cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Jaya Pramana
Contact Email
jayapram@gmail.com
Phone
-
Journal Mail Official
support@majalahpatologiindonesia.com
Editorial Address
Departemen Patologi Anatomik, Fakultas Kedokteran Universitas Indonesia Jl. Salemba Raya 6, Tromol Pos 3225, Jakarta 10002
Location
Unknown,
Unknown
INDONESIA
Majalah Patologi Indonesia
Published by Perhimpunan Ahli Patologi Indonesia
ISSN : 02157284     EISSN : 25279106     DOI : https://doi.org/10.55816/
Core Subject : Health,
Health Professions Public Health
Majalah Patologi Indonesia (MPI) digunakan sebagai wahana publikasi hasil penelitian, tinjauan pustaka, laporan kasus dan ulasan berbagai aspek di bidang patologi manusia. Tujuannya ialah menghadirkan forum bagi permakluman dan pemahaman aneka proses patologik serta evaluasi berbagai penerapan cara diagnostik sejalan dengan kemajuan perkembangan ilmu dan teknologi. Selain itu juga untuk merangsang publikasi barbagai informasi baru/mutakhir.
Arjuna Subject : Kedokteran - Patologi dan Kedokteran Kesehatan
Articles 384 Documents
 28   29   30   31   32 
Hubungan Profil Klinikopatologik dengan Rekurensi Karsinoma Payudara Invasif di Departemen Patologi Anatomik FKUI/RSCM Anggreani, Ineke; Rustamadji, Primariadewi
Majalah Patologi Indonesia Vol. 31 No. 2, Mei 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i2.506

Abstract

ABSTRACTBackgroundBreast cancer is the most common malignancy and the leading cause of death in women. Invasive breast carcinoma is a breastmalignancy originating from the glandular epithelium of the breast. Approximately 40% of invasive breast carcinomas had recur.There are several factors that influence the occurrence of recurrence, such as age, tumor size, lymphovascular invasion, incisionmargins, hormonal status and therapy. This study aims to determine the clinicopathological profile associated with recurrence 5years after therapy for invasive breast carcinoma.MethodsThis study is a retrospective study with data collection carried out through the archives of the Department of Anatomical Pathology,Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital within a period of 2 years (2014-2015). Theclinicopathological data was searched for up to 5 years of therapy.ResultsFrom the 54 cases of invasive breast carcinoma in this study, all were women with mean age 48.3 years. A total of 18 cases(33.3%) experienced recurrence, especially in patients aged ≤50 years, tumor mass size more than 2 cm and luminal B moleculartype. Tumor margin is difficult to evaluate because many review cases do not submit the tumor margin section. Therapy received bypatients was in accordance with standard procedures’ hospital, both neoadjuvant and adjuvant chemotherapy. From the statisticalanalysis, there was no significant relation between all profiles that studied with recurrence. It is because the comparison of numberof recurrent and non-recurrent cases is not equal.ConclusionOne third of advanced invasive breast carcinomas treated with neoadjuvant and showing a partial response have recurrence,whereas no complete response has recurrence. Tumor size, histologic grade, molecular type and adherence to routine follow-uptreatment influenced the recurrence within 5 years of treatment.
Profil Klinikopatologik Kasus Adenokarsinoma Prostat di RSCM Tahun 2010-2019 dengan Tinjauan Khusus Biopsi Robotik Rizky Prasetya, Gusti; Saraswati, Meilania; Rizal AH. Hamid, Agus; BRE. Matondang, Sahat
Majalah Patologi Indonesia Vol 31. No. 3, September 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i3.512

Abstract

BackgroundProstate adenocarcinoma is second most common malignancy in men and fourth leading death cause from malignancy worldwide. Prostate biopsy is the gold standard for diagnosing this disease. However, the difficulty of sampling is a weakness in this procedure. In Cipto Mangunkusumo hospital, biopsy technology is now available with robotic techniques for biopsy sampling, which is expected to increase prostate biopsy accuracy. This study was to determine prostate adenocarcinoma case profile in the Department of Pathology Anatomic Cipto Mangunkusumo Hospital for 10 years and to examine differences in sampling of biopsy preparations with robotic and non-robotic techniques. MethodsThis study was an exploratory descriptive study with cross-sectional design to determine prostate adenocarcinoma case profile in the Department of Anatomic Pathology FKUI-RSCM for 10 years. The data obtained between the Gleason score of prostate biopsy preparations and surgery. Robotic prostate biopsy results were compared with prostate imaging reporting and data system (PIRADS) score. ResultsThe mean age of the patients was 67 years old and several patients were aged <50 years old. Many poor differentiation cases were found. It appears that there is a relationship between WHO/ISUP degree and perineural invasion. In 14 patients who underwent histopathological examination more than once, it was found that 9 patients had the same WHO/ISUP degree and 5 patients had a changed WHO/ISUP degree. There are several discrepancies in PIRADS score and histopathological findings from 21 robotic preparations examined. ConclusionThe mean age of patients fit to theory of generalized prostate adenocarcinoma. Many cases of poor differentiation were found, possibly related to RSCM as a national referral center. The repeated sample examination results are similar to the results of other studies. Robotic method biopsy gives the sense of more comprehensive sampling in comparison to non-robotic method.
Hubungan Ekspresi E-cadherin dengan Derajat Histopatologik dan Tumor Budding pada Karsinoma Endometrium Jenis Endometrioid Pemuda, Haris; Asri, Aswiyanti; Zuryati Nizar, Rachmadijah; Yetti, Husna
Majalah Patologi Indonesia Vol 31. No. 3, September 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i3.515

Abstract

BackgroundEndometrial carcinoma is the fourth most common malignancy among women worldwide with increasing incidence and death rate every year. One of the types of endometrial carcinoma is endometrioid carcinoma, originated from atypical hyperplasia and develop into carcinoma. Lack of intercellular cohesiveness in the epithelial tumors such as endometrioid carcinoma occur due to lack of expression of E-cadherin. It can also causetumor invasion and metastatic through the epithelial-mesenchymal transition (EMT) process. Tumor differentiation and tumor budding are presumed to be histopathologic representations due to lack of cohesiveness and the occurrence of the EMT process so that these two things need to be related with the expression of E-cadherin on tumor cells.MethodsAn observational study was conducted using a cross-sectional approach with 46 cases of endometrioid endometrial carcinoma.Samples were obtained from 4 Anatomical Pathology Laboratories in West Sumatra during 2016-2019 in the form of paraffin blocks and HE slides that obtained from hysterectomy surgery. Reevaluation of tumor grade and tumor budding in HE slides was performed. E-cadherin expression in tumor cells was seen by immunohistochemical staining. Bivariate statistical analysis was performed using Fisher's Exact test and the results were considered significant if the p value was <0.05.ResultsSpecimens with negative E-cadherin expression were more common in grade 2 tumors (41.7%) and grade 3 tumors (50.0%) and in specimes with positive tumor budding (91.7%). Statistical analysis revealed a significant correlation between E-cadherin expression with tumor grade (p=0.000) and tumor budding (p=0.000).ConclusionExpression of E-cadherin has a significant correlation with the tumor grade and tumor budding in endometrioid endometrial carcinoma.
Hubungan antara Usia dan Jenis Kelamin dengan Tipe Histopatologi Karsinoma Nasofaring Melvern, Bryan; Karlowee, Vega; Dewi Kusuma Astuti, Meira
Majalah Patologi Indonesia Vol 31. No. 3, September 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i3.516

Abstract

BackgroundNasopharyngeal carcinoma (NPC) is a malignancy with a high incidence in Indonesia. Recent studies had found several factors that influence the incidence and prognosis of NPC including age, sex, and histopathological type. This study aimed to determine the relationship between age and sex with the histopathological type of NPC.MethodsSubjects were NPC patients diagnosed by the Anatomical Pathology Department of Dr. Kariadi General Hospital Medical Center (RSUP Dr. Kariadi) from 1st January 2017-31st December 2019. Data were collected from the medical record. The relationship between age and sex with the histopathological type of NPC was examined. ResultsThere were 201 NPC patients during 2017-2019 in RSUP Dr. Kariadi. The highest number of NPC incidence was in the range of 54-59 years old. There were more males than females at the ratio of 2.24:1. Undifferentiated non-keratinizing cell carcinoma type NPC was the most common type (90.5% of NPC patients), followed by differentiated non-keratinizing cell carcinoma and squamous cell carcinoma consecutively. Both age and sex had no significant relationship with the histopathological type of NPC (p>0.05).ConclusionThere was no relationship between age and sex with the histopathological type of NPC.
Akurasi Diagnostik dan Analisis Gambaran Sitomorfologi Biopsi Aspirasi Jarum Halus pada Lesi Kelenjar Liur Berdasarkan Klasifikasi The Milan System for Reporting Salivary Gland Cytology (MSRSGC) Fossetta Manatar, Amelia; Lisnawati
Majalah Patologi Indonesia Vol 31. No. 3, September 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i3.517

Abstract

BackgroundFine needle aspiration cytology (FNAC) is an effective, simple, and safe method of assessing salivary glandular lesions. The diagnosis of FNAC can be challenging for pathologists because of the heterogeneous morphological spectrum and overlapping of cytomorphologic salivary glands. The aim is to determine the diagnostic accuracy and analyze the cytomorphology of salivary glands aspiration based on The Milan System for Reporting Salivary Gland Cytology (MSRSGC). Methods A search for cytological preparations for salivary gland lesions in 2015-2019 was carried out in the archives of the Department of Anatomic Pathology, FKUI/RSCM. There were 215 cases of cytology of salivary gland lesions which re-evaluated and classified based on MSRSGC. There were 106 cases of cytologic-histopathologic paired data, 25 of which were excluded because the specimens were not filled the criteria for re-examination. ResultsThere were 81 cases of salivary gland lesions since 2015-2019 which were assessed and reclassified based on MSRSGC, consisting of 8 non-diagnostic, 1 non-neoplastic, 1 case of atypical of undetermined significance (AUS), 39 benign tumors, 10 salivary gland neoplasm of undetermined malignant potential (SUMP), 6 suspicious for malignancy (SFM) and 16 malignant tumors. Three of these cases had a different diagnosis result in false-negative on non-diagnostic and benign tumors. The sensitivity value was 91.17%, specificity 97.43%, positive predictive value (PPV) 96.87%, negative predictive value (NPV) 92.68% and 94.52% accuracy. ConclusionThe diagnosis of fine needle aspiration cytology can be accurately achieved by a combination of clinical information and radiological examination, however a histopathologic examination is still required for definitive diganosis. MSRSGC classification is very helpful in the diagnosis of salivary gland cytology.
Gambaran Klinikopatologi pada Respon Kemoterapi Neoadjuvan Triple Negative Breast Cancer di Rumah Sakit Umum Pusat Dr. Hasan Sadikin Savitri, Widya; Surjawathy Hernowo, Bethy; Suryanti, Sri
Majalah Patologi Indonesia Vol 31. No. 3, September 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i3.518

Abstract

BackgroundTriple Negative Breast Cancer (TNBC) accounts for 9-17% of all breast cancer diagnoses. TNBC has a high proliferation index and a poor prognosis with a higher response rate to neoadjuvant chemotherapy, but does not correlate with Overall Survival (OS) due to chemoresistence in more than 50% of TNBC. Neoadjuvant chemotherapy with anthracycline (doxorubicin) based regimens in combination with fluorouracil and cyclophosphamide (FAC) is still an option for TNBC. The aim of this study was to determine association between clinicopathological profile and response to neoajuvan chemotherapy in TNBC at Dr. Hasan Sadikin Bandung which is a referral hospital in West Java.MethodsThis study used an analytic observational method with a cross-sectional design. The research sample consisted of 40 TNBC cases from January 2017 to December 2019 at Dr. Hasan Sadikin hospital. Data obtained from medical records and archives of the Anatomical Pathology Laboratory consist of clinical response to neoadjuvant chemotherapy, age, tumor size, lymph node metastases and distant metastases, clinical stage, type of histopathology and lymphovascular vessel invasion.ResultsIn 40 cases of TNBC, 20 cases responded and 20 cases did not respond to neoadjuvant chemotherapy. In the non-response group, there were 90% of cases with histopathologic type invasive carcinoma of no special type and 75% showed invasion of lymphovascular vessels. There were no significant differences in age, tumor size, lymphovascular vessel invasion, stage, or histopathological type in the response and non-response groups.ConclusionThere is no correlation between clinicopathological features and neoadjuvant chemotherapy response in the case of Triple Negative Breast Cancer (TNBC). This can be caused by other factors including high heterogeneous tumor microenvironment (TME).
Peran Vascular Endothelial Growth Factor (VEGF) dalam Patogenesis Spektrum Plasenta Akreta 1 Linggodigdo, Michelle; Hellyanti, Tantri; Kusmardi
Majalah Patologi Indonesia Vol 31. No. 3, September 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i3.519

Abstract

Placenta accreta spectrum (PAS) is a cause of serious maternal morbidity and mortality. FIGO 2020 designated PAS into grade 1 (non-invasive), grade 2 (superficial invasion), grade 3A (deep invasion), grade 3D (deep invasion with disruption of the serosa), and grade 3E (deep invasion with adherence to extrauterine structures). Currently, the trophoblast cell in accreta spectrum is associated with similar characteristics to cancer. Both conditions can induce angiogenesis, marked by upregulation of vascular endothelial growth factor (VEGF). This resulted in the formation of extensive neovascularization. The secretion of VEGF is induced by hypoxia, which was related to risk factor of PAS occurrence; defect of the decidua due to endometrial tissue damage.
Profil Demografik dan Temuan Histomorfologik Karsinoma Payudara di Departemen Patologi Anatomik FKUI/RSCM Periode 2016-2019 Tinjauan Khusus pada Temuan Mitosis Atipik Juwitasari Wongkar, Fresia; Hellyanti, Tantri; Hayati, Amal
Majalah Patologi Indonesia Vol 31. No. 3, September 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i3.520

Abstract

BackgroundInvasive breast carcinoma (IBC) is the most commonly diagnosed cancer in woman in the world and Indonesia. IBC is classified into two main categories: IBC of no special type (NST) and special types. This retrospective study aims to provide histomorphological profile of mastectomy cases of IBC in Anatomical Pathology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital (PA FKUI/RSCM) 2016-2019.MethodsThis is a descriptive research with cross-sectional design of mastectomy cases, using secondary data from the archives of PA FKUI/RSCM, starting from 2016- 2019. Collecting clinical data as well as observing several histopathologic parameters including histological type, grade, atypical mitotic features, lymphovascular invasion, and lymph node metastases. Tumour classification was made based on the WHO breast criteria in 2019.ResultsDuring the 2016-2019 period there were 144 cases of IBC. 99.3% of cases occurred in female patients, mostly in the age group from 40 to 59 years and unilateral. The majority had tumour sizes ranging >2-5 cm and were stage II. About a third of cases had received neoadjuvant chemotherapy, most commonly in advanced local stage tumors. Most histologic type (65.3%) were IBC of NST and 52.8% of cases were grade 2. There were 92 (63.4%) cases with atypical mitotic features, most commonly found in stage III. Lymphovascular invasion was found in 38.9% of cases and lymph node metastasis was found in 63.2% of cases.ConclusionIBC is the most common cancer in woman, with the most common histologic type were IBC, grade 2, stage II or more. Most of the cases show atypical mitosis, which is most commonly found in stage III. The findings of lymphovascular invasion did not always coincide with the findings of lymph node metastases.
Relationship between Clinicohistomorphology Profile of Atypical Prostate Gland and Diagnosis Benign Lesion or Prostate Adenocarcinoma Litta Septina MZ; Yayi Dwina B
Majalah Patologi Indonesia Vol. 32 No. 1, Januari 2023
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v32i1.561

Abstract

BackgroundAtypical prostate gland especially atypical small acinar proliferation (ASAP) is a histopathological diagnosis that requires a follow-up biopsy 3-6 months after the first biopsy, because 17-60% of cases potentially to be malignant. The varied clinical and histomorphological characteristics of the atypical prostate gland make it difficult to confirm the final diagnosis as a benign lesion or prostate adenocarcinoma. This study aims to describe clinicohistomorphological cases of atypical prostate gland at Anatomical Pathology Department FKUI/RSCM and to identify histomorphological features of the atypical prostate gland as benign lesions or prostate adenocarcinoma on immunohistochemistry diagnosis.MethodsA histopathological investigation of prostate gland cases with atypical nuclei was carried out in 2011-2021 from archives of Anatomical Pathology Department FKUI/RSCM. Clinical and histomorphological characteristics were assessed and categorized into benign lesions or prostate adenocarcinoma based on immunohistochemistry appearance.ResultsThere were 109 cases of atypical prostate gland, 49 of which met the inclusion and exclusion criteria and could be analyzed. Corpora amylacea was found in 11 cases (84.6%) in the benign lesion group, statistically significant (p-value 0.005). Intraluminal crystalloids were found in 4 cases (100%) in the prostate adenocarcinoma group with p-value 0.050, close to significant. Other clinicohistomorphological characteristics did not show a significant relationship both in benign lesions and prostate adenocarcinoma groups (p-value 0.05).Conclusion On histopathological examination of the atypical prostate gland that is difficult to re-biopsy, the discovery of corpora amylacea may lead to the diagnosis of a benign lesion, while the discovery of intraluminal crystalloids may lead to the diagnosis of prostate adenocarcinoma. The diagnosis must be supported by immunohistochemistry characteristics.
Gambaran Klinis dan Histopatologis Limfoma Non Hodgkin Sistem Pencernaan di RSUP Dr. Hasan Sadikin Bandung Tahun 2018-2020 Maharani Tasyandita, Raina; Suryawathy Hernowo, Bethy; Yulianti, Herry
Majalah Patologi Indonesia Vol. 32 No. 1, Januari 2023
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v32i1.562

Abstract

BackgroundNon-Hodgkin's lymphoma (NHL) is an abnormal growth of lymphocytes that manifests as tumor or enlargement of lymph nodes (lymphadenopathy). New NHL cases in Indonesia in 2020 reached 16.125 cases (4.1%) with 9.024 deaths (3.6%). The WHO classification categorizes NHL into two, B cells and T/NK cells.2 NHL is also divided into low-grade and high-grade based on its progression. The gastrointestinal tract is the most frequently involved extranodal site in NHL. The clinical manifestations of NHL can be non-specific and vary depending on anatomic location. This study aims to determine the clinical and histopathological features in patients with gastrointestinal NHL.MethodsThis research is a descriptive study using medical record data of inpatients at RSUP Dr. Hasan Sadikin Bandung period 2018-2020 diagnosed with gastrointestinal NHL.ResultsPatient characteristics were dominated by patients aged 40 years and male (65.2%), with the most clinical manifestations being enlarged lymph nodes. NHL most often attacks the liver (26.1%) and most patients present at stage IV (34.8%). The most histopathological features were B cells (52.5%) and high-grade (43.5%).ConclusionThe risk of gastrointestinal LNH increases with age and the majority is in men. Clinical manifestations vary and can show local or constitutional symptoms. Most patients are found to be in the late stages and among all gastrointestinal system, most NHL attacks the liver. Many patients were not subjected to further immunohistochemical examination, but the most common histopathological features were B cells and high grade NHL.

Page 30 of 39 | Total Record : 384

 28   29   30   31   32 

Filter by Year

2010 2025


Reset
Filter By Issues
All Issue Vol. 34 No. 3, September 2025 Vol. 34 No. 2, Mei 2025 Vol. 34 No. 1, Januari 2025 Vol. 33 No. 3, September 2024 Vol. 33 No. 2, Mei 2024 Vol. 33 No. 1, Januari 2024 Vol. 32 No. 3, September 2023 Vol. 32 No. 2, Mei 2023 Vol. 32 No. 1, Januari 2023 Vol 31. No. 3, September 2022 Vol. 31 No. 2, Mei 2022 Vol 31 No 2 (2022): MPI Vol 31 No 1 (2022): MPI Vol. 31 No. 1, Januari 2022 Vol 30 No 3 (2021): MPI Vol. 30 No. 3, September 2021 Vol 30 No 2 (2021): MPI Vol. 30 No. 1 (2021): MPI Vol 30 No 1 (2021): MPI Vol 29 No 3 (2020): MPI Vol 29 No 2 (2020): MPI Vol. 29 No. 1 (2020): MPI Vol 29 No 1 (2020): MPI Vol 28 No 3 (2019): MPI Vol 28 No 2 (2019): MPI Vol 28 No 1 (2019): MPI Vol 27 No 3 (2018): MPI Vol 27 No 2 (2018): MPI Vol 27 No 1 (2018): MPI Vol 26 No 3 (2017): MPI Vol 26 No 2 (2017): MPI Vol 24 No 3 (2015): MPI Vol 24 No 2 (2015): MPI Vol 26 No 1 (2017): MPI Vol 25 No 2 (2016): MPI Vol 25 No 3 (2016): MPI Vol 25 No 1 (2016): MPI Vol 23 No 2 (2014): MPI Vol 24 No 1 (2015): MPI Vol 23 No 3 (2014): MPI Vol 23 No 1 (2014): MPI Vol 21 No 3 (2012): MPI Vol 21 No 2 (2012): MPI Vol 21 No 1 (2012): MPI Vol 20 No 3 (2011): MPI Vol 20 No 2 (2011): MPI Vol 20 No 1 (2011): MPI Vol 22 No 3 (2013): MPI Vol 22 No 2 (2013): MPI Vol 22 No 1 (2013): MPI Vol 19 No 2 (2010): MPI Vol 19 No 1 (2010): MPI More Issue