years (76%), patients with male HIV transmission factors (38%), patients with high school education (40%), patients who work as private employees (40%), and the majority of HIV/AIDS patients receive artivla therapy (78%). HIV/AIDS patients undergoing antiretroviral treatment at dr. Agoesdjam Ketapang had a high level of treatment adherence (38%), moderate adherence (33%), and low adherence (29%). The conclusion of this study is the level of adherence to treatment of HIV/AIDS patients in RSUD dr. Agoesdjam Ketapang according to high compliance.
Identifikasi Senyawa Metabolit Sekunder Daun Spigelia anthelmia L. dan Uji Aktifitas Antioksidan Menggunakan Metode DPPH (1,1-Diphenyl-2-Picrylhidrazy) Muhammad Taupik; A. Mu’thi Andy Suryadi; Jafar La Kilo; Wiwit Zuriati Uno; Samsul Bahri Badjeber
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15927

Abstract

Spigelia anthelmia is a type of weed plant that is classified as toxic and is included in the list of herb of medicine. The research aims to determine the secondary metabolite content of Spigelia anthelmia L. leaves extract and antioxidant activity test using the DPPH (1,1-Diphenyl-2-Picrylhydrazy) method. The research samples are extracted by applying the total maceration method with methanol as a solvent and followed by partition method using n-hexane, ethyl acetate, and methanol as solvents. The identification of flavonoid compounds content is performed by employing Thin Layer Chromatography method with methanol as eluent: n-hexane (1:4), ethyl acetate:n-hexane (4:1), ethyl acetate:n-hexane (4:1). Meanwhile, the antioxidant activity test is performed by employing UV-Vis Spectrophotometry method. The result of identification by thin layer chromatography using AlCl3 spray reagent, Lieberman Burchard. Dragendrof, and cerium sulfate, indicate that the Spigelia anthelmia L. leaves extract contains alkaloids, flavonoids, and terpenoids. In addition, the antioxidant activity test of Spigelia anthelmia L. leaves extract is carried out at wavelength of UV 516 nm with an absorbance value of 0,654 A. with a linear equation of y = 0,027 x – 42,83 with a correlation coefficient (R2) = 0,0983 and has the strongest IC50 at the methanol fraction for 7,69 µg/ml.
Evaluasi Perbandingan Sistem Rantai Dingin Penyimpanan Vaksin Maelana Eka Dewi; Iswandi Iswandi; meta kartika
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.16485

Abstract

Vaccines are preparations of biological products that contain antigens or contain components of microorganisms that have been attenuated from genetic engineering. Defective vaccine quality can be caused by the time of the cold chain storage process that is not in procedure. This study aims to compare the vaccine cold chain system in the warehouse of the City Health Office and Salatiga City Health Center which is guided by the Indonesian Minister of Health Regulation Number 12 of 2017. This type of research uses a descriptive observational method. The data collected in the form of quantitative and qualitative. Collecting qualitative data obtained from interviews and observations. Qualitative data were obtained from vaccine storage data in 2021. The results of the study obtained that he cold chain compatibility system at the City Health Office and Salatiga City Health Center was in good category, with the percentage of the City Health Office 88.88%, Cebongan Health Center 77.77%, Mangunsari Health Center 70.37%, Kalicacing Health Center 85.18%, Tegalrejo Health Center 81.48%, Sidorejo Lor Health Center 81.48%, Sidorejo Kidul Health Center 77.77%. Supporting facilities for vaccine storage are in accordance with the guidelines of the Permenkes RI Nomor 12 tahun 2017, in good category. With the percentage of the City Health Office 99.64%, Cebongan Health Center 96.87%, Mangunsari Health Center 97.02%, Kalicacing Health Center 91.80%, Tegalrejo Health Center 94.11%, Sidorejo Lor Health Center 96.29%, Sidorejo Kidul Health Center 98,30%.
Analisis Penggunaan Kotak Pil (pill Box) Terhadap Kepatuhan Penggunaan Obat Pada Pasien Diabetes Melitus Tipe 2 Apriani Metya Pratiwi; Nurmainah Nurmainah; Mohammad Andrie
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15643

Abstract

Diabetes Mellitus (DM) is a chronic disease that occurs when the body cannot produce enough insulin. Adherence is a major factor in determining the success of treatment. The use of pillboxes is a common method of reminding patients of their medication schedule. The problems found in the community are not compliant in taking drugs, especially type 2 DM patients. These factors are known to hinder the success of achieving optimal DM treatment. The purpose of this study was to determine the effect of using a pill box on medication adherence in type 2 DM patients using the Morisky Medication Adherence Scale (MMAS-8) questionnaire. This study uses an experimental method with a cross sectional study, the sampling technique used is the quota sampling technique. Data was collected by filling out a questionnaire using the MMAS-8 questionnaire. The population used was adult patients with DM who were outpatients at Sungai Raya Dalam Public Health Center. The data collection process is carried out through visits to the patient's home (home visit). Data analysis in this study used the SPSS application. The results of the measurement of the highest level of compliance were obedient (24%) and a significant value was obtained from the Paired Sample t-Test test, which was 0.000 (0.05) which showed that the pill box could improve patient compliance in taking medication. The pill box makes it easier for patients to set the time to take medicine.
Identification of Paracetamol in Jamu Using Thin Layer Chromatography Analysis Method Iga Yastiara; Fajar Nugraha; Hadi Kurniawan
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15284

Abstract

Jamu is one of the Indonesian traditional medicine. Jamu is efficacious for health so it is widely consumed by the society. The high level of consumption causes trade competition from jamu industry in various regions, including in Pontianak City, West Kalimantan. However, several jamu industries in Pontianak have violated the law by adding medicinal chemicals to jamu. The most widely added medicinal chemical in jamu is paracetamol. Paracetamol which indicates as an analgesic-antipyretic can be harmful for health because it increases liver hepatotoxicity if consumed continuously.This study aims to identify paracetamol in herbal medicine. A total of 10 samples were obtained in Pontianak City, West Kalimantan by purchasing directly or from an online shop. This study used thin layer chromatography as an instrument of qualitative analysis. The results of the analysis using thin layer chromatography were Rf samples A, B, and G were 0.675, respectively; 0.6625; 0.6625 which is close to the standard Rf value for comparison of paracetamol, which is 0.675. Those three samples contained paracetamol because they had a different Rf value 0.05 from the standard Rf value.
Evaluasi Penggunaan Antibiotik pada Pasien Pediatri ISPA dengan Metode Gyssens Eva Najmah Novita; Ressi Susanti; Nurmainah Nurmainah
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15447

Abstract

Acute Respiratory Infection (ARI) is an upper or lower respiratory tract infection caused by a virus or bacteria. The high prevalence of ARI in Indonesian children can increase the risk of irrational use of antibiotics. This study aims to describe the types of antibiotics that are often used and analyze the rationality of antibiotics usage in pediatric ARI inpatient in Sultan Syarif Mohamad Alkadrie Public Hospital using the Gyssens method. This study is an observational study with a cross-sectional design. Data were collected retrospectively with consecutive sampling method. Data were analyzed using the Gyssens method based on therapeutic guidelines by IDAI, the Indonesian Ministry of Health, and WHO. The result showed that from 98 patients, the types of antibiotics were obtained as follows: third generation of cephalosporin group (66.16%), the penicillin group (19.23%), and the macrolide group (14.61%). Based on the results of the evaluation of antibiotics using the Gyssens method, the percentage of antibiotics usage that are in category 0 is 11,24%, category I (15,73%), category IIa (17,98%), category IIb (24,16%), category IIIa (0,56%), category IVa (15,73%), category IVc (1,69%), and category V (12,92%). It can be concluded that there is still irrational use of antibiotics in pediatric ARI inpatient in Sultan Syarif Mohamad Alkadrie Public Hospital in 2019-2020.

Page 12 of 20 | Total Record : 196

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