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All Journal Jurnal Ilmiah Farmasi Pharmaciana: Jurnal Kefarmasian Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Farmasains : Jurnal Ilmiah Ilmu Kefarmasian JURNAL EDUCATION AND DEVELOPMENT Jurnal Ilmu Kefarmasian Indonesia JURNAL FARMASIMED (JFM) Jurnal Kefarmasian AKFARINDO JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Media Farmasi Indonesia

Endang Darmawan

Unknown Affiliation

Author-ID : 259649

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Social Sciences Other

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GAMBARAN KADAR NITRIC OXIDE (NO) PADA MASYARAKAT YOGYAKARTA Agustina Susilowati; Akrom; Endang Darmawan
Jurnal Kefarmasian Akfarindo Vol 1 No 1 (2016)
Publisher : Akademi Farmasi Indonesia Yogyakarta

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Latar Belakang: Senyawa Nitric Oxide (NO) merupakan salah satu senyawa penting bagi tubuh.Nitric oxide merupakan faktor relaksan untuk pembuluh darah. Dalam jumlah wajar senyawa NO juga memegang peran fisiologis penting pada proses signaling dalam sel dan mengontrol inflamasi, namun dalam jumlah yang berlebihan NO bersifat oksidatif reaktif, genotoksik dan destrukstif bagi sel manusia maka dari itu perlu dilakukan penelitian mengenai gambaran kadar NO pada manusia.Tujuan: Mengetahui kadar NO pada masyarakat Yogyakarta bedasarkan jenis kelamin dan umur.Methode: Penelitian ini menggunakan desain penelitian cross-sectional. Subjek penelitian berjumlah 44 orang yang terdiri dari 11 laki-laki dan 33 perempuan yang tinggal di Yogyakarta. Sejumlah 44 responden yang telah memenuhi kriteria inklusi dan bersedia mengisi inform consent kemudian dilakukan pemeriksaan kadar NO plasma menggunakan metode ELISA. Hasil penelitian akan disajikan dalam bentuk deskriptif dan analisa statistika dengan taraf kepercayaan 95%.Hasil: Hasil penelitian analisa data berdasarkan jenis kelamin menunjukan bahwa kadar rata-rata NOpada responden laki-laki lebih tinggi dibandingkan perempuan. Kadar rata-rata NO responden laki-laki yaitu 21,58Â± Âµmol/L sedangkan responden perempuan yaitu 16,63Â± Âµmol/L. Namun berdasarkan analisa statistik ANOVA didapatkan nilai p=0,068 (p>0,05) yang berarti tidak terdapat perbedaan yang bermakna antara kadar NO plasma pada laki-laki dan perempuan. Analisa data kadar rata-rata NO berdasarkan umur menunjukan bahwa responden umur < 25th lebih rendah dari pada yang berumur >25th. Responden yang berumur <25th memiliki kadar NO 17,18Â± Âµmol/L sedangkan yang berumur >25th yaitu 21,51Â± Âµmol/L. Namun berdasarkan analisa statistik ANOVA didapatkan nilai p=0,181(p>0,05) yang berarti tidak terdapat perbedaan yang bermakna antara kadar NO plasma yang berumur <25th dan >25th.Kesimpulan: Berdasarkan jenis kelamin kadar rata-rata NO masyarakat Yogyakarta untuk laki-laki yaitu 21,58Â± Âµmol/L dan perempuan yaitu 16,63Â± Âµmol/L. Berdasarkan umur kadar rata-rata NO masyarakat Yogyakarta untuk berumur <25th yaitu 17,18Â± 1,31 Âµmol/L dan >25th yaitu 21,51Â± 2,21Âµmol/L.

AKTIVITAS ANTHELMINTIKA EKSTRAK ETANOL DAN EKSTRAK KLOROFORM RIMPANG BENGLE (Zingiber purpureum Roxb.) TERHADAP CACING Ascaridia galli Schrank SECARA IN VITRO BESERTA PROFIL KROMATOGRAFI LAPIS TIPIS Intan Permata Dewi; Wiharni Wiharni; C.J. Soegihardjo; Endang Darmawan
Jurnal Ilmiah Farmasi Vol. 2 No. 2 (2005)
Publisher : Universitas Islam Indonesia

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ABSTRACTPurple ginger (Zingiber Purpureum Roxb.) could be use as therapy for ascariasis. Theanthelmintic activity test by in vitro has been tested to get the validity of the effect. The maincomponents of the test is powder of purple ginger rhizoma which had been extracted bypercolation method with ethanol and maseration method with kloroform. Anthelmintic test had beendone by immersion method. The Ascaridia galli Schrank was soak in natrium chloride 0,9 %,pyrantel 0,125 %, extract ethanol 0,702 %, 1,404 %, 2,808 %, 5,616 % and exstract kloroform0,644 %, 1,288 %, 2,576 %, 5,152 %. From the test it could be concluded that the extract has theanthelmintic effect. The result evolution had been done by one way ANOVA method (P

HUBUNGAN JUMLAH OBAT YANG DIRESEPKAN DENGAN POTENSIAL PENGGUNAAN OBAT YANG TIDAK TEPAT PADA PASIEN PENYAKIT GINJAL KRONIS DI RS PKU MUHAMMADIYAH YOGYAKARTA Evi Mulyani; Endang Darmawan; Mustofa Mustofa
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Age-related decrease of physiological function caused some healt problem in elderly, so the problem of treatment in the elderly is also not uncommon found as polypharmacy and Potentially Inappropriate medication (PIMs). The purpose of this study to determine the relationship of the number of drug prescribed with PIMs in elderly patients with CKD in PKU Muhammadiyah Yogyakarta Hospital. PIMs identification by STOPP criteria, while the number of drugs prescribed seen by drugs control books. To assess the patient's medical history by interviews and search records. Patient characteristics were analyzed descriptively, correlations between variables were analyzed with chi square test. From 53 samples, PIMs identified 17% and average one sample got one PIMs, while of the 410 drugs that prescribed average patient receivingÂ 8 drugs (> 6). Bivariate test results showed that no significant relationship between the number of drug prescribed with PIMs.

PENGARUH KITOSAN DARI CANGKANG UDANG TERHADAP RED BLOOD CELL, HEMOGLOBIN, DAN TROMBOSIT PADA MODEL RHEUMATOID ARTHRITIS YANG DIINDUKSI CFA Suyandra Sah Putra; Endang Darmawan
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The research was conducted the effect of chitosan on rats blood alteration that induced arthtritis. In addition, the research used pre-post test group control design. than used Â was divided into groups (n=6) including normal groups, positive control, negatif control, and Â groups were treated byÂ khitosan at varian 50 mg/200gBB and 100 mg/200gBB doses. Adjuvant-induced was developed using complete Freundâ€™s Adjuvant on 1st day, than 17-47th days after treated given appropriate their groups. To evaluate did blodd counter on 0, 16th,and 47th days after treated with otomatic optic dan electronic resisten method. Than analyzed using ANOVA test and paired t-test (p<0,05). Result of the research is Chitosan 50 mg/200gBW fit to reduce of eritrocid 6,1% (p<0,05), hemoglobin 7,77% (p<0,05) and PLCR 35,29% (p<0,05), meanwhile of Chitosan 100 mg/200gBW fit to reduce of trombocyte 40,49% (p>0,05) and PLCR 35,66% (p<0,05). In additional research, khitosan 50 mg/200gBW fit to complete blood of the rheumatoid arthritic mouse well.

PENGGUNAAN POTENTIALLY INAPPROPRIATE MEDICATIONS (PIMs) PADA PASIEN GERIATRI RAWAT INAP OSTEOARTHRITIS DI RS PKU MUHAMMADIYAH YOGYAKARTA Andi Namirah Muh. Syuaib AS; Endang Darmawan; Mustofa Mustofa
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Potentially inappropriate medications (PIMs) use among elderly is a serious public health problem because it is intrinsically linked to increased morbidity, mortality, and healthcare costs. This studyÂ aims to determine the association between number of drug prescribed, duration of hospital stay and PIMs use among elderly hospitalized patients at PKU Muhammadiyah Yogyakarta General Hospital. This study was analytic observational with cross-sectional study. Beers criteria 2012 were used to identify PIMs use among elderly hospitalized patients with osteoarthritis. Logistic regression analysis were used to determine association between number drugs of prescribed, duration of hospital stay and PIMs use. The results showed that 7 (38.9%) out of 18 hospitalized elderly patients were identified PIMs use and all of patients received atleast one PIM. The most common agents involved in PIMs were estazolam (11.1%), and metoclopramide (11.1%). Polypharmacy is a major predictor factor of PIMs use in this study.

Factors relate to the hypercreatininemia event of patients at the risk of metabolic syndrome in Jetis I public health center Akrom Akrom; Endang Darmawan; Nuril Maulida
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Metabolic syndrome (MS) is a risk factor for chronic kidney disease (CKD). Adherence to drug therapy is one of the keys to achieving therapeutic targets in MS. Hyperuricemia (>7mg/dL in men &>5.4mg/dL in women) and hypercreatininemia (>1.3 mg/dL) is a sign of kidney function deficiency. Kidney function deficiency is the result of uncontrolled blood pressure and blood sugar levels in MS patients. The objective of the study was to know the description of the incidence of hypercreatininemia and factors related to the incidence of hypercreatininemia in outpatientÂ at risk of Â MS at Jetis Public health center (PHC) I, Bantul, Yogyakarta. The analytical observational research with cross sectional design was performed on 99 MS outpatient at Jetis I Public Health Center (PHC) who fulfilled the inclusion criteria and approved the participation in the study. Blood urea and creatinine levels were determined by spectrophotometer 5010. Demographic, diagnosis and treatment data were colleccted Â from medical record. Patient adherence data were collected by interview. Patient compliance was measured by a medication compliance questionnaire. Demographic and clinical Â data are presented descriptively. Bivariate analysis with chisquare was performed to determine the value of the relationship between sex, age, hyperuricemia and adherence to the incidence of hypercreatininemia. Â About 30.3% of total of outpatients at risk of MS at Jetis I PHC, Bantul, is non-adherence and 69.7% is adherence to the treatment. As many as 44.4% of respondents have hypercreatininemia and 8.1% of respondents have hyperuricemia. There was a relationship between adherence and female sex with the prevalence of hypercreatininemia with an odds ratio of 3.8, 0.26 and 7.1 respectively. Based on the data of the study concluded that non-adherence, male sex and hyperuricemia are associated with the prevalence of hypercreatininemia in patients at risk of MS in Jetis I PHC.

PENINGKATAN SISTEM IMUN OLEH KOMBINASI EKSTRAK ETANOL DAUN AWAR â€“ AWAR (Ficus septica burm. F) DAN EKSTRAK ETANOL DAUN KELOR (Moringa oleifera) SEBAGAI KO-KEMOTERAPI KANKER PADA TIKUS PUTIH BETINA GALUR SPRAGUE DAWLEY YANG DIINDUKSI DOKSORUBISIN Rizka Angerti Anovia; Dewi Indah Sari; Annisa Hardikasari Yazin; Ulfa Ismayani; Endang Darmawan
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Use of the drug doxorubicin for cancer therapy causes decreasing of immune system reported. Leaves of Ficus septica Burm. F and leaves of Moringa oleifera as immunostimulatory agents. The purpose of this study, among others, determine the combined effects of ethanol extract of Ficus septica Burm. F leaves and ethanol extract of Moringa oleifera leaves as co-chemotherapy for in female rats Sprague Dawley strain induced doxorubicin. Eighteen Sprague Dawley rats were divided into six treatment groups, normal group was given 0.9% NaCl 10ml / kgBB, positive control group were given by doxorubicin with dose of 4.67 mg / kgBB, single-dose treatment group were each given ethanol extract of Ficus septica Burm F leaves dose of 750 mg / kgBB and ethanol extract of Moringa oleifera leaves 500 mg / kgBB, treatment groups were given by combination of ethanol extract Ficus septica Burm. F leaves and Moringa oleifera leaves with a dose of 1.25 g / kgBB and a dose of 1 , 75 g / kgBB. treatment carried out for 7 days. On days 1 and 4 of each treatment groups except the normal group induced by doxorubicin 4.67 mg / kgBB intramuscularly. Blood sampling performed on day 0 and 7 th for lymphocytes CD3+ and lymphocytes CD8+ test. The results showed that the combination of ethanol extract Ficus septica burm. F leaves and Moringa oleifera leaves dose of 1.25 g / kgBB and the dose of 1.75 g / kgBB can enhanched immune system relative small which was not statistically significantly different (p> 0.05). However, a single dose of ethanol extract Moringa oleifera leaves dose of 500 mg/kg have immunostimulatory activity as lymphocytes CD3+ and lymphocytes CD8+ were more effective than a single dose of ethanol extract of Ficus septica Burm. F leaves dose of 750 mg/kgBB.

EFEK ANTI INFLAMASI KITOSAN DARI CANGKANG UDANG PANTAI TRISIK PADA TIKUS MODEL RHEUMATOID ARTHRITIS Nurul Hanifah; Endang Darmawan
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

This research was conducted to investigate the effect of chitosan as anti-inflammatory in rheumatoid arthritic in reduction of paw edema using plethysmometer. Chitosan was isolated from the shrimp shell on the Trisik Coastal were administered orally on 17-32th day with CMC 0,5%. This research using repeated measure design. To evaluate anti-inflammatory effect of the suspension, an arthritic rats model was developed using Complete Freund`s Adjuvant (CFA) on 1-16th day. In addition, the research was divided into 5 groups (n=6) including normal control groups, positive control groups, negative control groups, 1 group were treated by chitosan suspension at 50 mg/200 gram BW doses and the other group were treated by chitosan suspension at 100 mg/200 gram BW doses. The reduction of paw edema were determined every 3 day after 17th days then analyzed using general linear repeated measure test (p<0,05). The results showed that paw edema of arthritic rats were evidently decreased by chitosan suspension at 100 mg/200 gram BW doses (142,66%) better than chitosan suspensionÂ at 50 mg/200 gram BW doses (117,23%). In conclusion, the chitosan from shrimp shell of Trisik coastal is found to be effective as anti-inflammatory in rheumatoid arthritic rats model.

Evaluasi Kesesuaian Pemberian Antibiotik Empiris Terhadap Antibiogram dan Luaran Klinis pada Pasien Pneumonia Dewasa Mujiyanti Mujiyanti; Dyah Aryani P.; Endang Darmawan; Irma Risdiana
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 1 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i1.920

The mortality rate for Community-Acquired Pneumonia (CAP) in Indonesia is in the fourth rankand the top ten diseases each year. The main therapeutic principle of CAP is the administration of antibiotics.Improper antibiotic usage can aff ect the success of therapy. The pattern of antibiotics used in hospitals is usually based on clinical and empirical experience, not based on the germ pattern and the sensitivity of antibiotics. The study aims to describe the suitability of empiric antibiotics against the antibiogram profi le and treatment outcomes in inpatients with CAP at PKU Muhammadiyah Gamping Hospital. This study was conducted under the descriptive-analytic observational study design with a retrospective cohort design where the data source came from secondary data, namely the medical records of community pneumonia patients in 2019 and hospital antibiogram data. The data were collected by using the total sampling method. There were 79 community pneumonia patients. The results of the empirical antibiotic suitability test results on antibiograms and clinical outcomes showed that there was no signifi cant relationship between the suitability of empirical antibiotics to the clinical outcome of leukocytes (p = 0.550; RR = 0.725; 95% CI = 0.252-2.086), clinical outcome temperature (p= 0.545; RR = 0.576; 95% CI = 0.049-6.747) and clinical outcome length of stay (p = 0.631; RR = 0.767; CI95= 0.258-2.275). The conclutions there was no signifi cant relationship between the appropriateness of empirical using of antibiotics and antibiogram profi le include leukocyte, temperature and length of stay of the patients (p>0.05).

EVALUASI IMPLEMENTASI PELAYANAN KONSELING OBAT DI APOTEK KOTA YOGYAKARTA farida baroroh; endang darmawan
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 3 No. 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

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Therefore, it is important to give counseling for patients and their family. This study is to evaluate the counseling service implementation at several pharmacy in Yogyakarta Indonesia. This study was a cross-sectional design. The result showed that the implementation counseling service at pharmacy was 59,00% of 96,00% patients who required counseling service. The several pharmacy patient were out-patient who responsible to their therapeutical management. There was 55,93% patients experienced that the room for counseling service was comfortable. So, the communication aspects of counseling service at pharmacy in Yogyakarta had been well conducted. Based on the communication technique, the pharmacist communicated with body language such as practicing how to use the drug in counseling services was 64.41%. In conlusion, the implementation counseling service at pharmacy in Yogyakarta Indonesia was 59,00% of 96,00% patients who required counseling service. A number of 94.83% of patients stated that pharmacists use an understandable language in counseling services. It can be concluded that although only 58.59% of respondents who had received counseling but the desire to get counseling services of pharmacy in Yogyakarta is very high, reaching 95.96% of respondents

Co-Authors Abas, Siti Nur Rahmatiya Agustina Susilowati Akrom Akrom Akrom, Akrom Aminuyati Andi Namirah Muh. Syuaib AS Annisa Hardikasari Yazin C.J. Soegihardjo Candra, Novita Diana Ayu Dewi Indah Sari Dyah Aryani P. Dzulhaifa Dzulhaifa Evi Mulyani Farida Baroroh Haafizah Dania Hafni Nur Insan Iin Narwanti Intan Permata Dewi Ira Aprilia Wulandari Irma Risdiana Lolita Mujiyanti Mujiyanti Nia Kurniasih Nur Muhammad Herunda Putra Nuril Maulida Nurul Hanifah Puji Asmini Ria Putri Salma Rizka Angerti Anovia Siti Fatmawati Fatimah, Siti Fatmawati Sugiyarto Surono Suyandra Sah Putra Ulfa Ismayani Wiharni Wiharni Woro Supadmi

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