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Jurnal Biomedika dan Kesehatan
Published by Universitas Trisakti
ISSN : 2621539x     EISSN : 26215470     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Biomedika dan Kesehatan is an official publication of Faculty of Medicine Trisakti University. Jurnal Biomedika dan Kesehatan is a third-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Jurnal Biomedika dan Kesehatan online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic.
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Articles 14 Documents
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Search results for , issue "Vol 8 No 3 (2025)" : 14 Documents clear
Studi Kasus–Kelola Paparan Asap Rokok dan Kunjungan Antenatal pada Kejadian Kelahiran Prematur Zachrani, Aliviannisa Hasmah; Kurniasari, Kurniasari
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.298-307

Abstract

Background Preterm birth remains one of the leading contributors to infant mortality in Indonesia. In addition, premature infants are more likely to develop diseases. Obstetric factors, such as parity and frequency of antenatal visits, as well as environmental factors, such as exposure to cigarette smoke, can influence the incidence of preterm birth. In Indonesia, parity remains high, and the frequency of antenatal visits varies by region, along with limited understanding of the dangers of second-hand smoke for fetuses. This study aims to analyze the relationship between parity, frequency of antenatal visits, and second-hand smoking, and the incidence of preterm birth. Methods This case-control study included pregnant women aged 20 – 35 years who gave birth to premature and preterm babies between January 2022 and December 2023 in hospitals. Pregnant women with hypertension during pregnancy, antepartum hemorrhage, multiple pregnancies, smoking, alcohol consumption, or postterm gestational age (>42 weeks) at birth were excluded from this study. Data on parity, secondhand smoking history, frequency of antenatal visits in the last pregnancy, and gestational age at childbirth were collected using a questionnaire. Medical records and Maternal – Child Health Books were used to confirm the data collected through questionnaires. The relationships and magnitudes of risk associated with parity, secondhand smoking, and frequency of antenatal care contacts with preterm birth were analyzed using the Chi-Square Test. Results Exposure to cigarette smoke (p=0.036; OR=2.727 [CI: 1.058 - 7.031]) and antenatal visits (p=0.033; OR=4.167 [CI: 1.046 - 16.605]) were associated with the incidence of preterm birth, whereas parity was not associated (p=0.251; OR=1.699 [CI: 0.685 - 4.209]) with the incidence of preterm birth. Conclusions Mothers exposed to cigarette smoke ≥ 5 sticks/day and with non-routine antenatal visits had a 2,727-fold and 4,167-fold increased risk of premature birth.
Pengaruh Pemberian Penyuluhan terhadap Stigma Penyakit Kusta pada Pasien dan Keluarga Kontak: Suatu Pre - Post Study Sari, Luh Putu Sustiana Kartika; Karna, N. L. P Ratih Vibriyanti; Rusyati, Luh Made Mas; Karmila, I. G. A. A Dwi; Puspawati, Ni Made Dwi; Winaya, Ketut Kwartantaya
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.317-328

Abstract

Background Stigma toward leprosy patients remains a barrier to efforts to control this disease. Educational interventions are needed to increase public knowledge and reduce prejudice toward patients. This study aims to evaluate the effect of education on leprosy stigma among patients and their family contacts at Prof. Dr. I.G.N.G. Ngoerah General Hospital. Methods This study used a quasi-experimental design with a one-group pretest-posttest approach. The study was conducted at the Dermatology and Venereology Polyclinic of Prof. Dr. I.G.N.G. Ngoerah General Hospital in Denpasar, Bali, from February to July 2025. Data analysis was performed using SPSS version 26.0 at a significance level of α = 0.05. Results A total of 50 respondents were included, comprising 37 leprosy patients and 13 family members. A significant relationship was observed between stigma before and after health education (p = 0.031). Educational level (p = 0.001), clinical presentation (p = 0.002), and economic level (p = 0.029) were also significantly associated with stigma after health education. Respondents with higher education showed a significant decrease in stigma (OR = 11.245; 95% CI: 2.044–61.862; p = 0.005). Similarly, respondents with non-neurological disorders showed lower levels of stigma (OR = 12.415; 95% CI: 2.208–69.808; p = 0.004). Conclusions The findings of this study indicate that health education significantly reduced leprosy-related stigma, with educational level and clinical presentation identified as key determinants.
Efek Deferiprone dan Ekstrak Buah Phaleria macrocarpa terhadap Akumulasi Zat Besi pada Ginjal Tikus Wahyudy, Silvy; Haniifa, Saalima Nur; Estuningtyas, Ari
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.250-262

Abstract

Background Iron overload can cause oxidative stress and kidney damage by increasing reactive oxygen species (ROS) and decreasing antioxidant defenses, including total glutathione (T-GSH). Chelation therapy with deferiprone (DFP) as a standard treatment and ethanolic Phaleria macrocarpa (PM) fruit extract as a natural alternative is expected to lower renal iron buildup and restore redox balance. This study aimed to assess the effects of DFP, PM, and their combination on renal iron and T-GSH levels in a rat model of iron overload. Methods A total of 30 male Sprague-Dawley rats were randomly assigned to six groups (N, IO, D, PM, DPM-1, DPM-2). Iron overload was induced by intraperitoneal injections of iron-dextran (0.3 mL, approximately 15 mg Fe) twice weekly for three weeks, followed by five weeks of daily oral treatments. Renal iron levels were measured using atomic absorption spectrophotometry (λ 248.3 nm), and T-GSH was quantified colorimetrically (λ 412 nm). Iron data were analyzed with one-way ANOVA and LSD post-hoc test, while T-GSH levels were evaluated using the Mann-Whitney U test (p < 0.05). Results Renal iron levels were highest in the DPM-1 group at 50.46 ± 22.31 mg/kg, which is 1.95 times above normal; however, one-way ANOVA showed no statistically significant differences among groups (p = 0.490). T-GSH levels did not vary significantly across most treatments, except for a notable increase in the DPM-1 group compared to PM (Mann-Whitney, p = 0.034). Conclusions The DPM-1 combination shows a potential synergistic effect in increasing renal T-GSH levels, although it has not significantly lowered iron levels in the lower-dose DFP and PM combination (DPM-2). Additional studies with longer treatment periods and more antioxidant parameters are necessary to assess the protective potential of DFP-PM combinations against oxidative stress and renal ferroptosis caused by iron overload.
Sindroma Ovarium Polikistik (PCOS) Pada Remaja Wanita di Indonesia: Tantangan Baru dalam Kesehatan Reproduksi Wanita Murthi, Aditya Krishna; Wratsangka, Raditya; Sisca, Sisca; Kurniawan, Yani
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.245-249

Abstract

Adolescence is a crucial phase in individual growth and development, especially for young women, who experience significant physical and hormonal changes. These changes impact reproductive health, including the regularity of the menstrual cycle. Menstrual cycle irregularities can be an early manifestation of Polycystic Ovarian Syndrome (PCOS), one of the most common endocrine disorders in women of reproductive age. Hyperandrogenism, ovulatory disorders, and polycystic ovarian morphology characterize PCOS. Its prevalence in adolescents ranges from 6–10% and tends to increase with lifestyle changes such as a high-calorie diet, lack of physical activity, and psychological stress. Pathophysiologically, PCOS involves complex interactions among genetic, epigenetic, and environmental factors that disrupt the balance of hormones LH, FSH, and AMH and cause insulin resistance. This condition triggers hyperandrogenism, inhibits follicular maturation, and leads to chronic anovulation. The diagnosis of PCOS in adolescents requires caution based on the Rotterdam Consensus (2003) and the 2018 International Guidelines, taking into account similarities to the physiological symptoms of puberty. PCOS is strongly linked to obesity, metabolic syndrome, and family history, with insulin resistance playing a significant role in its development. Elevated Anti-Müllerian Hormone (AMH) levels indicate the severity of PCOS and are associated with metabolic disorders. Therefore, a preventive, holistic approach that promotes a healthy lifestyle is essential for adolescents, including education on balanced nutrition, increased physical activity, and stress management. These measures are expected to decrease the occurrence of PCOS and long-term complications such as infertility and metabolic syndrome in young women in Indonesia.

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