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JURNAL FARMASIMED (JFM)
Published by Institut Kesehatan Medistra Lubuk Pakam
ISSN : -     EISSN : 26550814     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal FARMASIMED (JFM) Volume I Nomor 1 Periode Mei - Oktober Tahun 2018. Jurnal ini memberikan ruang bagi akademisi, peneliti dan pengguna hasil penelitian dan pengabdian untuk mendiseminasikan, menginformasikan, mendiskusikan dan menggunakan hasil penelitian dan pengabdian sebagai upaya meningkatkan kualitas kebijakan di bidang farmasi yang berbasis ilmiah dan dapat dipertanggung jawabkan. Jurnal ini menyajikan hasil penelitian, pengabdian masyarakat serta artikel ilmiah di bidang farmasi.
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Articles 58 Documents
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Search results for , issue "Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)" : 58 Documents clear
Evaluation of The Chloroquine and Resveratrol Combination in Inhibiting β-Hematin Formation In Vitro Hermanto, Faizal; Wahyuningsih, Sri; Zamzami Adnan, Risky
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jxpeda42

Abstract

Malaria, caused by the Plasmodium parasite, remains a significant global health issue, exacerbated by drug resistance. This study aimed to explore the potential of combining chloroquine (CQ) and resveratrol in inhibiting β-hematin formation, a key process in the parasite's detoxification mechanism. The research began with the preparation of various concentrations of CQ and resveratrol, which were then combined and tested for their effects on inhibiting β-hematin in vitro using an ELISA reader. The results showed that both CQ and resveratrol individually inhibited β-hematin formation at moderate levels. However, their combination demonstrated a significant increase in inhibition, with the most effective combination being CQ at 164.03 μM and resveratrol at 0.98 μM. Statistical analysis confirmed that this combination was far more effective than using each compound separately. The study concluded that the combination of CQ and resveratrol can enhance the inhibition of β-hematin formation, providing a promising approach to improving malaria treatment efficacy, especially in the face of increasing drug resistance.
Formulation and Evaluation of Feminine Hygiene Preparation from Lemongrass (Cymbopogon nardus) and Its Inhibitory Activity Against Candida albicans rani, Yosi Darmirani; Fitri Siska
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/a4bs3k68

Abstract

Background: Fungal infections are a common health problem in tropical countries, including Indonesia, where the hot and humid climate favors the growth of pathogenic microorganisms. One of the fungi that frequently causes infections in women is Candida albicans, the main agent responsible for vaginal discharge. Synthetic antibacterial and antifungal compounds often cause side effects, adverse events, relatively high costs, and the risk of fungal resistance due to excessive use. This situation has encouraged people to return to natural ingredients (“back to nature”) as safer, more effective, and more economical alternatives. One plant with strong potential as a natural antifungal agent is citronella (Cymbopogon nardus). This plant is widely known as a cooking spice, massage oil ingredient, and traditional herbal remedy, and it is abundantly available in the Hutaginjang area, North Tapanuli Regency. Objective: This study aimed to formulate and evaluate a feminine hygiene preparation containing citronella extract and to test its antifungal activity against Candida albicans. Method: The research was conducted experimentally. Results: The results showed that all formulations met the physical property standards set by SNI, with viscosity ranging from 2000–50,000 cps and pH between 4.0–5.0, which is suitable for the vaginal area. Antifungal testing revealed that inhibition zones increased with higher extract concentrations—10%, 15%, and 20% extracts produced inhibition zones of 10.5 mm, 13.3 mm, and 17.1 mm, respectively. The 60% extract yielded a 22.5 mm inhibition zone (categorized as very strong), approaching that of the positive control ketoconazole (29.1 mm). Statistical analysis (Shapiro-Wilk, ANOVA, Tukey HSD, Duncan) indicated that the data were normal, homogeneous, and showed significant differences between treatments. Conclusion: It can be concluded that higher concentrations of citronella extract are more effective in inhibiting the growth of Candida albicans.
Formulation and Evaluation of Nanogel from Tubifex  Worms (Tubifex  sp.) as a Future Therapeutic Agent for Burn Wounds Syarifuddin, Aminah; Cucu Arum Dwi Cahya
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/p1z1pm37

Abstract

Background: Burns are one of the most common types of injuries found in the community. Burn treatment tends to be relatively expensive, which often leads to suboptimal care and prolonged healing time. Therefore, innovation in pharmaceutical formulations that are more effective, affordable, and based on natural ingredients is needed. One of the widely used dosage forms is semisolid gel, as it is practical, non-sticky, and comfortable to use. Currently, nanogel development has attracted significant attention because it can enhance the absorption of active compounds, provide more controlled drug release, and reduce toxicity. Indonesia, with its rich biodiversity, has great potential for the exploration of natural materials, including the aquatic worm Tubifex sp. Objective: This study aimed to formulate and evaluate Tubifex sp.-based nanogel as a therapeutic agent for burn wounds. Methods: The study employed an experimental method, including physical stability tests of the nanogel and in vivo tests on male white rats with controlled burn injuries. Results: The results showed that all treatment groups experienced progressive wound diameter reduction over 14 days. The negative control showed only 36.6% healing, while the positive control reached 90%. The Tubifex sp. nanogel demonstrated promising results, with formula F1 (3.75%) and F2 (7.5%) achieving 80–86.6% healing, while formula F3 (15%) reached 93.3%, even surpassing the positive control. The effectiveness of the nanogel is believed to be related to the protein, collagen, and antioxidant content in Tubifex sp., which play important roles in tissue regeneration.Conclusion: Tubifex sp. nanogel has the potential to become an innovative, natural-based therapy for burn treatment in the future.
Processing of Rice Straw (Oryza sativa) into Activated Carbon and Its Formulation in Facial Cleansing Soap Products Tampubolon, Regina Elianda; Wulandari, Suci; Sinurat, Jhon Patar; Br Karo, Reh Malem
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/cpmerg17

Abstract

Rice straw is an abundant agricultural by-product commonly used as livestock feed or burned as waste. It contains cellulose, hemicellulose, lignin, and silica, which can be processed into activated carbon capable of adsorbing impurities and excess oil from the skin. To date, the utilization of rice straw has been limited mainly to compost fertilizer and planting media. Meanwhile, facial cleansing soaps made from natural extracts, eco-friendly ingredients, and affordable materials are increasingly popular. The objective of this study was to produce activated carbon from rice straw and apply it in the formulation of a facial cleansing soap product.This research employed an experimental laboratory approach with a quantitative descriptive method to determine the effectiveness of rice straw–based activated carbon in facial soap formulations. The procedure began with the carbonization of rice straw powder, followed by characterization of the activated carbon through moisture content analysis, ash content test, and FT-IR functional group analysis. The liquid soap was formulated into three variations and evaluated for its quality through organoleptic observation, pH measurement, cleansing ability test, and oil adsorption test.The results showed that activated carbon derived from rice straw had a moisture content of 8.92%, ash content of 7.68%, and exhibited functional groups such as –OH, aliphatic C–H, aromatic C=C, aldehyde C=O, and alcohol C–O based on FT-IR analysis. The facial soap formulations containing rice straw–based activated carbon demonstrated safe pH values—F1 = 5.46, F2 = 6.04, and F3 = 6.8—and exhibited enhanced cleansing and oil-adsorbing properties, with the highest oil adsorption value reaching 86%. These findings indicate that activated carbon from rice straw can be effectively applied in the formulation of facial cleansing soap that is safe and beneficial for skin health.
Development of Molecularly Imprinted Polymer Materials as Selective Recognition Elements for Electrochemical Meropenem Sensors Herlina, Herlina; Ritonga, Ahmad Hafizullah; Andy Febriady; Asvia Rahayu; Sinaga, Naomi Geraldin
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/j884sv81

Abstract

The rising prevalence of bacterial resistance to carbapenem antibiotics, particularly meropenem, highlights the urgent need for rapid, selective, and efficient detection methods. This study reports the synthesis of molecularly imprinted polymers (MIPs) based on methyl methacrylate (MMA) as selective recognition elements for electrochemical meropenem sensors. Bulk polymerization was employed using MMA as the functional monomer, ethylene glycol dimethacrylate (EGDMA) as the crosslinker, dimethyl sulfoxide (DMSO) as the porogen, and benzoyl peroxide (BPO) as the initiator. Both non-imprinted polymers (NIPs) and molecularly imprinted polymers (MIPs) were prepared, followed by template extraction through sequential washing with acetonitrile, methanol–acetic acid, and methanol–deionized water to generate specific recognition cavities. Characterization using Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM) confirmed the success of molecular imprinting, as evidenced by the disappearance of characteristic meropenem bands and the formation of porous cavities in the MIP. Adsorption studies revealed that the MIP exhibited a higher adsorption capacity (8.9940 mg/g) compared to the NIP (3.9904 mg/g), yielding an imprinting factor (IF) of 2.25. Selectivity testing against the competing analyte amoxicillin produced a selectivity coefficient (α) of 1.06, indicating preferential binding toward meropenem despite modest discrimination. These results demonstrate that MMA–EGDMA-based MIPs possess promising potential as selective recognition elements for electrochemical meropenem sensors. The developed material not only contributes to the advancement of functional polymer research but also offers practical opportunities for real-time monitoring of antibiotic levels in clinical and environmental samples.
Combination of Essential Oils of Ylang-Ylang (Cananga Odorata), Jasmine (Jasminum Sambac), and Mint Leaves (Mentha Piperita) TestingAphrodisiac on Male Mice Formulated in Candle Forms marpaung, Tio Widia A.; Kintoko; Wahyu Widyaningsih; Moch Saiful Bachri; Amelia Regina Arsyad
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/7q01y176

Abstract

This study explored the potential of Jasminum sambac (jasmine) and Mentha piperita (peppermint) as natural sexual stimulants (aphrodisiacs) to enhance sexual activity in males and females through the use of essential oils. The main objective was to identify the most effective combination of essential oil formulations, which were evaluated through several biological and physiological parameters, including sexual behavior in mice, sperm quality, testicular histopathology, and wax-based formulations as the delivery medium. Three formulations were tested: P1 (3:1:1), P2 (1:3:1), and P3 (1:1:3), administered to mice using a humidifier via inhalation. Sexual behavior was assessed through mounting latency and mounting frequency as indicators of libido. Sperm quality parameters included morphology, motility, viability, and sperm count. Testicular histopathology was examined to evaluate tissue structure and spermatogenesis activity. The results demonstrated that the P1 formulation was the most effective, showing the highest aphrodisiac activity. In the sexual behavior test, P1 recorded an activity value of 21±6.2, indicating enhanced libido. Sperm quality testing also confirmed the superiority of P1, with the lowest sperm abnormalities (5.3±1.53), highest motility (82±7.5), highest viability (85.6±4.58), and the greatest sperm count (53,300±16,653.3). Although testicular histopathology revealed a slight reduction in spermatogenic cells across all treatment groups, the change was not significant in the P1 group compared to the control. Overall, the P1 formulation improved libido and sperm quality more effectively than P3 and the control group, indicating its potential to be developed as an aphrodisiac preparation based on natural essential oils.
Formulation of Emollient Preparation from Rose Essential Oil (Rosa Damascena) Combined with Vanilla Essential Oil (Vanilla Planifolia)in Increasing Body Weight in Baby Rats (Rattus Norvegicus) arsyad, regina; Kintoko; Wahyu Widyaningsih; Tio Widia Astuti Marpaung
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/80n03c83

Abstract

Rose and vanilla essential oils have potential as natural active ingredients in emollient formulations due to their moisturizing and aromatherapeutic relaxation effects. This study aimed to formulate an aromatherapy emollient with four variations in the composition of rose and vanilla essential oils: F1 (0.1 mL:0.4 mL), F2 (0.2 mL:0.3 mL), F3 (0.3 mL:0.2 mL), and F4 (0.4 mL:0.1 mL). Each formula contained a total of 0.5 mL essential oil dissolved in 100 mL sunflower seed oil as the base. Organoleptic evaluation showed that all formulas had a yellowish-white color and liquid texture. The resulting aromas differed among formulas: F1 produced a woody scent, F2 and F3 had an oriental woody fragrance, while F4 exhibited a dominant rose aroma. The pH values ranged from 5.12 to 6.00, which is within the normal skin range. Viscosity values were between 4.92–5.30 cPs, specific gravity ranged from 1.0181–1.0682, and refractive indices were 1.470–1.471, indicating good physical stability. Hedonic testing revealed that Formula F2 was the most preferred by panelists in terms of aroma, texture, and after-feel on the skin. Skin irritation tests on rabbits showed no negative reactions, confirming the formulation’s safety for topical use. Biological activity tests on infant mice demonstrated significant increases in body weight and length compared to the control group. Based on overall results, Formula F2 (0.2 mL rose oil and 0.3 mL vanilla oil) was determined to be the best formulation, offering a balanced aroma, good physical stability, and optimal emollient and relaxation effects.
Antihyperglycemic Effectiveness Test of 96% Ethanol Extract of Nutmeg (Myristica fragrans Houtt.) Stem Bark in Streptozotocin-Induced Mus musculus Nurfitria Junita; Nirwana Putri Mastur
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/yysjpg86

Abstract

Background: Diabetes mellitus (DM) is a metabolic disorder characterized by an increase in blood glucose levels. The bark of nutmeg (Myristica fragrans Houtt.) is known to have antihyperglycemic potential because it contains bioactive compounds such as flavonoids, alkaloids, tannins, and saponins. The nutmeg plant has benefits as an antidiabetic, antifungal, and antibacterial agent. Objective: This study aimed to evaluate the effectiveness of 96% ethanol extract of nutmeg bark as a blood glucose-lowering agent in male mice (Mus musculus) induced with streptozotocin. Method: This experimental research was conducted on 25 mice using a randomized design, divided into five groups of five mice each. The material was extracted using the maceration method with 95% ethanol. Results: Diabetes in mice was induced with streptozotocin at a dose of 40 mg/kg BW. Group I received 1% Na-CMC (negative control), Group II received glibenclamide (positive control), and Groups III–V received ethanol extract of nutmeg bark at doses of 50, 100, and 200 mg/kg BW, which reduced glucose levels by 11.3%, 12.7%, and 13.9%, respectively. One Way ANOVA analysis showed a p value < 0.05, indicating a significant difference in blood glucose reduction among the concentrations of 96% ethanol extract of nutmeg bark. Conclusion: The 96% ethanol extract of nutmeg bark has been proven to have an antihyperglycemic effect, with the most effective dose at 200 mg/kg BW.Bottom of Form.
The Effect Of Cocoa Cream (Theobroma Cacao L) Administration On Breast Engorgement In Primigravida Postpartum Mothers HARYONO, NATHASIA; Sri Putriani Sinaga; Fiyola Ladyvia; Ismah Khaerunisa
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/9rk55z42

Abstract

Breast engorgement is a common problem among postpartum mothers, especially primigravida, which can cause pain, swelling, and hinder the breastfeeding process. Conventional management such as warm compresses often provides only temporary relief, thus alternative therapies that are more effective and natural are needed. Cocoa (Theobroma cacao L.) contains flavonoids, polyphenols, and cocoa butter with anti-inflammatory, antioxidant, and emollient properties. This study aimed to determine the effect of cocoa cream on reducing breast engorgement in primigravida postpartum mothers. This research employed a quasi-experimental design with a pretest-posttest control group approach. A total of 36 primigravida postpartum mothers were recruited and divided into two groups: the intervention group (cocoa cream) and the control group (warm compresses). Measurements were conducted on days 1, 3, 5, and 7 using breast circumference measurement and the Visual Analog Scale (VAS) for pain. Data were analyzed using Paired t-test and Independent t-test with a significance level of p<0.05. Independent t-test results showed no significant differences at pretest (p=0.674) and day 3 (p=0.068). However, significant differences were observed from day 5 (p=0.003) and became more pronounced on day 7 (p=0.000), with the intervention group demonstrating greater reduction in pain and swelling compared to the control group. Cocoa cream was more effective than warm compresses in reducing breast engorgement among primigravida postpartum mothers, particularly after the fifth day postpartum. Cocoa cream may be recommended as a safe, natural, and non-invasive complementary therapy to support successful breastfeeding.
Evaluation of Antidiabetic Potential (α-Glucosidase and α-Amylase Enzyme Inhibition Assay) of Mundu Leaf Extract [Garcinia dulcis (Roxb.) Kurz] Purba, Novandi; Br Turnip, Nur Ulina M.; Sinurat, Jhon Patar
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/nex3ag44

Abstract

Diabetes Mellitus (DM) is a chronic disease that requires appropriate solutions for its management. To date, synthetic antidiabetic drugs frequently cause side effects in the body. The search for natural antidiabetic agents has therefore been carried out by exploring the potential of mundu leaves, which are considered safer as they originate from natural sources. Mundu leaves contain flavonoids, phenols, and tannins, which may act as natural antidiabetic agents due to their richness in hydroxyl and aromatic compounds. Antioxidant compounds play a role in protecting body cells from oxidative stress, which is strongly associated with diabetes. Several species from the Garcinia genus have been studied, but to date, no research has focused on the antidiabetic potential of mundu leaves. Through assays of mundu leaf extract in inhibiting α-amylase and α-glucosidase enzymes, as well as antioxidant tests, DM could potentially be better controlled, providing a reference for its use as a natural antidiabetic and antioxidant agent. Mundu leaves were prepared and macerated using ethanol as a solvent, followed by evaporation with a rotary evaporator. Phytochemical screening was conducted to detect the presence of active compounds. The inhibitory activity of mundu leaf extract against α-glucosidase and α-amylase enzymes was measured using a UV-Visible spectrophotometer to obtain absorbance values. The absorbance data were then used to determine the percentage of inhibition, allowing the calculation of IC50 values as a benchmark for antidiabetic activity. The results demonstrated that the mundu leaf extract exhibited antidiabetic properties, with IC50 values of 51.058 ppm and 33.004 ppm, categorized as strong and very strong, respectively.

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