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Contact Name
Solikhatun
Contact Email
solikhatun@ugm.ac.id
Phone
+62331334293
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jid@unej.ac.id
Editorial Address
Jl. Kalimantan 37 Kampus Tegalboto Jember 68121 Telp. 62 331 334293 Fax. 62 331 330225
Location
Kab. jember,
Jawa timur
INDONESIA
Jurnal Ilmu Dasar
Published by Universitas Jember
ISSN : 24425613     EISSN : -     DOI : https://doi.org/10.19184/jid.v24i2.36657
Jurnal ILMU DASAR (JID) is a national peer-reviewed and open access journal that publishes research papers encompasses all aspects of natural sciences including Mathematics, Physics, Chemistry and Biology. JID publishes 2 issues in 1 volume per year. First published, volume 1 issue 1, in January 2000 and avalaible in electronically since 2012 with ISSN 1411-5735 (Print) and avalaible in electronically since 2012 with ISSN 2442-5613 (online). Jurnal ILMU DASAR is accredited SINTA 3 by the Ministry of Education, Culture, Research, and Technology of the Republic of Indonesia (Kemendibukristek) No. 152/E/KPT/2023 (September 25, 2023), Ministry of Research, Technology and Higher Education of the Republic of Indonesia (RISTEKDIKTI), No. 200/M/KPT/2020 (December. 23, 2020). All accepted manuscripts will be published worldwide JID has been indexed in DOAJ, Dimension, OCLC WorldCat, PKP Index, Crossref, Google Scholar, Base, Garuda, and OneSearch. JID have been collaborated in KOBI-ID (Konsorsium Biologi Indonesia) and HKI (Himpunan Kimia Indonesia) since 2017.
Articles 415 Documents
The Expression of The PfEMP1-DBL2β Recombinant Protein of Plasmodium falciparum Isolated From Indonesia Hasanah, Fathul Hidayatul; Sulistyaningsih, Erma; Sawitri, Widhi Dyah
Jurnal ILMU DASAR Vol 21 No 1 (2020)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (123.49 KB) | DOI: 10.19184/jid.v21i1.10494

Abstract

The binding of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) to Intracellular Adhesion Molecule-1 (ICAM-1) is a major pathological mechanism in severe malaria including cerebral malaria. The binding is mediated by PfEMP1-DBL2β domain. The study aimed to explore there combinant protein of PfEMP1-DBL2β domain of P. falciparum isolated from Indonesia. DNA was isolated from a severe malaria patient. The DBL2β domain was amplified using Polymerase Chain Reaction (PCR) with specific primer and cloned into the pJET1 cloning vector. The DBL2β recombinant protein was constructed from DBL2β-pJET1 clone using pET-30a expression vector and expressed in Escherichia coli BL21-DE3. PCR colony and digestion of plasmid clones using restriction enzymes were conducted to confirm cloning result, and the expression of recombinant protein was analyzed using Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis (SDS-PAGE). The expression of DBL2β-PfEMP1 domain is higher in pellet than in supernatant fraction. In conclusion, the DBL2β-PfEMP1 domain recombinant protein of P. falciparum isolated from Indonesia expressed as a ~66 kDa protein in full length. Keywords: DBL2β domain, Indonesia, PfEMP1, Plasmodium falciparum, recombinant protein.
Triterpenoid Pentacyclic Antimalarial Activity from the Leaves of Erythrina variegata Tati Herlina; Unang Supratman; Anas Urbanas; Supriyatna Sutardjo; Noor Rain Abdullah; Hideo Hayashi
Jurnal ILMU DASAR Vol 12 No 2 (2011)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

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Abstract

In the course of our continuing research for novel antimalarial agent from Indonesian plants, the methanol extract of the Erythrina variegata leaves showed significant antimalarial activity against Plasmodium falciparum strain K1 in vitro with IC50 6.8 μg/mL. The methanol extract was separated by using variety of chromatography techniques. The chemical structure of an antimalarial compound was determined on the basis of spectroscopic evidence and compared to previous data then this compound is identified as a pentacyclic triterpenoid oleane derivative, namely 3,22,23-trihydroxy-oleane-12-ene. The pentacyclic triterpenoid, 3,22,23-trihydroxy-oleane- 12-ene showed antimalarial activity against 3D7 and K1 strains with IC50 4.3 μg/mL and 24 μg/mL, respectively. These results strongly suggested that E. variegata is a promising sources of antimalarial agents.
Kinetics of Complex Reaction of Eugenol Hydrogenation to 2-Methoxy-4-Propylphenol in Pd/Y Catalyst Asep Kadarohman
Jurnal ILMU DASAR Vol 11 No 1 (2010)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

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Abstract

Eugenol and isoeugenol hydrogenations using Pt, Pd, Ni as a single or combined metal, that was supported on X and Y zeolite have been carried out. The experiment result showed that in hydrogenation reaction using metal that was supported on zeolite, eugenol is more easily hydrogenated than isoeugenol. Pd metal that was supported on Y zeolite as a catalyst in eugenol hydrogenation is more effective than Ni, Pt or combined metal (Pt,Pd,Ni/X). The highest conversion selectivity of eugenol hydrogenation is in 6% catalyst of Pd (10%)/Y that produced 98.24% of 2-methoxy-4- propylphenol. Kinetic of reaction is very important data that is needed in processing for industry scale, because kinetic can show how fast the starting material is converted into products. In this research, kinetic of the reaction was done by eugenol hydrogenation at 245oC with variation of time using Pd/Y catalyst. The result shows that eugenol hydrogenation is a complex reaction, because the reaction yields not only 2-methoxy-4-propylphenol as a main product, but also cis-isoeugenol and trans-isoeugenol as the side products. The reaction pathway of eugenol hydrogenation in Pd/Y catalyst is a combination of parallel and consecutive pathway and pseudo first order reaction with k = 0.5509.
Antimicrobial Activity of the Extract and Fraction of Red Betel Leaf (Piper betle Linn.) Julia Reveny
Jurnal ILMU DASAR Vol 12 No 1 (2011)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

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Abstract

Antimicrobial activity of ethanolic extract of red betel leaf (Piper betle Linn.), n-hexane fraction and ethyl acetate against Staphylococcus aureus, Escherichia coli and Candida albicans had been carried out. Red betel leaf powder was extracted with 80% ethanol, followed fractionate with n-hexane and ethylacetate. The result was tested in vitro with agar diffusion method using a steel cylinder. Phytochemical screening test was performed to betel leaf powder, while the extract and each fraction were tested with antimicrobial activity in vitro. The thin layer chromatography (TLC) was performed with stationary phase silica gel GF 254 and moving phase of n-hexane: ethyl acetate (8:2), (7:3), (6:4), (5:5) toluene: ethyl acetate (6:4), chloroform: methanol (7:3). Phytochemical screening result indicated the presence of glycosides, triterpenoids/steroids, flavonoids, tannins and anthraquinon. Both of 80% ethanol extract and fractions of red betel leaf (Piper betle Linn.) have antimicrobial activity with Minimum Inhibitory Concentration (MIC) of ethanol extract 80% against Staphylococcus aureus, Escherichia coli and Candida albicans are 2.5%, 2.5%, 10%. The n-hexane fractions were 20%, 15%, 10% and the ethyl acetate fractions are 2.5%, 1%, 2.5%, while the water fraction did not show any antimicrobial effects. The ethanol extract indicated a higher inhibitory effect in Escherichia coli, while the ethyl acetate fraction showed a higher effect on Staphylococcus aureus and Candida albicans. The TLC results showed the presence of terpenoids/steroids, flavonoids, and tannins in ethanol extract, tannin and flavonoid in ethyl acetate, terpenoid/steroids in n-hexane fraction.
The Centre of Some Skew Polynomial Rings Amir Kamal Amir
Jurnal ILMU DASAR Vol 10 No 2 (2009)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

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Abstract

Let R be any ring with identity 1, σ be an endomorphism and δ be a left σ-derivation. In this paper, we will investigate the centre of some skew polynomial rings in the case when R is a commutative domain and σ is anautomorphism. More precisely, let D be a commutative domain with its quotient field K and σ be an  automorphism of  D. Then, we will show that intersection of  the centre of  skew  polynomial  rings D[x;σ] and D[x;σ,δ].
Forecasting Interest Rate of Bank Indonesia Certificate Based on Multivariate Fuzzy Time Series Data Agus Maman Abadi; Subanar Subanar; Widodo Widodo; Samsubar Saleh
Jurnal ILMU DASAR Vol 11 No 2 (2010)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

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Abstract

The aim of this research is to establish a model for forecasting interest rate of Bank Indonesia Certificate (BIC)based on six-factors one-order fuzzy time series data where the main factor is interest rate of BIC and thesecondary factors are interest rate of deposit, exchange rate, deposit supply, inflation rate and money supply.Steps to forecasting interest rate of BIC are based on Wang’s method. The result of this research is thatprediction of interest rate of BIC using multivariate fuzzy time series model has higher accuracy than that usingneural network method with average forecasting error 3.1256% and MSE value = 0.2699.
A Lamp Controller via Missed Calls Based On The Microcontroller AVR AT90S2313 Jazi Eko Istiyanto; Andik Dwi Kuntoro
Jurnal ILMU DASAR Vol 11 No 1 (2010)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

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Abstract

Missed calls have a potential for low-cost control and monitoring of a remote instrumentation system as compared to SMS (Short-Message Service) and DTMF (Dual-Tone Multiple Frequencies). The design of an instrumentation system model in which a set of lamps can, remotely, be turned on/off just by issuing a set of unanswered calls and the programming of the AT90S2313 microcontroller to serve the purpose of controlling and status monitoring of a set of six lamps (AC bulbs) are presented in this paper. Two cellular phones are used: one as the calling phone, and the other as the receiving end (the transceiver). The transceiver is attached to the microcontroller circuitry. The calling phone issues two sets of RINGs and the transceiver is programmed to disregard any RING. The first set of RINGs is interpreted as a command to select one of the six lamps, then the second set of RINGs constitutes a command to turn the selected lamp on/off. This is possible because the cellular system records the number of RINGs before a call qualifies as a missed call.The system has successfully been built, tested, and proven to work well. The limitation is, apart from the GSM signal availability, the inability of the current system to verify/authenticate the calling phone number. 
‘Propolis’ Protective Effect to Prevent Oxidative Stress Caused by Strenous Physical Activity (Swimming Stress) Hairrudin Hairrudin
Jurnal ILMU DASAR Vol 10 No 2 (2009)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

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Abstract

Strenous physical activity may give not only a possitive impact but also the negative one. One of the factors that produce negative impact is the increasing formation of oxydant that may cause tissues’ damages. In this kind of circumstances, the oxydant could make damages to the various components in the body, it calls oxydative stress. The effect of the oxydant to the unsaturated fatty acid cause a chain reaction that will break the fatty acid to become different kinds of substances, such as malondialdehid (MDA). The MDA produced then released into the circulatory system, made the serum level of MDA increasing. The influence of propolis as antioxidant may be prevent this problem. This study is a laboratory experiment using posttest-only control group design.  The samples of the experiment are 3-month male white rat with average weight between 180-220 grams. These samples are divided to three groups: (1) control group (2) exposure group that have to do strenous activity (30 days swimming stress) and (3) exposure group that have to do strenous activity (30 days swimming stress) and given propolis, each group consists of eight rats. The result of the study showed a higher average serum MDA level in exposure group (89.63 nmol/mL) than the control group (42.38 nmol/ml) significantly (p = 0.000). The influence of propolis could prevent oxidative stress wich was indicated by lower average serum MDA level (32.35 nmol/ml) significanly (p = 0.000).
Studies Polymorphism of Blood Plasm Protein in Gurami (Osphronemus gouramy Lac) in Jember County Rike Oktarianti; Mamik Pristiwindari
Jurnal ILMU DASAR Vol 8 No 1 (2007)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

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Abstract

The objective of this research was to study the blood protein polymorphism of gurami (Osphronemus gouramy Lac). Blood sample were collected from 55 gurami. Polyaacrilamide Gel Electrophoresis (PAGE) was used in the blood plasm protein analysis. Identification of protein bands on gel are determinated by comparing the molecul weight of those test group protein with the marker protein. The result showed that the locus albumin, pre-albumin and transferin are polymorphic. Locus albumin, pre-albumin and transferin are controlled by three alleles ie A, B and C. The total heterozygozity of gurami is 52 %.
Coal Ash Characteristic from Bukit Asam as Raw Material for Ceramics Production Pulung Karo-Karo; Simon Sembiring
Jurnal ILMU DASAR Vol 9 No 2 (2008)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

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Abstract

This study was carried out to characterize coal ash obtained from Bukit Asam, Tarahan Lampung, after the samples were sintered at various temperatures ranging from 900C - 1300C. The characteristics of the investigated samples included density, porosity, hardness, structure and microstructure. The results indicated that porosity decreased with increasing sintering temperature, while density and hardness increased with increasing temperature. The x-ray diffraction (XRD) study revealed that the main crystalline phase was silicon dioxide (SiO2), with the minor constituents of CaSiO2, MgSiO3, FeSiO4 and Ca12Al14O33. SEM investigations clearly demonstrated the presence of a fine crystallised phase dispersed in the microstructure.