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Bioscientia Medicina : Journal of Biomedicine and Translational Research

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Published by Universitas Sriwijaya

ISSN : - EISSN : 25980580 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

BioScientia Medicina is an open access international scholarly journal in the field of biomedicine and translational research aimed to publish a high-quality scientific paper including original research papers, reviews, short communication, and technical notes. This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to medical sciences, Traditional Herb, genetics, immunology, environmental health, toxicology, bioinformatics and biotechnology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.

Arjuna Subject : Kedokteran - Anatomi

Articles 1,209 Documents

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Systemic Inflammatory Immune Index (SII) Predicts Disease Activity in Systemic Lupus Erythematosus (SLE) Patients: A Cross-Sectional Study Susanto, Edi; Yuniza; Legiran; Nova Kurniati; Eddy Mart Salim
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1237

Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by widespread inflammation and diverse clinical manifestations. The systemic inflammatory immune index (SII), calculated as platelet count * neutrophil count/lymphocyte count, has emerged as a potential marker of systemic inflammation in various conditions. This study aimed to investigate the relationship between SII and disease activity in SLE patients. Methods: We conducted a cross-sectional study involving 60 SLE patients diagnosed according to the 2019 EULAR/ACR classification criteria. Demographic and clinical data were collected, and disease activity was assessed using the Mexican Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI). Blood samples were analyzed to determine SII values. Statistical analysis included Spearman's correlation to assess the relationship between SII and MEX-SLEDAI scores. Results: The study population predominantly consisted of women (98.3%), with a median age of 29 years. A strong positive correlation was observed between SII and MEX-SLEDAI scores (r = 0.931, p < 0.001). Patients with higher SII values exhibited significantly greater disease activity. Conclusion: Our findings suggest that SII is a promising predictor of disease activity in SLE patients. This readily available index may aid clinicians in assessing disease severity and tailoring treatment strategies. Further research is warranted to validate these findings and explore the utility of SII in monitoring disease progression and treatment response.

Successful Surgical Management of Grade IV Internal Hemorrhoids in a Pediatric Patient: A Case Report Bayu Kusumo; Azzam Hizbur Rahman; Muhammad Yurizar Yudhistira
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1240

Background: Anorectal malformations are congenital conditions with a range of clinical presentations. They can be associated with portal hypertension or anatomical anomalies that obstruct venous outflow. While anorectal issues are common in pediatrics, their etiology and management can differ significantly from those in adults. This report presents a successful case of pediatric hemorrhoids managed surgically with a satisfactory outcome. Case presentation: A 4-year-old girl presented with a protruding anal lesion and intermittent constipation, first noticed at age 1. She was born aterm with no abnormalities. Physical examination revealed a 0.5 to 1 cm circular lesion obstructing the anal orifice, diagnosed as a grade-IV internal hemorrhoid. Laboratory results were within normal limits. Due to the severity of the lesion, a Whitehead hemorrhoidectomy was performed. Follow-up showed no complications, such as secondary wound healing, anal stricture, or mucosal ectropion. Conclusion: Whitehead hemorrhoidectomy is an effective treatment for severe pediatric hemorrhoids, as demonstrated by this case with a complication-free recovery. Accurate surgical technique and vigilant follow-up are key to a successful outcome.

Clinical Spectrum of Orbital Cellulitis: Case Series From Subperiosteal Abscess to Life-Threatening Cavernous Sinus Thrombosis Putri Amanda; Havriza Vitresia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1242

Background: Orbital cellulitis encompasses a range of orbital infections with varying severity. This case series highlights the diverse clinical presentations, management strategies, and outcomes of orbital cellulitis, emphasizing the importance of prompt diagnosis and treatment. Case presentation: We present two cases of orbital cellulitis with contrasting presentations. The first case involved a 16-year-old male with acute rhinosinusitis who developed severe orbital cellulitis complicated by cavernous sinus thrombosis (CST), requiring aggressive medical and surgical interventions. The second case involved a 2-month-old female with a subperiosteal abscess secondary to ethmoid and maxillary sinusitis, who responded well to medical management alone. Conclusion: Orbital cellulitis presents a wide spectrum of clinical scenarios, ranging from localized infections to life-threatening intracranial involvement. Early recognition, appropriate imaging, and timely intervention are crucial for optimizing outcomes. While CST necessitates aggressive measures, subperiosteal abscesses can often be managed medically, particularly in young children.

Clinical and Demographic Profile of Chronic Kidney Disease Patients Undergoing Kidney Transplantation at a Tertiary Hospital in Indonesia Khairil Faiz Amir; Ade Asyari; Harun, Harnavi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1243

Background: Chronic kidney disease (CKD) is a global health problem, and kidney transplantation is the treatment of choice for end-stage renal disease (ESRD). This study aimed to describe the clinical and demographic profile of CKD patients undergoing kidney transplantation at Dr. M. Djamil General Hospital, Padang, Indonesia. Methods: A descriptive retrospective study was conducted using medical records of CKD patients who underwent kidney transplantation between 2015 and 2023. Data on age, gender, duration of hemodialysis, donor-recipient relationship, blood pressure, blood type, crossmatch results, serum urea and creatinine levels, and etiology of CKD were collected and analyzed. Results: The study included 18 patients, all aged 19 to 59 years. The majority of patients were male (55.6%) and had undergone hemodialysis for less than 3 years (55.6%). Prehypertension and hypertension were the most prevalent blood pressure categories (44.4% each). Blood types A and O were most common (27.8% each), with consistent crossmatch results across groups. High levels of serum urea and creatinine were predominant, and hypertension was the most frequent etiology of CKD (66.7%). Conclusion: This study provides valuable insights into the characteristics of CKD patients undergoing kidney transplantation in Indonesia. The findings highlight the importance of early detection and management of CKD, particularly hypertension, to reduce the burden of ESRD and the need for transplantation.

Immunomodulatory Effects of Mesenchymal Stem Cell Secretome in Systemic Lupus Erythematosus: A Meta-Analysis Narisa Felinka Kusuma; Nova Kurniati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1244

Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by immune system dysregulation and multi-organ damage. Mesenchymal stem cells (MSCs) have emerged as a promising therapeutic option due to their immunomodulatory properties, primarily mediated through their secretome (MSCS). This meta-analysis aimed to evaluate the efficacy and safety of MSCS in SLE patients. Methods: A systematic search of PubMed, Embase, and Web of Science was conducted for studies published between 2013 and 2024 investigating the effects of MSCS in SLE. Randomized controlled trials (RCTs) comparing MSCS with placebo or standard care were included. The primary outcome was SLE disease activity, assessed using the SLE Disease Activity Index (SLEDAI). Secondary outcomes included immunological markers (e.g., anti-dsDNA antibodies, complement levels), quality of life, and adverse events. Data were pooled using a random-effects model. Results: Nine RCTs (n=485 patients) met the inclusion criteria. MSCS therapy significantly reduced SLEDAI scores compared to controls (standardized mean difference [SMD] -0.78, 95% CI -1.25 to -0.31, p=0.001). Significant improvements were also observed in anti-dsDNA antibody levels (SMD -0.62, 95% CI -1.01 to -0.23, p=0.002) and complement C3 levels (SMD 0.55, 95% CI 0.21 to 0.89, p=0.002). MSCS was generally well-tolerated, with no serious adverse events reported. Conclusion: This meta-analysis demonstrates that MSCS therapy has significant immunomodulatory effects in SLE, leading to improved disease activity and immunological profiles. Larger, well-designed RCTs with longer follow-up periods are needed to confirm these findings and assess the long-term efficacy and safety of MSCS in SLE.

Procalcitonin Levels in Pulmonary Tuberculosis and Bacterial Pneumonia: A Cross-Sectional Study at a Tertiary Hospital in Indonesia Abdullah Fikri; Hadi Nugraha Mustofa; Zen Ahmad; Zen Hafy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1245

Background: Pulmonary tuberculosis (TB) and bacterial pneumonia are respiratory infections with high morbidity and mortality rates. Despite having similar clinical symptoms and radiological findings, these conditions require different treatment approaches. Procalcitonin is a potential biomarker to differentiate these conditions, as its levels tend to increase in bacterial infections but not in TB. This study aims to compare procalcitonin levels in patients with pulmonary TB and bacterial pneumonia. Methods: This research employed an observational analytic design with a cross-sectional approach conducted at Dr. Mohammad Hoesin General Hospital (RSMH), Palembang. The study subjects were patients with pulmonary TB and bacterial pneumonia who met the inclusion and exclusion criteria. Procalcitonin levels were measured using ELISA methods. Data were analyzed to determine differences in procalcitonin levels between the two groups. Results: The study found that procalcitonin levels in bacterial pneumonia patients were significantly higher than those in pulmonary TB patients (p<0.05). These findings indicate that procalcitonin levels can serve as a diagnostic parameter to distinguish between the two conditions. Conclusion: Procalcitonin levels can be a useful biomarker for differentiating pulmonary TB from bacterial pneumonia. This biomarker is expected to assist clinicians in making more accurate diagnoses and expediting clinical decision-making.

Anesthesia Management in a Neonate with Esophageal Atresia Undergoing Esophagotomy and Thoracotomy: A Case Report Galih Puspitasari; Muhammad Ridho Aditya; Raden Theodorus Soepraptomo
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1247

Background: Esophageal atresia (EA) and tracheoesophageal fistula (TEF) are congenital anomalies requiring surgical repair in the neonatal period. Anesthetic management for these cases is complex, involving careful planning and execution to ensure a safe perioperative course. This case report details the anesthetic challenges and management of a neonate with EA undergoing thoracotomy and esophagotomy. Case presentation: A five-day-old male infant presented with EA, pneumonia, and sepsis. After preoperative optimization, the neonate underwent thoracotomy and esophagotomy under general anesthesia with invasive monitoring. The perioperative course was complicated by the patient's comorbidities, requiring meticulous airway management, hemodynamic monitoring, and temperature regulation. Conclusion: Successful anesthetic management of neonates with EA undergoing thoracotomy necessitates a multidisciplinary approach, addressing the unique challenges posed by the condition and associated comorbidities. This case highlights the importance of preoperative optimization, careful intraoperative management, and vigilant postoperative care in achieving a positive outcome.

A Rare Case of Systemic Lupus Erythematosus with Concomitant Inflammatory Bowel Disease: A Diagnostic and Therapeutic Challenge Made Cantika Kumara Dipa; Ketut Suryana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1248

Background: Systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD) are chronic conditions with complex pathophysiologies. While both diseases can affect the gastrointestinal tract, their co-occurrence is rare and presents unique diagnostic and therapeutic challenges. This case report describes a patient with SLE who developed IBD, highlighting the complexities of managing such cases. Case presentation: A 27-year-old female with a history of SLE presented with hematochezia, abdominal pain, and weight loss. A colonoscopy revealed findings consistent with IBD. The patient's SLE was well-controlled on immunosuppressive therapy, but the addition of IBD required careful medication adjustments to manage both conditions effectively. Conclusion: The coexistence of SLE and IBD is an uncommon but significant clinical scenario. This case underscores the importance of a thorough evaluation of IBD in SLE patients presenting with gastrointestinal symptoms. Furthermore, it emphasizes the need for a multidisciplinary approach to optimize treatment strategies and improve patient outcomes.

Magnesium and Osteoporosis: A Meta-Analysis of the Effects on Bone Turnover Markers, Fracture Incidence, and Quality of Life Sari, Mia Indah; Surya Darma
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1249

Background: Osteoporosis, a prevalent bone disease characterized by reduced bone mineral density (BMD) and increased fracture risk, poses a significant public health challenge. Magnesium, an essential mineral involved in bone metabolism, has emerged as a potential therapeutic agent. This meta-analysis aimed to evaluate the effects of magnesium supplementation on bone turnover markers, fracture incidence, and quality of life in individuals with osteoporosis. Methods: A systematic search of PubMed, Embase, and Cochrane Library databases was conducted from January 2013 to December 2024 to identify randomized controlled trials (RCTs) investigating the impact of magnesium supplementation on adults diagnosed with osteoporosis. The primary outcomes were changes in bone turnover markers (serum calcium, phosphorus, alkaline phosphatase, and osteocalcin), fracture incidence, and quality of life scores. Standardized mean differences (SMD) and risk ratios (RR) with 95% confidence intervals (CI) were calculated using random-effects models. Results: Nine RCTs met the inclusion criteria, encompassing a total of 825 participants. Magnesium supplementation demonstrated a significant improvement in bone turnover markers, with a decrease in serum alkaline phosphatase (SMD = -0.35; 95% CI: -0.62, -0.08; p = 0.01) and osteocalcin (SMD = -0.29; 95% CI: -0.51, -0.07; p = 0.009). A trend towards reduced fracture incidence was observed in the magnesium group (RR = 0.72; 95% CI: 0.51, 1.02; p = 0.06). Furthermore, magnesium supplementation significantly improved quality of life scores, as measured by the Osteoporosis Quality of Life Questionnaire (OQLQ) (SMD = 0.41; 95% CI: 0.15, 0.67; p = 0.002). Conclusion: This meta-analysis provides evidence that magnesium supplementation may have beneficial effects on bone turnover markers and quality of life in individuals with osteoporosis. Although a trend towards reduced fracture incidence was observed, further large-scale RCTs are warranted to confirm this finding.

Procalcitonin Outperforms NLR as a Sepsis Predictor in Pneumonia Patients: A Cross-Sectional Study from a Tertiary Hospital in Padang, Indonesia Dina Fitri Fauziah; Aidillah Mayuda; Wici Septiyeni; Siska Armeinesya; Firmaweni; Atikah Dafri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1251

Background: Pneumonia remains a significant cause of morbidity and mortality worldwide, with sepsis being a severe complication. Early identification of sepsis is crucial for prompt treatment and improved outcomes. This study aimed to evaluate the performance of procalcitonin (PCT) and neutrophil-lymphocyte ratio (NLR) as predictors of sepsis in pneumonia patients at a tertiary hospital in Padang, Indonesia. Methods: A cross-sectional study was conducted on 110 adult pneumonia patients admitted to Dr. M. Djamil General Hospital Padang between 2022 and 2023. Data on demographics, clinical characteristics, NLR, and PCT levels were collected from electronic medical records. Sepsis was defined according to established clinical criteria. Receiver operating characteristic (ROC) curve analysis was performed to assess the diagnostic accuracy of NLR and PCT in predicting sepsis. Results: The study population had a mean age of 57.72 ± 14.41 years, with 56.4% being male. Of the 110 patients, 73.6% had community-acquired pneumonia (CAP) and 26.4% had hospital-acquired pneumonia (HAP). Sepsis was present in 55.5% of the patients. The median NLR and PCT levels were significantly higher in the sepsis group compared to the non-sepsis group (NLR: 14 vs. 6.6, p=0.002; PCT: 2.17 vs. 0.24, p=0.000). ROC analysis showed that PCT had a higher area under the curve (AUC) compared to NLR (0.724 vs. 0.676), indicating better diagnostic accuracy. The optimal cut-off point for PCT was 0.455, with a sensitivity of 65.6% and specificity of 65.3%. For NLR, the cut-off point was 10.375, with a sensitivity of 63.9% and specificity of 63.3%. Conclusion: PCT demonstrated superior diagnostic accuracy compared to NLR in predicting sepsis among pneumonia patients in this study. However, NLR remains a valuable tool, especially in resource-limited settings where PCT testing may not be readily available.

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Kab. ogan ilir,

Sumatera selatan

INDONESIA