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Majalah Patologi Indonesia
Published by Perhimpunan Ahli Patologi Indonesia
ISSN : 02157284     EISSN : 25279106     DOI : https://doi.org/10.55816/
Core Subject : Health,
Health Professions Public Health
Majalah Patologi Indonesia (MPI) digunakan sebagai wahana publikasi hasil penelitian, tinjauan pustaka, laporan kasus dan ulasan berbagai aspek di bidang patologi manusia. Tujuannya ialah menghadirkan forum bagi permakluman dan pemahaman aneka proses patologik serta evaluasi berbagai penerapan cara diagnostik sejalan dengan kemajuan perkembangan ilmu dan teknologi. Selain itu juga untuk merangsang publikasi barbagai informasi baru/mutakhir.
Arjuna Subject : Kedokteran - Patologi dan Kedokteran Kesehatan
Articles 392 Documents
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Karakteristik Klinikopatologik serta Hubungan Derajat Keganasan dengan Subtipe Molekular Luminal B pada Pasien Karsinoma Payudara di RSUP Mohammad Hoesin Palembang Tahun 2014-2016 Awaliah, Reihan Putri; Dewi, Citra; Puspita Rasyid, Riana Sari
Majalah Patologi Indonesia Vol. 31 No. 1, Januari 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i1.488

Abstract

BackgroundBreast carcinoma is the second highest malignant disease that causes death in Indonesia with 58,256 new cases in 2018. LuminalB has more aggressive clinical behavior and is considered as having unfavorable prognosis. This study aimed to determine theclinicopathological characteristics and the relationship histological grade with breast carcinoma subtype molecular luminal B.MethodsThis is a descriptive analytic study with cross sectional design using secondary data of breast carcinoma patients registered atRSUP Mohammad Hoesin Palembang during the period of January 1st, 2014 to December 31st, 2016.ResultsFrom 903 breast carcinoma patients in Mohammad Hoesin Hospital Palembang during 2014 to 2016, 43.63% had luminal Bmolecular subtype. The highest incidence and prevalence washappened in year 2016, whichwere 4.7 and 4.4 per 10 breastcarcinoma patients, respectively. The majority of breast carcinoma of luminal B molecular subtype occurs in the group of patientsaged ≥40 years (81.7%), female (98.7%), Malay race (100%), marital status (98.8%), housewives (68.3%), histopathologicalcarcinoma of invasive non-specific type (75.9%), high grade/ grade III (63.7%), localized (60.6%), no metastases (60.0%), rightsided tumor laterality (50.8%) and with negative HER2 (65.2%). There was a significant relationship between the histopathologicalgrade and breast carcinoma luminal B molecular subtype (p=0.009).ConclusionThe incident of breast carcinoma molecular subtype luminal B at Mohammad Hoesin Hospital Palembang has increased in the lastthree years with the poor clinicopathological characteristics.
Profil Klinikopatologik Karsinoma Payudara Invasif Metastasis Jauh di Departemen Patologi Anatomik FKUI/RSCM Tahun 2019 Kurnianingrum, Laurencia Leny; Tjahjadi, Hartono
Majalah Patologi Indonesia Vol. 31 No. 1, Januari 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i1.489

Abstract

BackgroundInvasive breast carcinoma (IBC) is the highest incidence and is the leading cause of malignancy-related death in women in theworld. Bones are the most common sites of IBC metastases. This study aims to provide clinical and histological characteristic datain cases of distant metastastic IBC in the Anatomical Pathology Department, Faculty of Medicine, Universitas Indonesia, Dr. CiptoMangunkusumo General Hospital (PA-FKUI/RSCM).MethodsThis is descriptive research with cross-sectional design, using secondary data from the archives of PA-FKUI/RSCM, starting fromJanuary 1, 2019 to December 31, 2019.ResultsDistant metastases of IBC was found 65.2% as bone metastases, 46.1% as pulmonary metastases, 26.1% as liver metastases, and8.7% as brain metastases. The largest age group was 40-59 years, median age was 49 years with range 27-78 years. The mostcommon of the classification of primary tumor size was 54.8% T4, and 87% unilateral cases. Most histologic subtypes were 90.4%cases no special type, then lobular and mucinous subtypes. Lymphovascular invasion was 24.3% cases. The most commonmolecular subtype was luminal B Luminal and mostly as bone metastases and triple negative breast cancer (TNBC) in lungmetastases. The greatest histological grade was grade 2.ConclusionBone was the most common IBC metastatic. The most common of the classification of primary tumor size was T4 and histologicsubtype was no special. Luminal B was the most common molecular subtypes and the highest was bone metastases.
Hubungan Ekspresi Vascular Endothelial Growth Factor (VEGF) dengan Derajat Diferensiasi dan Invasi Limfovaskular pada Adenokarsinoma Kolorektal Liana, Nana; Hilbertina, Noza; Devianti, Loli; Yetti, Husna
Majalah Patologi Indonesia Vol. 31 No. 1, Januari 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i1.490

Abstract

BackgroundColorectal carcinoma is the third most common malignancy in the world. Colorectal carcinoma is a heterogeneous tumor withdifferent clinical pathologic features and prognostic values. For the same tumor-stage, patients could have difference prognosis andit has been suggested that the angiogenesis might be correlated with the prognosis, especially expression of vascular endothelialgrowth factor (VEGF) as the main pro-angiogenic factor. High VEGF expression in colorectal adenocarcinoma is associated withincreased blood vessels in invasive tumor area, cell proliferation and metastases. However, relation VEGF expression with thedegree of differentiation and lymphovascular invasion is not known.MethodsThis was a retrospective observational study with cross sectional approach. Samples were obtained from 39 paraffin blocks withdiagnosis adenocarcinoma not otherwise specific (NOS) in four Anatomical Pathology Laboratory in West Sumatera 2018 andevaluated for degree of differentiation and lymphovascular invasion. VEGF expressions in tumor cell were analyzed usingimmunohistochemistry staining. Bivariate statistical analysis used Fisher's Exact test and value p<0.05 was considered significant.ResultsColorectal adenocarcinoma with high grade differentiation entirely had high VEGF expression (100%), while low gradedifferantiation with high VEGF expression was 60.7%. Lymphovascular invasion positive was mostly found with high VEGFexpression (80.6%). Statistical analysis showed significant association between VEGF expression with degree of differentiation(p=0.017) and lymphovascular invasion (p=0.028).ConclusionThe conclusion was VEGF expression had significant association with degree of differentiation and lymphovascular invasion ofcolorectal adenocarcinoma.
Akurasi Diagnosis Pemeriksaan Biopsi Aspirasi Jarum Halus Tumor Tulang di Departemen Patologi Anatomik FKUI/RSCM Tahun 2015- 2019 Putri, Vabiayu; Stephanie, Marini
Majalah Patologi Indonesia Vol. 31 No. 1, Januari 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i1.491

Abstract

BackgroundFine needle aspiration biopsy (FNAB) is a safe and rapid technique and has an important role in making the preoperative diagnosisof bone tumors because it can help clinicians determine treatment for patients. This retrospective study aims to assess the accuracyof the FNAB cytological examination compared with the histopathological examination in preoperative diagnosis of bone tumors.MethodsThe data comes from the archives of the Department of Anatomic Pathology, FKUI/RSCM 2015-2019 in the form of a cytologicalexamination of FNAB lesions on bone. Then the histopathological examination data were searched for each cytology preparation.There were 133 pairs of cytology, and histopathology preparations. The preparations were reviewed by the investigator andsupervisor, assessed for the suitability of the cytologic diagnosis, and compared with the histopathological diagnosis.ResultsThere were 84 (63.2%) cases of malignant tumors, 44 (33.1%) cases of benign tumors, and 5 (3.7%) cases of non-tumors. Thediagnostic test results showed an accuracy rate of 86.5% with a sensitivity of 85.9%, a specificity of 100%, a positive predictivevalue (PPV) of 100%, and a negative predictive value (NPV) of 21.7%.ConclusionFNAB cytology examination of bone tumors that have adequate sample quality, supported by complete clinical information andinformative radiological images can produce an accurate preoperative diagnosis
Mastitis Granulomatosa: Sebuah Tantangan Diagnosis Dewi, Citra; Amalia, Ella; Kurniawati, Nyiayu Fauziah; Maria Ulfa,, Maria Ulfa,; Pratama, Eka Putra; Murti, Krisna
Majalah Patologi Indonesia Vol. 31 No. 1, Januari 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i1.492

Abstract

BackgroundGranulomatous mastitis (GM) is often found in reproductive-age women. These patients are treated by the administration ofantituberculosis drugs. It is difficult to determine the exact cause of GM cytologically and histopathologically. Various etiologies i.e.,tuberculosis, sarcoidosis, foreign bodies and immunological diseases may provide granulomatous inflammation features in thetissue. High-sensitivity tests such as PCR can help to detect the presence of Mycobacterium tuberculosis (MT) as one of possibleetiologic agent. Accurate diagnosis will improve the treatment quality thus a better quality of life. The aim of this study was todetermine whether the granulomatous mastitis patients who referred to the Department of Anatomic Pathology Faculty of MedicineUniversitas Sriwijaya/Dr. Moh. Hoesin Palembang Hospital were caused by MT.MethodsA descriptive observational study was performed. Thirty paraffin blocks of GM patients during the period of 1st October 2018 to 29thSeptember 2020 were collected. DNAs were extracted from tissue scrapings of the slides. Then, PCR analysis was conducted usinga specific primer IS6110 with around 200 bp PCR product.ResultsThe mean age of the patients was 40.8 years (range: 23-67 years). There were six samples (20%) of GM produced the expectedamplicon. However, only three of six samples morphologically consistent with tuberculosis.ConclusionGranulomatous inflammatory reactions in the breast are not only caused by tuberculosis. Further study is needed to determine theexact cause of this lesion. Despite high costs, PCR examination may become an alternative approach in determining the etiology ofGM.
Hubungan Subtipe Molekular pada Karsinoma Payudara Invasif dengan Grade, Invasi Limfovaskular dan Metastasis KGB di Departemen Patologi Anatomik FKUI/RSCM Tahun 2019 Bethania, Kristina Anna; Rustamadji, Primariadewi
Majalah Patologi Indonesia Vol. 31 No. 1, Januari 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i1.493

Abstract

BackgroundBreast cancer is classified into molecular subtypes: luminal A, luminal B, HER2 enriched and triple negative breast cancer based onits immunohistochemical profile. This study aims to assess the relationship between histologic grade, lymphovascular invasion andlymph node metastasis with molecular subtypes in invasive breast carcinoma at Cipto Mangunkusumo Hospital from January 1,2019 to December 31, 2019.MethodsA descriptive, cross-sectional study was conducted in Anatomical Pathology Department, FKUI/RSCM over a period of January toDecember 2019. A total of 652 histologic specimens with a diagnosis of invasive breast carcinoma which were immunostained withER, PR, HER2, and Ki67 were reviewed, then grouped into the appropriate molecular subtypes. A Chi-square test was performed toassess the association between histologic grade, lymphovascular invasion and regional lymph node metastases with molecularsubtypes.The p-value <0.05 was statistically significant.ResultsThe molecular subtypes of breast cancer, from the highest to the least number, were luminal A (40.2%), luminal B (37.7%), TNBC(13.6%), and HER2 enriched (8.6%). There was a significant association between grade and molecular subtypes of breast cancer.(p=<0.001). There was a significant association between lymph node metastasis and molecular subtypes of breast cancer(p=0.038).ConclusionThe most common molecular subtype of invasive breast cancer found was Luminal A. There was a significant association betweenlymph node grade and metastasis and the molecular subtype of breast cancer.
Karakteristik Klinikopatologi Adenokarsinoma Prostat di Rumah Sakit Hasan Sadikin dari Tahun 2016-2023 Farera, Farah; Yantisetiasti, Anglita; Agustina, Hasrayati
Majalah Patologi Indonesia Vol. 35 No. 1 (2026): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v35i1.657

Abstract

Background Prostate adenocarcinoma (PA) ranks as the fifth most prevalent malignancy in men and the fifth leading cause of death in Indonesia. The growing number of elderly population and increased use of Prostate Specific Antigen (PSA) testing have led to a threefold rise in Prostate Carcinoma (PC) incidence in recent years. This study aims to profile the clinicopathological characteristics of PA cases at Hasan Sadikin General Hospital (RSHS) in Bandung during the period 2016-2023.   Methods We conducted a descriptive, cross-sectional study at RSHS in Bandung, utilizing medical records for data collection. Inclusion criteria comprised all histopathologically diagnosed PA cases between 2016 and 2023, with exclusion criteria pertaining to patients with incomplete medical records.   Results Our study revealed an average patient age of 72±9.0 year old. The most prevalent age group was those aged 70-79 years old (n=73, 38.8%). The mean PSA level among patients was 256±375.5 ng/ml). The majority of patients were diagnosed at stage IV (n=128, 68.1%). Biopsy was the most frequently used specimen collection method (n=154, 81.9%). Most samples exhibited a Gleason Score of 9 (n=65, 34.6%), belonged to Grade Group 5 (n=84, 44.7%), and had a poorly differentiated histopathological grade (n=132, 70.2%). Approximately 68.1% of patients presented with metastatic disease, with bone metastases being the most common (n=55,70,5 %).   Conclusion PA typically manifests in older individuals, frequently manifesting in 70-79 age group with less favorable histopathological features.
Profil ekspresi von Hippel-Lindau (pVHL) pada adenokarsinoma duktal pankreas dan jaringan pankreas non-neoplastik serta hubungannya dengan faktor klinikopatologi Prisscila, Jessica; Stephanie, Marini; Rahadiani, Nur; Manatar, Amelia Fossetta; Krisnuhoni, Ening
Majalah Patologi Indonesia Vol. 35 No. 1 (2026): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v35i1.658

Abstract

Introduction Pancreatic malignancy, primarily Pancreatic Ductal Adenocarcinoma (PDAC), presents a significant challenge due to its aggressive nature and late-stage diagnosis. This study explores the role of von Hippel-Lindau gene product (pVHL) in PDAC and non-neoplastic pancreatic tissues, investigating their relationship with PDAC clinicopathological characteristics. Method This research was carried out at the Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital.   The cases analyzed spanned from January 2012 to September 2023. Immunohistochemistry of pVHL was used, and the Histoscore/H-score calculations were utilized to classify pVHL expression as either high or low. Results A total of 54 cases of PDAC and non-neoplastic pancreatic tissue exhibited varying levels of pVHL expression. Cases of PDAC with positive surgical margin, absence of lymphovascular and perineural invasion, pT2, pN0, M0 stage, and survival exceeding 7 months were the profiles in which low pVHL expression was detected. Significant result was found on the correlation between pVHL with pN status. Conclusion The levels of pVHL expression varied between PDAC and non-neoplastic pancreatic tissue. There were no differences in the clinicopathological profile of PDAC tumors, except for pN stage. Further research, with a larger sample size, is needed to determine pVHL's diagnostic value and its expression in different clinicopathological profiles.
PROFIL HISTOPATOLOGIS LIMFOMA EKSTANODAL: PENELITIAN RETROSPEKSTIF SELAMA 5 TAHUN Patikawa, Febria Rizky; Kurniasari, Nila; Fauziah, Dyah
Majalah Patologi Indonesia Vol. 35 No. 1 (2026): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v35i1.659

Abstract

Introduction Extranodal lymphomas account for 30% of all lymphomas. The diverse location and various clinical manifestation of extranodal lymphoma lead to difficulty in diagnosis. The different types of extranodal lymphoma behave and respond differently to therapy. The information regarding the incidence of extranodal lymphoma is still limited, hence further study is needed. Methods Descriptive observational research design with a retrospective approach. This study used data from anatomical pathology examinations at the Dr. Soetomo General Academic Hospital, Surabaya, over a 5-year period, with the diagnosis of lymphoma originating from organs other than lymph nodes and no prior history of lymphoma in the lymph node. Result As many as 379 cases were diagnosed as lymphoma originating from extranodal. The highest age group was 51-60 years old (27.70%), male patient is slightly higher (55.91%) and the highest location is in the head and neck region (48.11%). On anatomical pathology examination, the most common diagnosis were high grade B cell NHL (48.11%). Conclusion This study showed the incidence of extranodal lymphoma, with the majority of cases occurring in the fifth decade of life, with M:F ratio is 1.33:1 and the most common location was in the head and neck area. The most common histological diagnosis was high grade B cell NHL, with DLBCL being the most common subtype. This study provided initial information on the epidemiology of extranodal lymphoma at Dr. Soetomo General Academic Hospital in Surabaya. Further research is needed to determine the relationship between variables and patient survival. 
Correlation between Poly ADP Ribose Polymerase (PARP) expression with Chemotherapy Response in Ovarian Carcinoma Yuniarti, Ria; Wresnindyatsih, Wresnindyatsih; Rusminan, Suly Auline; Bahar, Erial
Majalah Patologi Indonesia Vol. 35 No. 1 (2026): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v35i1.661

Abstract

Background Germline mutations in BRCA1 and BRCA2 are high risk factors for ovarian and breast cancer. The risk of ovarian cancer in BRCA1 mutation carriers is 16-68% and 11-30% in BRCA2 mutation carriers.1,2 The enzyme poly ADP ribose polymerase (PARP) plays an important role in DNA damage repair and genome stability and cancer cells change its regulation as a way for tumor cells to survive cell death due to chemotherapeutic agents.3,4 Positive PARP expression is associated with high-grade tumors. advanced stage and is an indicator of aggressive disease. The aim of this study was to examine the relationship between PARP expression and the response to chemotherapy in ovarian carcinoma. Methods A cross sectional study was conducted using 34 samples of paraffin blocks and slides of ovarian carcinoma from oophorectomy and biopsy of patients registered at the Anatomical Pathology Department Faculty of Medicine Sriwijaya University/Dr. Mohammad Hoesin Hospital Palembang for the period January 2019 to December 2021. Each sample was stained by PARP monoclonal antibody. Qualitative interpretation by assessing semi-quantitatively, namely assessing the area/proportion (P) and intensity (I) of the polished, the score is obtained by multiplying the area by the intensity, the results are grouped into 2, score 0-4 was a weak expression, score 6 was a strong expression. Analysis of the relationship between PARP expression and response to chemotherapy was performed using Chi-square test and Spearmann correlation. Results Chi-square test showed that there was a significant relation PARP expression with chemotherapy response, age, CA 125 levels post chemotherapy and stage with p values were 0.008, 0.005, 0.020 dan 0.006 respectively. There was no relation between PARP expression with histopathology subtype with p values was 0.053. Conclusion There is a significant correlation between PARP expression with chemotherapy response, age, CA 125 levels post chemotherapy and stage in ovarian carcinoma

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