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Bioscientia Medicina : Journal of Biomedicine and Translational Research

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Published by Universitas Sriwijaya

ISSN : - EISSN : 25980580 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

BioScientia Medicina is an open access international scholarly journal in the field of biomedicine and translational research aimed to publish a high-quality scientific paper including original research papers, reviews, short communication, and technical notes. This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to medical sciences, Traditional Herb, genetics, immunology, environmental health, toxicology, bioinformatics and biotechnology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.

Arjuna Subject : Kedokteran - Anatomi

Articles 1,209 Documents

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Guava Leaf Extract: A Promising Alternative to Chlorhexidine for Reducing Streptococcus mutans Colonization on Orthodontic Appliances Davin; Firdha Muharraran; Weni Selvina
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1252

Background: Streptococcus mutans is a major contributor to the formation of dental plaque and the initiation of caries. Orthodontic appliances, particularly removable ones, can create favorable conditions for S. mutans colonization, increasing the risk of caries and other oral health issues. Chlorhexidine is a commonly used antimicrobial agent in dentistry, but it can have side effects like tooth staining and altered taste. Guava leaf extract has shown promising antibacterial properties due to its rich content of flavonoids, tannins, and other bioactive compounds. This study aimed to compare the effectiveness of guava leaf extract and chlorhexidine in reducing S. mutans colonization on acrylic-based removable orthodontic appliances. Methods: This in vitro study used 25 acrylic plates, which were divided into five groups: guava leaf extract at concentrations of 75%, 80%, and 90%, chlorhexidine gluconate 0.2% (positive control), and aquades (negative control). The acrylic plates were first contaminated with S. mutans and then immersed in the respective solutions for 10 minutes. The number of S. mutans colonies was then counted using a colony counter. Results: The mean number of S. mutans colonies was significantly lower in the chlorhexidine group (27.8 ± 6.6 CFU/ml) and the guava leaf extract groups (9.4 ± 3.3 CFU/ml for 90%, 42 ± 7.8 CFU/ml for 80%, and 381 ± 81.1 CFU/ml for 75%) compared to the aquades group (1461.2 ± 274.5 CFU/ml). There was no significant difference between the chlorhexidine group and the 90% and 80% guava leaf extract groups. Conclusion: Guava leaf extract, particularly at concentrations of 90% and 80%, is as effective as chlorhexidine in reducing S. mutans colonization on orthodontic appliances. Guava leaf extract may be a promising natural alternative to chlorhexidine for maintaining oral hygiene in orthodontic patients, especially those with concerns about chlorhexidine's side effects.

Pomegranate Extracts as a Natural Denture Cleanser: A Promising Alternative to Sodium Bicarbonate for Inhibiting Candida albicans Wijaya, Cindy Denhara; Sumitro; Annisa Rizqi Ramadhani Sitio; Fitriah Khairani Harahap
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1253

Background: Denture stomatitis, caused primarily by Candida albicans overgrowth, is a common oral health issue among denture wearers. Maintaining denture hygiene is crucial for prevention. This study investigated the efficacy of red pomegranate (Punica granatum L.) peel and fruit extracts as natural denture cleansers compared to sodium bicarbonate, a standard denture cleansing agent. Methods: Heat-cured acrylic resin plates were fabricated and contaminated with C. albicans. Samples were divided into four groups and soaked for 8 hours in: 75% pomegranate peel extract, 75% pomegranate fruit extract, 5% sodium bicarbonate solution (positive control), and aquadest (negative control). C. albicans colony counts were performed using the spread plate technique and colony counter. Data were analyzed using Kruskal-Wallis and Mann-Whitney tests. Results: Both pomegranate peel and fruit extracts significantly reduced C. albicans growth compared to the negative control (p<0.05). The peel extract showed comparable efficacy to sodium bicarbonate (p>0.05), while the fruit extract demonstrated slightly lower but still substantial antifungal activity. Conclusion: Red pomegranate peel and fruit extracts hold promise as natural denture cleansers for inhibiting C. albicans and potentially preventing denture stomatitis. Further research is warranted to evaluate their long-term effects on denture materials and clinical efficacy.

Diagnostic Accuracy of Pulmonary Function Tests in Identifying Shrinking Lung Syndrome: A Meta-Analysis M Haikal; Fenty Anggrainy; Masrul Basyar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1254

Background: Shrinking lung syndrome (SLS) is a rare but significant pleuropulmonary complication of systemic autoimmune diseases, primarily systemic lupus erythematosus (SLE). Early and accurate diagnosis is crucial for timely intervention, but often challenging due to the insidious onset and overlapping symptoms with other respiratory conditions. This meta-analysis aims to synthesize the existing evidence on the diagnostic performance of various PFT parameters in identifying SLS. Methods: We conducted a systematic search of PubMed, Embase, Scopus, and Web of Science databases from January 2013 to May 2024. We included studies that reported the diagnostic accuracy of PFTs (specifically, total lung capacity [TLC], forced vital capacity [FVC], diffusing capacity for carbon monoxide [DLCO], and maximal inspiratory pressure [MIP]) in differentiating SLS from other respiratory conditions or healthy controls in patients with systemic autoimmune diseases. Heterogeneity was assessed using the I² statistic. Results: Nine studies, comprising a total of 685 patients with systemic autoimmune diseases (215 with SLS and 470 without SLS), were included. The pooled sensitivity and specificity of TLC ≤ 80% predicted for diagnosing SLS were 0.85 (95% CI, 0.78-0.90) and 0.72 (95% CI, 0.63-0.80), respectively. For FVC ≤ 80% predicted, the pooled sensitivity and specificity were 0.78 (95% CI, 0.69-0.85) and 0.65 (95% CI, 0.55-0.74), respectively. DLCO showed lower sensitivity (0.68; 95% CI, 0.57-0.77) but higher specificity (0.80; 95% CI, 0.71-0.87). MIP demonstrated a sensitivity of 0.75 (95% CI: 0.61, 0.85) and a specificity of 0.60 (95% CI: 0.44, 0.74). Significant heterogeneity was observed across studies (I² > 50% for most analyses). Conclusion: PFTs, particularly TLC, are valuable tools in the diagnostic workup of SLS. While TLC demonstrates good sensitivity, its moderate specificity necessitates a comprehensive evaluation, integrating clinical findings, imaging, and potentially other biomarkers.

High-Frequency Chest Wall Oscillation versus Conventional Airway Clearance Techniques in Non-Cystic Fibrosis Bronchiectasis: A Meta-Analysis Dzaki Murtadho; Irvan Medison; Deddy Herman
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1255

Background: Non-cystic fibrosis bronchiectasis (NCFB) is a chronic lung disease characterized by irreversible airway dilation and impaired mucociliary clearance, leading to chronic cough, sputum production, and recurrent infections. This meta-analysis aims to compare the efficacy of high-frequency chest wall oscillation (HFCWO) with conventional airway clearance techniques (CACT) in adults with NCFB. Methods: A systematic search of PubMed, Embase, Cochrane Library, Web of Science, and Scopus databases was conducted from January 2013 to March 2024. Randomized controlled trials (RCTs) comparing HFCWO with CACT (postural drainage, percussion, active cycle of breathing technique, positive expiratory pressure therapy) in adults with NCFB were included. The primary outcomes were a change in forced expiratory volume in one second (FEV1) and sputum weight. Secondary outcomes included quality of life, exacerbation frequency, and adverse events. The risk of bias was assessed using the Cochrane Risk of Bias 2 tool. Data were pooled using a random-effects model, and heterogeneity was assessed using the I² statistic. Results: Nine RCTs involving a total of 485 participants were included. The meta-analysis showed no statistically significant difference in FEV1 change between HFCWO and CACT (mean difference [MD] 0.05 L, 95% confidence interval [CI] -0.02 to 0.12; I² = 45%). HFCWO was associated with a statistically significant increase in sputum weight compared to CACT. SGRQ total score showed a statistically significant improvement in the HFCWO group compared to CACT (MD -4.21, 95% CI -7.88 to -0.54; I² = 58%). Conclusion: HFCWO may provide a modest benefit in terms of increased sputum clearance and improved quality of life compared to CACT in adults with NCFB. However, there was no significant difference in lung function (FEV1) or exacerbation frequency. The moderate to high heterogeneity in some outcomes suggests that further research is needed to confirm these findings and identify patient subgroups who may benefit most from HFCWO.

A Rare Case of Adult-Onset Still's Disease Presenting with Hypercoagulability and Ocular Vasculitis Mustofa, Hadi Nugraha; Abdullah Fikri; Surya Darma
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1256

Background: Adult-onset Still's disease (AOSD) is a rare systemic autoinflammatory disorder characterized by fever, arthritis, rash, and hyperferritinemia. While AOSD commonly presents with systemic and articular manifestations, it can rarely involve other organ systems, including the eye and the coagulation system. Case presentation: We present a case of an 18-year-old male with AOSD who developed hypercoagulability and ocular vasculitis. The patient presented with high-grade fever, polyarthritis, and the characteristic salmon-pink rash. Laboratory investigations revealed leukocytosis, elevated inflammatory markers, and a significant elevation of serum ferritin. Imaging studies ruled out other diagnoses. During the course of his illness, the patient developed hematomas and was found to have elevated fibrinogen and D-dimer levels, suggestive of hypercoagulability. He also experienced ocular symptoms and was diagnosed with ocular vasculitis. The patient was treated with systemic corticosteroids, methotrexate, and anticoagulation therapy, which led to the resolution of his symptoms. Conclusion: This case highlights the rare and serious complications of AOSD, including hypercoagulability and ocular vasculitis. Early recognition and prompt treatment are crucial to prevent morbidity and mortality associated with these complications.

A Case of Concurrent COPD Exacerbation, Osteoporosis, and Fracture: Unveiling the Interplay Fadhilla Annisa Efendi; Masrul Basyar; Deddy Herman; Yessy Susanty Sabri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1257

Background: Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory condition with systemic effects, including an increased risk of osteoporosis and fractures. This case report presents a patient with acute COPD exacerbation, osteoporosis, and vertebral fractures, highlighting the complex interplay between these conditions. Case presentation: A 68-year-old male patient presented with acute exacerbation of COPD. He had a history of smoking, hypertension, and a previous diagnosis of pulmonary tuberculosis. Clinical examination revealed signs of respiratory distress, and imaging confirmed emphysema, pneumonia, osteoporosis, and vertebral fractures. The patient received treatment for COPD exacerbation and osteoporosis, showing improvement in respiratory symptoms and pain. Conclusion: This case underscores the importance of recognizing the association between COPD, osteoporosis, and fractures. Early diagnosis and appropriate management of these co-morbidities are crucial for improving patient outcomes and quality of life.

Unveiling the Hidden Patterns: A Dermoscopic Analysis of Vitiligo Lesions at a Tertiary Care Center in Surakarta, Indonesia Sesia Pradestine; Muhammad Eko Irawanto; Osdatilla Esa Putri; Trya Oktaviani; Benedicta Lauda Anandita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1258

Background: Vitiligo, a common depigmenting disorder, presents with a variety of clinical manifestations. Dermoscopy, a non-invasive skin imaging technique, has emerged as a valuable tool for evaluating pigmentary disorders. This study aimed to analyze the dermoscopic patterns of vitiligo lesions in a cohort of patients at a tertiary care center in Surakarta, Indonesia, and to correlate these patterns with disease stability. Methods: This cross-sectional study included 20 adult patients diagnosed with vitiligo at the Dermatology and Venereology Outpatient Clinic of Dr. Moewardi Regional General Hospital Surakarta in July 2023. A dermoscopic examination was performed on all patients using a polarized light dermoscope. Dermoscopic features were analyzed and categorized based on the BPLeFoSK criteria (Border, Pigment Network, Lesions, Follicular, Koebner). Disease stability was assessed based on clinical and dermoscopic findings. Results: The majority of patients were female (75%) and between 21-40 years old (65%). All patients exhibited the characteristic "white glow" under dermoscopy. Other common findings included reduced or absent pigment network (40% each), perifollicular hyperpigmentation (30%), and perilesional hyperpigment (30%). Satellite lesions and micro-Koebner phenomenon, indicative of disease activity, were observed in 10% of patients each. Based on these findings, 80% of patients were classified as having stable vitiligo, while 20% had unstable vitiligo. Conclusion: Dermoscopy revealed a spectrum of patterns in vitiligo lesions, with the "white glow" being a universal finding. The majority of patients in this cohort had stable vitiligo. Dermoscopy can aid in assessing disease activity and guiding treatment decisions in vitiligo patients.

Profound Alpha-Fetoprotein Elevation in Hepatocellular Carcinoma with Concomitant Cirrhosis: A Case Report Fadhilaturrizqie Siregar; Efrida
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1259

Background: Hepatocellular carcinoma (HCC) is a primary liver cancer that often arises in the setting of chronic liver disease, most commonly cirrhosis. Alpha-fetoprotein (AFP) is a tumor marker frequently elevated in HCC, but its diagnostic performance varies. We present a case of HCC with concomitant cirrhosis and a significant elevation of AFP. Case presentation: A 30-year-old male presented with hematemesis, abdominal distension, and jaundice. He had a history of heavy alcohol consumption. Physical examination revealed anemia, icterus, hepatomegaly, and palmar erythema. Laboratory investigations showed elevated AFP (>400 IU/mL), reactive hepatitis B surface antigen (HBsAg), anemia, coagulopathy, and liver dysfunction. Imaging studies confirmed HCC and cirrhosis. This case highlights the diagnostic value of AFP in HCC, particularly when combined with clinical and imaging findings. The patient's history of alcohol abuse and HBsAg positivity are well-established risk factors for both cirrhosis and HCC. The marked elevation of AFP, along with the characteristic imaging features, strongly supported the diagnosis of HCC. Conclusion: AFP remains a valuable tool in the diagnosis and monitoring of HCC, especially in patients with cirrhosis. However, it is essential to interpret AFP levels in conjunction with other clinical and laboratory data to ensure accurate diagnosis and timely management.

Garcinia mangostana L. Nanoextract Improves Early Inflammatory Phase Bone Fracture Healing in Diabetes Mellitus by Targeting IL-1β and TNF-α: A Comprehensive Meta-Analysis Gregorius Gathot Garudanto; Yuriz Bakthiar; MI Widiastuti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1260

Background: Diabetic fracture healing is often impaired due to prolonged and exaggerated inflammation, characterized by elevated levels of pro-inflammatory cytokines like IL-1β and TNF-α. Garcinia mangostana L. (mangosteen) has demonstrated anti-inflammatory properties, and nanoformulations may enhance its bioavailability and efficacy. This meta-analysis aimed to evaluate the effect of Garcinia mangostana L. nanoextract on IL-1β and TNF-α levels during the early inflammatory phase of fracture healing in diabetic models. Methods: A systematic search was conducted in PubMed, Scopus, Web of Science, and Cochrane Library databases for studies published between 2013 and 2024. Studies investigating the effects of Garcinia mangostana L. nanoextracts on IL-1β and TNF-α levels in in vivo or in vitro models of diabetic fracture healing were included. Data on cytokine levels, fracture healing parameters (where available), and study characteristics were extracted. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were calculated using a random-effects model. Heterogeneity was assessed using the I² statistic. Results: Nine studies met the inclusion criteria. Meta-analysis revealed that Garcinia mangostana L. nanoextract significantly reduced IL-1β levels (SMD = -2.85, 95% CI: -3.97 to -1.73, p < 0.00001; I² = 88%) and TNF-α levels (SMD = -2.14, 95% CI: -3.08 to -1.20, p < 0.00001; I² = 82%) compared to control groups in diabetic fracture healing models. Subgroup analyses indicated significant reductions in both in vivo and in vitro studies. Conclusion: This meta-analysis provides evidence that Garcinia mangostana L. nanoextract significantly reduces IL-1β and TNF-α levels during the early inflammatory phase of fracture healing in diabetic models. These findings suggest that Garcinia mangostana L. nanoextract holds therapeutic potential for improving fracture healing outcomes in individuals with diabetes mellitus.

Mangosteen Nanoextract and Bone Regeneration in Diabetes: A Meta-Analysis of ALP and Osteocalcin Modulation during Fracture Callus Formation Chrisantus Ronald Bria Seran; Yuriz Bakthiar; MI Widiastuti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1261

Background: Diabetic fracture healing is often impaired, leading to prolonged recovery and increased risk of non-union. Garcinia mangostana L. (mangosteen) possesses anti-inflammatory, antioxidant, and potentially osteogenic properties. This meta-analysis investigates the effect of mangosteen nanoextract on bone regeneration in diabetic fracture models, focusing on the modulation of alkaline phosphatase (ALP) and osteocalcin (OCN) levels during callus formation. Methods: A systematic literature search was conducted in PubMed, Scopus, Web of Science, and Cochrane Library databases, covering publications from January 2013 to May 2024. Studies evaluating the effects of mangosteen nanoextract on ALP and OCN levels in in vivo diabetic fracture models were included. Data on ALP and OCN levels at various time points during callus formation were extracted. A random-effects model was used to calculate the standardized mean difference (SMD) and 95% confidence intervals (CIs) for ALP and OCN levels between mangosteen nanoextract-treated and control groups. Heterogeneity was assessed using the I² statistic. Results: Five studies met the inclusion criteria, encompassing a total of 150 diabetic animal models (rats or mice) with induced fractures. Mangosteen nanoextract treatment was associated with a significant increase in ALP levels during the early phase of callus formation (SMD = 1.25; 95% CI: 0.80, 1.70; p < 0.001; I² = 65%). Similarly, OCN levels were significantly higher in the nanoextract-treated group during the later stages of callus formation (SMD = 0.98; 95% CI: 0.55, 1.41; p < 0.001; I² = 58%). Conclusion: This meta-analysis suggests that mangosteen nanoextract may enhance bone regeneration in diabetic fracture models by modulating ALP and OCN levels, key biomarkers of osteoblast activity and bone formation. Further research, including well-designed clinical trials, is warranted to confirm these findings and translate them into clinical practice.

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Rachmat Hidayat

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dr.rachmat.hidayat@gmail.com

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Kab. ogan ilir,

Sumatera selatan

INDONESIA