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Majalah Patologi Indonesia
Published by Perhimpunan Ahli Patologi Indonesia
ISSN : 02157284     EISSN : 25279106     DOI : https://doi.org/10.55816/
Core Subject : Health,
Health Professions Public Health
Majalah Patologi Indonesia (MPI) digunakan sebagai wahana publikasi hasil penelitian, tinjauan pustaka, laporan kasus dan ulasan berbagai aspek di bidang patologi manusia. Tujuannya ialah menghadirkan forum bagi permakluman dan pemahaman aneka proses patologik serta evaluasi berbagai penerapan cara diagnostik sejalan dengan kemajuan perkembangan ilmu dan teknologi. Selain itu juga untuk merangsang publikasi barbagai informasi baru/mutakhir.
Arjuna Subject : Kedokteran - Patologi dan Kedokteran Kesehatan
Articles 384 Documents
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KEMAMPUAN PEWARNAAN ZIEHL-NEELSEN DAN FITE FARACO UNTUK MENDETEKSI MYCOBACTERIUM SP. PADA SAMPEL JARINGAN : A LITERATURE REVIEW Dwi Putri, Riska; Usman, Hermin Aminah; Agustina, Hasrayati
Majalah Patologi Indonesia Vol. 34 No. 2, Mei 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i2.625

Abstract

Histopathology is an essential method for disease diagnosis. It is crucial for clinicians to have an ideal diagnostic method that is simple, specific, and highly sensitive. The sensitivity and specificity of a test can be determined by comparing it with other tests. Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Mycobacterium tuberculosis is diagnosed using Ziehl-Neelsen staining, which dif erentiates acid-fast bacilli from non-acid-fast bacilli. The Fite Faraco staining technique is used to detect Mycobacterium sp in tissue specimens. All reviewed articles show that Ziehl-Neelsen staining has a sensitivity between 21% - 97.6%, specificity between 85.7% - 92%, NPV between 34.3% - 75%, PPV between 30.9% - 100% in detecting Mycobacterium sp in tissue samples. Fite Faraco staining shows a sensitivity between 50% - 74.6%, specificity between 84% - 100%, NPV between 33.6% - 56.7%, PPV 38.1% in detecting Mycobacterium sp in tissue samples.It is detected that Ziehl-Neelsen and Fite Faraco can be used to detect bacteria, Mycobacterium sp especially bacteria Mycobacterium tuberculosis and Mycobacterium leprae. However, Ziehl-Neelsen staining has better ability in terms of sensitivity, PPV, and NPV than Fite Faraco in detecting bacteria Mycobacterium sp, especially Mycobacterium tuberculosis. As Fite-Faraco staining is superior in terms of specificity. Other things that must be Considered in carrying out Ziehl-Neelsen and Fite Faraco staining are specific types of samples, making modifications such as modifying microwave heating on the Ziehl-Neelsen staining method and combining examination with H&E staining and multiplex PCR to increase the validity of the two staining methods.
Comparison of Peritumoral Budding Features in Colorectal Adenocarcinoma NOS by Hematoxylin-Eosin (HE) Staining and Pancytokeratin (AE1/AE3) Immunohistochemistry Listiyaningsih, Listiyaningsih; Laksmi, Lidya Imelda; Mariedina, Causa Trisna; Betty, Betty; Chrestella, Jessy
Majalah Patologi Indonesia Vol. 34 No. 2, Mei 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i2.639

Abstract

Background Colorectal adenocarcinoma is defined as a malignant epithelial tumor of the large intestine (colon and rectum) that shows glandular and mucinous differentiation, accompanied by invasion through the muscular mucosae into the submucosal layer. Peritumoral budding refers to tumor budding at the leading edge of the tumor and can be considered one of the prognostic factors. Immunohistochemistry Pancytokeratin (AE1/AE3) is observed in the epithelium, and most carcinomas (tumors originating from epithelial cells) are stained in the cytoplasm. Method The analytical study involved 48 paraffin block samples diagnosed as colorectal adenocarcinoma NOS at Haji Adam Malik Central General Hospital in Medan and the laboratory of the Faculty of Medicine, Universitas Sumatera Utara. The assessment of tumor budding using hematoxylin-eosin staining and pan-cytokeratin (AE1/AE3) immunohistochemical staining was classified equally into three categories: low budding category if 0-4 buds of tumor budding were observed, intermediate budding category if 5-9 buds of tumor budding were observed, and high budding category if ≥10 buds of tumor budding were observed. Results There is no difference in assessing peritumoral budding using Hematoxylin-Eosin (HE) staining and pan-cytokeratin (AE1/AE3) immunohistochemical staining. Conclusion Assessment of peritumoral budding is recommended using Hematoxylin-Eosin (HE) staining.
SOX10 and The Tendency of Perineural Invasion in Salivary Gland Adenoid Cystic Carcinoma Safnita, Dewi; Hilbertina, Noza; Mulyani, Henny; Tofrizal; Khambri, Daan; Yetti, Husna
Majalah Patologi Indonesia Vol. 34 No. 3, September 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i3.641

Abstract

Background Adenoid cystic carcinoma is a malignant salivary gland tumor with unique features, including slow growth, progressive, poor prognosis, recurrence propensity, and perineural invasion tendency. SOX10 is a transcription factor expressed in the majority of tumors. SOX10 overexpression was hypothesized to play an important role in tumor-stroma interactions, especially perineural invasion and histopathological patterns.   Method A cross-sectional study was performed using 30 blocks of formalin-fixed embedded specimens previously diagnosed as salivary gland adenoid cystic carcinomas. Perineural invasion and histopathological patterns were evaluated followed by immunohistochemical staining to evaluate SOX10 expression. The staining intensity and proportion of positively stained cells in both tumor and stroma cells were grouped into high and low expression levels. Chi-square tests were used for statistical analysis.   Result The cribriform pattern was the most common histopathological pattern in both high and low SOX10 expression. The majority of tumors with high SOX10 expression (66.67% in stroma cells and 73.33% in tumor cells) were found to have more perineural invasion.   Conclusion There was a tendency for perineural invasion in tumors with high SOX10 expression, although this was not statistically significant. There was no significant association between SOX10 expression and histopathological pattern.
Subcategorization of the AUS/FLUS Thyroid Nodule Based on the 2017 Bethesda System at Dr. Cipto Mangunkusumo Hospital from 2018-2021 Linggodigdo, Michelle; Rachmadi, Lisnawati
Majalah Patologi Indonesia Vol. 34 No. 3, September 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i3.647

Abstract

IntroductionThe AUS/FLUS (Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance) category is one of the most challenging diagnoses in thyroid fine-needle aspiration biopsy (FNAB) for pathologists. This is due to the heterogeneous cytomorphological features with low Risk of Malignancy (ROM) accuracy, which is crucial to determining further management. The 2017 Bethesda System introduced subcategorization of AUS/FLUS to improve ROM accuracy. However, the widespread adoption of this subcategorization remains limited. MethodsA retrospective analytical cross-sectional study was carried out using secondary data of thyroid FNAB cases diagnosed with AUS/FLUS followed by surgical procedures at the Department of Anatomical Pathology, Faculty of Medicine, University Indonesia/Dr. Cipto Mangunkusumo Hospital from 2018 to 2021. Furthermore, a review and subcategorization into AUS-C1 (focal nuclear atypia), AUS-C2 (mild nuclear atypia), AUS-A (architectural atypia), AUS-C&A (nuclear and architectural atypia), AUS-H (Hűrthle cell aspiration), AUS-NOS (atypia not otherwise specified), and AUS-L (lymphoid cell atypia other than lymphoma) was performed. ResultAmong a total of 2,082 patients, 599 (28.7%) were diagnosed as AUS/FLUS. There were 75 patients with AUS/FLUS who proceeded with surgery, while 64 (85.3%) showed malignancy. The most common subcategory was AUS-C1 (60%), followed by AUS-NOS (21.3%), AUS-C&A (9.3%), AUS-C2 (8%), and AUS-H (1.4%). ROM subcategory AUS-C1 was significantly higher compared to AUS-C2 (p=0.009) and AUS-NOS (p=0.011). Conclusion The percentage of AUS/FLUS diagnoses at Dr. Cipto Mangunkusumo Hospital from 2018 to 2021 was 28.7% with ROM ranging from 10.6% to 85.3%. There was a significant difference in ROM between AUS-C1 and AUS-C2, as well as AUS-C1 and AUS-NOS. Therefore, it was concluded that AUS-C1 thyroid nodules with or without architectural atypia require more aggressive management compared to those with AUS-C2 and AUS-NOS features.
Clinicopathological Characteristics of Ocular Surface Squamous Neoplasia in National Eye Center, Cicendo Eye Hospital Bandung from 2019 to 2022 Nia Nuraeni; Aminah, Hermin; Agustina, Hasrayati; Mardianty, Friska
Majalah Patologi Indonesia Vol. 34 No. 2, Mei 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i3.649

Abstract

Introduction Ocular surface squamous neoplasm (OSSN) comprises a broad spectrum of dysplastic alterations of the squamous epithelium of the conjunctiva, ranging from conjunctival squamous intraepithelial neoplasm (CSIN) to squamous cell carcinoma (SCC). The aim of this study was to describe the clinicopathological characteristics of OSSN at National Eye Center, Cicendo Eye Hospital Bandung from January 2019 to December 2022. Methods We collected OSSN data from 2019 to 2022. The collected data were the patient's age, gender, education, occupation, laterality, clinical features, recurrence, and classification of tumor according to the 2022 WHO classification. Results: A total of 128 cases were collected. The most common tumor identified was SCC (48.4%), followed by CSIN with severe dysplasia (25%), moderate dysplasia, and mild dysplasia (14.8% and 11.7%, respectively). The average patient’s age was 53.1 years (M = 53.1, SD =16.9), predominantly males (68%), education completed elementary school (52.3%), and more patients worked outdoor (59.4%). The most common affected site was the left eye (53.9%), and the tumor located in the nasal region (78.1%) with clinical features is papilliform (64.1%). Conclusion OSSN was predominant in elderly male patients. The majority of cases were seen in the left eye, primarily in the nasal area. The majority of patients had completed elementary school and worked outdoors. Additionally, the clinical symptoms showed that most patients had papilliform. In patients with OSSN, SCC was the most common anatomical pathology discovered. Moreover, recurrence was higher in SCC cases.
Relationship Between Histopathology Grading (Nottingham System) and Expression of HER2/Subtype Luminal B in Breast Carcinoma with Lymph Node Metastases Irmaya, Dita; Hernowo, Bethy S.; Dewayani, Birgitta M.
Majalah Patologi Indonesia Vol. 34 No. 3, September 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i3.650

Abstract

Background Molecular subtypes of breast carcinoma, histological grade, and lymph node msetastases are significant in determining the therapy and prognosis of the patient. The luminal B subtype comprises 15%-20% of breast cancers and has a more aggressive phenotype, higher histological grade, proliferative index, and a worse prognosis. This study aimed to evaluate the relationship between histopathological grading and expression of  HER2 with lymph node metastases in luminal B subtype breast carcinoma. Methods We analyzed 279 invasive breast carcinoma luminal-B subtypes from the anatomic pathology laboratory of Dr. Hasan Sadikin Bandung between January 2017 and March 2023. Histological grade using the Nottingham system, expression of HER2 using immunohistochemistry examination, and lymph node metastases status were obtained from anatomic pathology records. The association between histological grade and expression of HER2 with lymph node metastases was examined with chi-square tests. Result: In the current study, we included 279 subjects, dominated by patients whose age at diagnosis was less than 50 years old. The Chi-square analysis showed no statistically significant difference in tumor size between patients with metastasis and those without metastasis,P = 0.74. The Chi-square analysis showed a significant relationship between histopathological grade and lymph node metastases, p < 0.01 and expression HER2 status and lymph node metastasis  p < 0.05 Conclusion This study found that patients present with larger tumors classified as T3 and moderate to poor grade III and grade II histological grades. The statistical analysis showed no significant difference in the age of diagnosis between patients with metastasis and those without. However, the Chi-square analysis revealed a significant correlation between the histopathological grade and HER2 expression with lymph node metastasis.
Prognosis Factor and KRAS Mutation Status in Association with Overall Survival in Patients with Colorectal Adenocarcinoma in Hasan Sadikin General Hospital Ichfa Namira; Aminah, Hermin; Yulianti, Herry
Majalah Patologi Indonesia Vol. 34 No. 2, Mei 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i2.655

Abstract

Introduction: Colorectal adenocarcinoma is a malignant epithelial tumor originating from the colon. Colorectal adenocarcinoma is the most common colorectal carcinoma. We aim to analyze the association between prognostic factors and KRAS mutation status with overall survival in patients with colorectal adenocarcinoma in Hasan Sadikin General Hospital. Methods: This retrospective analysis investigated the prognostic factors and KRAS mutation status in 27 patients with stage III and IV colorectal adenocarcinoma. KRAS mutations were assessed using PCR. Results: A total of 27 cases were collected and analyzed. Patients dominated with female patients (74.1%), with more than half of the patients aged>50 years old (55.6%). Most patients had tumors in their right colon (48.1%) and stage III when they were diagnosed (81.5%). 55.6% of patients had a mutation dominated by KRAS codon 12 (25.9%). The median overall survival was 13 months. Age and tumor site were statistically significant to overall survival (p<0,05); the median OS was seven months for patients whose diagnosis was < 50 years old. The median OS of patients with tumors in the right colon had a median OS of 30.6 months. Gender, KRAS mutation, and stage at diagnosis had no statistical significance on overall survival. Conclusions: Adenocarcinoma colorectal in Hasan Sadikin Hospital from 2016 until 2020 mainly occurred in women over 50 years old, with the most common location being in the right colon and most of the patients were at stage III when they were diagnosed. Most of patient’s in this study have mutation in KRAS. Age and tumor site had statistical significance on overall survival. Keywords: Adenocarcinoma colorectal, KRAS mutation, overall survival, prognostic factor
Correlation between GATA3 Immunohitsochemistry and TP53 on some Ovarium Carcinoma Histopathology Subtype Alamanda, Intan Nefia; Betty, Betty; Delyuzar, Delyuzar; Chrestella, Jessy; Soekimin, Soekimin
Majalah Patologi Indonesia Vol. 34 No. 2, Mei 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i3.665

Abstract

Background Ovarian carcinoma is a cancer with high mortality in women, although comprehensive treatment with surgery and chemotherapy is at an advanced stage, survival rates are still low. GATA3 and p53 are predictors of some malignancies, but results vary in ovarian carcinoma. Objective To examine correlation between immunohistochemical expression of GATA3 and p53 in patients with ovarian carcinoma with various histopathological subtypes. Materials and Methods Cross sectional design is the method of this study conducted on slides of 28 ovarian carcinoma patients in several subtypes of hitopathology. Each slide was stained with hematoxylin and eosin (H&E) to assesses hitopathological subtypes and stained with GATA3 and p53 antibodies. Expression GATA3 was assessed using H-score and p53 quick score. A logistic regression assay (p<0.005) was used to assessed the association of GATA3 and TP53 immunohistochemical expression in several histopathological subtypes of ovarian carcinoma. Statistical analysis between GATA3 and p53 was performed using the eta correlation test is used because the data is nominal-ordinal. Results Among 28 specimens in patients with ovarian carcinoma, Cases was most prevalent in the age group >50-60 years (age range 58 years), history of nullipara parity, and most in the group of stage III ovarian malignancy. Positive immunohistochemical p53 expression is more prevalent in serous carcinoma. Positive GATA3 immunohistochemical expression is more prevalent in serous carcinoma. Conclusion There is no significant relationship. Immunohistochemical expression of GATA3 and TP53 in some histopathological subtypes of ovarian carcinoma. However, immunohistochemical expression of GATA3 high p53 positive tends to be found in high-grade serous carcinoma. Keywodrs: GATA3, p53, karsinoma ovarium, Serous carcinoma, Mucinous carcinoma, Endometrioid carcinoma, Clear cell carcinoma.
English: English Ramkita, Nora; Krisna Murti; Citra Dewi
Majalah Patologi Indonesia Vol. 34 No. 2, Mei 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i2.668

Abstract

Background A frozen section or vries coupe (VC) is an examination procedure performed by a pathologist during a patient operation on the surgical table. VC provides immediate information to surgeons regarding the benign or malignant status of a tissue, as well as determines the incision margin free from tumor mass. Objective This study aimed to evaluate diagnostic accuracy using the slide preparation archives of VC and histopathology at the Anatomic Pathology Department of Dr. Mohammad Hoesin Central General Hospital (RSUP), Palembang. Methods: Samples of patients were collected from 1 January 2021 to 1 October 2023, while sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for VC were assessed compared to the definitive diagnosis of histopathology. A reassessment was conducted by two pathologists on slide preparations with unmatched results between VC and histopathological diagnosis. Result VC examination showed sensitivity, specificity, PPV, and NPV of 99.7%, 99.7%, 98.3%, and 98.3% for benign tumors as well as 98%, 99.6%, 98.3%, and 98.3% for malignant tumors, respectively. The reassessment of the inappropriate slide preparations obtained a weighted kappa value of 0.586, signifying moderate agreement. Diagnostic discordance is caused by the experience of pathologists, freezing artifacts, and challenges in obtaining precise samples under a limited timeframe. Conclusion This study provided valuable insights into the effectiveness of VC procedure in intraoperative tissue diagnosis, showing the need for collaborative efforts and experienced pathologists to achieve improved accuracy.
Gambaran Klinikopatologi Limfoma Sel B Besar Difus Tidak Tertentu di Rumah Sakit Umum Pusat Dr. Hasan Sadikin Bandung Tahun 2018-2023 Afiati; Hernowo, Bethy S.; Aminah, Hermin; Oehadian, Amaylia
Majalah Patologi Indonesia Vol. 34 No. 3, September 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i3.675

Abstract

Introduction Diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS), is the most common group of non-Hodgkin malignant lymphoma globally, representing 25%-40% of adult lymphoma cases. According to the cell of origin(COO), DLBCL NOS is classified into DLBCL germinal center B-cell like(GCB) and DLBCL non-germinal center B-cell like(non-GCB). Since the COO affects the prognosis of DLBCL NOS, this examination is important. Hans algorithm is the most frequently used to distinguish the GCB from non-GCB. This study aims to describe clinicopathological characteristics of DLBCL NOS at Dr. Hasan Sadikin General Hospital Bandung, 2018-2023. Methods The subjects of this retrospective descriptive study were DLBCL GCB and non-GCB patients based on Hans algorithm by IHC examination of CD10, BCL6, and MUM1 who received R-CHOP therapy at Dr. Hasan Sadikin General Hospital from 2018 to 2023. All data contained age, gender, B-symptoms, primary tumor location, stage, total International Prognostic Index (IPI) score, and immunochemotherapy status.  Results A total of 55 patients diagnosed with DLBCL NOS were collected in this study. 50 patients(90.9%) were classified as DLBCL non-GCB and 5 patients(9.1%) were classified as DLBCL GCB. The average age was 62 years, predominantly males(52.7%), extranodal disease(54.5%), no B symptoms(76.4%), and early stage(83.7%). 52 patients(94.6%) had a total IPI score of 0-1, 3 patients(5.4%) had a total IPI score of 2. 21 patients(38.2%) had a response, 13 patients(23.6%) had non-response, and 21 patients(38.2%) are still ongoing to R-CHOP therapy. Conclusion DLBCL NOS at Dr. Hasan Sadikin General Hospital from 2018-2023 mainly occurred in men with an average 62 years old and extranodal disease without B-symptoms. DLBCL non-GCB was predominant than GCB. Both DLBCL Non-GCB and GCB were mostly diagnosed at early stage, IPI low-risk group, and had response status to R-CHOP therapy similar to those are still ongoing to R-CHOP therapy.

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