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Journal Syifa Sciences and Clinical Research (JSSCR)
Published by Universitas Negeri Gorontalo
ISSN : 26568187     EISSN : 26569612     DOI : 10.37311/jsscr
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Journal Syifa Sciences & Clinical Research (JSSCR) is a national journal intended as a communication forum for scientists from many practitioners who use Pharmacology Development in research.
Arjuna Subject : -
Articles 196 Documents
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Gambaran Efek Samping Obat Antituberkulosis Pada Pasien Tuberkulosis Widysusanti Abdulkadir; Endah Nurrohwinta Djuwarno; Nur Rasdianah; Faramita Hiola
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.14292

Abstract

Pulmonary tuberculosis is a communicable disease caused by Mycobacterium tuberculosis bacteria that mostly attack lungs, yet they also possibly attack other organs. The use of tuberculosis drug oftentimes leads to side effects on the patients. This research intends to determine the side effects of anti-tuberculosis drugs of tuberculosis patients. It employed a cross-sectional approach, in which the data were collected from questionnaires. As many as 50 patients were selected as the sample using purposive sampling, i.e., a sampling technique based on inclusion and exclusion criteria. The results indicate that the majority of the patients suffering from tuberculosis are men (27 people, 54%), aged 16-27 years (30%), graduating from elementary school (60%), with another job (farmer, 76%).  In addition, the frequently-occurring side effects include red urine (22%), nausea (18%), being limp (14%), vomit (12%), joint pain and itch (8%), and loss of appetite (2%).
Moringa Oleifera Leaf extract as anti-breast cancer: Narrative Review Magfirah Septiani Yusuf; Robert Tungadi
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.14218

Abstract

Breast cancer is a malignant tumor that attacks the cell tissue in the breast but breast cancer therapy can cause cancer cells to spread through the blood vessels to other parts. Ttherefore, there is a need for effective treatment to prevent the spread of cancer cells which is one of them by suppressing cancer cells sel. Moringa leaves contain flavonoid compounds that can be efficacious as anti-breast cancer. This review examines the potential of moringa oleifera as an anticancer of the breast in different concentrations. National and international literature studies include identification and data download of articles and scientific journals using internet sources from the PubMed, Google Scholar, PubMed, and Science Direct databases using keywords Breast Cancer, Flavonoids, Apoptosis, Moringa Leaf Extract. Although further pre-clinical studies still need to be done, the results of this review show Moringa Leaf Extract is effective against inhibiting cancer cell proliferation and triggering apoptosis.
Formulasi dan Evaluasi Kestabilan Fisik Krim Ekstrak Biji Lada Hitam (Piper nigrum L.) Menggunakan Variasi Emulgator Andi Nur Zam Zam; Musdalifah Musdalifah
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14146

Abstract

Black papper seed extract has known for its antivitiligo potential. The  addition  of  black papper seed  extract was predicted can influence the physical  stability  of  the  cream.  Therefore, this research was aimed to test the physical stability of cream contained  black papper seed extract in varity of emulgator there is tween® 60-span® 60, tween® 80-span® 80, novemer®, dan viscolam®. Physical stability test using the cycling test method by storing the preparation at 4 ° ± 2 ° C for 24 hours and then storing it at 40°±2°C) for 24 hours. The storage time at these two different temperatures is considered as one cycle and carried out for 12 days. The stability parameters were organoleptic observations, homogeneity, dispersion, pH, viscosity and cycling test results. The results showed that there were differences in organoleptic values, pH, viscosity, homogeneity and dispersibility. The most stable cream was obtained, namely the cream formula using emulgator Tween® 60-span® 60, had a good organoleptic value, cream type m/a, pH 5.10, viscosity 46,800 cPs, spreadability 4.2 cm2, homogeneous cream . The results of this study indicate that black pepper seed extract cream can be formulated into a stable cream preparation.
Pengukuran Kualitas Hidup Pasien Diabetes Melitus Tipe 2 Menggunakan Instrumen Diabetes Quality Of Life Clinical Trial Questionnaire (DQLCTQ) Siti Nurhaliza; Nera Umilia Purwanti; Muhammad Akib Yuswar
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14404

Abstract

Diabetes mellitus is a chronic disease that is not contagious. Diabetes mellitus can be characterized by high blood sugar levels accompanied by disorders of carbohydrate, lipid, and protein metabolism that can trigger the risk of complications of other diseases. This is have an impact on the quality of life of people with type 2 diabetes mellitus. This study aimed to measure the quality of life of patients with type 2 diabetes mellitus at the Siantan Public Health Center using the Diabetes Quality of Life Clinical Trial Questionnaire (DQLCTQ).) This study used an observational method with a cross-sectional and prospective design. The data were collected using the purposive sampling technique by fulfilling the inclusion and exclusion criteria. Data analysis was carried out in this study, namely the scoring of the questionnaire, and the results were interpreted descriptively. The results of measuring the quality of life in patients with type 2 diabetes mellitus at the Siantan Tengah Health Center were in the low category of 58.69% (27 respondents) and high category of 41.31% (19 respondents). Quality of life of patients based on the type of treatment carried out, the group of patients who received a single antidiabetic drug had a quality of life value above the average value necessarily wordy.
Potensi Antioksidan Masker Gel Peel-Off dari Ekstrak Buah Tomat A. Mu’thi Andy Suryadi; Juliyanty Akuba; Fika Nuzul Ramadhani; Ariani H. Hutuba
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.14299

Abstract

Tomatoes are well-known as the source of antioxidants due to the content of lycopene, i.e., a potential free radical inhibitor. Gel peel-off masks are among the chemical products containing antioxidants. The objective of this study is to formulate and examine the antioxidant activity of the gel peel-off mask made of tomato (Solanum Lycopersicum L.) extract using the DPPH method. The first step of the study was extracting tomato fruits by macerating the fruits using alcohol solvents 96%. The obtained thick extract was used as the material of the gel mask; the percentage of the extract comprised 3% (F1), 5% (F2), and 7% (F3), and it used PVA basis 11% and viscolam 3%. According to the result, the gel peel-off masks meet the requirements of physical and storage stability evaluation. The result of the antioxidant test reveals that the IC50 value of the three masks is F1 189.22 µg/mL, F2 89.34 µg/mL, and F3 36.77 µg/mL. Further, the result of T-Test reveals that P-value = 0.019 (α = 0.05), indicating a difference in the result of the antioxidant test of the three formulae in day one (t0) and day 28 (t28).
Efek Antelmintik Ekstrak Metanol Kulit Batang Nangka (Artocarpus heterophyllus) terhadap Cacing Ascaris lumbricoides Hamsidar Hasan; Nur Ain Thomas; Muhammad Taupik; Gita Potabuga
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.14217

Abstract

Jackfruit (Artocarpus heterophyllus) is a type of plant that grows in Indonesia which functions as a food ingredient and as traditional medicine. Generally, this genus contains prenylated flavonoid compounds. This study aimed to determine the anthelmintic effect of jackfruit bark extract against Ascaris lumbricoides worms by utilizing total maceration with methanol solvent as the extraction method, which yielded 6.61%. Roundworm Ascaris lumbricoides are found in pig intestines. The samples were divided into 5 groups, including positive control of 250 mg combantrin solution, negative control of NaCMC and a treatment group of jackfruit bark extract with a concentration of 1%, 3%, and 5%. Each group consisted of three worms, incubated at 37oC for 24 hours with a 6 hours interval. The results showed that at a concentration of 5%, a jackfruit bark extract was efficient as an anthelmintic caused two worms to lyse at 6 hours and  one at 12 hours.
Tingkat Pengetahuan Mahasiswi Fakultas Kedokteran Universitas Tanjungpura Tentang Manfaat Jahe Merah Terhadap Penurunan Dismenore Hapizah Saputri; Ressi Susanti; Nurmainah Nurmainah
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14169

Abstract

The use of conventional drugs in overcoming dysmenorrhea (painful menstruation) is known to cause side effects. Alternative medicine that can be done to overcome dysmenorrhea by using red ginger. The purpose of this study was to describe the level of knowledge of age in students of the Faculty of Medicine, Tanjungpura University, Department of Medicine, Pharmacy, and Nursing about the benefits of red ginger in reducing dysmenorrhea. This research is a descriptive observational study using a cross sectional research design. The technique used in sampling is purposive sampling technique. The research instrument was an online questionnaire in the form of a google form. Univariate analysis was used to describe the distribution of respondents from each variable. The results showed that respondents with a good level of knowledge aged 17-18 years were 57 (82.61%) respondents, respondents aged 19-20 years were 131 (81.88%), and respondents aged 21-22 years were found. as many as 68 (88.31%). The conclusion of this study is that the level of knowledge of female students about the benefits of using red ginger in overcoming dysmenorrhea is quite good (83.66%).
Aplikasi Diabetes Quality of Life Clinical Trial Questionnaire (DQLCTQ) Untuk Mengukur Tingkat Kualitas Hidup Pasien Diabetes Melitus Tipe 2 Arva Rizqa Maharani; Nera Umilia Purwanti; Muhammad Akib Yuswar
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14411

Abstract

Diabetes mellitus type 2 is a chronic disease that can not be completely cured, which is characterized by the increasing of glucose level in blood or hyperglycemia. Diabetes mellitus type 2 has a deficient impact on the quality of life. The aim of this study is to determine the profile of therapeutic treatment and the quality of life of patients with diabetes mellitus type 2 at Siantan Hulu Public Health Center. This research is a descriptive study with a cross sectional method using Diabetes Quality of Life Clinical Trial Questionnaire (DQLCTQ) which consists of 8 domains. The data is collected by using purposive sampling technique with 67 patients as the respondents. The result of the questionnaire is converted into numbers for scoring. The quality of life is determined to be low if the value is 59 which is obtained from the average of the quality of life total value. The quality of life of patients with diabetes mellitus type 2 at Siantan Hulu Public Health Center has 16 respondents with a low quality of life (53,33%) and 14 respondents with a high quality of life (46,67%) The quality of life of patients with diabetes mellitus type 2 at Siantan Hulu Public Health Center is still relatively low. The characteristics of patients with low quality of life are female, 45 years old, are at the elementary school level, do not work, and and have a widow/widower status.
Evaluasi Kemampuan Tabir Surya Ekstrak Biji Jagung (Zea mays L.) Secara In Vitro Menggunakan Metode Spektrofotometri UV-Vis Muhammad Taupik; Wiwin R. kunusa; Jafar La Kilo; A. Mu’thi Andy Suryadi; Zul Fikar Ahmad
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.14314

Abstract

Corn kernels (Zea mays L.) are plants serving as a natural sunscreen due to the presence of phenol and flavonoid compounds. The sunscreen compounds are able to protect skin from the effect of ultraviolet ray emitted by the sun. The purpose of this study was to determine the activity of corn kernels (Zea mays L.) as a in vitro sunscreen by the UV-Vis spectrophotometry method. The study was started by maceration of extracted seed samples using three various solvents, i.e., hexane, ethyl acetate and ethanol 70%. In the preliminary test, it was found that 70% positive ethyl acetate and ethanol extract contained phenol and flavonoid compounds, so that the step proceeded to the sunscreen activity test. The sunscreen activity test was determined based on the value of sun protecting factory value tested at wavelengths from 290 to 320 nm, the percentage of erythema transmission (% Te), and the percentage of pigmentation transmission (%Tp) values tested at wavelengths of 292.5-372.5 nm at 5 nm intervals. From these tests, the results revealed that the best activity was indicated by a concentration of 600 ppm for ethyl acetate extract and 70% ethanol with an average SPF value of 24.1724.18 ± 0.0852 (ultra protection) and 10.23 ± 0.021 (maximum protection). Te% of ethyl acetate and ethanol extract 70% were 3.92 ± 0.015 (extra protection) and .62 ± 0.026 (regular syringe), respectively. % Tp in 70% ethyl acetate and ethanol extract gets 19.61 ± 0.527 (total block) and 32.66 ± 2,594 (total block), respectively. The statistical analysis revealed that the normality and homogeneity test of significance value 0.05, meaning that the data distribution was not normal and homogeneous. By that, the step continued to the Kruskal-Wallis test. Based on the Kruskal-Wallis test, the significance value 0.05 showed that the significant differences in the ethanol and ethyl acetate samples per concentration with the SPF,% Te and% Tp values obtained was significant.
Evaluasi Kesesuaian Peresepan Obat Pada Pasien Poliklinik Penyakit Dalam Terhadap Formularium di Rumah Sakit Teti Sutriati Tuloli; Madania Madania; Nur Rasdianah; Indah Pramesty Gobel
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.14219

Abstract

National formulary is a list of medicines compiled by a national committee established by the Minister of Health based on cutting-edge, efficacious, safe, and affordable scientific evidence referred for drug use by national health insurance. This study aims to determine the evaluation of drug prescribing in the Hospital formulary. This retrospective study involved subjects qualified for the inclusion criteria i.e. 73 sheet recipes in August - December 2019. some prescribed drugs that are not listed in the hospital formulary in the following percentage: August (100%), September (60%), October (50%), November (81%), and December (65%) with the average of 71%. This indicates that the prescription does not conform to the hospital formulary regulation of 100%. In conclusion, there are some drugs prescribed by the doctor that is not conformed to the hospital formulary, which means tight supervision for the prescribing is required.

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