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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 20 Documents
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Search results for , issue "Vol. 30 No. 3 (2024)" : 20 Documents clear
Ultra-Low Anti-Müllerian Hormone Levels in Recurrent Cystic Ovarian Neoplasm: A Case Report Merci Monica br Pasaribu; Naufal Arkan Abiyyu Ibrahim; Dayu Satriani
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 3 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i3.1940

Abstract

Fertility has been a major issue in the management of cystic ovarian neoplasm. This case report presents an extreme case of ultra-low AMH levels in a young female with recurrent cystic ovarian neoplasm and analyzes the potential causes. A twenty-two-year-old female presented with stomach discomfort. The patient had undergone two surgeries for ovarian neoplasm within the last six years. The patient had another abdominal lump suspected to be a residual tumor mass. After further examination, the patient was diagnosed with cystic ovarian neoplasm. The laboratory findings showed low T4 levels, increased TSH levels, and ultra-low AMH levels (0.023 ng/mL). Management of cystic ovarian neoplasm should concern the effect on fertility. The AMH level can be used for pre-treatment counseling in these patients.
Transient Abnormal Myelopoiesis in Down Syndrome Patients Widya Pratiwi; Amaliyah T. Lopa; Darwati Muhadi; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 3 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i3.2024

Abstract

Neonates with Down Syndrome (DS) have a propensity to develop the unique myeloproliferative disorder, Transient Abnormal Myelopoiesis (TAM). Transient abnormal myelopoiesis usually resolves spontaneously in < 3 months, but approximately 10% of patients with TAM die from hepatic or multi-organ failure. After remission, 20% of patients with TAM progress into acute myeloid leukemia associated with down syndrome (ML-DS). The patient was a full-term 2-day-old baby girl with a birth weight of 3300 gr. Physical examination revealed dysmorphic facial features, hypertelorism, macroglossia, and low set ears, which is a characteristic sign of DS face, skin rash, and there was no anus. On examination of peripheral blood smears and bone marrow aspiration, hematological abnormalities, and circulating blast cells were found. Early diagnosis of low-lying anorectal malformation (MAR) without fistula and down syndrome. In treating patients with TAM, it is first necessary to know whether they have trisomy 21 syndrome, then trace the existing hematological disorders to find the GATA 1 genetic mutation. The most crucial hematological problem in patients with DS is leukemia. Mutations in the GATA 1 gene and the presence of DS can result in abnormal proliferation of megakaryocytes and erythroid progenitors in the fetus and hematological abnormalities in TAM. Transient abnormal myelopoiesis can be fatal in up to 10% of patients and resolves spontaneously. Therefore, laboratory examinations are very significant, including blood tests, peripheral blood smears, supporting examinations such as bone marrow aspiration, monitoring of clinical symptoms, and close monitoring of comorbidities. Examination repeat or follow-up bone marrow aspiration is required within six months of patient follow-up to reduce the risk of further complications. In this case, a follow-up examination is highly recommended because if there are no changes, the further examination must be carried out.
Analysis of Albumin to Globulin Ratio as A Prognostic Predictor in Lupus Nephritis Patients St. Sandra Karyati Serel; Yuyun Widaningsih; Fitriani Mangarengi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 3 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i3.2125

Abstract

Lupus Nephritis (LN) is a manifestation of Systemic Lupus Erythematosus (SLE), which targets the kidney. Based on histopathology, the World Health Organization divides the disease into five classes: normal pattern, mesangial, focal, diffuse proliferative, and membranous. Albumin to Globulin Ratio (AGR) compares serum albumin with serum globulin levels. Low AGR value is associated with poor prognosis of diseases such as cancer, liver cirrhosis, and other chronic inflammatory diseases such as LN. This study aimed to analyze the AGR value as a prognostic predictor in LN patients based on disease classes with a retrospective descriptive cross-sectional approach. Total subjects were 109, which consisted of class 1 (n=15), class 2 (n=37), class 3 (n=9), class 4 (n=21), and class 5 LN (n=27). Data of disease classes, serum albumin, and serum globulin/total protein levels were collected. SPSS version 25, Mann-Whitney, Kruskal-Wallis, Chi-Square, and Spearman's correlation test were used for statistical analysis. The ROC curve determined the cut-off. Test results were significant if p <0.05. The lowest mean AGR value (0.79) was found in class 4 LN (p<0.05). The optimal cut-off AGR was 1.10 to categorize mild-moderate and severe degrees. AGR prognostic value: sensitivity=95.8%; specificity=78.8%; Positive Prediction Value (PPV)=78.0%; Negative Prediction Value (NPV)=96.0%, accuracy = 86.2%. There was a negative strong correlation between the AGR value and LN class with a correlation coefficient R of -0.777 (p<0.001). AGR marker has a good sensitivity and specificity as a predictor of LN progression.
Correlation between PLR and NLR with Tumor Size in Breast Cancer Patients Sri Widyaningsih; Zelly Dia Rofinda
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 3 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i3.2199

Abstract

Breast cancer is the most common malignancy in females globally and one of the main causes of cancer death. There are several markers of cancer-related inflammation to help predict the relationship between pathologic characteristics of breast cancer. The research objective was to analyze the correlation between PLR and NLR with associated tumor size in breast cancer. This was a retrospective study with a cross-sectional design. This study used secondary data from the medical records of breast cancer patients who met the inclusion criteria at Siti Khodijah Hospital, Sidoarjo from January 2021 to March 2023. The sample size was 54 subjects, patients with breast cancer confirmed by pathology anatomy. The exclusion criteria were patients with infection, autoimmune disease, and hematology disorder. All the subjects were female. The mean age at the time of breast cancer diagnosis was 50.18±10.23 years, range of 27-80 years old. Most of the patients were over 50 years as much as 28 (51.85 %), while there were 26 (48.14%) > 50 years. The PLR range was  15.45-600.0, the NLR range was  0.58-9.98, tumor size range was 0.5-10.0 cm. Correlation between PLR and NLR with tumor size in breast cancer (p=0.351 and p=0.339). Correlation analysis showed that PLR and NLR had no significant correlation with tumor size ( r= -0.129, p=0.351 and r= -0.133, p=0.339). In conclusion, there is no significant correlation between PLR and NLR with histopathology of tumor size in patients with breast cancer.
Correlation between VCAM-1 Level and Absolute Monocyte Count in Coronary Artery Disease Anastasha Faustine; Andreas Arie Setiawan; Dwi Retnoningrum; Ariosta Ariosta
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 3 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i3.2201

Abstract

To prove the correlation between VCAM-1 level and absolute monocyte count among Coronary Artery Disease (CAD) patients. The study was an observational analytic study with a cross-sectional approach. The research subjects were 74 CAD patients who had been proven by coronary angiography and were treated in the Cardiology Department of Central General Hospital by Dr. Kariadi Semarang. This study was conducted from March to July 2021. VCAM-1 levels were examined with the ELISA method, using BioTek ELX800 Microplate reader (USA), and absolute monocyte count was analyzed with flow cytometry method, using Hematology Analyzer SYSMEX XN-1000 (Japan). Statistical analysis was done by Pearson's correlation coefficient test, in which p<0.05 was considered significant. The mean VCAM-1 level was (361.78±128.01) ng/mL. The mean absolute monocyte count was (0.48±0.17) ×103/µL. The result of the Pearson correlation test showed a moderate positive correlation between VCAM-1 levels and absolute monocyte count in CAD patients (p=0.00; r=0.46). There was a moderate positive correlation between VCAM-1 level and absolute monocyte count in CAD patients. A positive correlation exists between VCAM-1 level and absolute monocyte count among CAD patients.
Optimized Novel Antibacterial Production from Geobacillus kaustophilus Tm6T2 (a) as Treatment for Salmonella typhimurium Akeyla Tabina Tawangalun; Ani Melani Maskoen; Emma Rachmawati; Candra Arumimaniyah; Shinta Asarina; Ratu Safitri; Tri Yuliana
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 3 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i3.2202

Abstract

Geobacillus sp. is recognized for its potential to produce bacteriocins, antibacterial substances that hold promise in addressing gastrointestinal illnesses. This study aimed to optimize the medium and pH conditions for producing antibacterial substances by Geobacillus kaustophilus Tm6T2 (a). The research employed a descriptive and experimental methodology. Growth studies were conducted in Mueller Hinton Broth with CaCl2 and MgSO4 and Nutrient Broth with KCl and MgCl2 across 6, 7, and 8 pH values. Subsequently, antibacterial substance production was achieved at the late logarithmic phase and was assessed against the gastrointestinal pathogen Salmonella typhimurium. Interestingly, findings indicated that antibacterial substance production might not solely correlate with bacterial cell count. Despite a lower bacterial cell count, the highest inhibition zone against S.typhimurium was observed at 13.11 mm in NB salt at pH 8. Analytical results show that the variation of pH and both mediums significantly affects the presence of the inhibition zone (p < 0.10). This finding suggests the complexity of factors influencing antibacterial activity. Overall, the optimum condition for antibacterial production in G.kaustophilus Tm6T2(a) was identified at pH 8 using NB salt. These findings have potential implications for developing antibacterial solutions targeting gastrointestinal pathogens.
Correlation Glucose, Uric Acid, and Cholesterol Levels Towards Health Conditions in the Highlands: POCT Approach Arifa Mustika; Yetti Hernaningsih; Puspa Wardhani; Siti Khaerunnisa; Nastasya Nunki; Baiq Nasha Islaeli; Uli Mas'uliyah Indarwati; Musholli Himmatun Nabilah; Teguh Satrio; Alfino Validita Sidiq; Fita Triastuti; Mochammad Reza Desianto; Agil Saputra; Novi Ersanto; Widaninggar Rahma Putri; Desty Indah Sari
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 3 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i3.2203

Abstract

Degenerative diseases arise when age increases due to the weakening of the body's physiological condition. The purpose of this study was to measure glucose, uric acid, and cholesterol levels in residents of Segunung Village to improve lifestyles and quality of life. As many as 110 residents of Segunung Village were used as subjects in this cross-sectional study. Glucose, uric acid, and cholesterol levels were measured using Point of Care Testing (POCT). A cut-off value of <200 was used to define high cholesterol levels. Only cholesterol levels showed an increase when compared with reference values, while glucose and uric acid levels were normal. Interestingly glucose was significantly correlated with age (r=0.309, p=0.001). The approach using POCT describes the overall condition of Segunung villagers and can be used as a basis for glucose, uric acid, and cholesterol screening tests.
Susceptibility Pattern, Genotyping, and Mutations of Klebsiella pneumoniae at Dr. H. Abdul Moeloek General Hospital Hidayat Hidayat; Ida Parwati; Eko Agus Srianto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 3 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i3.2206

Abstract

Klebsiella pneumoniae is one of the most common causes of severe hospital-acquired infection. ESBL-producing Klebsiella pneumoniae causes a major problem for clinical management and epidemiological study. The other factor identified was OmpK35 which is often poorly or not expressed and it can be altered by factors such as point mutations. This study aimed to determine the susceptibility pattern, and the genotyping and to investigate the mutations in OmpK35 of Klebsiella.pneumoniae. This is a cross-sectional study using susceptibility pattern data from the ninety isolates of Klebsiella pneumoniae from the patients admitted to Dr. H. Abdul Moeloek General Hospital, Lampung. The Genotype of ESBL genes and OmpK35 gene were determined by polymerase chain reaction and sequencing for identification of the mutation. The susceptibility rate of Klebsiella pneumoniae belonged to Ampicillin was 0%. The susceptibility rate belonged to Amikacin (96.6%), Meropenem (94.4%), and Ertapenem (94.4%).  From 90 isolates, the genotype blaSHV was found in 86.7%, and most of the isolates had OmpK35 genes (91.2%). Among the thirty isolates, 20% harbored mutations in the OmpK35 protein with substitution mutations. This finding indicated a high prevalence of antibiotic resistance, a high prevalence rate of ESBL gene production, and a high frequency of porin mutations among Klebsiella pneumoniae isolates.
Carbapenem Susceptibility Rate Against Gram-Positive and Gram-Negative Bacteria and Its Correlation with Consumption George Arthur Mantiri; Rheza Paleva Uyanto; Meita Hendrianingtyas
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 3 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i3.2207

Abstract

Antibiotic susceptibility is significant in patient management and needs close monitoring. This study aims to evaluate the Carbapenem susceptibility profiles and correlation between Carbapenem consumption and susceptibility of the most frequent isolates from blood, sputum, and urine in 2020–2022 from the non-intensive inpatients. The proportion of males and females was 54% and 46%, with the median age group of males and females both being 65-74 years. Higher Meropenem susceptibility was shown in urine isolates of female patients. Lower susceptibility to Meropenem was shown in 2021 compared to 2020 and 2022. Lower susceptibility was shown in isolates from sputum compared to blood and urine. The three-year susceptibility of Carbapenem was decreased compared to 3 years before. The susceptibility of E.coli and S.aureus to Meropenem showed relatively high proportions 95% and 88%, compared to K.pneumoniae (46%), A.baumanii (30%), P.aeruginosa (29%), and others.  The susceptibility of isolates from non-intensive-care inpatients in 2020-2022 showed lower rates compared to the hospital-wide and the previous three years' rates. Meropenem consumption was highest compared to Imipenem with inhibitor and Doripenem. The susceptibility of Gram-negative rods to Meropenem showed higher proportions (58.9%) compared to Gram-positive cocci (26.2%). Carbapenem susceptibility was decreased, along with increased Carbapenem consumption but no significant statistical correlation between the susceptibility rates and the monthly defined daily dose.
Distribution of SARS-CoV-2 Variants in West Java Based on Genomic Surveillance Data, 2021-2022 Cut Nur Cinthia Alamanda; Ida Parwati; Gusti Ayu Prani Pradani; Azzania Fibriani
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 3 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i3.2209

Abstract

Coronavirus Disease 19 (COVID-19), the disease caused by SARS-CoV-2, was declared a pandemic in early 2020. With the emergence of different strains of SARS-CoV-2 mutations, efforts to reduce infection rates and help vulnerable populations remain in question. Genomic surveillance has been carried out on COVID-19 cases to detect new variants and monitor trends in circulating variants. Genomic surveillance is important because it can detect virus characteristics, estimate the prevalence of specific variants in the community, assess the extent to which medication can combat the variants, and analyze virus transmission in outbreaks. The purpose of this study was to investigate the prevalence of SARS-CoV-2 genomic variants in West Java and to inform policymakers in developing strategies to reduce the transmission rate of the SARS-CoV-2 virus. According to the inclusion criteria, variant sequence data were acquired from Global Initiative on Sharing All Influenza Data (GISAID) for the period January 1st, 2021-December 31st, 2022 and evaluated cross-sectional descriptively. This data were obtained from West Java. The majority of the samples came from Bandung Regency, where the Delta (AY), BA1 and BA5 variations predominated. The dynamic of the SARS-CoV-2 cases was influenced by government policies such as imposition of the restriction on community activities and public holiday. Because SARS-CoV-2 is subject to mutations, the various varieties must still be monitored to determine the influence on society. In the future, surveillance for any microorganisms with the potential to cause epidemics is urgently needed in order to mitigate the spread of the disease.

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