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JURNAL FARMASIMED (JFM)
Published by Institut Kesehatan Medistra Lubuk Pakam
ISSN : -     EISSN : 26550814     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal FARMASIMED (JFM) Volume I Nomor 1 Periode Mei - Oktober Tahun 2018. Jurnal ini memberikan ruang bagi akademisi, peneliti dan pengguna hasil penelitian dan pengabdian untuk mendiseminasikan, menginformasikan, mendiskusikan dan menggunakan hasil penelitian dan pengabdian sebagai upaya meningkatkan kualitas kebijakan di bidang farmasi yang berbasis ilmiah dan dapat dipertanggung jawabkan. Jurnal ini menyajikan hasil penelitian, pengabdian masyarakat serta artikel ilmiah di bidang farmasi.
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Articles 58 Documents
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Search results for , issue "Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)" : 58 Documents clear
The Relationship of Risk Factors for Medication Error in the Electronic Prescription Prescribing Phase in the Outpatient Pharmacy Installationof Hospital X Sekar Pratiwi, Arum; Endah Lestari, Yovita; Annisa Primadiamanti
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/80vdkc63

Abstract

Backrgound: Medication errors are avoidable drug misuse incidents that occur during the drug administration process. Medication errors occur at various stages, such as writing a prescription (prescribing), translating a prescription (transcribing), providing and compounding medication (dispensing) and administering medication (administration. Prescribing errors are the most common type of error found in prescription services. Objective: This study was conducted to determine the percentage of medication errors in the prescribing phase of electronic prescriptions and the relationship between prescription characteristics, including the clinic where the prescription was issued, the type of drug, and the number of drugs, with the occurrence of medication errors. Methods: The study was conducted as a retrospective, non-experimental, observational cross-sectional study. The study used electronic prescription data from outpatient pharmacy installations from January to February 2025, with a total of 400 samples. A description of medication error events and an analysis of the relationship between variables were performed using the Chi-Square test. Results: The results showed that medication errors in administrative requirements were 100%, pharmaceutical requirements were 69.5%, and clinical requirements were 80%. There was a significant association between polyclinic origin of prescription and medication error in pharmaceutical and clinical requirements (p-value < 0.05). There was a significant relationship between drug type and medication error in pharmaceutical and clinical requirements (p-value < 0.05). There was a significant relationship between the number of drugs and medication errors in pharmaceutical and clinical requirements (p-value < 0.05). Conclusion: This study reveals a relationship between risk factors, including the polyclinic origin of the prescription, type of drug, and number of drugs, and the occurrence of medication errors in the prescribing phase.
Evaluation of the Effectiveness of Ethanol Extract of (Acalypha indica L.) Leaves as a Treatment for Gastric Ulcers in Male Rattus norvegicus Rats Wulandari, Suci; Hasni Yaturramadhan Harahap; Rinanda Desela Br Tambunan; Basyariah Lubis
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/bvmsms48

Abstract

Acalypha indica L., commonly known as Indian copperleaf, is a wild medicinal plant typically found along roadsides and in gardens. Its leaves contain various bioactive compounds, including saponins, flavonoids, alkaloids, and tannins. Traditionally, the plant has been used for its anti-inflammatory, antibacterial, antifungal, and antioxidant properties, which help combat oxidative stress caused by free radicals. This study aimed to evaluate the effectiveness of ethanol extract of Acalypha indica L. leaves in treating gastric ulcers in male Wistar rats (Rattus norvegicus). This research was a true experimental study involving the extraction of Acalypha indica L. leaves using ethanol, preparation of the extract suspension, and induction of gastric ulcers in rats using aspirin at a dose of 800 mg/kg body weight (BW) administered orally. A total of 30 male Rattus norvegicus rats were divided into six groups. Three control groups is Ulcer control, Negative control, Positive control. Three treatment groups receiving ethanol extract of Acalypha indica leaves (EEAIL) at doses of: EEDAA 50 mg/kgBB, EEDAA100 mg/kg BB, EEDAA 200 mg/kgBB. Ulcer induction was carried out daily until surgical examination was performed on days 4, 9, and 14. Macroscopic observations of the stomach were conducted to assess the number of ulcers and ulcer scores. Statistical analysis was performed using one-way ANOVA, followed by Tukey’s post hoc test to determine significant differences between groups. Macroscopic examination showed that the ethanol extract of Acalypha indica leaves (EEAIL) reduced the number of gastric ulcers. Complete healing of ulcers was observed in the positive control group, as well as in the groups receiving EEAIL at 200 mg/kg BW and 100 mg/kg BW, by day 14. In contrast, the 50 mg/kg BW group and the ulcer control group showed no signs of healing by the end of the observation period. The most effective dose was 200 mg/kg BW, demonstrating the highest capacity to reduce the number of gastric ulcers.
Determination of Total Flavonoid Levels Of Cinnamon Leaf Infusion (Cinnamomum burmanni (Nees & T.Nees) Blume.) Using UV-Vis Spectrofotometry Lovena, Tri Nova; Dewi Gulyla Hari; Encik Juliansyah Arief
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/x2vajr20

Abstract

Background: Cinnamon leaves (Cinnamomum burmanni (Nees & T.Nees) Blume.) are natural plants used as traditional medicine because they have secondary metabolite compounds, namely flavonoids, tannins, saponins, alkaloids, and triterpenoids. Objective: This study aims to determine the total flavonoid compound levels found in cinnamon leaves (Cinnamomum burmanni (Nees & T.Nees) Blume.). Methods:The extraction method used is the infusa method using aquadest solvent. Qualitative analysis used phytochemical screening and quantitative analysis used is by UV Vis Spectrophotometry with standard comparison using quercetin. Results: For parametric data analysis using One Way Annova analysis. The results of phytochemical screening examination of cinnamon leaves (Cinnamomum burmanni (Nees & T.Nees) Blume.) are positive for flavonoid compounds with the total flavonoid compound content using the UV-Vis Spectrophotometry method is 0.5691 mgQE/g, and the results of parametric data analysis using One Way Annova analysis show a significant value of flavonoid content of 1.000> 0.05. This indicates that the flavonoid levels in the sample are relatively stable and homogeneous, so the treatments applied did not result in significant variation. This may suggest that the treatment factors in the study did not significantly affect the amount of flavonoids contained in the cinnamon leaf extract. Thus, the detected flavonoid content is likely more influenced by the natural characteristics of the plant rather than by the treatments tested. Conclusion: The cinnamon leaf (Cinnamomum burmanii) showed a positive result for the presence of flavonoid compounds.
Determination of Flavonoid Content of Ethanol Extract of Yellow Pumpkin Leaves (Cucurbita moschata Dulchesne ) Using Uv-Vis Spectrophotometry Dewi Gulyla Hari; Tri Nova Lovena; Ummul Khairiah
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/3rps7m67

Abstract

Background: Flavonoids are one of the most abundant groups of secondary metabolite compounds found in plant tissues. Pumpkin leaves (Cucurbita moschata Dulchesne ) can generally be used as antidiabetic, analgesic, nephroprotective and anticancer for stomach pain, jaundice, skin infections, lowering cholesterol, and blood sugar levels, and contain flavonoid compounds. Purpose: to determine the levels of flavonoid compounds contained in 70% ethanol extract of pumpkin leaves (Cucurbita moschata Dulchesne ). Methods: using the UV-Vis spectrophotometry method and to determine the flavonoid content from the results of phytochemical screening in the ethanol extract of pumpkin leaves. Pumpkin leaf extract was obtained through maceration techniques with 70% ethanol as the solvent. Results: The study showed that there was flavonoid content in pumpkin leaves, which was orange in color and the results of the study determined the flavonoid levels using UV-Vis spectrophotometry at a wavelength of 428 nm. om the resultsobtained from the measurement of the standard curve of quarcetin, it can be concluded that the higher the concentration used, the higher the absorbance value obtained and it can be seen that the results obtained total flavonoid content in the 70% ethanol extract sample of pumpkin leaves is 7.2672 mgQE/g.  Conclusion: There is a flavonoid compound content contained in pumpkin leaves.
Evaluation of Inpatient Antibiotic Use at Hospital X, Semarang Regency, in 2023 Using Quantitative Methods Ivana; Avianti Eka Dewi Aditya Purwaningsih; Fadhila Shaumi Chunaesiana
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/q734wz44

Abstract

Background: Antibiotic resistance is a critical global health problem resulting from the inappropriate use of antibiotics. Understanding the pattern of antibiotic utilization is necessary to support rational prescribing and reduce resistance.Objective: This study aimed to evaluate the pattern of antibiotic use among inpatients at Hospital X in Semarang Regency in 2023. Methods: A retrospective study was conducted among inpatients aged 19–59 years who received antibiotic therapy between January and December 2023. Data were analyzed using the Anatomical Therapeutic Chemical/Defined Daily Dose method and Drug Utilization 90% to assess consumption patterns. Results: A total of 1,402 patients were included, with most patients being female and within the 49–59 age group. The majority of hospital stays lasted 1–5 days. Ceftriaxone injection is the most frequently used antibiotic and records the highest defined daily dose, followed by levofloxacin and ampicillin sulbactam. Conclusion: The study shows that ceftriaxone injection dominates antibiotic utilization. Regular evaluation using standardized methods is essential to ensure appropriate use and prevent resistance. Antibiotic procurement policies should be guided by actual consumption data to improve efficiency in drug management.
Profile of Pulmonary Tuberculosis Patients with dan without Diabetes at Prof. Dr. H. Aloei Saboe Regional General Hospital Gorontalo City Abas, Siti Nur Rahmatiya; Sugiyarto Surono; Haafizah Dania; Lolita; Endang Darmawan
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/7aryfn34

Abstract

Background: Pulmonary tuberculosis (TB) is still a leading cause of death from infectious diseases worldwide, and diabetes mellitus (DM) exacerbates its impact by increasing the risk of infection, worsening clinical manifestations, and lowering treatment success. Objective: To compare the characteristics of pulmonary TB patients with and without DM. Methods: An observational analytic study with a retrospective design was conducted using medical records of pulmonary TB patients at Prof. Dr. H. Aloei Saboe Hospital, Gorontalo, from January to September 2024. Results: TB-DM is most frequently found in the 55–64 years age group, whereas TB without DM is most prevalent in the 45–54 years group. Female patients dominate the TB-DM group, while male patients are more common in the TB without DM group. Conclusion: that age and sex are important determinants in the distribution of TB-DM and TB without DM, emphasizing the need for integrated screening in patients aged ≥45 years and gender-sensitive interventions for TB control.
Antibiotic Use in Inpatients with Diarrhea in Children: A Quantitative Evaluation at Hospital X, Semarang Regency, 2023 Widiastuti, Zulfia; Purwaningsih, Avianti Eka Dewi Aditya; Ulum, Amalia Nurul
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/s8qfqn40

Abstract

Background : Infection remain one of the leading causes of morbidity in tropical regions such as Indonesia, with Escherichia coli being one of the most freequently identified pathogens. The high incidence of Escherichia coli-related infections has led to increased antibiotics use, considering that this commensal gut bactericum can cause both asymptomatic infections and symtomatic diarrhe, either bloody or non-bloody. Objective : This study aimed to evaluate use in pediatric patiens with diarrea at Hospital X, Semarang Regency, in 2023. Methods: This was a retrospective study uutilizing medical records of 323 pediatric patiens who met the inclusion and exclusion criteria. Data analysis was performed using the Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) methodology. Result:The analysis revealed that Ceftriaxone injection was the most frequently used antibiotic (61.95%), followed by Ampicillin, Amikacin, Gentamicin, and Cefotaxime. Ceftriaxone was often prefered due to its efficacy against both gram-positive and gram-negative bacteria comonly associated with pediatric diarrhea, as well as the advantage of accurate dosing trough injectable formulations. Most diarrhea cases occurred in boys (62.54%) and in children under five years of age (65.63%). Conclusion:Injectable formulations were chosen to reduce the risk of vomiting and to facilitate precise and effective dosing. Evaluation using the ATX/DDD method highlighted the need for more rational antibiotic management to prevent bacterial resistance in the future. Optimizing antibiotic stewardship is crucial to ensure targeted in the future. Optimizing antibiotic stewardship is crucial to ensure targeted, effective use and to preserve therapeutic efficacy in the long term. 
Activity Test of Daun Jati Belanda (Guazuma ulmifolia Lamk.) on Lymphocyte Proliferation and Immunoglobulin G Expressionas an Immunostimulatory Agent Sihombing, Yanna Rotua; Fitri Siska
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/7mw45p98

Abstract

Background: Infections that attack the immune system have become a major global health issue, including in Indonesia. In 2019, the emergence of Coronavirus created an urgent need for immediate therapy, followed by increased attention to other diseases such as tuberculosis (TB), PCP pneumonia (Pneumocystis jirovecii), candidiasis, and toxoplasmosis. If left untreated, infections can damage tissues and organs. Although immune-boosting drugs are available in healthcare settings, their side effects and potential drug interactions highlight the need for complementary therapies derived from natural ingredients. Indonesia’s biodiversity offers great potential for the development of natural immunostimulants. One such plant is Jati Belanda (Guazuma ulmifolia Lamk.), which is widely found in Deli Serdang, North Sumatra. Empirically, its leaves have been used to treat diarrhea, cough, abdominal pain, and as a tonic and astringent. Research has shown that Guazuma ulmifolia contains alkaloids, tannins, and flavonoids with antihyperlipidemic, antiviral, and anti-inflammatory properties, as well as potential immune-enhancing effects.Objective: This study aimed to analyze the immunostimulatory activity of Guazuma ulmifolia leaf extract on lymphocyte proliferation and IgG expression using male rats. Methods: The experimental method was applied, including a lymphocyte proliferation assay using the MTT method and serum IgG measurement using the ELISA technique. Results: The results showed that the extract significantly increased lymphocyte proliferation and IgG levels. The EC50 value of the extract (4.720 µg/mL) was comparable to that of Imboost (4.282 µg/mL), indicating similar effectiveness. Increased absorbance at various extract concentrations reflected enhanced cell proliferation. A dose of 400 mg/kg body weight effectively elevated IgG levels, strengthening the humoral immune response. The presence of flavonoids, tannins, and saponins is thought to play a role by activating B cells, promoting plasma cell differentiation, and modulating the NF-κB signaling pathway. Conclusion: Therefore, Guazuma ulmifolia leaf extract has potential as a natural immunostimulant that supports the body’s defense against pathogens.
Optimization of the Preventive Potential of Andaliman (Zanthoxylum acanthopodium DC) as a Natural Biofilter Against Cigarette SmokeExposure Through TNF-α Expression Situmorang, Novidawati Boru; Andy Febriady
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/d1tsbq73

Abstract

Background: Indonesia ranks third in the world for the highest smoking prevalence after China and India. Smokers often smoke both indoors and outdoors, exposing others to harmful cigarette smoke. Cigarette smoke can trigger oxidative stress, which induces the release of pro-inflammatory cytokines such as Tumor Necrosis Factor (TNF-α). Objective: This study aimed to analyze the optimization of andaliman (Zanthoxylum acanthopodium DC) as a natural biofilter against cigarette smoke exposure through TNF-α expression as a potential preventive measure. Methods: An experimental method was used by measuring TNF-α expression in serum isolated from mice blood using the Enzyme-Linked Immunosorbent Assay (ELISA) technique. Results: TNF-α levels measured by ELISA showed that andaliman extract at doses of 50–400 mg/kg body weight significantly reduced TNF-α levels in mice exposed to cigarette smoke compared to the negative control group (p < 0.05). This reduction is likely related to the presence of flavonoids and alkaloids in andaliman, which act as antioxidants and immunomodulators that inhibit inflammatory pathways triggered by oxidative stress from cigarette smoke. With its anti-inflammatory potential, andaliman can be developed as an eco-friendly natural biofilter to prevent the harmful effects of cigarette smoke, although further studies are needed regarding its optimal dosage and long-term safety. Conclusion: Andaliman extract (Zanthoxylum acanthopodium DC) effectively reduced TNF-α levels in mice exposed to cigarette smoke, demonstrating anti-inflammatory potential as a natural biofilter. Its flavonoid and alkaloid content act as antioxidants and immunomodulators that suppress inflammatory pathways induced by cigarette smoke toxins. Andaliman shows promise as an environmentally friendly natural preventive agent to mitigate the negative impacts of cigarette smoke exposure.
Innovation of Banana Blossom Herbal Tea in Enhancing Interleukin-1 and Interleukin-2 Levels as an Immunomodulatory Approach for Cancer Prevention HARAHAP, SUSILAWATI; Siska Futri Nasution
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/cts2c934

Abstract

Background: Cancer remains one of the foremost causes of mortality worldwide, including in Indonesia. Its steadily increasing prevalence has positioned cancer as a critical global health challenge and a major focus of international public health initiatives. Pathologically, cancer is characterized by the uncontrolled and progressive proliferation of abnormal cells, ultimately impairing immune system function. Phytochemical profiling of the banana blossom has revealed the presence of bioactive compounds, including alkaloids, phenolic steroids such as β-sitosterol, saponins, as well as flavonoids such as quercetin, tannins, anthraquinones, and terpenoids. Flavonoids and phenolic compounds within the banana blossom demonstrate potential immunoenhancing properties, exhibit antioxidant activity against free radicals, and function as immunomodulatory agents with prospective applications in cancer prevention. Purpose: This study aimed to evaluate the immunomodulatory and anticancer potential of banana blossom extract through IL-1 and IL-2 regulation using male rats as experimental models, assessed through ELISA. Research method: An experimental design was employed, encompassing the preparation of the herbal tea, metabolite profiling, and measurement of IL-1 and IL-2 levels in serum isolated from the blood of rats administered the banana blossom herbal tea. Results: A significant increase in IL-1 and IL-2 levels was observed following treatment with banana blossom herbal tea and quercetin in both experimental groups compared with the negative control group. Administration of the extract at a dose of 400 mg/kg BW, as well as quercetin, demonstrated higher immunostimulatory activity compared with levamisole as the positive control. Conclusion: Banana blossom herbal tea exhibits immunomodulatory activity through an immunostimulatory mechanism and possesses potential for development as a therapeutic agent in cancer prevention.

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