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Majalah Patologi Indonesia

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Published by Perhimpunan Ahli Patologi Indonesia

ISSN : 02157284 EISSN : 25279106 DOI : https://doi.org/10.55816/

Core Subject : Health,

Health Professions Public Health

Majalah Patologi Indonesia (MPI) digunakan sebagai wahana publikasi hasil penelitian, tinjauan pustaka, laporan kasus dan ulasan berbagai aspek di bidang patologi manusia. Tujuannya ialah menghadirkan forum bagi permakluman dan pemahaman aneka proses patologik serta evaluasi berbagai penerapan cara diagnostik sejalan dengan kemajuan perkembangan ilmu dan teknologi. Selain itu juga untuk merangsang publikasi barbagai informasi baru/mutakhir.

Arjuna Subject : Kedokteran - Patologi dan Kedokteran Kesehatan

Articles 384 Documents

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Profil Klinikopatologik Karsinoma Payudara Invasif Metastasis Jauh di Departemen Patologi Anatomik FKUI/RSCM Tahun 2019 Laurencia Leny Kurnianingrum; Hartono Tjahjadi
Majalah Patologi Indonesia Vol 31 No 1 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundInvasive breast carcinoma (IBC) is the highest incidence and is the leading cause of malignancy-related death in women in theworld. Bones are the most common sites of IBC metastases. This study aims to provide clinical and histological characteristic datain cases of distant metastastic IBC in the Anatomical Pathology Department, Faculty of Medicine, Universitas Indonesia, Dr. CiptoMangunkusumo General Hospital (PA-FKUI/RSCM).MethodsThis is descriptive research with cross-sectional design, using secondary data from the archives of PA-FKUI/RSCM, starting fromJanuary 1, 2019 to December 31, 2019.ResultsDistant metastases of IBC was found 65.2% as bone metastases, 46.1% as pulmonary metastases, 26.1% as liver metastases, and8.7% as brain metastases. The largest age group was 40-59 years, median age was 49 years with range 27-78 years. The mostcommon of the classification of primary tumor size was 54.8% T4, and 87% unilateral cases. Most histologic subtypes were 90.4%cases no special type, then lobular and mucinous subtypes. Lymphovascular invasion was 24.3% cases. The most commonmolecular subtype was luminal B Luminal and mostly as bone metastases and triple negative breast cancer (TNBC) in lungmetastases. The greatest histological grade was grade 2.ConclusionBone was the most common IBC metastatic. The most common of the classification of primary tumor size was T4 and histologicsubtype was no special. Luminal B was the most common molecular subtypes and the highest was bone metastases.

Hubungan Ekspresi Vascular Endothelial Growth Factor (VEGF) dengan Derajat Diferensiasi dan Invasi Limfovaskular pada Adenokarsinoma Kolorektal Nana Liana; Noza Hilbertina; Loli Devianti; Husna Yetti
Majalah Patologi Indonesia Vol 31 No 1 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundColorectal carcinoma is the third most common malignancy in the world. Colorectal carcinoma is a heterogeneous tumor withdifferent clinical pathologic features and prognostic values. For the same tumor-stage, patients could have difference prognosis andit has been suggested that the angiogenesis might be correlated with the prognosis, especially expression of vascular endothelialgrowth factor (VEGF) as the main pro-angiogenic factor. High VEGF expression in colorectal adenocarcinoma is associated withincreased blood vessels in invasive tumor area, cell proliferation and metastases. However, relation VEGF expression with thedegree of differentiation and lymphovascular invasion is not known.MethodsThis was a retrospective observational study with cross sectional approach. Samples were obtained from 39 paraffin blocks withdiagnosis adenocarcinoma not otherwise specific (NOS) in four Anatomical Pathology Laboratory in West Sumatera 2018 andevaluated for degree of differentiation and lymphovascular invasion. VEGF expressions in tumor cell were analyzed usingimmunohistochemistry staining. Bivariate statistical analysis used Fisher's Exact test and value p<0.05 was considered significant.ResultsColorectal adenocarcinoma with high grade differentiation entirely had high VEGF expression (100%), while low gradedifferantiation with high VEGF expression was 60.7%. Lymphovascular invasion positive was mostly found with high VEGFexpression (80.6%). Statistical analysis showed significant association between VEGF expression with degree of differentiation(p=0.017) and lymphovascular invasion (p=0.028).ConclusionThe conclusion was VEGF expression had significant association with degree of differentiation and lymphovascular invasion ofcolorectal adenocarcinoma.

Akurasi Diagnosis Pemeriksaan Biopsi Aspirasi Jarum Halus Tumor Tulang di Departemen Patologi Anatomik FKUI/RSCM Tahun 2015- 2019 Vabiayu Putri; Marini Stephanie
Majalah Patologi Indonesia Vol 31 No 1 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundFine needle aspiration biopsy (FNAB) is a safe and rapid technique and has an important role in making the preoperative diagnosisof bone tumors because it can help clinicians determine treatment for patients. This retrospective study aims to assess the accuracyof the FNAB cytological examination compared with the histopathological examination in preoperative diagnosis of bone tumors.MethodsThe data comes from the archives of the Department of Anatomic Pathology, FKUI/RSCM 2015-2019 in the form of a cytologicalexamination of FNAB lesions on bone. Then the histopathological examination data were searched for each cytology preparation.There were 133 pairs of cytology, and histopathology preparations. The preparations were reviewed by the investigator andsupervisor, assessed for the suitability of the cytologic diagnosis, and compared with the histopathological diagnosis.ResultsThere were 84 (63.2%) cases of malignant tumors, 44 (33.1%) cases of benign tumors, and 5 (3.7%) cases of non-tumors. Thediagnostic test results showed an accuracy rate of 86.5% with a sensitivity of 85.9%, a specificity of 100%, a positive predictivevalue (PPV) of 100%, and a negative predictive value (NPV) of 21.7%.ConclusionFNAB cytology examination of bone tumors that have adequate sample quality, supported by complete clinical information andinformative radiological images can produce an accurate preoperative diagnosis

Mastitis Granulomatosa: Sebuah Tantangan Diagnosis Citra Dewi; Ella Amalia; Nyiayu Fauziah Kurniawati; Maria Ulfa, Maria Ulfa,; Eka Putra Pratama; Krisna Murti
Majalah Patologi Indonesia Vol 31 No 1 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundGranulomatous mastitis (GM) is often found in reproductive-age women. These patients are treated by the administration ofantituberculosis drugs. It is difficult to determine the exact cause of GM cytologically and histopathologically. Various etiologies i.e.,tuberculosis, sarcoidosis, foreign bodies and immunological diseases may provide granulomatous inflammation features in thetissue. High-sensitivity tests such as PCR can help to detect the presence of Mycobacterium tuberculosis (MT) as one of possibleetiologic agent. Accurate diagnosis will improve the treatment quality thus a better quality of life. The aim of this study was todetermine whether the granulomatous mastitis patients who referred to the Department of Anatomic Pathology Faculty of MedicineUniversitas Sriwijaya/Dr. Moh. Hoesin Palembang Hospital were caused by MT.MethodsA descriptive observational study was performed. Thirty paraffin blocks of GM patients during the period of 1st October 2018 to 29thSeptember 2020 were collected. DNAs were extracted from tissue scrapings of the slides. Then, PCR analysis was conducted usinga specific primer IS6110 with around 200 bp PCR product.ResultsThe mean age of the patients was 40.8 years (range: 23-67 years). There were six samples (20%) of GM produced the expectedamplicon. However, only three of six samples morphologically consistent with tuberculosis.ConclusionGranulomatous inflammatory reactions in the breast are not only caused by tuberculosis. Further study is needed to determine theexact cause of this lesion. Despite high costs, PCR examination may become an alternative approach in determining the etiology ofGM.

Hubungan Subtipe Molekular pada Karsinoma Payudara Invasif dengan Grade, Invasi Limfovaskular dan Metastasis KGB di Departemen Patologi Anatomik FKUI/RSCM Tahun 2019 Kristina Anna Bethania; Primariadewi Rustamadji
Majalah Patologi Indonesia Vol 31 No 1 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundBreast cancer is classified into molecular subtypes: luminal A, luminal B, HER2 enriched and triple negative breast cancer based onits immunohistochemical profile. This study aims to assess the relationship between histologic grade, lymphovascular invasion andlymph node metastasis with molecular subtypes in invasive breast carcinoma at Cipto Mangunkusumo Hospital from January 1,2019 to December 31, 2019.MethodsA descriptive, cross-sectional study was conducted in Anatomical Pathology Department, FKUI/RSCM over a period of January toDecember 2019. A total of 652 histologic specimens with a diagnosis of invasive breast carcinoma which were immunostained withER, PR, HER2, and Ki67 were reviewed, then grouped into the appropriate molecular subtypes. A Chi-square test was performed toassess the association between histologic grade, lymphovascular invasion and regional lymph node metastases with molecularsubtypes.The p-value <0.05 was statistically significant.ResultsThe molecular subtypes of breast cancer, from the highest to the least number, were luminal A (40.2%), luminal B (37.7%), TNBC(13.6%), and HER2 enriched (8.6%). There was a significant association between grade and molecular subtypes of breast cancer.(p=<0.001). There was a significant association between lymph node metastasis and molecular subtypes of breast cancer(p=0.038).ConclusionThe most common molecular subtype of invasive breast cancer found was Luminal A. There was a significant association betweenlymph node grade and metastasis and the molecular subtype of breast cancer.

Papiloma Sinonasal dan Keganasan Terkait Papiloma Sinonasal: Studi dari Pusat Rujukan Tersier di Indonesia David Sitinjak; Lisnawati Rachmadi; Yayi Dwina Billianti
Majalah Patologi Indonesia Vol 31 No 2 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Background Sinonasal papilloma is a benign tumor arising from Schneiderian epithelia in sinonasal mucosa. It has the propensity towards malignant transformation. This preliminary study aims to report clinicopathological aspects of sinonasal papilloma and its malignant transformation rate. Methods A descriptive, cross-sectional study was conducted in Anatomical Pathology Department, FKUI/RSCM over a period of 2014-2019) A total of 127 histologic specimens with diagnosis of sinonasal papilloma obtained from 80 cases. Results The prevalence of sinonasal papilloma among all sinonasal neoplasms is 17.6%. Inverted papilloma was the most common histologic type 91.3%, exophytic papilloma 6.3% and oncocytic papilloma 2.5%, among male (70%), age rate 50 years old. Malignant transformation of squamous cell carcinoma 12.5%, and recurrence 21.3%, nasal congestion was the most complaint 50%. Cases were usually in T3 of Krouse stage 37.5% and managed with functional sinus endoscopic surgery 51.3%. Histological parameters were grade II 54.4%, surface keratinization 17.5%, bony trabeculae 41.3%, nasal polyps 20% and dense lymphocytic infiltrates 53.8%, foam cell infiltrates 2.5%. Mild to moderate dysplasia 8.8% and severe dysplasia 18.8%. Conclusion Sinonasal papilloma was rare sinonasal benign tumor. Inverted papilloma type was local aggressive, recurrence, dysplastic and malignant transformation, among male, age 50 years old, main complaint of nasal congestion, in Krouse stage T3, and managed by Functional Sinus Endoscopy Surgery (FSES

Hubungan Ekspresi Vascular Endothelial Growth Factor (VEGF) dengan Derajat Diferensiasi dan Invasi Limfovaskular pada Karsinoma Urotelial Infiltratif Kandung Kemih Dini Andri Utami; Salmiah Agus; Yenita; Husna Yetti
Majalah Patologi Indonesia Vol 31 No 2 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Background Urothelial carcinoma is the most common malignancy in the bladder with an incidence up to 95% and 70-85% of them are bladder infiltrating urothelial carcinoma. To improve the management of bladder urothelial carcinoma, prognostic factors are required. One such factor is angiogenesis, which affects growth, development and metastasis. Vascular endothelial growth factor (VEGF) is the main pro-angiogenic factor to control angiogenesis. Expression of VEGF is correlated with progression of bladder infiltrating urothelial carcinoma, such as grade and lymphovascular invasion. The aim of this study was to determine the correlation of VEGF expression with grade of differentiation and lymphovascular invasion in bladder infiltrating urothelial carcinoma. Methods This research was a retrospective observational cross sectional study with 48 cases of bladder infiltrating urothelial carcinoma in four Anatomical Pathology Laboratory in West Sumatera 2018 and 2019. Samples were reevaluated of HE slide for grade of differentiation and lymphovascular invasion. VEGF expressions in tumor cell s were analyzed using immunohistochemistry staining. Bivariate statistical analysis used Fisher's Exact test and value p<0.05 was considered significant. Results Bladder infiltrating urothelial carcinoma high grade had more positive VEGF expression (91.7%), while low grade had more negative VEGF expression (58.3%). Lymphovascular invasion positive was mostly found with positive VEGF expression (75%). Statistical analysis showed significant correlation between VEGF expression with grade of differentiation (p=0.001) and lymphovascular invasion (p=0.004). Conclusion The conclusion was VEGF expression had significant correlation with grade of differentiation and lymphovascular invasion of bladder infiltrating urothelial carcinoma.

Karakteristik Klinikopatologik Karsinoma Sel Skuamosa Serviks dan Hubungannya dengan Tumor-Associated Neutrophil Nanda Safira Alisa; Joko M; Citra Dewi; Susilawati; Ika Kartika Edi Pudjo
Majalah Patologi Indonesia Vol 31 No 2 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundCervical carcinoma is one of the most common cancers in women, according to data from World Health Organization (WHO).Cervical carcinoma ranks the fourth most deadly type of cancer. Squamous cell carcinoma is the most common type of this cervicalcancer and it is generally caused by Human Papilloma Virus (HPV) types 16 and 18. Tumor-Associated Neutrophil (TAN) are foundin various types of cancer, the density of TAN can determine the prognostic type of tumor or cancer in each individual. This studywas aimed to identify correlation between clinicopathological characteristics of cervical squamous cell carcinoma (SCC) and TAN incervical SCC patients registered at RSUP Dr. Mohammad Hoesin Palembang.MethodsThis type of research is analytic with a cross-sectional method. Data collection in this study used a 37 slides archive which werediagnosed as cervical squamous cell carcinoma in Anatomic Pathology in RSUP Dr. Mohammad Hoesin Palembang for the periodof 2017-2019.ResultsFrom 37 cervical SCC patients, the clinicopathological characteristics of the majority of cervical SCC patients occurred in the agegroup of 51 year-old (51.4%), with histopathological type of non-keratinizing SCC (75,7%) and the most frequent differentiationdegree was moderately differentiated (75,7%). The TAN density was mostly found at low TAN densities (73%). There wassignificant correlation between age and TAN density (p=0.035) and there was no significant correlation between age and TANdensity (p=0.269).ConclusionIt was explained that the higher the degree of differentiation, the lower the density value, however the neutrophils in this studycannot be ascertained whether the neutrophils of anti-tumor (N1) or pro-tumor (N2) characteristic

Faktor-faktor Histopatologik yang Memengaruhi Metastasis ke Kelenjar Getah Bening pada Karsinoma Sel Skuamosa Laring di Departemen Patologi Anatomik FKUI/RSCM Tahun 2015-2019 Ela Laelasari; Lisnawati
Majalah Patologi Indonesia Vol 31 No 2 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundLaryngeal squamous cell carcinoma (LSCC) is the second most common epithelial carcinoma of the head and neck. This carcinomahas a poor prognosis if there have been metastases in the neck lymph nodes and did not get proper therapheutical management.The aims of the study is to determine the histopathologic characteristics of LSCC with partial or total laryngectomy and neckdissection, as well as its relationship with the incidence of metastases to lymph nodes.MethodsAnalytical descriptive study with cross-sectional design of secondary data on LSCC cases obtained through total or partiallaryngectomy accompanied by neck dissection from the archives of the Department of Anatomic Pathology FKUI / RSCM fromJanuary 2015 to December 2019. The histopathological data obtained were analyzed by comparative statistical test.ResultsKSSL was more frequently found in men as much as 155 cases (94.5%) with the most common age was over 60 years old. In thisstudy, LSCC with lymph nodes metastases was found in 65 cases, the most common was tumor size >4 cm in 40 cases (61.5%),medium differentiated tumors in 47 cases (72.3%), pT3-pT4 in 57 cases. (87.7%). There was a significant association betweenmetastasis to cervical lymph nodes with tumor size, poorly differentiated tumors, lymphovascular invasion and pT3-pT4.ConclusionHistopathologic factors including tumor size, pT3-pT4, poor differentiation, lymphovascular invasion are factors that play a role in theoccurrence of metastases to cervical lymph nodes in LSCC

Kasus Toksoplasmosis Serebri Tak Terduga dengan Gambaran Radiologi yang Menyerupai Keganasan Cempaka Harsa Sekarputri; Anisia Indiralia; Roebijanti
Majalah Patologi Indonesia Vol 31 No 2 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

ABSTRACTToxoplasmosis was Toxoplasma Gondii infection. In HIV-infected patients, the prevalence of toxoplasma infectionranges was 3-97%. Diagnosis cerebral toxoplasmosis almost failed to recognized varians clinical and radiologicalfeatures on organism identifiied from brain biopsy which difficult to extract from alive patient. This case reportdiscussed cerebral toxoplasmosis of brain biopsy HIV positive patient which unknown status HIV patient, previously.A 52-year-old male patient came complained not only loss of apatit and dizzy two months ago, but also fainted.MSCT Scan with and without contrast showed right temporooccipital glioblastoma. Brain MRI showed a lesion on theright temporoparietal area with perifocal edema pressing on the right lateral ventricle. Microscopical feature showedglial tissue containing large areas of necrosis with karyorrhexis debris, PMN and mononuclear leucocyte infiltration,scaterred of tachyzoites and bradyzoites, no signs of malignancy. HIV serological examination was confirmed and thepatient's results were found to be anti-HIV reactive. Conclusion diagnosis as cerebral toxoplasmosis.

Page 28 of 39 | Total Record : 384

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